The goal of this Diploma Thesis was the detection of the potential trends of manufactural and business activities in manufactural division AZ KLIMA, Ltd and to suggest the appropriate measures .The starting situation of this company is described in an extensive analytical part. The output is a summary of its strenghts and weakness aspects, opportunities and threats. The suggest of strategy is presented by an extended marketing mix. The emphasis is placed first of all on product sphere. There are mentioned technological and organisational impacts of commencement of production of bolting and welding ducts, spiral tubes and ending distribution elements. Afterwards there are suggested methods of economy in manufactural process, market targeting and personal impacts. At the end there are outlined the time-dependent implementation harmonogram of suggested strategy, feasibility control and evaluation of expected benefits.

The goal of this thesis is to create a methodic and a system, which would involve customized computing and consequent design of the transition duct using input and applied data effectively and would achieve optimized set of parameters. The methodic described in the thesis is applied on transition duct within air main ducting between the filter and gas turbine. Transition duct is a huge mounted assembly consisting of welded parts. NX 5 application was chosen as system environment of the thesis. Master model is a root for both design model and computing model. Weight and material optimization is a desired result which will serve as basis for designing. It is not the goal of this thesis to create one perfect computation model BUT to create a methodic, which would be manageable by any designer equipped by basic knowledge of engineering.

Tato diplomová práce se zabývá návrhem dvojtlakého horizontálního kotle využívající teplo spalin za spalovací turbínou na zemní plyn. Zahrnuje návrh a výpočet jednotlivých výměníků, jejich základní uspořádání s ohledem na požadované parametry výstupní páry a dané vstupní a výstupní parametry spalin. Dále tato práce zahrnuje výpočet a konstrukční návrh parních bubnů, zavodňovacích trubek a převáděcích potrubí. Tato práce je zakončena výpočtem a prověřením tlakových ztrát mezi vstupem a výstupem kotle. Důležitou součástí této práce je přiložena výkresová dokumentace.

Loss of hearing affects more than 10 % of the population, and one newborn in a thousand is born with defects of the inner ear. Transcriptional factors involved in the development of inner ear are important in our understanding of the causes of inner ear defects. ISLET1 is one of these factors. ISLET1 expression is detected in the sensory and neuronal cells of the inner ear. It participates in otocyst formation, and the specification and differentiation of cells of cochlea and vestibular system. The functional role of ISLET1 during inner ear development was investigated. Its role was studied by using Pax2-Isl1 transgenic mice that overexpress Islet1 under the control of the Pax2 promoter. Two transgenic lines were generated, Pax2-Isl1/300 and Pax2- Isl1/52. Two copies of the Pax2-Isl1 transgene were inserted to Pax2-Isl1/300 genome and one copy was inserted to the Pax2-Isl1/52 genome. Defects in sense of hearing were detected in both lines and circling behavior, a defect of balance, was detected in the Pax2-Isl1/300 transgenic mice. We observed high postnatal lethality in heterozygote transgenic mice. Pax2-Isl1/52 homozygote mutation is lethal at embryonic day 10 (E10,5). Pax2-Isl1/300 homozygote letality couldn't be detected because of the inability to breed heterozygote mutated mice of this line....

The differentiation, in an infant with cholestasis, between extrahepatic biliary atresia (EHBA) and the neonatal hepatitis syndrome (NHS) is important in that laparotomy is always indicated in EHBA but is undesirable in NHS. This differentiation is particularly difficult in those infants with complete cholestasis. Hepatobiliary scintigraphy is a commonly used investigation in infants with obstructive jaundice. The scintigraphic demonstration of excretion into the gut excludes extrahepatic obstruction, however, absence of excretion may be due to EHBA, severe cholestasis with patent extrahepatic bile ducts or poor uptake of the agent, and is therefore not diagnostic. This study has examined the quantitative measurement of the hepatic uptake of p-butyl IDA and Sn colloid, and an estimation of liver shape, in a group of patients with complete cholestasis in whom conventional scan interpretation, based on excretion into the-gut, would not be useful. The scans were recorded as dynamic studies and the resultant time-activity curves were subjected to curve fitting to calculate a rate constant for uptake of radiopharmaceutical. Liver shape was determined from the anterior static image of the colloid scan. The results show a significant difference between the EHBA and the NHS patients in the rate of uptake of p-butyl IDA, in the ratio of the rate of uptake of p-butyl IDA/the rate of uptake of colloid and in the measurements used to express liver shape. Using this method of scan interpretation, a diagnostic accuracy of 85% was achieved in this study of patients who clinically, and on scan, had no evidence of bile flow. Hepatic scintigraphy is therefore a useful investigation in the diagnostic work-up of infants presenting with obstructive jaundice even when bile flow is completely absent.

