The thesis proposes a hybrid broadband equivalent model extraction method, and our goal is to combine via structure and irregular transmission line in print circuit board for extraction of broadband SPICE-compatible model by using the time domain algorithm and full wave simulation in frequency domain, respectively. We can construct broadband SPICE-compatible macro-model scalable library with two kind of different extraction methods, tow kind of extraction of equivalent model can construct the circuit structure for designer demand. Every modules of the broadband macro model of the two extraction models are represented by the optimum pole-residue forms. Using a systematic lumped-model extraction technique, all the optimum pole-residue rational functions can be transfered into a corresponding lumped circuit model. The accuracy of Extraction of Broadband Equivalent Models is demonstrated in frequency -domain responses compared with the 3D-FDTD or HFSS simulation. In addition, the extraction model can simulate in commercial tools effectively, ex: Hspice¡BADS. Even the model can simulate signal integrality and power integrality in Hspice or ADS.

In this thesis, design and analyses of honeycomb structures are investigated. Primary goal is to develop an equivalent orthotropic material model that is a good substitute for the actual honeycomb core. By replacing the actual honeycomb structure with the orthotropic model, during the finite element analyses, substantial advantages can be obtained with regard to ease of modeling and model modification, solution time and hardware resources . To figure out the best equivalent model among the approximate analytical models that can be found in the literature, a comparison is made. First sandwich beams with four different honeycomb cores are modeled in detail and these are accepted as reference models. Then a set of equivalent models with the same dimensions is generated. The material properties of the equivalent models are taken from different studies performed in the literature. Both models are analyzed under the same loading and the boundary conditions. In finite element analyses, ANSYS finite element program is used. The results are compared to find out the best performing equivalent model. After three major analyses loops, decision on the equivalent model is made. The differences between the total reaction forces calculated by the equivalent model and the actual honeycomb model are all found to be within 10%. The equivalent model gives stress results at the macro-scale, and the local stresses and the strains can not be determined. Therefore it is deemed that for stress analysis, equivalent model can be used during the preliminary design phase. However, the equivalent model can be used reliably for deflection analysis, modal analysis, stiffness determination and aero-elastic analysis.

This thesis, for the first time in literature, introduces a comprehensive study about analog controller designs for MEMS vibratory gyroscopes. A controller of a MEMS gyroscope is mandatory for robust operation, which is insensitive to sensor parameters and ambient con- ditions. Errors in the controller design not only deteriorate transient performance, such as settling time and overshoot, but also cause performance degradation due to stability problems. Accordingly, true controller design for a gyroscope is critical work in terms of functionality and system performance. This thesis gives details for modeling, analysis of closed-loop sys- tems, and design procedure for drive and sense modes. Controller loops are implemented both with discrete components and in a CMOS technology as an integrated circuit. Simulation and test results verify the modeling, analysis, and design procedure discussed in this thesis. Drive mode system developed previously at METU is optimized by taking circuit imperfec- tions into account, which results in an improved transient performance of 50 msec settling time with no overshoot for a 4&mu / m drive mode oscillation amplitude. This system has a 60 phase margin with the help of the pole-zero cancellation technique. In addition, a new gener- iv ation and simple drive mode controller for tactical grade applications is designed and verified with a moderate transient performance. Two different sense mode controller design procedures are also developed according to a new base-band equivalent model derived for mismatch operation, as a new contribution to the literature. Firstly, a PID controller is designed for low frequency separation between the drive and sense modes of the gyroscope. Secondly, an integral controller is used for moderate and high mismatch amount. The controller system designed with the new base-band equivalent model improves the linearity, angle random walk, and bias instability by factors of 4, 9, and 3, respectively. Proposed drive and sense mode controllers are also designed and implemented using a 0.6&mu / m standard CMOS process. These chips are the first functional chips developed at METU de- signed for MEMS gyroscopes. Functionality of the proposed three systems, i.e., conventional drive mode controller, new generation drive mode controller, and sense mode controller, are verified with tests. The first prototypes result in 0.033 degree/sqrt/(hr) angle random walk and 3 degree/hr bias instability for open-loop operation, which is very promising and can be improved even further in future designs.

