Orientador: Fernanda Klein Marcondes / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-08T02:16:22Z (GMT). No. of bitstreams: 1 Rocha_VanessadeMoraes_M.pdf: 1061559 bytes, checksum: 4455455a00850fa30a24f9a89ea8dd5e (MD5) Previous issue date: 2006 / Resumo: Os esteróides androgênicos anabólicos (EAA) são usados no tratamento de hipogonadismo masculino, andropausa associada ao envelhecimento, osteoporose, anemia associada à doença renal crônica, síndrome de imunodeficiência adquirida, politraumatismo e em períodos pós-operatórios. Porém, o uso de EAA, com finalidades não¿terapêuticas, e em altas doses, apresenta graves efeitos colaterais que incluem alterações de humor, agressividade e aumento da incidência de suicídios. O objetivo deste estudo foi avaliar o efeito do decanoato de nandrolona sobre o nível de ansiedade de ratos. Ratos machos Wistar, com 2 meses de idade foram aleatoriamente divididos em 6 grupos (n = 12- 15/grupo): controle, veículo, nandrolona, controle + diazepam, veículo + diazepam e nandrolona + diazepam. Animais tratados com veículo ou nandrolona receberam administração de propilenoglicol (0,2 mL/ Kg i.m.)ou decanoato de nandrolona (5mg/Kg i.m.), respectivamente, 2 vezes por semana, durante 6 semanas. Ratos do grupo controle foram submetidos somente aos procedimentos relacionados à rotina do biotério. No fim de 6 semanas, todos os grupos foram submetidos ao teste do LCE, 24 h após a última administração de veículo ou nandrolona, ou período equivalente para o grupo controle. Para validação farmacológica dos resultados comportamentais, alguns animais foram tratados com diazepam (1mg/Kg i.p.), 30 min antes do teste comportamental. Os resultados foram comparados por análise de variância, e teste de Tukey (p<0,05). Animais tratados com o nandrolona apresentaram menor porcentagem de tempo nos braços abertos (1,46 ± 0,90) quando comparados àqueles tratados com veículo (3,96 ± 0,85) e controles (3,80 ± 0,97 %). O grupo tratado com nandrolona também apresentou menor porcentagem de entradas nos braços abertos (6,00 ± 1,67) em relação aos grupos veículo (15,06 ± 2,80) e controle (16,75 ± 3,30 %). Contudo, a nandrolona não promoveu alteração no número de entradas nos braços fechados, na avaliação de risco e no número de idas ao final dos braços abertos. O tratamento com diazepam reverteu os efeitos causados pela nandrolona na porcentagem de tempo e no número de entradas nos braços abertos. Estes dados sugerem que o decanoato de nandrolona induziu aumento no nível de ansiedade em ratos de laboratório / Abstract: Androgenic anabolic steroids (AAS) are used for the treatment of male hypogonadism, andropause associated with elderly, osteoporosis, anemia associated with kidney failure, acquired immunodeficiency disease syndrome, politraumatism and postsurgery periods. However, the AAS abuse and non-therapeutic use, in higher doses show side effects, including mood alteractions, aggressiveness and higher suicide incidence. The aim of this study was to evaluate the nandrolone decanoate effect on the anxiety levels in rats. Male Wistar rats (2 mo.) were randomly divided into 6 groups (n = 12-15/groups: control, vehicle, nandrolone, control + diazepam, vehicle + diazepam, and nandrolone + diazepam. The vehicle or nandrolone treated animals received injection of propilenglycol (0,2mL/Kg, i.m.) or nandrolone decanoate (0,5 mg/Kg i.m.), respectively, twice a week, for 6 weeks. Control group rats were subject only to procedures related to their routine living conditions. By the end of 6 weeks, all groups were submitted to the elevated pluz maze (EPM), 24 hours after the last vehicle or nandrolone injection, or equivalent period for the control group. In order to pharmacological validation, some animals were treated with diazepam (1 mg/Kg i.p.) 30 min before the EPM. Data were analyzed by Two-way ANOVA and post-hoc Tukey test (p<0,05). Nandrolone treated animals showed less percentage of time spent in the open arms (1.46 ± 0.49) compared with control (3.80 ± 0.97) and vehicle (3.96 ± 0.85 %) groups. Nandrolone treated animals also showed less percentage of open arms entries (6,00 ± 1,67) in relation to vehicles groups (15,06 ± 2,80) and control groups (16,75 ± 3,30 %). However, nandrolone did not promote any changes in enclosed arms entries, risk assessment and final open arms end- exploring. Diazepam treatment reverted the effects of nandrolone in the time and entries percentage in the open arms. The present data showed that the treatment with a high dose of nandrolone decanoate induced an increase in the anxiety level in rats / Mestrado / Fisiologia Oral / Mestre em Odontologia

Orientadores: Luiz Manoel Aleixo, Oswaldo E. S. Godinho / Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica / Made available in DSpace on 2018-07-23T06:59:49Z (GMT). No. of bitstreams: 1 Gomes_SandraTerezinhaMarques_D.pdf: 3400371 bytes, checksum: f579f07964f5142b6020fa1c3dd23fc8 (MD5) Previous issue date: 1997 / Doutorado

No description available.

