The cellular networks are evolving to meet the future requirements of data rate,coverage and capacity. The fourth generation mobile communication system, LTEhas been developed to meet these goals. LTE uses multiple antenna features andlarger bandwidths in order to accomplish this task. These features will furtherextend the requirements of data rate, coverage, latency and flexibility. LTE also utilizes the varying quality of the radio channel and the interferencefrom other transmitters by adapting the data rate to the instantaneous channelquality at all the time. This is typically referred to as Link Adaptation. Thelink adaptation fails from time to time due to the varying channel quality as wellas the interference from other transmitters. In order to counteract these failures,retransmission methods are employed. These methods detect the errors on thereceiver side and signals the transmitter for the retransmission of the erroneousdata. The efficiency of link adaptation increases if combined with a properly designedretransmission scheme at the expense of delays due to retransmissions. This master thesis focuses on the study of the retransmission schemes with fasterfeedback, resulting in a reduction in delay. The feedback is generated by makingan early estimate of the decoding outcome and sending it early to the transmitterresulting in faster retransmission. This is important in certain applications wherethe data transmission is intolerant to delays.The thesis work shows by system performance simulations that fast packet retransmission,precisely called Early HARQ Feedback, significantly affects the systemperformance together with the utilization of the link adaptation. The study alsoshows that the link adaptation, in certain scenarios, can be optimized to improvethe system performance. In that respect, it is also possible to increase the numberof retransmissions within the same resource utilization. That optimization is basicallycalled aggressive link adaptation. Consequently, Early HARQ Feedback incombination with aggressive link adaptation provides a large improvement in thedownlink performance of the studied cases.

IntroduÃÃo: Os estados reacionais da hansenÃase, classificados como tipo 1 (reaÃÃo reversa - RR) e tipo 2 (Eritema Nodoso HansÃnico â ENH) e neurite isolada, levam ao risco potencial de desenvolver incapacidades e deformidades antes, durante o tratamento e apÃs a alta. Necessitam diagnÃstico precoce e tratamento adequado. Este estudo justifica-se pela escassez de estudos sobre ocorrÃncia, seguimento e fatores associados aos episÃdios reacionais apÃs a alta do tratamento especÃfico, bem como o desconhecimento dos problemas enfrentados do diagnÃstico, ao manejo terapÃutico, sob a perspectiva das pessoas com reaÃÃes hansÃnicas. MÃtodos: estudo transversal, a partir da populaÃÃo alvo identificada, consistindo de avaliaÃÃo neurolÃgica simplificada, exame dermato-neurolÃgico e entrevista individual (Projeto MAPATOPI). Foram incluÃdos cinco municÃpios em Ãreas do cluster: AraguaÃna (TO), Floriano (PI), Bacabal e Caxias (MA) e Marabà (PA). A populaÃÃo alvo consistiu de todos os indivÃduos que apresentaram reaÃÃes hansÃnicas, em pÃs-alta do tratamento poliquimioterÃpico, residentes e acompanhados nos serviÃos de saÃde no perÃodo de 2007 a 2009, independente da data de inicio de tratamento. Utilizou-se a comparaÃÃo do escore OMP (olho-mÃo-pÃ) ou EHF (Eyes-Hand-Foot) do diagnÃstico com o atual. Outro desfecho binÃrio utilizado foi analisar a presenÃa de incapacidade 0-1 no escore OMP atual. Na anÃlise binÃria utilizou-se o teste chi quadrado de Pearson. Naquelas associaÃÃes onde o valor esperado era menor que cinco utilizou-se o teste exato de Fischer. Resultados: foram incluÃdos 280 pacientes. 