This diploma thesis is focused on pupils with average and below-average school results. The author of the thesis compares two teaching methods - drama teaching education and frontal teaching with modern teaching methods (in the thesis this method is being referred to as traditional education). The aim of the thesis is to find out which of these two methods pupils mentioned above prefer. In order to achieve this aim in the empirical part, the author of the thesis used both methods while teaching and compared the results - the amount of information that the pupils managed to remember from the lessons from the methods had been used. A questionnaire was used to validate the research results. The theoretical part is devoted to a lower school pupil and his ability to study. Then the author of the thesis is focused on Czech school system after 1989, especially on approaches of a school / a teacher to a pupil. To drama education, which is very important for this thesis, the whole chapter was devoted. The final part of the theoretical part is devoted to research methods. In the practical part, the conditions of the realization of the author's research, its realization and reflection are being mentioned. In the conclusion, the results from the obtained data are presented.

In Europe, the deployment characteristics of frontal crash restraints are generally optimised to best protect an average young male, since a 50th percentile male dummy is used in a stylised frontal impact scenario. These single point restraint systems may not provide similar levels of effectiveness when the crash scenarios vary with respect to the regulatory and consumer crash test procedures. Previous research has demonstrated that varying restraint deployment characteristics according to occupant and crash variation can provide further injury reduction in frontal impacts. This thesis reports the investigation conducted to assess the potential real world injury reduction benefit of smart restraint systems in frontal impacts. The intelligent capability of the restraint was achieved by varying the seat belt load limiter (SBL) threshold, according to the frontal crash scenario. Real world accident data (CCIS) were analysed to identify the target population of vehicle occupants and frontal impact scenarios where employing smart load limiters could be most beneficial, particularly in reducing chest injury risk. From the accident sample, the chest was the most frequently injured body region at an AIS 2+ level in frontal impacts (7% of front seat occupants). The proportion of older vehicle front seat occupants (>64 years old) with AIS 2+ injury was also greater than the proportion of younger occupants. Additionally, older occupants were more likely to sustain seat belt induced serious chest injury in low and moderate speed frontal crashes. Numerical simulations using MADYMO software were conducted to examine the effect of varying the load limiter thresholds on occupant kinematics and injury outcome in frontal impacts. Generic baseline driver and front passenger numerical models were developed using a 50th percentile dummy and were adapted to accommodate a 5th and 95th percentile dummy. Simulations were performed where the load limiter threshold was varied in five frontal impact scenarios which were selected to cover as wide a range of real frontal crash conditions as possible. From the simulation results, it was found that for both the 50th and 95th percentile dummy in front seating positions (driver and passenger), the low SBL provided the best chest injury protection, without increasing the risk to other body regions. In severe impacts, the low SBL allowed the dummy to move further towards the front facia, thus increasing the chance of occupant hard contact with the vehicle interiors. The Smart load limiters predicted no injury risk reduction for the 5th percentile drivers, who are shorter and tend to sit closer to the steering wheel. The potential injury reduction of the smart load limiters was quantified by applying the estimated injury risk reduction from the simulation to the real world accident data sample. Thoracic injury predictions from the simulations were converted into injury probability values using AIS 2+ age dependent thoracic risk curves which were developed and validated based on a methodology proposed by Laituri et al. (2005). Real world benefit was quantified using the predicted relative AIS 2+ risk reduction and assuming an appropriate adaptive system was fitted to all the cars in the real world sample. When applying the AIS 2+ risk reduction findings to the weighted accident data sample, the risk of sustaining an AIS 2+ seat belt injury reduced from 1.3% to 0.9% for younger front seat occupants, 7.6% to 5.0% for middle aged front seat occupants and 13.1% to 8.6% for the older front seat occupants. The research findings clearly demonstrate a chest injury reduction benefit across all age groups when the load limiter characteristics are varied. It suggests that employing a smart load limiter in a vehicle would not only benefit older occupants but also middle aged and young occupants. The benefit does appear to be most pronounced for older occupants, since the older population is more vulnerable to chest injury. As the older population of car users is rapidly rising, the benefits of smarter systems can only increase in the future.

