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11	Neurotoxicity of root canal medicaments a thesis submitted in partial fulfillment ... endodontics / Schippers, Douglas John. January 1986 (has links) Thesis (M.S.)--University of Michigan, 1986.
12	A patient utility analysis of treatment modalities for a single non-vital tooth Barbat, Sahar Syoufjy. January 2007 (has links) Thesis (M.S.)--University of Michigan, 2007. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 40-42, 81-83).
13	Die klinische Behandlung von Zahn- u. Kieferkrankenheiten unter besonderer Berücksichtigung der Tätigkeit der Westdeutschen Kieferklinik in Düsseldorf / Heesen, Josef. January 1933 (has links) Thesis (doctoral)--Münster, 1933.
14	Neurotoxicity of root canal medicaments a thesis submitted in partial fulfillment ... endodontics / Schippers, Douglas John. January 1986 (has links) Thesis (M.S.)--University of Michigan, 1986.
15	Achados clínicos de afecções orais em bugios ruivos (Alouatta guariba clamitans) (Cabrera, 1940) Dias Neto, Ramiro das Neves [UNESP] 16 July 2014 (has links) (PDF) Made available in DSpace on 2014-11-10T11:09:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-07-16Bitstream added on 2014-11-10T11:57:44Z : No. of bitstreams: 1 000789727_20150716.pdf: 366218 bytes, checksum: 4deff4d8086255dc15b393f1a1be9d06 (MD5) Bitstreams deleted on 2015-08-03T12:21:08Z: 000789727_20150716.pdf,. Added 1 bitstream(s) on 2015-08-03T12:22:21Z : No. of bitstreams: 1 000789727.pdf: 974732 bytes, checksum: 189352ee65332c2853b0f0f894bdc0cd (MD5) / O objetivo deste estudo foi investigar problemas dentários de bugios-ruivos (Alouatta guariba clamitans) mantidos em cativeiro. A hipótese é que a identificação e diagnóstico das afecções podem contribuir para o controle e prevenção de lesões orais. Foram estudados dezesseis bugios-ruivos (Alouatta guariba clamitans), oito fêmeas e oito machos, pesando entre 3,9 a 6,8 quilogramas. Sob anestesia geral, a cavidade oral e os dentes foram avaliadas por inspeção visual, palpação, sondagem e exame radiográfico intraoral. Os resultados foram registrados em odontogramas específicos para primatas. Dos 16 primatas avaliados no presente estudo, 88% (n = 14) apresentaram algum tipo de distúrbio dental. As afecções observadas foram cálculo dentário (88%), desgaste dentário (81%), ausência dentária (38%), a gengivite (19%), retração gengival (6%), fratura dentária (19%), exposição de polpa (19%) e escurecimento dental (25%). Alouatta guariba clamitans mantidos em cativeiro têm alto índice de problemas dentários / The aim of this study was to investigate dental disorders of Brown howler monkeys (Alouatta guariba clamitans) maintained in captivity. The hypothesis is that the identification and diagnosis of the lesions may contribute to control and prevention. Sixteen intact red howler monkeys (Alouatta guariba clamitans), 8 females and 8 males, weighing from 3.9 to 6.8 kg were studied. Under general anesthesia, the teeth were evaluated by visual inspection, probing, palpation, and intraoral radiographic exam. The findings were registered on dental chart specific for primates. From the 16 monkeys evaluated in the present study, 88% (n=14) had some type of dental disorder. The lesions observed were dental calculus (88%), dental wear (81%), missing tooth (38%), gingivitis (19%), gingival recession (6%), dental fracture (19%), pulp exposition (19%), and dental staining (25%). Alouatta guariba clamitans maintained in captivity have high rate of dental problems Guariba (Macaco) Dentes - Doenças - Tratamento Tratamento dentario Manifestações orais de doenças Dental therapeutics