190 (67,9%) eram do sexo masculino. A idade mÃnima de 8 a 85 anos, com media de 46,5 anos. Seis eram menores de 15 anos e cinco entre 15 e 17 anos. A renda mÃdia por mÃs foi de R$ 1077,00 com valores entre R$ 60,00 e R$ 6.000,00 reais. Mais de noventa por cento residia na zona urbana. Quanto à escolaridade 53 (18,9%) eram analfabetos e 53,6% tinham o primeiro grau incompleto. No total 45 (16,1%) foram classificados como PB e 232 (83,7%) foram classificados como MB. A forma clÃnica predominante foi a dimorfa com 115(41,1%), seguida da virchowiana 82 (29,6%). A reaÃÃo tipo 1 estava presente em 104 (37,1%), tipo 2 (18,6%), a neurite isolada (13,9%). A neurite associada foi encontrada em 51,9% dos pacientes com tipo 2. A quantidade de episÃdios reacionais variou de um atà seis episÃdios. Um episÃdio foi desenvolvido por 215 (77,3%). O primeiro episÃdio ocorreu durante o tratamento para 121 (43,2%), seguido, em frequÃncia de ocorrÃncia, em pacientes pÃs-alta. O escore OMP (EHF) no diagnÃstico variou de 0 a 11 e na avaliaÃÃo atual, de 0 a 10, com maior distribuiÃÃo no intervalo entre 1 a 4. Quanto à piora do escore OMP 88/198 (44,4%) pioraram. Entre as variÃveis sÃcio-demogrÃficas, o risco de piora foi associado a: ser analfabeto (RP= 1, 64; IC de 95% 1,21 â 2,21; p=0,003), viÃvo (RP= 1,98; IC de 95% 1,20 â 3,96, p=0,013). E como fator de proteÃÃo ter segundo grau de escolaridade (RP= 0,4; IC de 95% 0,23 â 0,71 p=0,000). Quanto à piora do OMP associada a variÃveis clÃnicas, a forma clÃnica dimorfa (RP= 3,71; IC de 95% 1,00 â 13,70; p=0,009), ter reaÃÃo durante a PQT (RP= 1, 70; IC de 95% 1,13 â 2,54 P=0,004), ter algum nervo espessado ((RP= 1, 78; IC de 95% 1,30 â 3,08; p=0,024). Quanto ao percurso atà o diagnÃstico, a autopercepÃÃo foi encontrada em 240 (85,8%), entre os sinais e sintomas 176 (62,9%) buscaram os serviÃos por dermatoses em geral. Na busca do diagnÃstico, a atenÃÃo primÃria foi a primeira entrada para 95 (34%) na rede de assistÃncia. As principais manifestaÃÃes de reaÃÃes citadas foram sinais dermatolÃgicos 115 (42%) e neurolÃgicos 97 (35,4%). No total, 206/280 (73,5%) responderam que a hanseniase trouxe mudanÃas, problemas e transtornos para a sua vida. Dentre as mudanÃas intrapessoais, as alteraÃÃes fÃsicas tiveram papel importante para 129 (62,6%) participantes. Essas alteraÃÃes levaram a limitaÃÃes do seu desempenho no trabalho e renda, seguindo do comprometimento das atividades de vida diÃria. ConclusÃes: EpisÃdios reacionais agravam o comprometimento fÃsico, psico-social de participaÃÃo social e comprometem o trabalho e a realizaÃÃo das atividades de vida diÃria. à necessÃrio foco na qualidade de vida dos indivÃduos no pÃs-alta, principalmente entre aqueles com incapacidades fÃsicas instaladas. O escore OMP à um importante instrumento para detectar a progressÃo das incapacidades fÃsicas e deve ser utilizado no diagnÃstico, alta e durante os episÃdios reacionais em todos os pacientes. Os serviÃos de atenÃÃo primÃria e secundÃria dos municÃpios envolvidos necessitam melhorar o acompanhamento aos indivÃduos no perÃodo pÃs-alta, nÃo apenas para aqueles indivÃduos com incapacidades jà instaladas (grau um e dois), mas tambÃm naqueles que nÃo apresentaram incapacidades no momento da alta. EvidÃncias apontaram a necessidade do empoderamento das pessoas afetadas pela hansenÃase em lidar eficazmente com os sinais e sintomas de reaÃÃes apÃs a PQT. Sugere-se instituir um sistema de monitoramento e vigilÃncia dos estados reacionais por um perÃodo mÃnimo de seis meses atà cinco anos apÃs a alta, considerando a existÃncia de grupos de pacientes onde o comprometimento neurolÃgico ocorre lenta e silenciosamente, com possibilidade de danos nÃo sà fÃsicos, mas psicossociais. / Introduction: Leprosy reactions are classified as type 1 (reversal reaction - RR), type 2 (Erythema Nodosum Leprosum - ENL) and pure neuritis. These lead to a potential risk of developing disabilities and deformities before and during anti-leprosy treatment as well as after release from treatment (RFT). Reactions must be diagnosed early and treated effectively. This research is justified by the scarcity of studies on the occurrence of reactions, monitoring practices of patients and factors associated with reaction episodes after RFT. We know little about existing diagnostic problems, about case management from the perspective of the affected persons with reactions.Methods: Transversal study design, consisting of a simplified neurological examination, a dermato-neurological examination and interviews of the defined target group. Five municipalities were included in the cluster areas: Araguaina (Tocantins), Floriano (PiauÃ), Bacabal and Caxias (MaranhÃo) and Marabà (ParÃ). The target population consisted of all resident individuals with leprosy reactions after being released from multidrug therapy, who presented themselves to the health services in the period 2007 to 2009, regardless of the date of start of treatment. We compared the EHF (eye-hand-foot) scores at diagnosis