Background: Although several neurophysiological models have been proposed for panic disorder with agoraphobia (PD/AG), there is limited evidence from functional magnetic resonance imaging (fMRI) studies on key neural networks in PD/AG. Fear conditioning has been proposed to represent a central pathway for the development and maintenance of this disorder; however, its neural substrates remain elusive. The present study aimed to investigate the neural correlates of fear conditioning in PD/AG patients. Method: The blood oxygen level-dependent (BOLD) response was measured using fMRI during a fear conditioning task. Indicators of differential conditioning, simple conditioning and safety signal processing were investigated in 60 PD/AG patients and 60 matched healthy controls. Results: Differential conditioning was associated with enhanced activation of the bilateral dorsal inferior frontal gyrus (IFG) whereas simple conditioning and safety signal processing were related to increased midbrain activation in PD/AG patients versus controls. Anxiety sensitivity was associated positively with the magnitude of midbrain activation. Conclusions: The results suggest changes in top-down and bottom-up processes during fear conditioning in PD/AG that can be interpreted within a neural framework of defensive reactions mediating threat through distal (forebrain) versus proximal (midbrain) brain structures. Evidence is accumulating that this network plays a key role in the aetiopathogenesis of panic disorder.

The diploma thesis compares the efficiency of teaching Old Czech and Moravian Tales by method of structured drama comparing with the efficiency of frontal teaching of the same topic. The research aim is focused on the comparison of learning results of pupils who were taught by the method of structured drama with the results of pupils who were taught by the method of frontal teaching. Furthermore, the diploma thesis finds out if structured drama helps pupils to better understand the negotiation of other people. The theoretical part includes the definition of drama education, the goals of drama education, the principles of drama education, a description of drama education as a method of teaching, and evaluation in drama education. The main focus from the methods and techniques of drama education is on structured drama. The theoretical part is also dedicated to frontal teaching - it is basic characteristics, a brief history, frontal teaching in modern schools, plus the advantages and disadvantages of frontal teaching. The conclusion of the theoretical part is devoted to the comparison of drama education with frontal teaching. The practical part includes a description of the course of pretestation - the characteristics of the school, courses, and reflection of pretestation. Also included are...

The human central auditory system can automatically extract abstract regularities from a variant auditory input. To this end, temporarily separated events need to be related. This study tested whether the timing between events, falling either within or outside the temporal window of integration (~350 ms), impacts the extraction of abstract feature relations. We utilized tone pairs for which tones within but not across pairs revealed a constant pitch relation (e.g., pitch of second tone of a pair higher than pitch of first tone, while absolute pitch values varied across pairs). We measured the mismatch negativity (MMN; the brain’s error signal to auditory regularity violations) to second tones that rarely violated the pitch relation (e.g., pitch of second tone lower). A Short condition in which tone duration (90 ms) and stimulus onset asynchrony between the tones of a pair were short (110 ms) was compared to two conditions, where this onset asynchrony was long (510 ms). In the Long Gap condition, the tone durations were identical to Short (90 ms), but the silent interval was prolonged by 400 ms. In Long Tone, the duration of the first tone was prolonged by 400 ms, while the silent interval was comparable to Short (20 ms). Results show a frontocentral MMN of comparable amplitude in all conditions. Thus, abstract pitch relations can be extracted even when the within-pair timing exceeds the integration period. Source analyses indicate MMN generators in the supratemporal cortex. Interestingly, they were located more anterior in Long Gap than in Short and Long Tone. Moreover, frontal generator activity was found for Long Gap and Long Tone. Thus, the way in which the system automatically registers irregular abstract pitch relations depends on the timing of the events to be linked. Pending that the current MMN data mirror established abstract rule representations coding the regular pitch relation, neural processes building these templates vary with timing.:Introduction; Materials and methods; Results; Discussion; Conclusion

