Current computer systems fill the demand of operating systems and applications for ever greater amounts of random access memory by paging the least recently used data to the hard disk drive. This paging process is called "virtual memory," to indicate that the hard disk drive is used to create the illusion that the computer has more random access memory than it actually has. Unfortunately, the fastest hard disk drives are over five orders of magnitude slower than the DRAM they are emulating. When the demand for memory increases to the point that processes are being continually saved to disk and then retrieved again, a process called "thrashing" occurs, and the performance of the entire computer system plummets. This thesis sought to find alternatives for home and small business computer users to the hard disk drive for virtual memory which would not suffer from the same long delays. Virtual memory is especially important for older computers, which often are limited by their motherboards, their processors and their power supplies to a relatively small amount of random access memory. Thus, this thesis was focused on improving the performance of older computers by replacing the hard disk drive with faster technologies for the virtual memory. Of the different technologies considered, flash memory was selected because of its low power requirements, its ready availability, its relatively low cost and its significantly faster random access times. Two devices were evaluated on a system with a 512MB of RAM, a Pentium 4 processor and a SATA hard disk drive. Theoretical models and a simulator were developed, and physical performance measurements were taken. Flash memory was not shown to be significantly faster than the hard disk drive in virtual memory applications.

The field of synthetic biology seeks to use design principles of life to create new genes, organisms and populations to both better understand biology as well as generate species with useful properties. Budding yeast has been a workhorse for synthetic biology, as well as an important model organism in the broader fields of molecular biology and genetics. This thesis aimed to create genome engineering tools for the manipulation of genomes, with direct applications in yeast. I focused developing high-throughput and highly efficient methods for making genomic modifications in yeast to allow for the generation of large libraries of precisely modified yeast genomes. By manipulation of endogenous DNA recombinases and mismatch repair enzymes in yeast, we were able to develop an oligonucleotide only method for genome engineering to generate libraries as large as 10^5 individuals with a frequency of modification as high as 1%. Additionally, we validated the use of RNA-guided CRISPR/Cas9 endonucleases to make changes in yeast genomes, resulting in frequencies of genome modification >90% in transformed populations. We further optimized this method to generate larger libraries as high as 10^5 individuals and explored a proof of concept epistasis experiment involving thermotolerance. Lastly, the propagation of changes to successive generations is useful when engineering organisms on the population level. To this end we explored the use of RNA-guided gene drives to bias inheritance in S. cerevisiae. We show that inheritance of these selfish elements can be biased to over 99% and is reversible.

English title: Another Point of View The aim of this study is to find traces of learning in the process of peer response. This is explored by investigating the experiences expressed by the students and their work of trans­forming criteria into peer response questions. An analysis is also made of which criteria they focus on in their feedback. A close-up study of the meeting between the student, the response group and the text has been made consisting of three students and their groups. The teacher has ranked the groups from her expectations of their performances. Analytical tools are the criteria themselves, metalanguage (Hansson 2001) and local and global text levels (Hoel 2001). The theoretical framework is taken from Ewa Bergh Nestlog and her thesis from 2012. Based on systematic functional linguistics, critical discourse analysis and a dialogical conception of language she presents a transaction cycle. The transaction cycle explains the connection between metaunderstanding, the production and the reception of texts, and it is used in this study for understanding peer response. The study explores how Swedish students in upper secondary school make meaning in peer response. Eighteen students aged 16–17 have digitally been receiving and providing feedback in groups of three while writing an argumentative text. All the students are following a theoretical curriculum. Sources for the material are various written texts by the students. The data analysed consists of the students’ questions to the criteria, their feedback comments on Google Drive and their self-evaluations. The analysis of the self-evaluations shows that receiving and giving feedback helps the students to use a metaperspective while writing and editing their own texts. The students describe how the teaching activities and materials focusing on structure in text have helped them to focus on structure when giving a response. This is confirmed by the analysis of the feedback which shows that the students in their comments give critical and concrete feedback on structure using an adequate language. The results indicate that the chosen focus of teaching activities influences the focus of the students’ response and writing. The results also indicate a need for more teaching activities concerning grammatical terms. The close-up study shows that the students in the groups highly valued by their teacher have an ability to adjust their feedback according to both the text and their peers. The group less valued by their teacher gives very little response and the students do not participate in the self-evaluation.