The first part of the thesis focuses on developing a numerical methodology to simulate the acoustic properties of a hybrid liner consisting of a perforated plate, a porous layer and a Helmholtz cavity. Liners are always a standard way to reduce noise in today’s aeroengines, e.g. the fan noise can be reduced effectively through the installation of acoustic liners as wall treatments in the ducts. In order to optimize a liner in the design phase, an accurate and efficient prediction tool is of interests. Hence, a unified Linearized Navier-Stokes equations(LNSE) approach has been implemented in the thesis, combining the LNSE in frequency domain with the fluid equivalent model. The LNSE is applied in the vicinity of the perforated plate to simulate sound propagation including viscous damping effect, and the fluid equivalent model is used to model the sound propagation in the porous material including absorption. The second part of the thesis focuses on the prediction of thermoacoustic instabilities. Thermoacoustic instabilities arise when positive coupling occurs between the flame and the acoustics in the feedback loop, i.e. the flame acts as an amplifier of the disturbances (acoustic or fluid) at a natural frequency of the combustion system. Once the thermoacoustic instabilities occur, it will lead to extremely high noise levels within a relatively narrow frequency range, resulting in a huge damage to the structure of the combustors. Hence, a solution must be found, which breaks the link between the combustion process and the structural acoustics. The numerical prediction of thermoacoustic instabilities in the thesis is performed by two different numerical methodologies. One solves the Helmholtz equation in combination of the flame n − tau model with the low Mach number assumptions, and the other solves the Linearized Navier-Stokes equations in frequency domain with mean flow. The result show that the mean flow has a significant effect on the thermoacoustic instabilities, which is non-negligible when the Mach number reaches to 0.15. / <p>QC 20151221</p> / TANGO

Electromagnetic Interference (EMI), primarily common mode (CM), is problematic in a wide range of electronic circuits due to its propensity to radiate, particularly in high power applications. It is routine for much effort and resources to be dedicated to its characterization and reduction as EMI compliance is a requirement for most electronic systems and devices, including power electronics. Many well-known factors contribute to a system’s EMI performance including intentional coupling from system components as well as unintentional coupling from parasitics. Sources of intentional coupling may include Y-capacitors intended to mitigate EMI as part of a filter. Unintentional coupling is more elusive and can exist throughout the system in PCB layout, cabling, load construction, and internal to components such as inverter bridges. Lesser-known contributions to EMI performance irregularities can be EMI filter asymmetries, switching asymmetries, line impedance variances, and galvanic coupling from the metrology intended to measure EMI. It is critical to understand these contributors to facilitate designs with optimal EMI performance. EMI filters are often added to designs with no consideration to asymmetries in construction and component tolerances. This proposal evaluates the impact to CM currents in cases of coupling or leakage inductance imbalances of a CM choke. Similarly, CM currents are also evaluated for cases when EMI filter Y-capacitor imbalances span the components tolerance band. Also analyzed are switching asymmetries in a typical converter topology to understand EMI impact and evaluate potential benefits if intentional asymmetric switching is applied. A practical method is introduced to measure line impedance upstream of devices under test as line impedance variation can impact the performance of EMI filter design. However, few documented practices exist to measure line impedance without specialized instrumentation. Finally, this work proposes a streamlined method for conducted emissions evaluation employing an oscilloscope, differential voltage probes, and post-processing software implemented in MATLAB. This method eliminates unintended metrology ground coupling that can significantly impact EMI measurements and minimizes risk of instrumentation damage particularly in high power systems.