16	Achados clínicos de afecções orais em bugios ruivos (Alouatta guariba clamitans) (Cabrera, 1940) / Dias Neto, Ramiro das Neves. January 2014 (has links) Orientador: Carlos Roberto Teixeira / Banca: Sheila Canevese Rahal / Banca: Elisangela Perez Freitas / Resumo: O objetivo deste estudo foi investigar problemas dentários de bugios-ruivos (Alouatta guariba clamitans) mantidos em cativeiro. A hipótese é que a identificação e diagnóstico das afecções podem contribuir para o controle e prevenção de lesões orais. Foram estudados dezesseis bugios-ruivos (Alouatta guariba clamitans), oito fêmeas e oito machos, pesando entre 3,9 a 6,8 quilogramas. Sob anestesia geral, a cavidade oral e os dentes foram avaliadas por inspeção visual, palpação, sondagem e exame radiográfico intraoral. Os resultados foram registrados em odontogramas específicos para primatas. Dos 16 primatas avaliados no presente estudo, 88% (n = 14) apresentaram algum tipo de distúrbio dental. As afecções observadas foram cálculo dentário (88%), desgaste dentário (81%), ausência dentária (38%), a gengivite (19%), retração gengival (6%), fratura dentária (19%), exposição de polpa (19%) e escurecimento dental (25%). Alouatta guariba clamitans mantidos em cativeiro têm alto índice de problemas dentários / Abstract: The aim of this study was to investigate dental disorders of Brown howler monkeys (Alouatta guariba clamitans) maintained in captivity. The hypothesis is that the identification and diagnosis of the lesions may contribute to control and prevention. Sixteen intact red howler monkeys (Alouatta guariba clamitans), 8 females and 8 males, weighing from 3.9 to 6.8 kg were studied. Under general anesthesia, the teeth were evaluated by visual inspection, probing, palpation, and intraoral radiographic exam. The findings were registered on dental chart specific for primates. From the 16 monkeys evaluated in the present study, 88% (n=14) had some type of dental disorder. The lesions observed were dental calculus (88%), dental wear (81%), missing tooth (38%), gingivitis (19%), gingival recession (6%), dental fracture (19%), pulp exposition (19%), and dental staining (25%). Alouatta guariba clamitans maintained in captivity have high rate of dental problems / Mestre Bugio. Dente - Doenças - Tratamento. Tratamento dentario. Manifestações orais de doenças. Dental therapeutics
17	Iodo povidine associado a instrumentação periodontal no tratamento de lesões de bifurcação : avaliações clinica e bioquimica / Providone-iodine used as an adjunct to non-surgical treatment of furcation involvements Ribeiro, Erica Del Peloso 23 February 2005 (has links) Orientadores: Marcio Zaffalon Casati, Sergio de Toledo / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-04T05:05:03Z (GMT). No. of bitstreams: 1 Ribeiro_EricaDelPeloso_M.pdf: 1796294 bytes, checksum: 9bd1ed49b1a4f14b073dca3cf4bbb7e2 (MD5) Previous issue date: 2005 / Resumo: O objetivo do presente estudo foi avaliar a ação de uma solução de iodo povidine (PVP-I), associada à raspagem e alisamento radicular, no tratamento de lesões de bifurcação. Foram selecionados 44 pacientes com pelo menos um molar com lesão de bifurcação classe II, em face livre, profundidade de sondagem ³ 5 mm e sangramento à sondagem. Os pacientes foram divididos aleatoriamente em 2 grupos: grupo controle - raspagem e alisamento radicular com ultra-som e água destilada como solução refrigerante; grupo teste - raspagem e alisamento radicular com ultra-som e PVP-I 10% como solução refrigerante. Foram avaliados os seguintes parâmetros clínicos: índice de placa (IP), sangramento à sondagem (SS), posição da margem gengival (PMG), nível clínico de inserção relativo (NICr), profundidade de sondagem (PS) e nível clínico de inserção horizontal relativo (NICHr). A avaliação bioquímica da atividade de enzimas tipo tripsina no biofilme subgengival foi feita pelo teste BAPNA. Os parâmetros descritos acima foram avaliados antes do tratamento, 1, 3 e 6 meses após. Ambos os grupos apresentaram médias semelhantes de redução da PS, ganho de NICr e de NICHr. Aos 6 meses, esses valores foram, respectivamente, 2,31 mm, 1,17 mm e 1,00 mm no grupo controle e 2,31 mm, 1,23 mm e 1,02 mm no grupo teste (p>0,05). Diferença estatisticamente significante também não foi observada entre os grupos quanto ao número de sítios que ganharam 2 mm ou mais de inserção. Aos 6 meses, os grupos controle e teste apresentaram, respectivamente, 45,16% e 30,77% das áreas com ganho de inserção = 2 mm. Na comparação entre os grupos quanto ao SS das lesões de bifurcação aos 6 meses e à quantidade de áreas que exigiram retratamento no 3° mês foi encontrado p=0,06, favorecendo o grupo teste. O teste BAPNA não detectou diferença entre os grupos, entretanto, foi observada diferença intra-grupo, indicando