and during the respondentsâ examinations. In another analysis we compared the presence of disability scores (0-1) to the current EHF scores. In the analysis we used the Chi square test and for those associations where the expected value was less than 5 we used Fischerâs exact test. Results: A total of 280 patients were included in the study. Of those, 190 (67.9%) were male. The ages ranged from 8 to 85 years, with a mean of 46.5 years. Six patients were under 15 years and five aged between 15 and 17 years. The average monthly income of the respondents was R$ 1,077.00 (around â400) with values between R$ 60 (â22) and R$ 6,000 (â2200). More than ninety per cent lived in urban areas. As for education, 53 persons (18.9%) were illiterate and 53.6% had an incomplete primary education. In total 45 patients (16.1%) were classified as PB and 232 (83.7%) were classified as MB. The predominant clinical form (Madrid classification) was dimorphous in 115 (41.1%) cases, followed by 82 lepromatous forms (29.6%). Type 1 reaction was present in 104 patients (37.1%), type 2 reactions in 18.6% of cases and pure neuritis in 13.9%. An associated neuritis was found in 51.9% of patients with type 2 reactions. The frequency of reaction episodes ranged from one to six. One episode only was developed by 215 patients (77.3%). The first episode occurred during anti-leprosy treatment for 121 patients (43.2%), followed in frequency of occurrence by patients after RFT. The EHF score at the time of diagnosis ranged from 0 to 11. At the time of the examination the EHF score range was 0-10, with a predominance of scores between 1 and 4. In 88 out of 198 patients (44.4%) their scores worsened. The risk of worsening was associated with the following socio-demographic variables: being illiterate (PR = 1.64, 95% CI: 1.21 - 2.21, p = 0.003), being widower (PR = 1.98, 95% CI: 1.20 - 3.96, p = 0.013). A protective factor was found: having completed secondary school education (PR = 0.4, 95% CI: 0.23 - 0.71 p = 0.000). Worsening of the EHF scores was associated with borderline leprosy (PR = 3.71, 95% CI: 1.00 - 13.70, p = 0.009), having had a reaction during MDT (PR = 1, 70; 95% CI 1.13 to 2.54 P = 0.004), and the presence of a thickened nerve (PR = 1, 78, 95% CI: 1.30 - 3.08 p = 0.024). In the patientsâ health seeking behaviour towards diagnosis, self-perception of symptoms was reported by 240 respondents (85.8%). Dermatological symptoms were the main complaint, in 176 (62.9%) cases. Primary health care services were the first point of entry for 95 patients (34%). The main reaction symptoms mentioned were of dermatological nature, in 115 (42%) cases Neurological complaints were mentioned by 97 (35.4%) respondents. In total, 206 out of the 280 patients (73, 5%) responded that leprosy brought about changes, problems and troubles in their lives. Among the intrapersonal changes, physical changes played an important role for 129 (62.6%) participants. These changes led to limitations in work performance and income, as well as causing restrictions in activities of daily living. Conclusions: Episodes of reactions worsen physical and psycho-social impairments, reduce social participation, cause problems at work and hamper activities of daily living. It is necessary to focus on the quality of life of individuals after RFT, especially among those with already established physical disabilities. The EHF score is an important tool to detect the progression of physical disability. The tool should be used in the diagnostic procedure, at the time of RFT and during reactions for all patients. Primary health care services and reference centres in the municipalities involved need to improve monitoring persons after RFT. Improved monitoring is needed not just in those patients with existing disabilities (DG1 and DG2), but also for those without disability present at discharge. Evidence indicates the need for empowerment of people affected by leprosy to deal effectively with the signs and symptoms of reaction after MDT. It is suggested to establish a system for monitoring and surveillance of reactions for a period of minimally six months up to five years after RFT. This surveillance is especially important considering that patients may develop neurological impairment gradually and without presenting symptoms, with the subsequent possibility of physical and psycho-social harm.

