Utilizando a teoria de função de estimação linear ótima (Crowder, 1987), propomos equações de estimação generalizadas para modelos de regressão beta (Ferrari e Cribari-Neto, 2004) com medidas repetidas. Além disso, apresentamos equações de estimação generalizadas para modelos de regressão simplex baseadas nas propostas de Song e Tan (2000) e Song et al. (2004) e equações de estimação generalizadas para modelos lineares generalizados com medidas repetidas baseadas nas propostas de Artes e Jorgensen (2000) e Liang e Zeger (1986). Todas essas equações de estimação são desenvolvidas sob os enfoques da modelagem da média com homogeneidade da dispersão e da modelagem conjunta da média e da dispersão com intuito de incorporar ao modelo uma possível heterogeneidade da dispersão. Como técnicas de diagnóstico, desenvolvemos uma generalização de algumas medidas de diagnóstico quando abordamos quaisquer equações de estimação definidas tanto para modelagem do parâmetro de posição considerando a homogeneidade do parâmetro de dispersão como para modelagem conjunta dos parâmetros de posição e dispersão. Entre essas medidas, destacamos a proposta da influência local (Cook, 1986) desenvolvida para equações de estimação. Essa medida teve um bom desempenho, em simulações, para destacar corretamente pontos influentes. Por fim, realizamos aplicações a conjuntos de dados reais. / Based on the concept of optimum linear estimating equation (Crowder, 1987), we develop generalized estimating equation (GEE) to analyze longitudinal data considering marginal beta regression models (Ferrari and Cribari-Neto, 2004). The GEEs are also presented to marginal simplex models for longitudinal continuous proportional data proposed by Song and Tan (2000) and Song et al. (2004) and to generalized linear models for longitudinal data based on the proposes of Artes and J$\\phi$rgensen (2000) and Liang and Zeger (1986). All of them are developed focusing the assumption of homogeneous dispersion and with varying dispersion. For the diagnostic techniques, we generalize some diagnostic measures for estimating equations to model the position parameter considering an homogeneous dispersion parameter and for joint modelling of position and dispersion parameters to take in account a possible heterogeneous dispersion. Among these measures, we point out the local influence (Cook, 1986) developed to estimating equations. This measure can correctly show influential observations in simulation study. Finally, the theory is applied to real data sets.

This research develops a framework to estimate the effective sample size of Global Positioning System (GPS) based panel surveys in urban travel behavior studies for a variety of planning purposes. Recent advances in GPS monitoring technologies have made it possible to implement panel surveys with lengths of weeks, months or even years. The many advantageous features of GPS-based panel surveys make such surveys attractive for travel behavior studies, but the higher cost of such surveys compared to conventional one-day or two-day paper diary surveys requires scrutiny at the sample size planning stage to ensure cost-effectiveness. The sample size analysis in this dissertation focuses on three major aspects in travel behavior studies: 1) to obtain reliable means for key travel behavior variables, 2) to conduct regression analysis on key travel behavior variables against explanatory variables such as demographic characteristics and seasonal factors, and 3) to examine impacts of a policy measure on travel behavior through before-and-after studies. The sample size analyses in this dissertation are based on the GPS data collected in the multi-year Commute Atlanta study. The sample size analysis with regard to obtaining reliable means for key travel behavior variables utilizes Monte Carlo re-sampling techniques to assess the trend of means against various sample size and survey length combinations. The basis for the framework and methods of sample size estimation related to regression analysis and before-and-after studies are derived from various sample size procedures based on the generalized estimating equation (GEE) method. These sample size procedures have been proposed for longitudinal studies in biomedical research. This dissertation adapts these procedures to the design of panel surveys for urban travel behavior studies with the information made available from the Commute Atlanta study. The findings from this research indicate that the required sample sizes should be much larger than the sample sizes in existing GPS-based panel surveys. This research recommends a desired range of sample sizes based on the objectives and survey lengths of urban travel behavior studies.

