Global ETD Search

81	CLIC5 maintains lifelong structural integrity of sensory stereocilia by promoting Radixin phosphorylation in hair cells of the inner ear Waddell, Benjamin B. 27 April 2016 (has links) No description available. Biomedical Research Neurosciences CLIC5 RDX ERM radixin stereocilia jitterbug Jbg2J hair cells hearing deafness Ezrin Moesin CLIC microvilli hair cell inner ear cochlea actin cytoskeleton GST Jbg age-related hearing loss hearing loss biochemistry pull down
82	A drug development from risk management perspective / Vývoj léků z pohledu risk managementu Hulín, Michal January 2011 (has links) The purpose of this diploma thesis is to understand financing of drug development from an enterprise risk management perspective as well as to critically assess the efficiency of the ISO framework and risk management techniques used for determining whether to fund drug development or not. The diploma thesis is divided into theoretical and practical part. The first part starts with perception and assessment of uncertainty and risk in the past. It describes how risk-averse individuals attempted to deal with uncertainty and different risk. This is followed by the evolution of traditional risk management into the fast developing enterprise risk management. The text further analyses commonly used risk management standards COSO ERM and ISO 31000:2009. However, the main focus is on the critical assessment of analytical tools which are frequently used for evaluating and assessing risks, especially financial ones, during drug development. The theoretical part is finished by a drug development process, whose phases are briefly described. The practical part was written in co-operation with AstraZeneca, a top-notch pharmaceutical company. The overview of its business is preceded by an explanation of current issues in the pharmaceutical industry. Furthermore, the risk analysis is conducted with respect to the ISO framework. Subsequently, selected risk assessment techniques are applied on the simplified financial model of two different drugs, which was created based on AstraZeneca's real data. These risk assessment tools are used in different phases of drug development so it could be seen clearly how the results are changing during a project. The outcomes of this risk analysis are compared with original plans used by AstraZeneca which were used for deciding whether to fund drug development or not.
83	Migrating from integrated library systems to library services platforms : An exploratory qualitative study for the implications on academic libraries’ workflows Grammenis, Efstratios, Mourikis, Antonios January 2018 (has links) The present master thesis is an exploratory qualitative study in academic libraries regarding the transition from the integrated library systems to the next generation integrated library systems or library services platforms and the potential implications in their internal workflows. Nowadays, libraries all over the world are facing up with a number of challenges in terms of acquiring, describing and making available to the public all the resources, both printed and electronic, they manage. In particular, the academic libraries have more reasons to wish to fulfill their users’ needs since the majority of them use the library sources more and more for scientific research and educational purposes.In this study we attempt to explore the phenomenon in the globe using the available literature and to identify the implications in libraries’ workflows and the possible future developments. Moreover, through observation and semi-structured interviews we try to identify the current developments in the Greek context regarding the adoption of next ILS and possible implications in their workflows. Finally, we attempt a comparison between the Greek situation and the international one. Migration Migrating Integrated library systems library services platforms academic libraries workflows implications exploratory qualitative study exploratory qualitative qualitative research librarian Workflow Greece Library Management System Library Information System Integrated Library System as a Service ILSaS Hellenic Academic Library Link HEALLink Hermeneutics Hermeneutic Cycle Transition Digital capability Research design Observation Electronic Resources Librarian Acquisitions Cataloguing Circulation Interlibrary loan Electronic Resources Management ERM transition ροές εργασίας βιβλιοθηκονόμος ΟΠΣΒ Μετάπτωση Μετάβαση Ηλεκτρονικές πηγές Information Systems

Page generated in 0.0287 seconds