Ziel: Das Ziel der vorliegenden Studie war einen Zusammenhang zwischen posttraumatischen Riechstörungen und Frontalhirnläsionen zu beweisen. Methode: Dafür wurden 51 Patienten mit posttraumatischen Riechstörungen und 50 Patienten mit Riechstörungen anderer Ätiologie untersucht. Der Grad der Riechstörungen wurde mit dem orthonasalen Testverfahren der Sniffin‘ Sticks sowie dem retronasalem Schmeckpulvertest eingestuft. Zusätzlich wurden neuropsychologische Tests (TMT-A, COWA, WCST, d2-R) durchgeführt, um Funktionen, die als typisch für die Frontallappen angesehen werden, zu überprüfen. Außerdem sollte jeder Patient den Fragebogen des Beck Depressions Inventars für eine Einschätzung seiner depressiven Tendenz beantworten. Ergebnisse: Es konnte in beiden untersuchten Patientengruppen kein Zusammenhang zwischen dem Riechvermögen und der neuropsychologischen Leistung festgestellt werden. Allerdings wurde in der posttraumatischen Patientengruppe eine signifikante, inverse Korrelation zwischen der Punktzahl des BDI und der Punktzahl im Diskriminationstest beobachtet. In der Kontrollgruppe bestand zwischen diesen Faktoren kein Zusammenhang. Schlussfolgerungen: Trotz der Ergebnisse dieser Studie kann ein Zusammenhang zwischen posttraumatischen Riechstörungen und Frontalhirnläsionen nicht ausgeschlossen werden, da u.a. die Funktionen der Frontallappen aufgrund ihrer Komplexität und Unspezifität schwierig zu messen sind. Außerdem waren die Traumata der Patienten sowie der klinische Verlauf sehr variabel und individuell. Frontalhirnläsionen können allerdings dramatische Einschnitte bedeuten, auf die klinisch besonders geachtet werden sollte. Olfaktorische Probleme können darüber hinaus zusätzlich die Lebensqualität stark beeinträchtigen und sollten daher ebenfalls Bestandteil der posttraumatischen Diagnostik sein.:Inhaltsverzeichnis 1 ABKÜRZUNGSVERZEICHNIS IV 2 EINLEITUNG 1 2.1 POSTTRAUMATISCHER RIECHVERLUST 1 2.2 FRONTALHIRN 3 3 ZIELSETZUNG DER STUDIE 9 3.1 HYPOTHESE 9 3.2 ERWARTETE ERGEBNISSE 10 4 MATERIAL UND METHODEN 10 4.1 PATIENTEN 10 4.2 METHODEN 10 4.2.1 RIECHTESTS 10 4.2.2 NEUROPSYCHOLOGISCHE TESTS 17 4.3 STATISTISCHE AUSWERTUNG 24 5 ERGEBNISSE 25 5.1 DESKRIPTIVE STATISTIK 25 5.1.1 PATIENTENKOLLEKTIV 25 5.1.2 POSTTRAUMATISCHE PATIENTEN 27 5.1.3 KONTROLLGRUPPE 28 5.2 KORRELATIONSPRÜFUNGEN 29 5.2.1 KORRELATION DER ERGEBNISSE DER RIECHTESTS MIT DEN ERGEBNISSEN DER NEUROPSYCHOLOGISCHEN TESTS 29 5.2.2 KORRELATION DER NEUROPSYCHOLOGISCHEN TESTS UNTEREINANDER 35 5.2.3 KORRELATION DER ERGEBNISSE DER RIECHTESTS MIT DER PUNKTZAHL DES BDI 36 6 DISKUSSION 39 6.1 METHODEN 40 6.1.1 RIECHTESTS 40 6.1.2 NEUROPSYCHOLOGISCHE TESTS 41 6.1.3 BECK DEPRESSIONS INVENTAR 43 6.2 ERGEBNISSE 43 6.2.1 ZUSAMMENHANG RIECHLEISTUNG MIT ERGEBNISSEN DER NEUROPSYCHOLOGISCHEN TESTS 43 6.2.2 ZUSAMMENHANG DISKRIMINATIONSLEISTUNG MIT PUNKTZAHL DES BECK DEPRESSIONS INVENTARS 48 7 AUSBLICK 50 8 ZUSAMMENFASSUNG 52 9 SUMMARY 53 10 ABBILDUNGSVERZEICHNIS V 11 TABELLENVERZEICHNIS VII 12 LITERATURVERZEICHNIS VIII 13 ERKLÄRUNG ZUR ERÖFFNUNG DES PROMOTIONSVERFAHRENS XXI 14 EINHALTUNG DER AKTUELLEN GESETZLICHEN VORGABE XXII 15 DANKSAGUNG XXIII 16 CURRICULUM VITAE XXIV 17 PUBLIKATIONEN XXVI

5 Summary So far, no commercially used device, capable of evaluating the condition of the deep stabilizing spine system (DSSS), has appeared on the market. Therefore, a so called muscle dynamometer (SD01, SD02), has been constructed that enables to reveal a possible dysfunction of the DSSS. During a six-week-rehabilitation-course, aimed at correcting the body posture and strengthening the DSSS muscles, a statistically significant change (p<0.001) between the values of input and output measurements of the chosen group tested has been obtained. Correctness of the approach to objectify the initial state of the patient and his progress during the treatment was shown by the completed measurements. The effectiveness of therapeutical training was confirmed. Based on positive experience from SD01, a new version of muscle dynamometer, SD02, was constructed. Measurements by SD02 were to establish the condition of DSSS (frontal spine stabilization) by a lay-sit test repeatedly from the test battery UNIFITTEST 6-60 and by the diaphragm test. Measurements were conducted on 45 samples. Basic somatic measurements were performed and then measurements with the SD02 were conducted during the diaphragm test and UNIFITTEST. For comparison of the values the pairing t-test was used (normal data distribution was verified by the...