近幾年來，國人自殺死亡率不斷提高，且自殺死亡從1997年起已連續多年列於國人十大死亡原因之一，所以自殺防治工作刻不容緩。本研究採用自殺防治中心在桃園縣六家居家服務單位(龍祥、中國、仁愛、紅十字、家輔及寬福)所做之問卷調查資料，目的在於找出何種特性者，BSRS5 (The Five-Item Brief Symptom Rating Scale)分數及自殺意念分數可能較高。本研究屬於時序性追蹤資料，自民國96年5月份起，由居服人員針對受測對象進行訪談，大約每隔兩週收集一次，總共進行四次。 針對問卷進行基本敘述性統計、單項排名分析以及交叉分析後發現，在人口特質方面，男女性比例相當，年齡層主要皆在65~84歲，教育程度以不識字及國小為主；在BSRS5五題排名方面，以第一題「睡眠困難(難以入睡或早醒)」的平均分數最高，第四題「覺得比不上別人」平均分數最低；由交叉分析的結果發現身體狀況為一個重要的變數，身體狀況差的人BSRS5總分6分以上或自殺意念2分以上明顯較多。 對資料配適廣義估計方程式及Alternating Logistic Regressions的結果，發現在反應變數為BSRS5總分時，女性、身體狀況差及曾經看過精神科者BSRS5分數達到6分以上的可能性較高。若反應變數為自殺意念時，無論是利用廣義估計方程式或Alternating Logistic Regressions，從模型配適的結果發現只有BSRS5的效應顯著。不管利用BSRS5總分或是各題分開來看，BSRS5對自殺意念是一個相當有效的檢測工具，BSRS5分數愈高則自殺意念2分以上的機會也愈高。此外利用多層結構分析方法配適廣義估計方程式，針對BSRS5與受測次數間的關聯性分析，發現與配適傳統unstructured相關性矩陣的估計結果差異不大，但是可以減少許多參數估計，並且在電腦計算時間上是較快速的。 / In Taiwan, suicide has been among the top ten causes of death since 1997, and suicide prevention has thus attracted much attention since. Using the data provided by Taiwan Suicide Prevention Center (TSPC), this study is aimed to find out possible personal characteristics that might have some impacts on the BSRS5 (the Five-Item Brief Symptom Rating Scale) and suicide ideation scores The data come from a longitudinal study in which subjects from six elderly home service centers in Taoyuan County, Taiwan were visited four times between May and July, 2007, about two weeks between each visit. The total number of subjects is 1981. The proportions of male and female are nearly the same, the age range is from 65 to 84, and most of them have only an elementary school degree. Preliminary analyses indicate that among the five items in BSRS5, insomnia (the first item) is ranked the highest, and inferiority (the fourth item) is the lowest. In addition, health status is highly correlated to the BSRS5 and suicide ideation scores, the worse the health status, the higher the BSRS5 and suicide ideation scores. Fitting the data with Generalized Estimating Equation (GEE) and Alternating Logistic Regressions models with respect to the BSRS5 score, we further find that female, those who have bad health status, and those who have ever consulted a psychiatrist have higher probability that the BSRS5 score is greater than 6. As far as the suicide ideation score is concerned, the BSRS5 score is the only covariate that is statistically significant, an indication that BSRS5 is a useful tool for screening subjects at risk of committing suicide. While the conclusions stay the same whether the data are analyzed through GEE with commonly used unstructured correlation structure or newly developed multiblock and multilayer correlation structure, the latter approach reduces the computer time significantly.

A literatura dispõe de métodos de diagnóstico para avaliar o ajuste de modelos lineares generalizados (MLGs) para medidas repetidas baseado em equações de estimação generalizada (EEG). No entanto, tais métodos não contemplam a distribuição binomial nem bancos de dados com observações faltantes. O presente trabalho generalizou os métodos já desenvolvidos para essas duas situações. Na construção de gráficos de probabilidade meio-normal com envelope simulado para a distribuição binomial, foi proposto um método para geração de variáveis aleatórias com distribuição marginal binomial correlacionadas, baseado na convolução de variáveis com distribuição de Poisson independentes. Os métodos de diagnóstico desenvolvidos foram aplicados em dados reais e simulados. / Literature provides diagnostic methods to assess the fit of generalized linear models (GLM) for repeated measures based on generalized estimating equations (GEE). Still, such methods do not include the binomial distribution or databases with missing observations. This work generalizes the methods already developed for these two situations. A method for generating random variables with correlated marginal binomial distributions based on convolution of independent Poisson random variables has been proposed for the construction of half-normal probability plots. The diagnostic methods developed were applied to real and simulated data.