[pt] Devido às exigências da largura de banda, especialmente nas comunicações sem fios que são cada dia maiores pelo aumento do numero de usuários, é necessário estudar a banda de EHF(Extremely High Frequency). A transmissão e recepção de dados em EHF constitui uma possível solução para aliviar a escassez do espectro e satisfazer a crescente demanda de maiores velocidades tentado resolver as limitações dos sistemas atuais. As ondas de radio na banda EHF vão de 30 até 300 GHz e são chamadas ondas milimétricas, já que seus comprimentos de onda vão de 10 mm até 1 mm. Neste trabalho, a montagem de um sistema de geração e detecção de ondas de EHF a partir do batimento de dois lasers é apresentada. Técnicas de modulação e demodulação em fase, amplitude e frequência na faixa de 200-300 GHz são demonstradas. / [en] The capacity of wireless communications has started to reach the top and the unstoppable increase of users is becoming a problem because more bandwidth is needed, which has gave rise to the study of EHF (Extremely High Frequency) band. Transmission and reception of data in EHF is shown as a solution to alleviate the scarcity of the spectrum and to meet the request of faster speeds to solve the limitation of the actual systems. The range of radio waves in EHF band go from 30 to 300 GHz, and are called millimeter waves since their wavelengths are between 10mm and 1mm. In this work is presented a system capable to generate and detect EHF waves from the beating of two lasers, and at the same time different modulation and demodulation techniques (phase, amplitude and frequency) are presented.

Dans ce mémoire sont résumés mes travaux de recherche dans le domaine de la caractérisation large bande de fréquence. Après une présentation des techniques large bande, deux applications sont décrites : le cas du radar pour l'étude de la SER de cibles aériennes en vue de leur identification, et le cas des systèmes de radiocommunications, l'étude et la modélisation du canal de propagation. Ce mémoire se décompose donc en deux parties principales.<br />La première est consacrée au développement de systèmes radars HF – VHF à large bande de fréquence et à diversité de polarisation pour la classification et l'identification de cibles aériennes. Deux approches sont étudiées, une multifréquence et l'autre à balayage de fréquence. Dans un premier temps, les systèmes utilisant ces techniques, ainsi que leurs performances, sont décrits. Des exemples de mesures de SER d'avions non coopératifs sont présentés.<br />Les méthodes d'identification de cibles reposent généralement sur la comparaison de mesures à une base de données. Dans un second temps, les méthodes numériques utilisées pour la simulation de SER sont décrites et analysées. Dans un troisième temps, les méthodes d'identification développées sont présentées, discutées et illustrées par des résultats d'identification sur des cibles réelles.<br />Dans la deuxième partie sont regroupés mes travaux sur la caractérisation large bande de fréquence et la modélisation du canal de propagation. Les différents chapitres de cette partie s'organisent en fonction de la fréquence. On trouve tout d'abord la bande HF dans laquelle un modèle de prévisions de propagation a été développé afin d'évaluer le comportement large bande du canal. Différentes applications, telles que la réactualisation et la localisation à station unique, illustrent cette partie. Dans la bande UHF, des travaux ont été menés sur la caractérisation du canal de propagation radio-mobile et le développement de nouveaux outils de sondage.<br />Des campagnes de mesures ont été menées à l'aide d'un sondeur à corrélation glissante SIMO (Single Input – Multiple Output) en milieu urbain. La technique de mesure par balayage de fréquence a aussi été étudiée par le développement d'un nouveau sondeur, l'objectif étant de réaliser un équipement MIMO (Multiple Input – Multiple Output) permettant la mesure simultanée de tous les canaux de propagation.<br />Dans la bande EHF, le canal étudié concerne les applications des radars dans le domaine de l'automobile. Des mesures ont été réalisées et un modèle de propagation en est déduit. La caractérisation du canal s'est appuyée sur un analyseur de réseau vectoriel. La méthodologie est explicitée et des comparaisons entre les simulations et les mesures sont présentées.<br />La dernière partie conclut en effectuant un bilan provisoire de mes activités et en présentant les perspectives de mon travail sur la caractérisation à large bande de fréquence dans le domaine du radar et du sondage de canal. Enfin, une liste des mes publications, des différents encadrements, des contrats de recherche sur lesquels j'ai travaillé, de mes activités pédagogiques et administratives et des fonctions électives et autres responsabilités, est donnée.

