Bone quality influences bone strength with important consequences for osteoporosis, fracture risk and dental implant success. Whilst imaging that is capable of capturing bone structure in 3D is becoming more common, quantitative clinical measures of bone quality rely on bone quantity, not structure. If bone quality could be more accurately measured, and the influence of bone architecture better understood, strength may be better predicted. This thesis presents methods for making structural comparisons between successive micro-CT images of loaded bone and explores the limitations of these. I present a novel method to detect where damage occurs in loaded rat vertebrae based on multiscale rigid registration and difference measures. Together these methods represent a quantitative approach to image guided failure analysis. Time-lapsed micro-CT images of 14 successively loaded rat vertebrae were acquired and damaged regions found using these. Using a random forest classifier I tested whether the damaged regions could be predicted by several commonly used structural measures (bone area and volume), three-dimensional texture measures (co-occurrence matrices and fractal dimension) and a more novel type of architectural measure (based on the structure tensor). A combination of parameters was able to predict damage regions with specificities in the range 70-90% and sensitivities of 60-70%.Using ovariectomised rats as a model of osteoporosis I have performed a pilot experiment to investigate how changes in bone quality might effect our results. The wider applicability of my methods are demonstrated by applying them to dental cone beam images of healthy and osteoporotic patients.

There are various types of test performed on Integrated Circuits, (IC), for detecting and locating defects and faults during failure analysis. Functional, logic, parametric and IDDQ tests are among the most common. Functional IC tests are designed to verify whether the IC performs its intended function. Logic tests verify the logic operation of gates and registers. AC and DC parametric tests are used to measure time, voltage and current-varying parameters associated with the operational limits of the IC. Test parameters in parametric testing include, among others, propagation delay, operating current and signals rise and fall time. Currently, almost all ICs are manufactured or refurbished in Asia. A greater portion of the ICs are processed in China and Malaysia. Presently issues with component reliability are compromised since the ICs are not tested before they leave the factory, are sometimes only remarked with different part numbers and date codes or resold even though they do not work properly. These activities lead to a high level of uncertainty among consumers all over the world. The purpose of this research was the design of a software-defined semiconductor validation test system using the PCI eXtension for Instrumentation, (PXI), platform. The test system was to be capable of performing Open and Short Circuit Tests for CMOS components. Open and Short Circuit Tests verify for faults at the protection diode circuitry of CMOS chips level. The test system reduces the overall test timing compared to the tests performed by a functional instrument such as a curve tracer. PXI is a modular instrumentation platform originally introduced in 1997 by National Instruments, (NI). PXI is an open, PC-based platform for test, measurement and control. PXI possesses the highest bandwidth and lowest latency with modular inputs and outputs for high-resolution from DC to RF frequencies. PXI was designed for measurement and automation applications that require high-performance. Concepts associated with the Systems of Systems Engineering, (SoSE), approach were applied to this research in order to facilitate the design process for the test system. The objective was to apply Systems Engineering methodologies to the design of this particular test system.

Power transmission grid infrastructures deliver electricity across large distance and are vital to the functioning of modern society. Increasingly these setups embody highly-coupled cyber-physical systems where advanced telecommunications networks are used to send status and control information to operate power transmission grid components, i.e., "smart grids". However, due to the high inter-dependency between the communication and power grid network layers, failure events can lead to further loss of control of key grid components, i.e., even if they are undamaged. In turn, such dependencies can exacerbate cascading failures and lead to larger electricity blackouts, particularly under disaster conditions. As a result, a range of studies have looked at modelling failures in interdependent smart grids. However most of these designs have not considered the use of proactive network-level survivability schemes. Indeed, these strategies can help maintain vital control connectivity during failures and potentially lead to reduced outages. Hence this thesis addresses this critical area and applies connection protection methodologies to reduce communication/control disruption in transmission grids. The performance of these schemes is then analyzed using detailed simulation for a sample IEEE transmission grid. Overall findings show a good reduction in the number of overloaded transmission lines when applying network-level recovery schemes.