A literatura dispõe de métodos de diagnóstico para avaliar o ajuste de modelos lineares generalizados (MLGs) para medidas repetidas baseado em equações de estimação generalizada (EEG). No entanto, tais métodos não contemplam a distribuição binomial nem bancos de dados com observações faltantes. O presente trabalho generalizou os métodos já desenvolvidos para essas duas situações. Na construção de gráficos de probabilidade meio-normal com envelope simulado para a distribuição binomial, foi proposto um método para geração de variáveis aleatórias com distribuição marginal binomial correlacionadas, baseado na convolução de variáveis com distribuição de Poisson independentes. Os métodos de diagnóstico desenvolvidos foram aplicados em dados reais e simulados. / Literature provides diagnostic methods to assess the fit of generalized linear models (GLM) for repeated measures based on generalized estimating equations (GEE). Still, such methods do not include the binomial distribution or databases with missing observations. This work generalizes the methods already developed for these two situations. A method for generating random variables with correlated marginal binomial distributions based on convolution of independent Poisson random variables has been proposed for the construction of half-normal probability plots. The diagnostic methods developed were applied to real and simulated data.

當資料屬於類別型的長期追蹤資料（Longitudinal categorical data）時，除了可以透過廣義估計方程式（General estimate equation, GEE）來求解模型參數估計值外，潛在移轉分析（Latent transition analysis, LTA）法也是一種可行的資料分析方法。若資料的期數不多，也可以選擇將資料適度分群後使用羅吉斯迴歸分析（Logistic regression）法。當探討的反應變數為二元（Binary）型態，且觀察對象於每一期提供多個測量變數值的情況之下，廣義估計方程式與羅吉斯迴歸分析法的使用，文獻上常見先將所有的測量變數值加總後，以「中位數」作為分類的切割點。不同於以上兩種方法，潛在移轉分析法則是直接使用原始資料來取得觀察對象的潛在狀態相關訊息，因此與前二者的作法不同，可能導致後續的各項分析結果有所差異存在。 為了能夠了解造成中位數分類法與移轉分析法差異的可能因素，我們架構在潛在移轉分析法的模型下，以不同的參數設定來進行電腦模擬，比較各參數條件下的兩分類方法差異。結果發現各潛在狀態下的測量變數反應機率形式、第一期潛在狀態的組成比例等皆會對兩分類方法是否具有相同分類有所影響。另外，透過分析「青少年媒體使用與健康生活調查」的實際資料得知，潛在移轉分析會將大部分的觀察對象歸屬於「網路成癮」，而中位數分類法則是將大部分的觀察對象歸屬於「無網路成癮」。此外，可以注意到「沮喪」、「線上情色每星期平均使用天數」、及「父母相處狀況」這幾個控制變數與各分組結果的關聯性，於上述三種資料分析方法中有所不同。 / Several methods can be used to analyze longitudinal categorical data, as among them Latent Transition Analysis (LTA), and Generalized Linear Models estimated by Generalized Estimating Equations (GEE) probably the most popular. In addition, if the number of periods is two, then with certain grouping of data, the Logistic Regression can also be applied to perform the analyses. When there are more than one manifest response variable for each study subject, LTA is able to classify the subjects in terms of the original manifest response variables and proceeds with necessary analyses. On the other hand, GEE method and Logistic Regression lack the flexibility, and require certain transformation to transform the manifest response variables into a categorical response variable first. One common way to form a binary response is to sum all manifest variables, and then taking median as a cut-point. In this study, we explore the differences of the classification resulted from LTA directly and using median as a cut-point through simulations. An empirical study is also provided to illustrate the classification differences, and the differences on the subsequent analyses using LTA, GEE method, and Logistic Regression approach.