[pt] Nos últimos anos, as bandas de frequências nas comunicações sem fio estão começando a saturar devido ao incremento do tráfego e o aumento dos usuários, é devido a isso que, é necessário estudar as bandas de frequências que não estão sendo utilizadas nas áreas das comunicações como a banda milimétrica e sub-milimétrica. A transmissão de dados na banda EHF o banda milimétrica constitui uma possível solução para conseguir transmitir maiores quantidades de informação a altas velocidades de transmissão aliviando as bandas de frequências atuais. Neste trabalho se estuda a transmissão de dados em frequências de 100, 200, 300 e 400 GHz, empregando a modulação Quadrature Phase-Shift Keying (QPSK) mediante uma arquitetura baseada no batimento de dois lasers, cujas frequências são combinadas em um Beam Splitter, para que a corrente resultante da soma dos campos elétricos dos dois lasers seja convertida em um sinal de alta frequência por meio de uma antena fotocondutora. O batimento dos dois lasers, com diferentes comprimentos de onda e com a mesma potência, ao interagir com uma antena fotocondutora dá como resultado uma frequência na ordem de Gigahertz. No experimento utilizaram-se dois tipos de diodos receptores, um de banda larga (menor que 4 GHz) e outro de banda estreita (menor que 1 MHz). As duas antenas foram testadas em diferentes distâncias e com diferentes frequências de portadora para verificar qual delas tinha o melhor desempenho na banda EHF para poder realizar a transmissão de dados. / [en] In recent years, the frequency bands in wireless communications are beginning to saturate due to the increase of traffic and the increase of users, and it for that reason that is necessary to study the frequency bands that are not begin used in the communication areas like millimeter and sub-millimeters bands. Data transmission in the EHF band is a possible solution to be able to transmit large amounts of information at high transmission speeds, alleviating current frequency bands. In this work, the transmission of data in frequencies of 100, 200, 300 and 400 Gigahertz is studied, using Quadrature phase-shift keying (QPSK) modulation with an architecture based on the beat of two lasers, whos frequencies are combined by means of Beam Splitter, so that result of the electric fields of two lasers is converted into a high frequency signal with the aid of a photoconductor antenna. The.beating of the two lasers, with different wavelengths and with the same power, when interacting with a photoconductor antenna results in a frequency in the order of Gigahertz. In the experiment, two types of receiver diodes were used, one Broadband (less than 4 GHz) and the other of narrowband (less than 1 MHz). The two antennas were tested at different distances and with different carrier frequencies to verify which one had the best performance in the EHF band in order to perform the data transmission.