La peau et son vieillissement sont un enjeu de santé publique. Les modèles expérimentaux disponibles pour l'étude du vieillissement cutané restent perfectibles. Dans ce contexte, nos objectifs étaient simultanément d'utiliser les modèles de peaux reconstruites (PR) développés dans notre laboratoire afin i) de mieux comprendre les mécanismes du vieillissement cutané, ii) de démontrer l'efficacité et le mécanisme d'action du sélénium comme « anti âge » et enfin iii) de les faire évoluer en utilisant le support poreux ou auto-assemblé avec des fibroblastes du même donneur prélevés à des âges différents. Ainsi, le modèle de PR cultivé sur une longue période a montré une surexpression du microARN miR30-a par RT qPCR dans les PR « âgées » avec une altération de la fonction barrière mesurée par la perte insensible en eau et une perturbation de la différenciation terminale (baisse d'expression de la loricrine et de l'involucrine). Avec le même modèle in vitro, nos résultats démontrent que la supplementation en sélénium retarde la sénescence des kératinocytes souches. Cette efficacité passe non pas par un effet antioxydant comme attendu mais par l'activation de leur adhésion à la lame basale, qui participe à les conserver souche et donc à préserver le renouvellement épidermique. Enfin, nous avons eu la chance exceptionnelle de préparer des PR avec des fibroblastes provenant d'un donneur unique prélevé à 36 et 72 ans. Les résultats immunohistologiques montrent que l'âge induit une augmentation de l'expression de l'élastine et de la fibrilline ainsi que leur co-expression. L'augmentation de LTBP1 et aSMA suggère que cette augmentation inattendue est due à une dérégulation de la voie TGF-ß et une différenciation des fibroblastes en myofibroblastes. En conclusion l'utilisation de différents modèles de PR a permis d'explorer les mécanismes conduisant au vieillissement cutané et de démontrer l'efficacité du sélénium comme anti âge / Skin and its aging is a public health issue. In vitro skin models available for the study aging remain perfectible. In this context, our objectives were simultaneously to use skin equivalent (SE) developed in our laboratory i) to better understand mechanisms of skin aging, ii) to demonstrate the effectiveness of selenium as “anti-aging” and finally iii) to improve SE using the porous or scaffold free model with fibroblasts from the same donor at different ages. Thus, the model of SE mimicking senescence showed an overexpression of microRNA miR30-a by RT qPCR in old SE with an alteration of the barrier function measured by the transepidermal water loss and a deficiency of epidermal terminal differentiation (decreased expression of loricrin and involucrin). With the same SE model, our results demonstrate that selenium supplementation delays the senescence of keratinocytes stem cells. This effectiveness does not involve antioxidant effect as expected but the activation of their adhesion to the basement membrane, which participates in preserving stemness and epidermal renewal. Finally, we had the opportunity to prepare SE with fibroblasts from a single donor at 36 and 72 years old. The histological results show that age induces an increase in the expression of elastin and fibrillin as well as their co-expression. The increase of LTBP1 and aSMA suggests that this unexpected increase is due to deregulation of the TGF-ß pathway and fibroblasts differentiation into myofibroblasts. In conclusion, the use of different models of SE helps us to explore some mechanisms leading to skin aging and to demonstrate the efficacy of selenium as “anti-aging”

It has previously been found that complexes comprised of vitronectin and growth factors (VN:GF) enhance keratinocyte protein synthesis and migration. More specifically, these complexes have been shown to significantly enhance the migration of dermal keratinocytes derived from human skin. In view of this, it was thought that these complexes may hold potential as a novel therapy for healing chronic wounds. However, there was no evidence indicating that the VN:GF complexes would retain their effect on keratinocytes in the presence of chronic wound fluid. The studies in this thesis demonstrate for the first time that the VN:GF complexes not only stimulate proliferation and migration of keratinocytes, but also these effects are maintained in the presence of chronic wound fluid in a 2-dimensional (2-D) cell culture model. Whilst the 2-D culture system provided insights into how the cells might respond to the VN:GF complexes, this investigative approach is not ideal as skin is a 3-dimensional (3-D) tissue. In view of this, a 3-D human skin equivalent (HSE) model, which reflects more closely the in vivo environment, was used to test the VN:GF complexes on epidermopoiesis. These studies revealed that the VN:GF complexes enable keratinocytes to migrate, proliferate and differentiate on a de-epidermalised dermis (DED), ultimately forming a fully stratified epidermis. In addition, fibroblasts were seeded on DED and shown to migrate into the DED in the presence of the VN:GF complexes and hyaluronic acid, another important biological factor in the wound healing cascade. This HSE model was then further developed to enable studies examining the potential of the VN:GF complexes in epidermal wound healing. Specifically, a reproducible partial-thickness HSE wound model was created in fully-defined media and monitored as it healed. In this situation, the VN:GF complexes were shown to significantly enhance keratinocyte migration and proliferation, as well as differentiation. This model was also subsequently utilized to assess the wound healing potential of a synthetic fibrin-like gel that had previously been demonstrated to bind growth factors. Of note, keratinocyte re-epitheliasation was shown to be markedly improved in the presence of this 3-D matrix, highlighting its future potential for use as a delivery vehicle for the VN:GF complexes. Furthermore, this synthetic fibrin-like gel was injected into a 4 mm diameter full-thickness wound created in the HSE, both keratinocytes and fibroblasts were shown to migrate into this gel, as revealed by immunofluorescence. Interestingly, keratinocyte migration into this matrix was found to be dependent upon the presence of the fibroblasts. Taken together, these data indicate that reproducible wounds, as created in the HSEs, provide a relevant ex vivo tool to assess potential wound healing therapies. Moreover, the models will decrease our reliance on animals for scientific experimentation. Additionally, it is clear that these models will significantly assist in the development of novel treatments, such as the VN:GF complexes and the synthetic fibrin-like gel described herein, ultimately facilitating their clinical trial in the treatment of chronic wounds.