redução na atividade de enzimas do tipo tripsina. Pôde-se concluir que o PVP-I, usado como adjunto da instrumentação periodontal traz benefícios clinicamente significantes ao tratamento de lesões de bifurcação classe II, em faces livres / Abstract: The aim of this randomized single-blind controlled clinical trial was to evaluate the effect of topically applied povidone-iodine (PVP-I), used as an adjunct to non-surgical therapy of furcation involvements. Forty-four patients presenting at least one class II furcation involvement that bled on probing, in bucal or lingual surfaces, with probing pocket depth ³ 5 mm were recruited. Patients were stratified into 2 treatment groups: subgingival instrumentation by an ultrasonic device using PVP-I (10%) as the cooling liquid (test group); identical treatment using distilled water as the cooling liquid (control group). The following clinical outcomes were evaluated: plaque index, bleeding on probing (BOP), position of the gingival margin, relative attachment level (RAL), probing pocket depth (PPD) and relative horizontal attachment level (RHAL). BAPNA test was used to analysis the trypsin-like activity in dental biofilm. The clinical and biochemical parameters were evaluated at baseline and 1, 3 and 6 months after therapy. Both groups had similar means of PPD reduction and RAL and RHAL gain. At 6 months, these variables were, respectively, 2.31 mm, 1.17 mm and 1.00 mm in the control group and 2.31 mm, 1.23 mm and 1.02 mm in the test group (p<0.05). No differences were observed in terms of the frequency distribution of sites demonstrating RAL gain ³ 2 mm. The comparison between groups on BOP of the furcation sites, at 6 months and on the number of sites referred for re-treatment at 3 months showed better values in the test group (p=0.06). The results of BAPNA test failed to demonstrate significant differences between groups. The use of topically applied PVP-I with subgingival instrumentation may provide additional clinical significant benefits to the treatment of class II furcation involvements / Mestrado / Periodontia / Mestre em Clínica Odontológica Dentes - Forqueadura - Raizes Assistência odontológica Iodo Periodontite Teeth - Roots - Furcation Dental therapeutics Iodine Periodontitis
18	Avaliação de doses em órgãos radiossensíveis expostos durante exames de tomografia computadorizada por feixe cônico e radiografia panorâmica / Dosimetry of radiosensitive organs exposed during cone beam computed tomography and panoramic radiograph Heiden, Katia Regina 07 October 2016 (has links) A radiografia panorâmica e a tomografia computadorizada por feixe cônico (TCFC) são métodos de imagem amplamente utilizados na Odontologia, pois fornecem uma visão geral do complexo dentomaxilofacial, sendo importantes no diagnóstico e tratamento de lesões que acometem esta região. A radiografia panorâmica é considerada um procedimento de baixa dose e a TCFC apresenta doses inferiores quando comparada à tomografia computadorizada (TC). Apesar de baixas, as doses provenientes destes exames expõem órgãos radiossensíveis, como tireoide e glândulas salivares, aos riscos da radiação ionizante. Conhecer os níveis de radiação à que estes órgãos estão expostos é importante para a escolha adequada do método de imagem e parâmetros de exposição a serem utilizados, reduzindo os riscos associados à radiação ionizante, conforme o princípio de radioproteção ALARA (As Low As a Reasonably Achievable - tão baixo quanto razoavelmente exequível). O objetivo deste estudo foi avaliar as doses absorvidas por estes órgãos radiossensíveis durante a realização de radiografias panorâmicas e exames de TCFC, utilizando diferentes parâmetros de exposição. Dosímetros termoluminescentes (TLDs - Thermoluminescent Dosimeters) foram inseridos em um phantom antropomórfico Alderson Radiation Therapy (ART) para identificar as doses absorvidas pela tireoide e glândulas salivares, em um equipamento de radiografia panorâmica e dois equipamentos de TCFC, com diferentes protocolos. As doses absorvidas variaram de 0,01 a 0,22 mGy na tireoide e de 0,26 a 2,96 mGy nas glândulas salivares. Na TCFC as doses variaram de acordo com o protocolo selecionado, porém foram superiores às doses