One hundred patients who were to have cataract extraction and intraocular lens replacement carried out were randomly assigned to one of two drug groups. The purpose was to compare droperidol/ fentanyl and diazepam/fentanyl for the following effects: central nervous system depression, cardiovascular depression and ability to alleviate anxiety. Patients, psychology observes, and surgeons were not cognizant of others' opionons, nor of assignment of drug treatment group. Experimental design was a between group single treatment design. Psychological testing consisted of State-Trait Anxiety Inventory of Spielberger, Gorsuch and Lushene, and the Sensory/Affect ratio pain descriptors of Gracely, Dubner and McGrath. Opinion of ease of carrying out the surgical procedure was obtained from the surgeon, and opinion of the anaesthetic outcome was obtained from the anaesthetist. While both drug combinations proved to be successful for use as a sedative adjunct to local anaesthetic for this type of surgical procedure some differences were found. Patients found the diazepam/ fentanyl combination provided for a less intense overall procedure, and had little if any recall of the procedure. The surgeons also found the patients less restless in the diazepam/fentanyl group. Anaesthetists rated the level of sedation as equivalent for both groups and found there was not a significant difference between the amount of sedation they observed. / Dentistry, Faculty of / Graduate

Thesis (M.S.)--University of Michigan, 1981.

Thesis (M.S.)--University of Michigan, 1981.

Assay methods have been developed which are specific for the analysis of diazepam in the presence of formulation excipients, closely related degradation products and manufacturing impurities. The methods developed used difference ultraviolet spectrophotometry and HPLC. These methods have been applied to the analysis of diazepam in formulations and to investigate the reaction kinetics of the acid hydrolysis of diazepam. From analysis of both fresh and stored samples of formulations, it was seen that solid dosage forms showed no degradation, but degradation products were detected in liquid formulations. Advantages and disadvantages were seen for both techniques and criteria were established for the choice of method. The reaction kinetics of the degradation of diazepam was studied, using HPLC and GC. Previous workers had investigated the acid hydrolysis of diazepam using non-specific analytical methods. An attempt was made to repeat their work using the specific chromatographic methods described. From initial work, it appears that the results obtained are similar to those previously generated. Further work is required to investigate this more fully.

Proefschrift Maastricht. / Lit. opg. - Met een samenvatting in het Nederlands.

Orientador: Jaime Aparecido Cury / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-07-14T04:04:25Z (GMT). No. of bitstreams: 1 Silva_FredericoAndradee_D.pdf: 1287739 bytes, checksum: 50d7be71d9f7ffdbb0dfa042aa377c81 (MD5) Previous issue date: 1989 / Resumo: Uma série de medicamentos podem modificar o fluxo salivar e provocar xerostomia com efeitos indesejáveis à cavidade bucal. Dentre estas drogas encontram-se os antidepressivos largamente utilizados pela população. Procurou-se neste trabalho estudar o efeito da administração crônica de diazepam (valium) nas propriedades das glândulas salivares de ratos. Foram utilizados 115 ratos de 21 dias de idade divididos em dois grupos, que receberam injeção diária de diazepam na dose de 0,28 mg/kg (Grupo Experimental) e NaCI a 0,9% (Grupo Controle). Após 30 dias analisou-se a saliva dos animais em termos de fluxo e concentração protéica. Nas glândulas submandibulares determinou-se a concentração de glicogênio, a atividade de glucose-6-fosfato desidrogenase e o quociente metabólico do tecido. Procurou-se também estudar o efeito da droga no crescimento dos animais. Os resultados mostraram que a única diferença significativa observada foi a diminuição do fluxo salivar dos animais que receberam a droga estudada, sugerindo que o diazepam mesmo utilizado cronicamente não afeta o metabolismo das glândulas salivares / Abstract: The flow of saliva plays a role in the pathogenesis of dental caries. Xerostomia induced by drugs can increase dental caries. ln this research we studied the effect of a sedative hypnotic drug (diazepan in rats salivary glands). It were used 115 rats with 21 days years old. The rats received daily injection of diazepan (0,28mg/kg) or NaCl 0,9% during 30 days. The salivary flow rate and saliva protein concentration were analysed. The glycogen concentration G6PD activity and the metabolic quocient were determined in the submandibular glands. The results showed that the only significative diffference was a decrease in the flow of saliva when the rats received diazepan. It was sugested that the chronic administration of diazepan does¿nt change the metabolism but inhibit its secretion rate / Doutorado / Farmacologia / Doutor em Odontologia