Made available in DSpace on 2016-06-02T20:06:02Z (GMT). No. of bitstreams: 1 2447.pdf: 2730026 bytes, checksum: 0c7b575bbfeb3fed2fc6c929b9785516 (MD5) Previous issue date: 2009-03-05 / Financiadora de Estudos e Projetos / The objective of this work is to present techniques of regression analysis for longitudinal data when the response variable is binary. Initially, there is a review of generalized linear models, marginal models, transition models, mixed models, and logistic regression methods of estimation, which will be necessary for the development of work. In addition to the methods of estimation, some structures of correlation will be studied in an attempt to capture the intra-individual serial dependence over time. These methods were applied in two situations, one where the response variable is continuous and normal distribution, and another when the response variable has the Bernoulli distribution. It was also sought to explore and present techniques for selection of models and diagnostics for the two cases. Finally, an application of the above methodology will be presented using a set of real data. / O objetivo deste trabalho é apresentar técnicas de análise de regressão para dados longitudinais quando a variável resposta é binária. Inicialmente, é feita uma revisão sobre modelos lineares generalizados, modelos marginais, modelos de transição, modelos mistos, regressão logística e métodos de estimação, pois serão necessários para o desenvolvimento do trabalho. Além dos métodos de estimação, algumas estruturas de correlação serão estudadas, na tentativa de captar a dependência serial intra-indivíduo ao longo do tempo. Estes métodos foram aplicados em duas situações; uma quando a variável resposta é contínua, e se assume ter distribuição normal, e a outra quando a variável resposta assume ter distribuição de Bernoulli. Também se procurou pesquisar e apresentar técnicas de seleção de modelos e de diagnósticos para os dois casos. Ao final, uma aplicação com a metodologia pesquisada será apresentada utilizando um conjunto de dados reais.

De nombreuses études cliniques ou interventions de lutte ont été faites ou sont en cours en Afrique pour la lutte contre le fléau du paludisme. En zone d'endémie, le paludisme est une maladie récurrente. La revue de littérature indique une application limitée des outils statistiques appropriés existants pour l'analyse des données récurrentes de paludisme. Nous avons mis en oeuvre des méthodes statistiques appropriées pour l'analyse des données répétées d'essais thérapeutiques de paludisme. Nous avons également étudié les mesures répétées d'hémoglobine lors du suivi de traitements antipaludiques en vue d'évaluer la tolérance ou sécurité des médicaments en regroupant les données de 13 essais cliniques.Pour l'analyse du nombre d'épisodes de paludisme, la régression binomiale négative a été mise en oeuvre. Pour modéliser la récurrence des épisodes de paludisme, quatre modèles ont été utilisés : i) Les équations d'estimation généralisées (GEE) utilisant la distribution de Poisson; et trois modèles qui sont une extension du modèle Cox: ii) le modèle de processus de comptage d'Andersen-Gill (AG-CP), iii) le modèle de processus de comptage de Prentice-Williams-Peterson (PWP-CP); et iv) le modèle de Fragilité partagée de distribution gamma. Pour l'analyse de sécurité, c'est-à-dire l'évaluation de l'impact de traitements antipaludiques sur le taux d'hémoglobine ou la survenue de l'anémie, les modèles linéaires et latents généralisés mixtes (« GLLAMM : generalized linear and latent mixed models ») ont été mis en oeuvre. Les perspectives sont l'élaboration de guides de bonnes pratiques de préparation et d'analyse ainsi que la création d'un entrepôt des données de paludisme. / Numerous clinical studies or control interventions were done or are ongoing in Africa for malaria control. For an efficient control of this disease, the strategies should be closer to the reality of the field and the data should be analyzed appropriately. In endemic areas, malaria is a recurrent disease. Repeated malaria episodes are common in African. However, the literature review indicates a limited application of appropriate statistical tools for the analysis of recurrent malaria data. We implemented appropriate statistical methods for the analysis of these data We have also studied the repeated measurements of hemoglobin during malaria treatments follow-up in order to assess the safety of the study drugs by pooling data from 13 clinical trials.For the analysis of the number of malaria episodes, the negative binomial regression has been implemented. To model the recurrence of malaria episodes, four models were used: i) the generalized estimating equations (GEE) using the Poisson distribution; and three models that are an extension of the Cox model: ii) Andersen-Gill counting process (AG-CP), iii) Prentice-Williams-Peterson counting process (PWP-CP); and (iv) the shared gamma frailty model. For the safety analysis, i.e. the assessment of the impact of malaria treatment on hemoglobin levels or the onset of anemia, the generalized linear and latent mixed models (GLLAMM) has been implemented. We have shown how to properly apply the existing statistical tools in the analysis of these data. The prospects of this work remain in the development of guides on good practices on the methodology of the preparation and analysis and storage network for malaria data.