The aim of the dissertation is to compare the efficiency of inquiry-based teaching versus standard frontal teaching on the topic of the human excretory system at secondary school. In the theoretical part of the thesis a content analysis of pedagogical and psychological literature, focusing on the efficiency of education and inquiry-based teachig, was conducted. Furthermore current Czech curricular documents were analyzed, i.e. the Framework Education Programme for secondary schools and available biology textbooks for secondary schools. In the practical part, based on these analyses and the study of pedagogical and psychological literature, lesson plans for the frontal teaching and inquiry-based teaching were prepared, including a proposal for research activities for experimental education. To compare the efficiency of selected teaching methods, a research tool was created - a pre-test, a post-test 1, a post-test 2 and questionnaires for students and teachers. Students and teachers of seven grammar schools in Prague were involved in the didactic experiment. The aim of the questionnaire was to provide further data and describe in detail the statistical data collected from the testing of the students. The analysis of the questionnaire data revealed a large consensus between students and their...

Lower leg injury is an important issue in frontal car crash. Although safety in cars has been improved by developments such as seat belts and airbags, lower leg injuries have not been reduced. These injuries are not life threatening but can result in long term disability and cost a lot to society. This study focused on the passenger occupant in offset frontal crashes and aimed at understanding and finding ways to reduce the injury criteria for the lower leg: tibia index. A finite element model was simplified to introduce parameters which influence on tibia index was investigated with a multivariate analysis. The model simplification consisted in removing irrelevant parts and replacing other parts by simple foam blocks. More than 1300 simulations were run with different parameter values. The results were then analysed by calculating correlations and effects of the parameters on tibia index. It was concluded that the presence of a knee bolster decreased tibia index. The results also showed a decrease of tibia index when the toe pan was angled towards the legs of the passenger. Moreover, a correlation between tibia index and the movement of the feet during the crash was found. It was concluded that restrained lower legs also presented decreased tibia indices compared to unrestrained ones. Most of the results proved to be also valid on the initial, unsimplified finite element model. / Underbensskador är ofta förekommande vid frontalkrock. Även om fordonssäkerheten har förbättrats i och med utveckling av bland annat säkerhetsbälte och krockkudde, har antalet underbensskador inte minskat. Denna typ av skada är inte livshotande men kan resultera i långvariga besvär och kan leda till stora kostnader för samhället. Detta examensarbete fokuserar på passageraren vid frontalkrock (offset) och syftet var att skapa förståelse kring skadekriteriet för underben: tibia index, samt hitta lösningar på hur tibia index kan minskas. En finit elementmodell förenklades och parametrar introducerades. Parametrarnas påverkan på tibia index undersöktes med en multivariat analys. Modellen förenklades genom att eliminera några delar och ersätta andra delar med enkla block. Simuleringar med olika värden på parametrarna skapades och ungefär 1300 kördes. Värdena från simuleringarna analyserades genom att beräkna korrelation och effekt på tibia index. Resultaten visade att implementering av ett slags mjukt knäskydd påverkar tibia index positivt. De visade också att tibia index förbättrades när den främre delen av golvet vinklades mot passagerarens ben. Vidare, fanns en korrelation mellan tibia index och fötternas förflyttning under krockförloppet. Slutsatsen var att kontrollerade underben förbättrar tibia index i jämförelse med okontrollerade ben. De flesta resultaten stämde även för den ursprungliga modellen.

The aim of this study is to investigate the neural mechanisms underlying the drawing of inferences based on a reader s knowledge during reading. Previous research studies have investigated this topic by using different types of text materials varying in coherence (e.g. Kuperberg et al., 2006), complexity (e.g. Xu et al., 2005), comprehensibility (e.g. Vandenberghe et al., 2002) or acceptability (e.g. Hagoort et al., 2004). Instead of using different types of text materials, we used a less explored method that manipulated the reader s reading goals to vary the level of engagement of inference processes. Cognitive psychologists have shown that the reader s reading goals have considerable influence on the cognitive processes of comprehension and on the content of the resulting representation of the text (Graesser et al., 1994). Here, two functional magnetic resonance imaging (fMRI) experiments were conducted to investigate the neural mechanisms of drawing strategic and routine inferences. The experimental data were analysed using two complementary approaches, namely conventional fMRI data analysis and effective connectivity analysis. Combined with an anatomical model developed in this study, the latter approach enabled us to quantify the interregional interactions modulated by the experimental conditions and to discriminate between several plausible hypotheses regarding how inferences are drawn. The results of both fMRI experiments show that the left inferior frontal gyrus (IFG) in Brodmann area (BA) 45/47 is involved in inference processes, regardless of whether inferences are drawn strategically or routinely, while the left anterior prefrontal cortex in BA 9/10 is only involved in retrieving strategic inferences. The effective connectivity analyses show that the retrieval of strategic and routine inferences consistently enhances the connectivity between the left posterior superior temporal sulcus and the left dorsal lateral IFG.