Orientador : Neury Jose Botega / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-07-31T19:14:53Z (GMT). No. of bitstreams: 1 Ribeiro_CarmenSylvia_M.pdf: 23696444 bytes, checksum: 9a057eb3e2a9fc3eb6252466beeda5e9 (MD5) Previous issue date: 2001 / Resumo: o objetivo desta pesquisa é investigar aspectos relacionados ao uso crônico de benzodiazepínicos, no caso, o diazepam. Foram estudados 41 pacientes, provenientes de selViços de atenção primária á saúde em Campinas, e que receberam prescrição desse fármacopor tempo mínimo de 3 anos. o estudo foi delineado em duas fases. Na primeira fase, através de exame de registros, investigamos variáveis relacionadas ao consumo de diazepam, focalizandomaior atenção sobre as doses utilizadas e sobre a origem da prescrição, particularmente quanto à especialidade do médico prescritor. Na segunda fase, estudo de campo, os pacientes foram submetidos à instrumentos psiquiátricos tais como: escala hospitalar de ansiedade e depressão (HAD)e Schedule for Clínical Assessment in Neuropsychiatry (SCAN), e instrumentos específicos para investigação de dados sociodemográficos da Associação Brasileira dos Estudos de Pesquisa de Mercado (ABIPEME).O padrão de uso de diazepam foi investigado atravésde uma entrevista semi-estruturada elaborada para estudar as seguintes variáveis: razões para o uso, efeitos da droga, alternativas para lidar com problemas emocionais sem uso de diazepam, percepções dos pacientes sobre atitudes de seus prescritores, tentativas de intelTompero consumo e sintomas de abstinência, entre outras. Nossos resultados demonstraram que usuários crônicos, em nosso meio, são mulheres, brancas, entre 50-69 anos, de baixa escolaridade, situação econômica desfavorável, que vivem sem companheiros e apresentam quadros depressivos subdiagnosticados, inapropriadamente tratados com benzodiazepínicos. Não houve tendência ao aumento progressivo de doses e a continuidade do consumo deveu-se, na maioria dos casos, a uma grande dificuldade para abandonar o uso devido ao temor em relação às reações de abstinência. Através da escala HAD, detectamos 64% de casos suspeitos de ansiedade, e 69,2% de casos suspeitos de depressão. Em relação aos diagnósticos estabelecidos pelo SCAN, identificamos transtornos depressivos em 63,4% dos casos, dependência de substâncias psicoativas em 29,6% dos casos, e transtornos do sono em 14,6% dos casos. Entre os demais diagnósticos, estabelecidos por esse critério, encontramos casos de transtornos de ansiedade (7,3%), somatoformes(7,3%), e outros emmenor proporção. Nossas conclusões apontam para a ausência de instrumentos diagnósticos específicos para estudar dependência de BDZ em nosso meio, e para a importância dos órgãos públicos de saúde incentivarem programas de intervenção sobre o uso crônico de BDZ, através de orientação de pacientes e profissionais da equipe de saúde / Abstract: The aim of this research waS to investigate aspects related to long-term use of BDZ. For this, we studied 41 outpatients ITomprimary care services in Campinas who had been taking prescribed benzodiazepines (BDZ) daily for a rninimumof 3 years. Our study was divided in two parts. First, we investigated the chronic use of medication, through examination of patient records, focusing on dosage and origin of prescription. On the second part of the study, sociodemographic details were collected using specific criteria (ABIPEME - Brazilian Association for Market Survey Studies). The patients were submitted to an investigation about associated diagnosis using structured psychiatric instruments (HAD - Hospital Anxiety and Depression Scale and SCAN - Schedule for ClínicalAssessment in Neuropsychiatry). The pattem of diazepam use and the drug effects on the subjects was examined using a semistructured interview designed to cover the following areas: reasons for use, drug effects, ways of managing their daily lives apart ITomthe drug, perceptions of their doctor's attitude to the BDZ prescription, efforts to stop taking the tablets and their attempts to withdraw and ways in which they coped with difficulties,other than by using the tablets. Our results showed that long term users tend to be white women, aged between 50-69 years old, not married, divorced or widows, low educational and sociodemographic levels, with depressive illnesses inappropriately diagnosed and treated with BDZ. There was no evidence of progressive increase in dosage and the chronic use was related to great difficulty in abandoning the medication because of a strong apprehension regarding the withdrawal symptoms. We detected by means of the HAD 64% of probable anxiety cases and 69.2% probable depression cases. In the diagnosis established by SCAN we found 63.4% depressive symptoms, 29.6% benzodiazepine dependence, and 14.6% sleep disorders, among other diagnoses. We also found anxiety (7.3%) and somatic disorders (7.3%) in lower rates, among others. Our conclusion points to the absence of specific diagnostic instruments to measure BDZ dependence in Brazil and to the recognized value of establishing guidelines for BDZ prescription and intervention programs based on orientation of patients and professionals ofthe public health system of our city / Mestrado / Saude Mental / Mestre em Ciências Médicas