<p>Rodon is a diagnostic tool developed by Sörman. SAAB’s interest in Rodon regards the possibility to use the tool for development and operations of aircraft systems. The main goal of this thesis was to evaluate the capacity of Rodon and determine how SAAB can use the diagnostic tool during development and operations.</p><p>The tool uses model based diagnosis with artificial intelligence for fault isolation which is a powerful approach. If Rodon is introduced at SAAB, then detailed models of systems will be necessary to create, including the nominal behavior of the system and different faulty behaviors. In order to achieve high quality fault isolation, it is necessary to have complete and consistent models. To be able to use all applications that Rodon feature for a modeled system, preferable characteristics are that the model should be static, have discrete control signals, and have well defined system behavioral modes.</p><p>During development of a system Rodon can be used to improve and easy the work for failure analysis, guidance of sensor placements, evaluation of tests, generation of decision structures, and fault isolation. Since design of tests during development is a desirable application that Rodon does not have, two different methods are presented that utilizes Rodon to generate all possible limit checking tests.</p><p>In conclusion, Rodon can be very useful in several different aspects if introduced, but benefits gained by using Rodon will have to be compared to the labor cost of creating good models.</p>

The objective of this work was to develop an analysis framework for the structural design of the Human-Powered Ornithopter (HPO). This framework was used in a kinematicaerostructural optimizer for apping-wing ight (Ornithia), as well as analytically to design the HPO, and focused on three goals. First was the development of an accurate and computationally inexpensive nite-element method, to be integrated with Ornithia, which would capture the geometric nonlinearity of the aerostructural interaction of the wing when subjected the large deformations in ight. Second was the assembly of a model by which the aircraft primary structure, the wing main spar especially, could be exactly characterized and designed. Third was the establishment of a process and toolbox for failure analysis which could be applied universally in the design of the HPO. The validation and tuning of these models involved extensive testing on prototype carbon ber composite components.

The objective of this work was to develop an analysis framework for the structural design of the Human-Powered Ornithopter (HPO). This framework was used in a kinematicaerostructural optimizer for apping-wing ight (Ornithia), as well as analytically to design the HPO, and focused on three goals. First was the development of an accurate and computationally inexpensive nite-element method, to be integrated with Ornithia, which would capture the geometric nonlinearity of the aerostructural interaction of the wing when subjected the large deformations in ight. Second was the assembly of a model by which the aircraft primary structure, the wing main spar especially, could be exactly characterized and designed. Third was the establishment of a process and toolbox for failure analysis which could be applied universally in the design of the HPO. The validation and tuning of these models involved extensive testing on prototype carbon ber composite components.

ITC/USA 2012 Conference Proceedings / The Forty-Eighth Annual International Telemetering Conference and Technical Exhibition / October 22-25, 2012 / Town and Country Resort & Convention Center, San Diego, California / The U.S. Air Force's next generation reusable booster (NGRSB) offers the opportunity for the Space Command to use intelligent equipment for decision making replacing personnel, increasing safety and mission assurance by removing decisions from program management personnel who may not have had any flight-test experience. Adding intelligence to launch vehicle and spacecraft equipment may include requiring the builder to use a prognostic and health management (PHM) program. The PHM was added to NASA's aircraft programs in 2009 and we have requested NASA HQ and NASA Marshal Space Flight Center adopt the NASA PHM in the procurement contracts used on the new Space Launch Systems, NASA's congressionally mandated replacement for the Space Shuttle. Space Vehicle Program managers often make decisions for on-orbit spacecraft without ever having on-orbit space flight experience. Intelligent equipment would have eliminated the catastrophic failures on the NASA Space Shuttle Challenger and Columbia. These accidents occurred due to the lack of space vehicle subsystem engineering personnel analyzing real-time equipment telemetry presented on strip chart and video data prior to lift off during pre-launch checkout for the Space Shuttle Challenger and the lack of space vehicle real-time equipment telemetry for Columbia. The PHM requires all equipment to include analog telemetry for measuring the equipment performance and usable life determination in real-time and a prognostic analysis completed manually will identify the equipment that will fail prematurely for replacement before launch preventing catastrophic equipment failures that may cause loss of life.

Directionally solidified Rene 80 (DS R80) and polycrystalline Inconel 738(IN 738) Superalloys were tested in thermo-mechanical fatigue (TMF) over the temperature range of 500-900°C and plastic strain range from 0.1 to 0.8% using a DSI Gleeble thermal simulator. Thermo-mechanical testing was carried out on the parent material (baseline) in the conventional solution treated and aged condition (STA), as well as gas tungsten arc welded (GTAW) with an IN-738 filler, followed by solution treatment and ageing. Comparison of the baseline alloy microstructure with that of the welded and heat treated alloy showed that varying crack initiation mechanisms, notably oxidation by stress assisted grain boundary oxidation, grain boundary MC carbides fatigue crack initiation, fatigue crack initiation from sample surfaces, crack initiation from weld defects and creep deformation were operating, leading to different “weakest link” and failure initiation points. The observations from this study show that the repaired samples had extra crack initiation sites not present in the baseline, which accounted for their occasional poor fatigue life. These defects include lack of fusion between the weld and the base metal, fusion zone cracking, and heat affected zone microfissures.