Long-range communication proves to be a challenge due to the Earth’s curvature, since electromagnetic waves propagate away from the Earth’s surface in a free atmosphere. A possible solution to beyond line-of-sight communication is the atmospheric phenomenon known as the evaporation duct. Ducting occurs when the refractive index of the atmosphere rapidly decreases with height, which leads to ray trajectories bending inward towards the surface of the Earth, effectively creating a waveguide and enabling long-distance communication. In this work, the models by Paulus-Jeske and Babin-Young-Carton are investigated and implemented in MATLAB for calculation of the evaporation duct height and for modelling the refractive index of the atmosphere. The rapid decrease in refractive index giving rise to evaporation ducts occurs due to evaporation of water within the atmosphericsurface layer (<100 m over the surface), which is the domain of turbulent mixing in the atmosphere. With atmospheric data from a Weather API by Meteomatics, Monin-Obukhov similarity theory for the atmospheric surface layer is combined with a bulk flux parameterization scheme from the COARE experiment to determine the air-sea fluxes in the lower troposphere. The surface layer variables with stability functions from Businger-Dyer, Beljaars-Holtslag, Cheng-Brutsaert, and the SHEBA experiment are used in the evaporation duct models proposed by Paulus-Jeske and Babin-Young-Carton to calculate the evaporation duct height, finding that the latter is a valid method with Monin-Obukhov stability functions based on the SHEBA experiment. The modelled refractive index is inserted into an already existing wave propagation model to investigate and validate the findings. / Långdistanskommunikation är en utmaning på grund av jordens krökning, eftersom elektromagnetiska vågor sprider sig bort från jordens yta vid propagering i fri atmosfär. En möjlig lösning för kommunikation bortom siktlinjen är det atmosfäriska fenomenet som kallas avdunstningskanal. Det uppstår när atmosfärens brytningsindex snabbt minskar med höjden, vilket leder till att strålbanorna böjer sig inåt mot jordens yta, vilket i praktiken skapar en vågledare och möjliggör långdistanskommunikation. I detta arbete undersöks och implementeras modeller beskrivna av Paulus-Jeske och Babin-Young-Carton i MATLAB för beräkning av avdunstningskanalens höjd och för modellering av atmosfärens brytningsindex. Den snabba minskningen av brytningsindexet som ger upphov till avdunstningskanaler beror på avdunstning avvatten i det atmosfäriska ytskiktet (<100 m över ytan), som är det område där den turbulenta blandningen i atmosfären sker. Med atmosfäriska data från Weather API av Meteomatics kombineras Monin-Obukhovs likvärdighetsteori för det atmosfäriska ytskiktet med ett parametriseringsschema för bulkflöden från COARE-experimentet för att bestämma luft- och havsflödena i den nedre troposfären. Variablerna för ytskiktet med stabilitetsfunktioner från Businger-Dyer, Beljaars-Holtslag, Cheng-Brutsaert och SHEBA-experimentet används i de modeller för avdunstningskanaler som föreslagits av Paulus-Jeske och Babin-Young-Carton för att beräkna avdunstningskanalens höjd, varvid det konstateras att den sistnämnda metoden är en giltig metod med Monin-Obukhovs stabilitetsfunktioner baserade på SHEBA-experimentet. Det modellerade brytningsindexet införs i en redan befintlig vågutbredningsmodell för att undersöka och validera resultaten.

