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Introdução: O Doppler tecidual (DT) surgiu como uma técnica ecocardiográfica para registro das velocidades do miocárdio e evoluiu para a determinação da deformação miocárdica regional com medida do strain rate (SR) e strain longitudinal e radial unidimensionais. Nosso objetivo foi determinar padrões de normalidade em neonatos e analisar seqüencialmente esses índices em períodos de alta e baixa resistência vascular pulmonar. Casuística e Método: Selecionaram-se 55 crianças com idade média de 20,14 ± 14,0 horas, constituindo o Grupo I (G I). Um segundo exame foi realizado em 30 crianças que retornaram após 31,9 ± 2,9 dias de vida, constituindo o Grupo II (G II). As velocidades do DT pulsado foram obtidas em cortes transversais (R) e longitudinais (L) do ventrículo esquerdo (VE) em posições apical 4 e 2 câmaras e no VD (paredes livre e inferior). Foram medidas velocidades sistólicas (onda Sm), diastólica inicial (Em), diastólica final (Am) de pico e a relação Em/Am. Pelo menos três ciclos cardíacos consecutivos com taxa de quadros/s superior a 300 foram digitalmente obtidos nos cortes mencionados e analisados posteriormente utilizando programa específico para medida das curvas de SR/strain e seus componentes sistólico, diastólico inicial e final. Resultados: As velocidades demonstraram gradiente bem definido com redução progressiva na direção base-ápice do coração. As velocidades do VD foram superiores às do VE quando comparadas com as medidas nas paredes septal (S), anterior (A) e lateral (L). No GI verificamos diferença significativa entre as medidas do SR/strain sistólicos do segmento basal da parede S em relação à apical (-1,90 ± 0,61, - 25,90 ± 4,90 vs -1,66 ± 0,25, - 24,23 ± 3,08), p=0,04 e p=0,02 e do segmento médio em relação ao apical (p=0,01 e 0,02). A avaliação regional do VD demonstrou strain sistólico maior no segmento médio em relação ao basal (-33,20 ± 6,34 vs -28,38 ± 4,90, p=0,00) e em relação ao segmento apical (-33,20 ± 6,34 vs -31,95 ± 5,06, p=0,021). Os valores absolutos de SR/strain e todos os seus componentes foram maiores na direção R quando comparados com a L (SR sistólico 2,99 ± 0,78 s-1 vs (-)1,90 ± 0,60 s-1 strain sistólico 49,72% ± 12,86% vs (-) 25,86% ± 4,83 p=0,00). Quando comparamos os GI e GII verificamos redução do strain sistólico do VE na direção R e L nas paredes S, L e A em todos os segmentos. O SR sistólico reduziu apenas na porção basal da parede L (-1,91 ± 0,46 s-1 vs - 1,71 ± 0,33 s-1, p=0,02). O VD apresentou no GII aumento significativo do strain sistólico e diastólico inicial em todos os segmentos e paredes. O SR sistólico também apresentou aumento dos valores nos segmentos basal e médio de sua parede livre e na parede inferior. A correlação entre a onda Sm e SR/strain sistólicos não foi significativa. Conclusão: Os índices regionais de deformação miocárdica constituem técnica clínica reproduzível em neonatos e podem monitorar alterações seqüenciais fisiológicas da circulação neonatal precoce e tardia. São mais robustos que as velocidades na quantificação da função regional. / Background: Color Doppler myocardial imaging (CDMI) has emerged as an echocardiographic technique for determining myocardial velocities and has been further developed to allow the determination of one-dimension regional longitudinal and radial strain rate (SR)and strain. Our goal was to determine normal values in neonates and sequentially analyse these indices in periods of high and low pulmonary vascular resistance. Study population and methods: Fifty-five term newborns with mean age of 20.14 ± 14.0 hours were selected to be part of Group I (GI). A second echo study was performed on 30 children that had returned with 31.9 ± 2.9 days after birth, being Group II (GII). Pulsed wave Doppler tissue velocities (PWDTV) were obtained in short axis (R) and longitudinal (L) axis of the left ventricle (LV) in apical 4 and 2 chamber view and in 4 and 2 chamber of the right ventricle (RV), including RV free lateral and inferior walls. Peak systolic (Sm), peak early diastolic (Em) and peak late diastolic (Am) motion velocities and Em/Am ratio were measured. At least three consecutive cardiac cycles with frame rate more than 300 fps were stored in digital format from the mentioned views for offline analysis by using dedicated software for measuring peak systolic and peak early and late diastolic SR/strain. Results: PWTDV have shown a well-defined gradient with progressive peak reduction from base to apex. RV velocities were higher than those of the LV whem compared to septal (S), anterior (A) and lateral (L) walls. In GI there was a significant difference between systolic SR/strain measurement of basal S segment in relation to apical (-1.90 ± 0.61, -25.90 ± 4.90 vs -1.66 ± 0.25, - 24.23 ± 3.08), p=0.04 e p=0.02 and from the mid in relation to the apical segment (p=0.01 e 0.02). Regional RV longitudinal function showed that systolic strain recorded from the mid segment was significantly higher than that recorded from the basal segment (-33.20 ± 6.34 vs -28.38 ± 4.90, p=0.00) and that from the apical segment (-33.20 ± 6.34 vs ?31.95 ± 5.06, p=0.021). The absolute and all components of SR/strain were significantly higher in R direction when compared to the L ones (systolic SR 2.99 ± 0.78 s-1 vs (-)1.90 ± 0.60 s-1 systolic strain 49.72% ± 12.86% vs (-)25.86% ± 4.83 p=0.00). When comparing data from GI and GII, we noticed reduction of LV systolic strain in the second group for both R and L, in all segments of S, L and A walls. Systolic SR showed reduction of the values in GII only in the basal segment of the L wall (-1.91 ± 0.46 s-1 vs ?1.71 ± 0.33s-1, p=0.02). Regional RV function showed systolic and early diastolic strain significantly higher in all segments of wall in GII. Systolic SR also showed higher values in the basal and mid segments of RV free lateral and inferior wall in GII when comparing to GI. The correlation between peak systolic velocity Sm and peak systolic SR/strain was not significant. Conclusion: Regional myocardial deformation indices are reproducible clinical techniques in neonates and can monitor physiological sequential circulatory changes of the early and late neonatal period. They are more robust than velocities in the quantification of the regional myocardial function.