Hydropower systems often contain complex river systems which cause the simulations and analyses of a hydropower operation to be computationally heavy. The complex river system is referred to as something called a Detailed model. By creating a simpler model, denoted the Equivalent model, the computational issue could be circumvented. The purpose of this Equivalent model is to emulate the results of the Detailed model. This thesis computes the Equivalent model for a large hydropower system using Particle Swarm Optimisation- algorithm, then evaluates the Equivalent model performance. Simulations are performed on ten rivers in Sweden, representing four trading areas for one year, October 2017 – September 2018. Furthermore, the year is divided into Quarterly and Seasonal periods, to investigate whether the Equivalent model changes over time. The Equivalent model performance is evaluated based on the relative power difference and computational time compared to the Detailed model. The relative power difference is 4%23% between Equivalent and Detailed models, depending on the period and trading area, with the computational time can be reduced by more than 90%. Furthermore, the Equivalent model changes over time, suggesting that when the year is divided appropriately, the Equivalent model could perform better. The relative power difference results indicate that the Equivalent model performance can still be improved by dividing the periods more appropriately, other than Quarterly or Seasonal. Nevertheless, the results provide a satisfactory Equivalent model, based on the faster computation time and a reasonable relative power difference. Finally, the Equivalent model could be used as a foundation for further analyses and simulations. / Vattenkraftsystem består ofta av komplexa älvsystem som gör att simuleringar och analyser av vattenkraftens operation blir beräkningsmässigt tunga. Det komplexa älvsystem kallas en Detaljeraded modell. Genom att skapa en enklare modell, betecknas som en Ekvivalent modell, beräkningsproblemen kan kringgås. Syftet med denna Ekvivalenta modell är att emulera resultaten av den komplexa Detaljerade modellen. Detta examensarbete beräknar den Ekvivalenta modellen för ett stort vattenkraftssystem med hjälp av Particle Swarm Optimisation- algorithmen, och utvärderar modellprestandan hos Ekvivalenten. Simuleringar utförs på tio älvar i Sverige, som representerar fyra handelsområden under ett år, från oktober 2017 september 2018. Dessutom är året uppdelat i kvartals- och säsongsperioder för att undersöka om den Ekvivalenta modellen förändras över tid. Denna Ekvivalenta modell utvärderas baserat på den relativa effektskillnaden och beräkningstiden jämfört med den Detaljerade modellen. Den relativa effektskillnaden är 4% 23% mellan de Ekvivalenta och Detaljerade modellerna, beroende på period och handelsområde, och beräkningstiden minskas med mer än 90%. Vidare ändras Ekvivalenta modellen över tiden, vilket tyder på att när året delas upp på rätt sätt kan den Ekvivalenta modellen prestera ännu bättre. De relativa effektskillnaderna indikerar att vissa perioder fortfarande kan förbättras genom att dela upp perioden mer korrekt. Trots allt, förser resultanten en tillfredsställande Ekvivalent modell som har en mer effektiv beräkningstid och rimliga effektskillnader. Slutligen skulle den Ekvivalenta modellen kunna användas som en grund för ytterligare analyser och simuleringar.