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Sound transmission loss of vehicle seals was studied in this thesis. Reverberation room test and semi-anechoic chamber test were respectively studied. By comparing the sound pressure level, sound intensity level and average sound power level at the receiving side, it proved that a simple sound pressure level test may obtain same measurement accuracy when there is little reflected sound. A semi-anechoic chamber was designed for testing sound transmission losses of the seals on a trial vehicle. By comparing the sound pressure levels between the location of the passenger ear and door area, it proved that most of outside sound energy passed through the door seals into the interior. The sound transmission losses of different sealing conditions were measured which included well sealed and imperfectly sealed conditions; Sound pressure levels at passenger’s ear in three different types of vehicles were also compared, these comparison results indicated this laboratory was capable of distinguishing different sealing conditions. The installation procedure was compared with the one in reverberation room test. Numerical analysis showed that the latter method produced a different compression shape which would definitely influence the sound insulation abilities of the seals.   The transmission mechanism of the acoustic waves through a vehicle seal was also discussed. Contact analysis showed high compression ratio leaded to tremendous inner stress intensity. But any further increase of the contact depth would not improve the effect of wind noise prevention. A vehicle seal with a complex shape was replaced by a simple model. The sound transmission theory of multiple partitions on the basis of mass law was applied. Whereas, compared with the experimental result, a different trend in the high frequency range was found. When taking the transmission though the side material and integration of incident angle into account, the result was quite similar to the experimental one. FEM analysis was also performed. The majority of sound power was believed to transmit along the seal wall into the interior instead of passing through the multiple partitions. A distorted circular duct model is believed to be close to the real geometry. / QC 20101117

An aerodynamic shape optimization procedure was performed on a low observable engineintake duct. The intake duct was fixed in its throat and aerodynamic interface plane (AIP)sections, while leaving up to 7 design parameters free to deformation in the centroid curveand mid section profile. The optimization setup consisted of an optimizer block implementedin MATLAB, where the NSGA-II optimization algorithm was implemented, and a simulationblock using computational fluid dynamics (CFD). The objective functions for the optimizationprocess were the pressure recovery and the DC60 distortion coefficient in the AIP section.In total, four optimizations with gradually increasing degrees of deformation were conducted.The first optimization process was a validation case, performed on a test duct design, whilethe remaining optimizations were performed using a duct designed by the Swedish DefenceResearch Agency (FOI) as a starting point, for cruise and take-off conditions. The connection of NSGA-II and the CFD setup proved useful, as the distortion was decreasedby up to 52.8% relative the original value while keeping the pressure recovery within 0.06% ofthe original duct. The algorithm was successful in finding an improvement for both consideredoperating conditions, with the largest improvement for the cruise case. In total 975 duct designswere evaluated in the four processes, using a uniform inflow boundary condition on a boundaryextruded one meter from the throat of the intake duct. The importance of the handling of non-converged solutions in the automated optimizationprocess was also pointed out, as an oscillating solution affected the third optimization, therebyrendering that solution useless. / En aerodynamisk formoptimering av en insynsskyddad luftintagskanal för en stridsdrönaregenomfördes genom att koppla den genetiska optimeringsalgoritmen NSGA-II samt CFD i enautomatiserad process. Optimeringens två målfunktioner var att maximera tryckåtervinstenoch minimera flödesdistorsionen på AIP-randen. Luftintagskanalen som användes som basför optimeringen var fixerad vid inlopps- samt AIP-profilerna, medan deformation tilläts imellanliggande delar, styrt av upp till 7 styrparametrar. Den kanal som användes som bas föroptimeringsprocessen togs fram av FOI, Totalförsvarets Forskningsinstitut, i samband med ettNATO-STO projekt för den obemannade stirdsdrönaren MULDICON. Totalt genomfördes fyra optimeringsprocesser, där 975 kanaler evaluerades, varav den förstaoptimeringen skedde på en något modifierad test-kanal som verifikationssteg, medan de senareoptimeringarna skedde på FOI-kanalen. Två optimeringar genomfördes på marschhöjdsförhållanden på 11km höjd, medan resterande optimeringar genomfördes för start-förhållandenpå standard havsnivå. Metoden gav goda resultat, med maximalt 52,8% relativ minskning av flödesdistorsionenmedan tryckåtervinsten bibehölls inom 0.06% av ursprungliga värdet. Det framgick att metodengav störst förbättring för fallet vid marschhöjd, jämfört med originalkanalen. Det påpekades också att den implementerade metoden har begränsningar och är känslig förkraftiga separationer och flödesinstabiliteter, vilket kan skapa oscillationer i lösaren och därmedge falska resultat. Det påverkade den tredje optimeringsprocessen där den optimala lösningenvar okonvergerad, och därmed inte gav verklig förbättring av kanalens prestanda