Recent government regulations for Enhanced 911 locating of wireless handsets require accuracy to within 50 and 300 meters. Two technologies under consideration are triangulation using existing wireless base stations and location using global positioning satellites (GPS). Satellite positioning is the leading candidate, however, reception of GPS signals within large buildings is difficult and considerable research is devoted to this topic. Conventional GPS receivers require line of sight to at least four satellites and, under outdoor conditions, the expected signal level is about -160 dBW. Within large buildings, detection is very difficult because there is high thermal noise and some satellite signals can be attenuated to less than -185 dBW while others can suffer little attenuation. In order to construct the pseudo-ranges necessary for position finding, the receiver must synchronize to the incoming codephase of each satellite and must operate with substantial Doppler frequency offset caused by satellite motion.<p> This thesis investigates the application of a parallel non-coherent spread spectrum synchronizer previously implemented as a very-large-scale integration (VLSI) circuit. The circuit processes one millisecond of incoming signal and uses a segmented matched filter (SMF) by which the segmentation provides some tolerance to Doppler shift. The thesis presents simulation results of averaging for tens of seconds. Through simulation, the SMF is compared with a transversal matched filter (TMF) under conditions of no Doppler shift; coherent and non-coherent integration are discussed. The simulation is conducted at 290 K (17°C) such that the Boltzmann noise is -204 dBW/Hz, with a GPS signal bandwidth of 2 MHz and signal level of -185 dBW, and the receiver input signal-to-noise ratio (SNR) is -44 dB.<p> The SMF is applied using differing segment lengths to high-sensitivity GPS data from indoor and urban simulated GPS data. The results demonstrate the SMFs ability to tolerate Doppler frequency offsets while allowing for long integration times to detect the weak GPS signals.

Recent government regulations for Enhanced 911 locating of wireless handsets require accuracy to within 50 and 300 meters. Two technologies under consideration are triangulation using existing wireless base stations and location using global positioning satellites (GPS). Satellite positioning is the leading candidate, however, reception of GPS signals within large buildings is difficult and considerable research is devoted to this topic. Conventional GPS receivers require line of sight to at least four satellites and, under outdoor conditions, the expected signal level is about -160 dBW. Within large buildings, detection is very difficult because there is high thermal noise and some satellite signals can be attenuated to less than -185 dBW while others can suffer little attenuation. In order to construct the pseudo-ranges necessary for position finding, the receiver must synchronize to the incoming codephase of each satellite and must operate with substantial Doppler frequency offset caused by satellite motion.<p> This thesis investigates the application of a parallel non-coherent spread spectrum synchronizer previously implemented as a very-large-scale integration (VLSI) circuit. The circuit processes one millisecond of incoming signal and uses a segmented matched filter (SMF) by which the segmentation provides some tolerance to Doppler shift. The thesis presents simulation results of averaging for tens of seconds. Through simulation, the SMF is compared with a transversal matched filter (TMF) under conditions of no Doppler shift; coherent and non-coherent integration are discussed. The simulation is conducted at 290 K (17°C) such that the Boltzmann noise is -204 dBW/Hz, with a GPS signal bandwidth of 2 MHz and signal level of -185 dBW, and the receiver input signal-to-noise ratio (SNR) is -44 dB.<p> The SMF is applied using differing segment lengths to high-sensitivity GPS data from indoor and urban simulated GPS data. The results demonstrate the SMFs ability to tolerate Doppler frequency offsets while allowing for long integration times to detect the weak GPS signals.