O espasmo hemifacial (EHF) é um distúrbio de movimento caracterizado por contrações tônico ou clônicas involuntárias, unilaterais, intermitentes e irregulares dos músculos inervados pelo nervo facial ipsilateral. Apesar de considerado como um transtorno benígno, promove influência significativa na qualidade de vida dos portadores através do comprometimento funcional físico e emocional que promove, englobando, desde o prejuízo na leitura e outras funções visuais, até o constrangimento social e distúrbios psiquiátricos associados, como depressão e ansiedade. Objetivo.: Descrever as características clínicas e demográficas, assim como a frequência de sintomas psiquiátricos de ansiedade generalizada, social e depressão, e a relação destes sintomas com a qualidade de vida nesta amostra de pacientes. Métodos.: 111 pacientes portadores de EHF primário foram avaliados. Foi aplicado questionário geral para coleta de dados demográficos e clínicos associados a evolução e tratamento do distúrbio de movimento com toxina botulínica. Os sintomas psiquiátricos foram avaliados através de escalas validadas para a população brasileira. A avaliação de qualidade de vida foi através de escala específica validada para avaliação funcional nos portadores de EHF. Resultados.: A idade média de início foi de 49±13,1 (intervalo: 12 -77) e tempo de evolução até o diagnóstico de 3±1,5 anos, com predomínio no sexo feminino (2,08:1). O lado esquerdo foi afetado em 61 (54,9%) pacientes e o músculo orbicular dos olhos foi o primeiro acometido na maioria dos casos (85,5%). Grande parte (n=87) referiu início insidioso e evolução gradual. Nervosismo, estresse e ansiedade são importantes contribuintes de piora do espasmo, relatado por mais de 82% (n=92) dos portadores de EHF, e momentos de relaxamento, tranquilidade, descanso e atividades de lazer foram responsáveis por aliviar o espasmo em 57 entrevistados. Mais de 90% (n=96) perceberam melhora importante do espasmo após aplicação de TXB, e 24,5% (n=26) relataram algum efeito adverso em última aplicação, sendo assimetria labial e ressecamento ocular os mais frequentes. Sobre os sintomas psiquiátricos, 41,7% (n=45) apresentavam pontuações que sugerem algum grau de depressão, até 56,4% (n=57) ansiedade generalizada e 34,2% (n=38) ansiedade ou fobia social. A leitura como domínio funcional físico e a vergonha, a tristeza e a preocupação com reação de outras pessoas foram os maiores prejuízos funcionais descritos nesses pacientes. Conclusão.: As características clínicas e demográficas nos pacientes com EHF se assemelham a outras evidências descritas na literatura, assim como uma maior frequência de sintomas de depressão, ansiedade generalizada e fobia social nesta população. Os sintomas psiquiátricos, mais do que a gravidade do espasmo, apresentaram uma maior correlação com a qualidade de vida nesta amostra de pacientes. / Hemifacial spasm (HFS) is a movement disorder characterized by involuntary, unilateral, intermittent, tonic or clonic contractions of muscles innervated by the ipsilateral facial nerve. Although considered as a benign disorder, it promotes a significant influence on the quality of life of the patients through the physical and emotional impairment it promotes, ranging from impairment in reading and other visual functions to social embarrassment, and associated psychiatric disorders, such as depression and anxiety. Objective.: To describe the clinical and demographic characteristics, as well as the frequency of psychiatric symptoms of generalized anxiety, social anxiety and depression, and the relation of these symptoms with quality of life in this sample of patients. Methods.: 111 patients with primary HFS were evaluated. A general questionnaire was used to collect demographic and clinical data associated with the evolution and treatment of the movement disorder with botulinum toxin (BTX). The psychiatric symptoms were evaluated through scales validated for the Brazilian population. The quality of life assessment was based on a specific validated scale for functional evaluation in patients with HFS. Results.: The mean age at onset was 49 ± 13.1 (range: 12-77) and time to diagnosis of 3 ± 1.5 years, with a predominance of females (2.08 :1). The left side was affected in 61 (54.9%) patients and the orbicularis oculi muscles were the first affected in the majority of cases (85.5%). A large part (n = 87) reported insidious onset and gradual evolution. Nervousness, stress, and anxiety are important contributors to worsening spasm, reported by more than 82% (n = 92) of HFS patients, and moments of relaxation, tranquility, rest, and leisure activities were responsible for relieving spasm in 57 interviewees. More than 90% (n = 96) reported significant improvement of spasm after BTX application, and 24.5% (n = 26) reported some adverse effects in the last application, with lip asymmetry and ocular dryness being the most frequent. On the psychiatric symptoms, 41,7% (n = 45) presented scores that suggest some degree of depression, up to 56.4% (n = 57) generalized anxiety and 34.2% (n = 38) anxiety or social phobia. Reading as a physical functional domain and shame, sadness and concern for other people\'s reactions were the major functional losses described in these patients