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In the fall of 2004, the High Speed Autonomous Vehicle Team, a group of 16 students took on the goal of converting a vehicle to drive-by-wire status. The main goal of this project was to convert a Cadillac SRX donated by General Motors, to fully by-wire control. This thesis presents the HSAVT brake-by-wire and the steer-by-wire solution. In addition, the results of a literary search on drive-by-wire systems are presented. The results of the project proved that the team came up with a solid, effective drive-by-wire vehicle and that the project met all of the primary goals of the project. / Master of Science

An infinitely variable transmission (IVT) is a transmission that can smoothly and continuously vary the speed ratio between an input and output from zero to some other positive or negative ratio; they are a subset of continuously variable transmissions (CVTs), which themselves do not have the ability to produce a zero gear ratio. In this thesis, the operation, analysis, and development of a novel, highly configurable, Cam-based Infinitely Variable Transmission of the ratcheting drive type is presented. There are several categories of CVTs in existence today, including traction, belt, and ratcheting types. Drives of these types, their attributes, and associated design challenges are discussed to frame the development of the Cam-based IVT. The operation of this transmission is kinematically similar to a planetary gearset, and therefore, its operation is described with that in mind including a description of the six major components of the transmission, those being the cam, followers, carriers, planet gears, sun gears, and one way clutches. The kinematic equation describing its motion is derived based on the similarities it shares with a planetary gearset. Additionally, the equations for the cam design are developed here as the operation of the CVT is highly dependent on the shape of the cam. There are six simple inversions of this device and each inversion has special characteristics and limitations, for example, the available gear range. A method was developed to select the most suitable inversion, gearing, and follower velocity for a given application. The contact stress between the rollers and cam is the limiting stress within the transmission. A parametric study is used to quantify the relationship between this stress and the transmission parameters. Based off those results, two optimization strategies and their results are discussed. The first is an iterative brute force type numerical search and the second is a genetic algorithm. The optimization results are shown to be similar and successfully reduced the contact stress by 40%. To further improve the transmission performance, several mechanisms were developed for this unique transmission. These include a compact and lightweight differential mechanism based on a cord and pulley system to reduce the contact force on the rollers. In addition, a unique external/inverted cam topology was developed to improve the contact geometry between the rollers and said cam. A prototype was built based on both the optimization strategies and these mechanisms and is described within. Finally, a Prony brake dynamometer with cradled motor was constructed to test the transmission; the results of those tests show the Cam-based IVT to be 93% efficient at low input torque levels. / Master of Science

Energy demands are steadily increasing as the world's population continues to grow. Automobiles are primary transportation means in a large portion of the world. The combination of fuel consumption by automobiles along with the shrinking fossil fuel reserves makes the development of new more energy efficient technologies crucial. Electric vehicle technologies have been studied and are still being studied today as a means of improving fuel efficiency. To that end, this work studies the effect of switching frequency on the efficiency of a hybrid electric vehicle traction drive, which contains both an internal combustion engine as well as electric motor. Therefore improving the efficiency of the electric motor and its drive will help improve the viability of alternative vehicle technologies. Automobiles spend the majority of their operational time in the lower speed, lower torque region. This work focuses on efficiency improvements in that region. To estimate the efficiency trend, the system is modeled and then tested both electrically and thermally. The efficiency is shown to increase at lower switching frequencies. The experimental results show that there are some exceptions, but the basic trend is the same. / Master of Science

The Hybrid Electric Vehicle Team (HEVT) of Virginia Tech is one of 16 university teams participating in EcoCAR 3, the latest competition in the Advanced Vehicle Technology Competitions (AVTC) organized by Argonne National Labs. EcoCAR 3 tasks teams with converting a 2016 Chevrolet Camaro into a hybrid electric vehicle with 5 main goals: reducing petroleum energy use and greenhouse gas emissions while maintaining safety, performance, and consumer acceptability. Over the last 4 years, HEVT has designed and built a plugin parallel hybrid electric vehicle with a unique powertrain architecture. This work deals with utilizing the unique powertrain layout of the HEVT Camaro to improve drive quality, a key component in consumer acceptability. Although there are many ways to approach drive quality, most aspects can be analyzed in the smoothness of the vehicle longitudinal acceleration response. This research is focused on improving the drive quality of the vehicle developed for EcoCAR 3. Multiple algorithms are developed to address specific aspects of drive quality that can only be done with the powertrain developed. This begins by researching the control strategies used in modern automatic transmissions, and moves into the modeling strategy used to begin algorithm development. Two main strategies are developed and calibrated in the vehicle. The first being a strategy for reducing jerk in pure electric mode by limiting motor torque response. The second strategy aims to improve transmission shift quality by using the electric motor to reduce torque fluctuations at the driveshaft. The energy consumption impact of both of these strategies is also analyzed to ensure that drive quality does not come at the large expense of energy consumption. / Master of Science / The Hybrid electric vehicle team (HEVT) of Virginia Tech is one of 16 university teams participating in EcoCAR 3, the latest competition in the Advanced Vehicle Technology Competitions (AVTC) organized by Argonne National Labs. EcoCAR 3 tasks teams with converting a 2016 Chevrolet Camaro into a hybrid electric vehicle with 5 main goals: reducing petroleum energy use and greenhouse gas emissions while maintaining safety, performance, and consumer acceptability. Over the last 4 years, HEVT has designed and built a plugin parallel hybrid electric vehicle with a unique powertrain architecture. This work deals with utilizing the unique powertrain layout of the HEVT Camaro to improve drive quality, a key component in consumer acceptability. Multiple strategies were examined and implemented for different driving conditions, and ultimately an improvement was made. However, new challenges are introduced by having some components remain stock that limit the success of smoothing gear shifts.