Reproduction de : Thèse de doctorat : Pathologie, Toxicologie, Génétique et Nutrition : Toulouse, INPT : 2008. / Titre provenant de l'écran-titre. Bibliogr. 179 réf.

Bonn, Universität, Thesis (doctoral), 2002.

In this work, a low-complexity two-dimensional (2D) frequency-scanned antenna is proposed to image a human using a Doppler radar. It consists of two back-to-back, air-filled microstrip leaky wave antennas (LWAs). The frequency-scanned pattern of the microstrip LWA is used to determine the target bearing in one dimension. Two such elements are used as an interferometer to determine the target bearing in the other dimension. In order to pack two LWAs closely, a design is proposed to achieve a minimal disturbance on the azimuth and elevation beam patterns. The design is measured with both static and Doppler targets to demonstrate the capability to form 2D frontal images. To investigate the potential performance of using the proposed antenna to image a human, a simulator that includes a dynamic human signature model and the frequency-scanned antenna pattern is developed. A radar waveform that is different from that used for the measurement conducted with simple Doppler targets is proposed. A simple five-point human model is tested first to understand the capability of the antenna to image a human. Next, the antenna design and the radar processing parameters are studied to improve the image quality. Simulated frontal images of a walking human are generated and discussed. With a redesigned antenna and new radar processing steps, simulation shows that frontal imagery of a human undergoing motion can be generated. / text

The development to date of a diode-laser based velocimeter providing point-velocitymeasurements in unseeded flows using molecular Rayleigh scattering is discussed. The velocimeter is based on modulated filtered Rayleigh scattering (MFRS), a novel variation of filtered Rayleigh scattering (FRS), utilizing modulated absorption spectroscopy techniques to detect a strong absorption of a relatively weak Rayleigh scattered signal. A rubidium (Rb) vapor filter is used to provide the relatively strong absorption; alkali metal vapors have a high optical depth at modest vapor pressures, and their narrow linewidth is ideally suited for high-resolution velocimetry. Semiconductor diode lasers are used to generate the relatively weak Rayleigh scattered signal; due to their compact, rugged construction diode lasers are ideally suited for the environmental extremes encountered in many experiments. The MFRS technique utilizes the frequency-tuning capability of diode lasers to implement a homodyne detection scheme using lock-in amplifiers. The optical frequency of the diode-based laser system used to interrogate the flow is rapidly modulated about a reference frequency in the D₂-line of Rb. The frequency modulation is imposed on the Rayleigh scattered light that is collected from the probe volume in the flow under investigation. The collected frequency modulating Rayleigh scattered light is transmitted through a Rb vapor filter before being detected. The detected modulated absorption signal is fed to two lock-in amplifers synchronized with the modulation frequency of the source laser. High levels of background rejection are attained since the lock-ins are both frequency and phase selective. The two lock-in amplifiers extract different Fourier components of the detected modulated absorption signal, which are ratioed to provide an intensity normalized frequency dependent signal from a single detector. A Doppler frequency shift in the collected Rayleigh scattered light due to a change in the velocity of the flow under investigation results in a change in the detected modulated absorption signal. This change in the detected signal provides a quantifiable measure of the Doppler frequency shift, and hence the velocity in the probe volume, provided that the laser source exhibits acceptable levels of frequency stability (determined by the magnitude of the velocities being measured). An extended cavity diode laser (ECDL) in the Littrow configuration provides frequency tunable, relatively narrow-linewidth lasing for the MFRS velocimeter. Frequency stabilization of the ECDL is provided by a proportional-integral-differential (PID) controller based on an error signal in the reference arm of the experiment. The optical power of the Littrow laser source is amplified by an antireflection coated (AR coated) broad stripe diode laser. The single-mode, frequency-modulatable, frequency-stable O(50 mW) of optical power provided by this extended cavity diode laser master oscillator power amplifier (ECDL-MOPA) system provided sufficient scattering signal from a condensing jet of CO₂ to implement the MFRS technique in the frequency-locked mode of operation.

published_or_final_version / abstract / toc / Electrical and Electronic Engineering / Doctoral / Doctor of Philosophy

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