O espasmo hemifacial (EHF) é um distúrbio de movimento caracterizado por contrações tônico ou clônicas involuntárias, unilaterais, intermitentes e irregulares dos músculos inervados pelo nervo facial ipsilateral. Apesar de considerado como um transtorno benígno, promove influência significativa na qualidade de vida dos portadores através do comprometimento funcional físico e emocional que promove, englobando, desde o prejuízo na leitura e outras funções visuais, até o constrangimento social e distúrbios psiquiátricos associados, como depressão e ansiedade. Objetivo.: Descrever as características clínicas e demográficas, assim como a frequência de sintomas psiquiátricos de ansiedade generalizada, social e depressão, e a relação destes sintomas com a qualidade de vida nesta amostra de pacientes. Métodos.: 111 pacientes portadores de EHF primário foram avaliados. Foi aplicado questionário geral para coleta de dados demográficos e clínicos associados a evolução e tratamento do distúrbio de movimento com toxina botulínica. Os sintomas psiquiátricos foram avaliados através de escalas validadas para a população brasileira. A avaliação de qualidade de vida foi através de escala específica validada para avaliação funcional nos portadores de EHF. Resultados.: A idade média de início foi de 49±13,1 (intervalo: 12 -77) e tempo de evolução até o diagnóstico de 3±1,5 anos, com predomínio no sexo feminino (2,08:1). O lado esquerdo foi afetado em 61 (54,9%) pacientes e o músculo orbicular dos olhos foi o primeiro acometido na maioria dos casos (85,5%). Grande parte (n=87) referiu início insidioso e evolução gradual. Nervosismo, estresse e ansiedade são importantes contribuintes de piora do espasmo, relatado por mais de 82% (n=92) dos portadores de EHF, e momentos de relaxamento, tranquilidade, descanso e atividades de lazer foram responsáveis por aliviar o espasmo em 57 entrevistados. Mais de 90% (n=96) perceberam melhora importante do espasmo após aplicação de TXB, e 24,5% (n=26) relataram algum efeito adverso em última aplicação, sendo assimetria labial e ressecamento ocular os mais frequentes. Sobre os sintomas psiquiátricos, 41,7% (n=45) apresentavam pontuações que sugerem algum grau de depressão, até 56,4% (n=57) ansiedade generalizada e 34,2% (n=38) ansiedade ou fobia social. A leitura como domínio funcional físico e a vergonha, a tristeza e a preocupação com reação de outras pessoas foram os maiores prejuízos funcionais descritos nesses pacientes. Conclusão.: As características clínicas e demográficas nos pacientes com EHF se assemelham a outras evidências descritas na literatura, assim como uma maior frequência de sintomas de depressão, ansiedade generalizada e fobia social nesta população. Os sintomas psiquiátricos, mais do que a gravidade do espasmo, apresentaram uma maior correlação com a qualidade de vida nesta amostra de pacientes. / Hemifacial spasm (HFS) is a movement disorder characterized by involuntary, unilateral, intermittent, tonic or clonic contractions of muscles innervated by the ipsilateral facial nerve. Although considered as a benign disorder, it promotes a significant influence on the quality of life of the patients through the physical and emotional impairment it promotes, ranging from impairment in reading and other visual functions to social embarrassment, and associated psychiatric disorders, such as depression and anxiety. Objective.: To describe the clinical and demographic characteristics, as well as the frequency of psychiatric symptoms of generalized anxiety, social anxiety and depression, and the relation of these symptoms with quality of life in this sample of patients. Methods.: 111 patients with primary HFS were evaluated. A general questionnaire was used to collect demographic and clinical data associated with the evolution and treatment of the movement disorder with botulinum toxin (BTX). The psychiatric symptoms were evaluated through scales validated for the Brazilian population. The quality of life assessment was based on a specific validated scale for functional evaluation in patients with HFS. Results.: The mean age at onset was 49 ± 13.1 (range: 12-77) and time to diagnosis of 3 ± 1.5 years, with a predominance of females (2.08 :1). The left side was affected in 61 (54.9%) patients and the orbicularis oculi muscles were the first affected in the majority of cases (85.5%). A large part (n = 87) reported insidious onset and gradual evolution. Nervousness, stress, and anxiety are important contributors to worsening spasm, reported by more than 82% (n = 92) of HFS patients, and moments of relaxation, tranquility, rest, and leisure activities were responsible for relieving spasm in 57 interviewees. More than 90% (n = 96) reported significant improvement of spasm after BTX application, and 24.5% (n = 26) reported some adverse effects in the last application, with lip asymmetry and ocular dryness being the most frequent. On the psychiatric symptoms, 41,7% (n = 45) presented scores that suggest some degree of depression, up to 56.4% (n = 57) generalized anxiety and 34.2% (n = 38) anxiety or social phobia. Reading as a physical functional domain and shame, sadness and concern for other people\'s reactions were the major functional losses described in these patients