El modelado se ha convertido en los últimos años en una herramienta esencial en el diseño de motores de combustión interna alternativos, ya que permite reducir considerablemente el tiempo y los costes de desarrollo. Las metodologías de diseño clásicas se basan en la fabricación de prototipos y la realización de pruebas de ensayo y error. Actualmente, la mayoría de estas pruebas han sido sustituidas por cálculos numéricos, de modo que sólo las opciones de diseño más prometedoras se prueban en realidad en banco motor. Durante años, los códigos unidimensionales de dinámica de gases en el dominio del tiempo han sido suficientes para modelar tanto las prestaciones y el consumo del motor como el ruido de admisión y escape. Sin embargo, para un nivel más exigente de diseño, una representación 1D puede no ser suficiente para describir con precisión el flujo en ciertos elementos. Esto es especialmente importante en el caso de silenciadores, donde la hipótesis unidimensional sólo se puede aplicar a geometrías simples. En el caso de las uniones de conductos es la existencia de estructuras tridimensionales de flujo complejas lo que establece el límite de la aplicabilidad de una descripción simple cero-dimensional. En vista de estas limitaciones, la primera opción sería el uso de un modelo de dinámica de fluidos computacional (CFD); sin embargo, su aplicación conllevaría un tiempo de cálculo excesivo. Una posible solución de compromiso viene dada por los modelos cuasi-3D, basados en esquemas tridimensionales, pero con ciertas simplificaciones capaces de reducir significativamente el tiempo de cálculo sin afectar excesivamente a la precisión. Tales soluciones se han convertido en estándar en los códigos comerciales y se han aplicado con éxito a los silenciadores, tanto para excitaciones acústicas en el régimen lineal como en condiciones reales de motor, típicamente no lineales. Esta tesis tiene como objetivo el desarrollo de un nuevo método numérico cuasi-3D en una malla escalonada, basado en la simplificación de la ecuación de la cantidad de movimiento, para ser incluido en un código unidimensional existente. Tal método, sin embargo, no está libre de inconvenientes. En particular, se ve afectado por la aparición de oscilaciones no físicas, especialmente en gradientes de presión significativos. De la revisión bibliográfica se determina que este comportamiento es típico en esquemas de segundo orden y se puede ver acentuado por las simplificaciones adoptadas. Tras estudiar las posibles soluciones aplicables a este problema, se desarrollan tres limitadores de flujo diferentes, basados en las metodologías MDT, FCT y TVD. Una vez definido el método numérico y asegurada su estabilidad, es necesario desarrollar las condiciones de contorno adecuadas que permitan su utilización. Con este objetivo, se desarrollan las condiciones de pulso de presión de entrada y de extremo anecoico, los cuales permiten simular un banco de impulso. No hay que olvidar, sin embargo, que el objetivo final es la conexión con un código unidimensional, por lo que hay que comprobar que el método numérico cuasi-3D creado es compatible con los unidimensionales existentes, mostrando algunos resultados preliminares. Finalmente, con el método ya completamente operativo, se procede a su validación en las aplicaciones para las que ha sido diseñado principalmente, las cuales son, modelado de silenciadores y uniones de conductos. Para el caso de los silenciadores, se modelan dispositivos de complejidad creciente, pasando por geometrías de sección constante hasta sistemas con geometrías reales. Los resultados obtenidos se validan con otras herramientas tanto lineales como no lineales. En el caso de las uniones de conductos, el objetivo principal es el de establecer el potencial del nuevo método numérico frente a los tradicionales unidimensionales, por lo que los resultados de ambos se comparan con datos experiment / Engine modelling has become an essential tool in the design of internal combustion engines, allowing considerable reductions in development time and cost. Classical design methodologies are based on prototype manufacturing and trial-and-error tests, but currently, most of those tests have been replaced by numerical computations, so that only the most promising design options are actually tested on engine bench. For years, one-dimensional gas dynamics codes in the time domain have offered sufficiently good solutions for modelling both engine performance and intake and exhaust noise. However, for a more demanding level of design, a 1D representation may not be sufficient to describe accurately the flow in certain elements. This is especially important in the case of silencers. In the case of duct junctions, the existence of complex 3D flow structures is what sets the applicability limit for a simple zero-dimensional description. In view of these limitations, the first option would typically be the use of a computational fluid dynamics (CFD) model; however, the application of such a model to a complete intake or exhaust system entails an excessive computational time. A possible compromise solution is given by quasi-3D models, based on three-dimensional schemes, but with certain simplifications able to significantly reduce the calculation time without excessively affecting the accuracy. Such solutions have become standard in commercial codes and have been successfully applied to silencers with perforated tubes and absorbing material, both in the linear acoustic regime and in real engine conditions, typically non-linear. The objective of this thesis is the development a new quasi-3D numerical method in a staggered-grid, based on the simplification of the momentum equation, to be included in an existing one-dimensional code. Such method however, is not hassle free. In particular, it is affected by the appearance of non-physical oscillations, specially near