de uma radiografia panorâmica. Os protocolos de TCFC que utilizaram longos tempos de exposição, considerados como protocolos de alta resolução, resultaram em doses superiores quando comparados aos protocolos que utilizaram baixos tempos de exposição. Protocolos que utilizaram campos de visão (FOVs - Fields Of View) maiores, expuseram a tireoide a níveis mais altos de radiação. Diante dos resultados obtidos, pode-se concluir que a TCFC somente deve ser solicitada caso a informação diagnóstica não possa ser obtida através da radiografia panorâmica, sendo a escolha adequada dos fatores técnicos imprescindível para reduzir a dose de radiação durante a realização de exames de TCFC. / Panoramic radiograph and cone beam computed tomography (CBCT) are imaging methods widely used in dentistry because they provide an overview of dentomaxillofacial complex, being important in the diagnosis and treatment of lesions that affect this region. Panoramic radiograph is considered a low-dose procedure and CBCT presents lower doses when compared with computed tomography (CT). Although low, the doses from these imaging methods expose radiosensitive organs, such as thyroid and salivary glands, to the risks of ionizing radiation. Knowing the levels of radiation these organs are exposed is important to select the appropiate imaging method and exposure parameters to be used, reducing the risks associated with ionizing radiation, according to the principle of radioprotection ALARA (As Low As a Reasonably Achievable). The aim of this study was to evaluate the absorbed doses by these radiosensitive organs during the course of panoramic radiographs and CBCT examinations, using different exposure parameters. Thermoluminescent dosimeters (TLDs) were inserted into an anthropomorphic phantom Alderson Radiation Therapy (ART) to identify the absorbed doses by the thyroid and salivary glands, in a panoramic x-ray unit and two CBCT units with different protocols. Absorbed doses ranged from 0.01 to 0.22 mGy in the thyroid and 0.26 to 2.96 mGy in the salivary glands. Doses in CBCT varied according to the selected protocol, but were higher than the dose of a panoramic radiograph. The CBCT protocols that used long exposure times, considered as high-resolution protocols, resulted in higher doses compared to protocols that used low exposure times. Protocols that used fields of view (FOVs) higher, exposed the thyroid at higher levels of radiation. Based on the results obtained, it can be concluded that CBCT should only be requested if the diagnostic information can’t be obtained through the panoramic radiograph and the appropriate choice of technical factors essential to reduce the radiation dose during examinations CBCT. Radiografia panorâmica Radiação ionizante Radiação Dosímetros Dentes - Radiografia Tratamento odontológico Engenharia biomédica Radiography, Panoramic Ionizing radiation Radiation Dosimeters Teeth - Radiography Dental therapeutics Biomedical engineering Engenharia Biomédica
19	TARGETED DELIVERY OF BONE ANABOLICS TO BONE FRACTURES FOR ACCELERATED HEALING Jeffery J H Nielsen (8787002) 21 June 2022 (has links) <div>Delayed fracture healing is a major health issue involved with aging. Therefore, strategies to improve the pace of repair and prevent non-union are needed in order to improve patient outcomes and lower healthcare costs. In order to accelerate bone fracture healing noninvasively, we sought to develop a drug delivery system that could safely and effectively be used to deliver therapeutics to the site of a bone fracture. We elected to pursue the promising strategy of using small-molecule drug conjugates that deliver therapeutics to bone in an attempt to increase the efficacy and safety of drugs for treating bone-related diseases.</div><div>This strategy also opened the door for new methods of administering drugs. Traditionally, administering bone anabolic agents to treat bone fractures has relied entirely on local surgical application. However, because it is so invasive, this method’s use and development has been limited. By conjugating bone anabolic agents to bone-homing molecules, bone fracture treatment can be performed through minimally invasive subcutaneous administration. The exposure of raw hydroxyapatite that occurs with a bone fracture allows these high-affinity molecules to chelate the calcium component of hydroxyapatite and localize primarily to the fracture site.