This work presents an analysis of a Piezoelectric Transformer (TP), showing the main types of devices, characteristics, operation modes, among others important points. The parameters of Mason Classic Model are determined by frequency response analysis. The nominal load is determined considering the maximum power transfer and the efficiency from the load tests. In order to obtain a more accurate equivalent model, an optimization methodology of equivalent model is proposed. The criterion used to optimize the model is the minimum standard square error between frequency response of TP and model. To prove the results obtained by the optimization meth-odology, it is presented, in impedance graphs, the curves of model obtained by fre-quency response, optimized model and TP. The optimized model is obtained for dif-ferent segments configurations of TP. The analysis of segments has the goal to adapt the TP to specific applications, enabling the parameters adjust, to different condi-tions of load impedance to maximum power transfer, voltage gain and efficiency, among others. The Half-Bridge practical results with nominal load are presented to all segments configurations, using as resonant converter. / Este trabalho apresenta uma análise sobre Transformador Piezelétrico (TP), mostrando os principais tipos de dispositivos, características, modos de operação, en-tre outros pontos importantes. Os parâmetros do modelo clássico de Mason são de-terminados pela análise da resposta em frequência. A carga nominal é determinada levando em conta a máxima transferência de potência e o rendimento a partir de tes-tes de carga. Para obter o modelo equivalente mais preciso é proposto uma metodolo-gia de otimização do modelo equivalente. O critério utilizado para otimizar o modelo é do menor erro quadrático normalizado e ponderado entre a resposta em frequência do modelo e a resposta experimental do TP. Para comprovar os resultados obtidos pela metodologia de otimização, são apresentados gráficos de resposta em frequência do modelo obtido pela resposta em frequência, do modelo otimizado e a resposta ex-perimental do TP. O modelo otimizado é estendido para diferentes configurações de segmentos do TP. A análise dos segmentos tem como objetivo adequar o TP para aplicações específicas, possibilitando o ajustes de parâmetros, para diferentes condi-ções de resistência de carga para máxima transferência de potência, ganho de tensão e rendimento, entre outros. Resultados práticos com carga nominal são apresentados para todas configurações de segmentos, utilizando como conversor ressonante o con-versor Half-Bridge.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Parting from Schumpeter s determinants of investment, an Evolutionary Theory is developed and with a base on the gene, identifying elements that encode routines and develop skills, establishing control, copying and imitation. Scientific technological knowledge, thus generated, can be created or replicated locally, creating what is called a "cluster of knowledge", leading to a dynamic Local Base of Innovation. A Federal Institution (FI) has two complementary roles: training human resources and accumulating techno-scientific knowledge to contribute to the implementation of a local socio-economy. These functions require a pattern of financing, which on the internal side, are derived by the application of "models of partition of OCC (Other Expenses and Capital)" by MEC / SESu determined by the Student-Equivalent Model, that is insufficient to take account the expansion plans of IFES. On the other hand, IFES seek external support to complement funding limitations via Projects, Programs, Parliamentary Amendments, among others, as was the case with UFS. To give consistency to our analysis, the case of the UFS was investigated, by historically analyzing results of approximately 10 years based on critical variables and parameters that make up the Student-Equivalent Model. We detected, despite the rapid growth of these variables, that elements of external and extra-budgetary partnerships were essential, illustrated by the examples of the NUPEG-SE and REUNI. The patterns of internal funding, allied by external partnerships, helped pave the way to consolidate UFS in its role as the Base of Local Innovation. / A partir dos determinantes Schumpeterianos do Investimento, desenvolvemos a Teoria Evolucionária e, com base no gene, apontamos os elementos que codificam a rotina e desenvolvem habilidades, estabelecendo o controle, a cópia e a imitação. O conhecimento científico-tecnológico, assim gerado, pode ser criado ou replicado localmente, originando o chamado cluster de conhecimento , dinamizando uma Base Local de Inovação. Uma Instituição Federal de Esnsino Superior (IFES) cumpre dois papéis complementares: formar recursos humanos e aportar conhecimentos tecnicocientíficos para a implementação de uma socioeconomia local. Essas funções exigem um padrão de financiamento que, pelo lado interno, resultam na aplicação de modelos de partição de OCC (Outros Custeios e Capital) pelo MEC/ SESu, sendo determinante o Aluno Equivalente ao se mostrar insuficiente para dar conta das pretensões de expansão das IFES . Por outro lado, as IFES buscam apoio externo e complementares para as suas carências de financiamento, mediante projetos, programas, emendas parlamentares, entre outras, como foi o caso da UFS. Para dar consistência à nossa análise aprofundamos o caso da UFS, recuperando historicamente, numa trajetória aproximada de 10 anos, as variáveis críticas e os parâmetros que compõem o Modelo Aluno-Equivalente. Detectamos, apesar do vigor de crescimento, que foram essenciais os elementos de parcerias externas e extra-orçamentárias, como o NUPEG-SE e o REUNI. Os padrões de financiamento interno, aliado às parcerias permitiram pavimentar o papel da UFS, para consolidação da Base Local de Inovação.