significant pressure gradients. From the literature review it is determined that this behaviour is typical among second-order schemes and it can be aggravated by the simplifications adopted. After researching the possible solutions to face this problem, three different flux limiters are developed, based on the MDT, FCT and TVD methodologies. In the case of the two latter methods, its effectiveness is well established for finite differences schemes, thus defining a clear improving line for quasi-3D models. Once the numerical method is defined and its stability assured, proper boundary conditions that allow its use must be developed. With this objective, a pressure pulse inlet and an anechoic termination boundary condition are developed, which allow the simulation of an impulse test rig. It should not be forgotten, however, that the ultimate objective is the connection with a one-dimensional code, therefore the compatibility of the quasi-3D numerical method created with the existing one-dimensional methods has to be tested, showing some preliminary results. Eventually, with a fully operative method, the validation process for the applications which it has been mainly developed for, takes place, namely, mufflers and duct junctions modelling. In the case of mufflers, increasingly complex devices are modelled, from constant section geometries to real geometry systems. The results obtained are validated with both linear and non-linear tools. In the case of duct junctions, the main objective is to establish the potential of the new numerical method against the traditional one-dimensional schemes, consequently, results from both approaches are compared to experimental measures, obtaining promising results. / El modelatge s'ha convertit en els últims anys en una eina essencial en el disseny de motors de combustió interna alternatius, ja que permet reduir considerablement el temps i els costos de desenvolupament. Les metodologies de disseny clàssiques es basen en la fabricació de prototips i la realització de proves d'assaig i error. Actualment, la majoria d'aquestes proves han sigut substituïdes per càlculs numèrics, de manera que només les opcions de disseny més prometedores es proven en realitat en banc motor. Durant anys, els codis unidimensionals de dinàmica de gasos en el domini del temps han sigut suficients per a modelar tant les prestacions i el consum del motor com el soroll d'admissió i escapament. No obstant això, per a un nivell més exigent de disseny, una representació 1D pot no ser prou per a descriure amb precisió el flux en certs elements. Açò és especialment important en el cas de silenciadors, on la hipòtesi unidimensional només es pot aplicar a geometries simples. En el cas de les unions de conductes és l'existència d'estructures tridimensionals de flux complexes el que establix el límit de l'aplicabilitat d'una descripció simple zero-dimensional. En vista d'estes limitacions, la primera opció seria típicament l'ús d'un model de dinàmica de fluids computacional (CFD); no obstant això, l'aplicació comporta un temps de càlcul excessiu. Una possible solució de compromís ve donada pels models quasi-3D, basats en esquemes tridimensionals, però amb certes simplificacions capaços de reduir significativament el temps de càlcul sense afectar excessivament la precisió. Tals solucions s'han convertit en estàndard en codis comercials i s'han aplicat amb èxit als silenciadors, tant per a excitacions acústiques en el règim lineal com en condicions reals de motor, típicament no lineals. Aquesta tesi té com a objectiu el desenvolupament d'un nou mètode numèric quasi-3D en una malla escalonada, basat en la simplificació de l'equació de la quantitat de moviment, per a ser inclòs en un codi unidimensional existent. Tal mètode, però, no està lliure d'inconvenients. En particular, es veu afectat per l'aparició d'oscil·lacions no físiques, especialment en gradients de pressió significatius. De la revisió bibliogràfica es determina que aquest comportament és típic en esquemes de segon ordre i es pot veure accentuat per les simplificacions adoptades. Després d'estudiar les possibles solucions aplicables a aquest problema, es desenvolupen tres limitadors de flux diferents, basats en les metodologies MDT, FCT i TVD. En el cas dels dos últims mètodes, la seua efectivitat està ben establida per als esquemes de diferències finites, la qual cosa definix una clara via de millora per als models quasi-3D. Una vegada definit el mètode numèric i assegurada la seua estabilitat, és necessari desenvolupar les condicions de contorn adequades que permeten la seua utilització. Amb aquest objectiu, es desenvolupen les condicions de pols de pressió d'entrada i d'extrem anecoic, els quals permeten simular un banc d'impuls. No cal oblidar que l'objectiu final és la connexió amb un codi unidimensional, per la qual cosa cal comprovar que el mètode numèric cuasi-3D creat és compatible amb els unidimensionals existents, mostrant alguns resultats preliminars. Finalment, es procedix a la seua validació en les aplicacions per a les que ha sigut dissenyat principalment, les quals són, modelatge de silenciadors i unions de conductes. Per al cas dels silenciadors, es modelen dispositius de complexitat creixent, passant per geometries de secció constant fins a sistemes amb geometries reals. Els resultats obtinguts es validen amb altres eines tant lineals com no lineals. En el cas de les unions de conductes, l'objectiu principal és el d'establir el potencial del nou mètode numèric front als unidimensionals tradicionals, per la qual cosa els resultats d'ambdós es comparen amb dades experim / Hernández Marco, M. (2018). A non-linear quasi-3D model for air management modelling in engines [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/103683