</div><div>Many bone-homing molecules (such as bisphosphonates and tetracycline targeting) have been developed to treat osteoporosis. However, many of these molecules have toxicity associated with them. We have found that short oligopeptides of acidic amino acids can localize to bone fractures with high selectivity and with very low toxicity compared to bisphosphonates and tetracyclines.</div><div>We have also demonstrated that these molecules can be used to target peptides of all chemical classes: hydrophobic, neutral, cationic, anionic, short, and long. This ability is particularly useful because many bone anabolics are peptidic in nature. We have found that acidic oligopeptides have better persistence at the site of the fracture than bisphosphonate-targeted therapeutics. This method allows for a systemic administration of bone anabolics to treat bone fractures, which it achieves by accumulating the bone anabolic at the fracture site. It also opens the door for a new way of treating the prevalent afflictions of broken bones and the deaths associated with them.</div><div>We further developed this technology by using it to deliver anabolic peptides derived from growth factors, angiogenic agents, neuropeptides, and extracellular matrix fragments. We found several promising therapeutics that accelerated the healing of bone fractures by improving the mineralization of the callus and improving the overall strength. We optimized the performance of these molecules by improving their stability, targeting ligands, linkers, dose, and dosing frequency.</div><div>We also found that these therapeutics could be used to accelerate bone fracture repair even in the presence of severe comorbidities (such as diabetes and osteoporosis) that typically slow the repair process. We found that, unlike the currently approved therapeutic for fracture healing (BMP2), our therapeutics improved functionality and reduced pain in addition to strengthening the bone. These optimized targeted bone anabolics were not only effective at healing bone fractures but they also demonstrated that they could be used to speed up spinal fusion. Additionally, we demonstrated that acidic oligopeptides have potential to be used to treat other bone diseases with damaged bone.</div><div>With these targeted therapeutics, we no longer have to limit bone fracture healing to casts or invasive surgeries. Rather, we can apply these promising therapeutics that can be administered non-invasively to augment existing orthopedic practices. As these therapeutics move into clinical development, we anticipate that they will be able to reduce the immobilization time that is the source of so many of the deadly complications associated with bone fracture healing, particularly in the elderly.</div> Genetics not elsewhere classified Nanobiotechnology Animal behaviour Clinical microbiology Endocrinology Nanomedicine Regenerative medicine (incl. stem cells) Solid state chemistry Molecular medicine Proteins and peptides Solution chemistry Radiation and matter Biomaterials Biomechanical engineering bone fracture healing Anabolic Agents/pharmacology Targeted Drug DeliveryDesign Bone fracture targeted drugs Bone theapeutics targeted therapies Growth factors Neuropepetides Extracellular matrix Extracellular matrix fragments spinal fusion Angiogensis Acidic oligopeptides osteoporosic fractures diabetic bone fractures Integrin alpha 5 Acelerated Bone fracture healing Hydroxyapatite Hydroxyapatite targeting Targeting peptides Peptide drugs osteomyelitis (OM) Rheumatoid arthritis Bone fractures osteogenic therapies osteotropic osteotropic nanomedicines osteoinductive capacity Molecular Medicine Organic Chemistry Proteins and Peptides Radiochemistry Solid State Chemistry Solution Chemistry Biochemistry Animal Behaviour Biological Engineering Biotechnology Genetics Medicine Pharmacology Biomaterials Biomechanical Engineering Biomechanics Endocrinology Nanobiotechnology Nanomedicine

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