Directionally solidified Rene 80 (DS R80) and polycrystalline Inconel 738(IN 738) Superalloys were tested in thermo-mechanical fatigue (TMF) over the temperature range of 500-900°C and plastic strain range from 0.1 to 0.8% using a DSI Gleeble thermal simulator. Thermo-mechanical testing was carried out on the parent material (baseline) in the conventional solution treated and aged condition (STA), as well as gas tungsten arc welded (GTAW) with an IN-738 filler, followed by solution treatment and ageing. Comparison of the baseline alloy microstructure with that of the welded and heat treated alloy showed that varying crack initiation mechanisms, notably oxidation by stress assisted grain boundary oxidation, grain boundary MC carbides fatigue crack initiation, fatigue crack initiation from sample surfaces, crack initiation from weld defects and creep deformation were operating, leading to different “weakest link” and failure initiation points. The observations from this study show that the repaired samples had extra crack initiation sites not present in the baseline, which accounted for their occasional poor fatigue life. These defects include lack of fusion between the weld and the base metal, fusion zone cracking, and heat affected zone microfissures.

Thesis (MEng)--Stellenbosch University, 2015. / ENGLISH ABSTRACT: The railway transportation system is fundamental in sustaining the economic activities of a country, by providing a safe, reliable and relatively affordable means of transporting people and goods; hence, the need to ensure its ongoing reliability is of paramount importance. The principle and applications of rail reliability have been reviewed, and reliability improvement in rail infrastructure has been investigated using failure mode and effect analysis (FMEA). Reliability improvement is a continuous process that is geared to meeting dynamic changes in operation and stakeholders’ expectations. Recently, growth has occurred in the amount of rail transport traffic utilisation undertaken, together with the degradation of the infrastructure involved. Such deterioration has amplified the operating risks, leading to an inadequacy in rail track maintenance and inspection that should have kept abreast with the changes. The result has been increased rail failures, and subsequent derailments. A case study of the Passenger Rail Agency of South Africa (PRASA) Metrorail maintenance policy was reviewed to evaluate its maintenance strategy and identifying the potential critical failure modes, so as to be able to recommend improvement of its reliability, and, thus, its availability. On the basis of the case study of PRASA Metrorail maintenance strategy and its performance, it is recommended that PRASA Metrorail change its maintenance policy through employing a cluster maintenance strategy for each depot. / AFRIKAANSE OPSOMMING: Die spoorwegvervoerstelsel is fundamenteel om die ekonomiese bedrywighede van ’n land te ondersteun deur die voorsiening van ’n veilige, betroubare en betreklik bekostigbare manier om mense en goedere te vervoer. Dus is dit van die allergrootste belang om die voortgesette betroubaarheid daarvan te verseker. Die beginsels en toepassings van spoorbetroubaarheid is hersien en die betroubaarheidsverbetering van spoorinfrastruktuur met behulp van foutmodus-eneffekontleding (“FMEA”) ondersoek. Betroubaarheidsverbetering is ’n voortdurende proses om tred te hou met dinamiese bedryfsveranderinge sowel as verskuiwings in belanghebbendes se verwagtinge. Die hoeveelheid spoorvervoerverkeer het onlangs beduidend toegeneem, terwyl die betrokke infrastruktuur agteruitgegaan het. Dié agteruitgang het die bedryfsrisiko’s verhoog, en lei tot ontoereikende spoorweginstandhouding en -inspeksie, wat veronderstel was om met die veranderinge tred te gehou het. Dit gee aanleiding tot ’n toename in spoorwegfoute en gevolglike ontsporing. ’n Gevallestudie is van die instandhoudingsbeleid van die Passasierspooragentskap van Suid- Afrika (PRASA) Metrorail onderneem om dié organisasie se instandhoudingstrategie te beoordeel en die moontlike kritieke foutmodusse te bepaal. Die doel hiermee was om verbeteringe in stelselbetroubaarheid en dus ook stelselbeskikbaarheid voor te stel. Op grond van die gevallestudie van die PRASA Metrorail-instandhoudingstrategie en -prestasie, word daar aanbeveel dat PRASA Metrorail sy instandhoudingsbeleid verander deur ’n klusterinstandhoudingsplan vir elke depot in werking te stel.