En France, alors qu'un quart des premières unions sont rompues dans les cinq années qui suivent leur formation, un nombre croissant de personnes vivent les conséquences sociales, familiales et économiques de la séparation. Ce travail porte sur les comportements familiaux après la séparation d'une première union cohabitante, et explicite les conséquences démographiques de la montée des ruptures. Nos résultats sont tirés d'analyses démographiques et statistiques effectuées à partir des données de l'enquête « Étude des relations intergénérationnelles » (Érfi, Ined-Insee, 2005), de l'«Enquête familles et employeurs » (EFE, Ined, 2004) et de l'enquête « Étude de l'histoire familiale » (EHF, Insee-Ined, 1999). Nous tirons trois grands enseignements de cette thèse. 1) La fréquence de remise en couple des femmes a augmenté au début des années 1980, au cours de la période de grands changements familiaux. Chez les hommes elle a légèrement baissé dans les dernières décennies, ce qui peut être lié à des changements d'ordre socio-économique. Les femmes séparées ayant des enfants se remettent moins souvent en couple, et celui-ci est alors plus fragile. 2) Les hommes et les femmes ont des comportements conjugaux différents, qui dépendent de leurs caractéristiques socioculturelles. Les personnes ayant vécu une première union plus engagée – par sa longueur, son statut ou même sa fécondité pour les hommes – paraissent plus attachées à la vie de couple en général. Notamment, les deuxièmes unions semblent plus stables lorsqu'elles suivent une première union engagée. 3) La hausse de la fréquence des ruptures serait à l'origine d'un retard et d'une baisse de la fécondité, car la séparation réduit la période de conception pour les femmes. La survenue d'une naissance dans une deuxième union dépend des caractéristiques combinées des deux conjoints : leur âge, et leurs enfants respectifs. Elle est particulièrement peu probable lorsque la femme atteint des âges moins fertiles ou si les deux conjoints ont déjà des enfants lors de la mise en couple.

With the growing trend of wireless electronics, frequency spectrum is crowded with different applications. High data transfer rate solutions that operate in license-exempt frequency spectrum range are sought. The most promising candidate is the 60 GHz multi-giga bit transfer rate millimeter wave circuit. In order to provide a cost-effective solution, circuits designed in CMOS are implemented in a single SOC. In this work, a modeling technique created in Cadence shows an error of less than 3dB in magnitude and 5 degree in phase for a single transistor. Additionally, less than 3dB error of power performance for the PA is also verified. At the same time, layout strategies required for millimeter wave front-end circuits are investigated. All of these combined techniques help the design converge to one simulation platform for system level simulation. Another aspect enabling the design as a single SOC lies in integration. In order to integrate digital and analog circuits together, necessary peripheral circuits must be designed. An on-chip voltage regulator, which steps down the analog power supply voltage and is compatible with digital circuits, has been designed and has demonstrated an efficiency of 65 percent with the specific area constraint. The overall output voltage ripple generated is about 2 percent. With the necessary power supply voltage, gate voltage bias circuit designs have been illustrated. They provide feasible solutions in terms of area and power consumption. Temperature and power supply sensitivities are minimized in first two designs. Process variation is further compensated in the third design. The third design demonstrates a powerful solution that each aspect of variations is well within 10%. As the DC conditions are achieved on-chip for both the digital and analog circuits, digital and analog circuits must be connected together with a DAC. A high speed DAC is designed with special layout techniques. It is verified that the DAC can operate at a speed higher than 3 Gbps from the pulse-shaping FIR filter measurement result. With all of these integrated elements and modeling techniques, a high data transfer rate CMOS RF SOC operating at 60 GHz is possible.

This thesis describes design and experimental verification of three types of the wideband antenna Bow-tie antenna, Vivaldi antenna and Spiral antenna. The tracked parameters are bandwidth, input impedance, gain and directivity patterns. Next step is design of millimeter-wave horn antennas. Attention is turned to the proper construction of a wideband feeder of the horn. For the final antenna structure, a bow-tie dipole and a Vivaldi antenna were chosen. The antenna construction is aimed to provide a wide bandwidth on one hand and a high gain on the other hand.