Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 4 uppsatser.

Thesis (Ph. D. in Human Genetics)--Vanderbilt University, May 2009. / Title from title screen. Includes bibliographical references.

Thesis (Ph. D.)--Duke University, 2008. / Includes bibliographical references.

Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 135-137).

Thesis (M.S.)--Brandeis University, 2009. / Title from PDF title page (viewed on May 29, 2009). Includes bibliographical references.

Thesis (Ph.D. in Biostatistics) -- University of Colorado at Denver and Health Sciences Center, 2006. / Typescript. Includes bibliographical references (leaves 237-239). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: 5857. Adviser: Momiao Xiong. Includes bibliographical references (leaves xx-xx).

Thesis (Ph.D.)--Mississippi State University. Department of Plant and Soil Science. / Title from title screen. Includes bibliographical references.

Made available in DSpace on 2015-03-03T11:52:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-07-14Bitstream added on 2015-03-03T12:06:49Z : No. of bitstreams: 1 000810899.pdf: 268181 bytes, checksum: 6ad3d008125d4cbb91861fe84019a265 (MD5) / É de extrema importância saber a natureza das variâncias e como essas afetam as característias produtivas e estimativas. Foram utilizadas aproximadamente 3500 bufálas em lactação, predominantemente da raça Murrah, genotipadas através do chip “Illumina Infinium bovine HD bead Chip” , obtidos do banco de dados do campus de Jaboticabal da UNESP, para se avaliar a produção de leite acumulada aos 305 dias(PL), produção de proteína(PPRO) e produção de gordura(PGOR) neste animais, estimando-se parâmetros de herdabilidade e variâncias Foi utilizado um modelo misto com duas propostas distintas, uma tradicional e outra onde é considerada a heterogeneidade das variâncias, tanto aditiva quanto residual, dividindo os animais em dois grupos de acordo com o nível de produção. Dentro de ambos os modelos, foram utilizadas informações de genotipagem. As estimativas de herdabilidade foram moderadas e dentro do que se encontra na literatura para todos os modelos, entretanto nos modelos onde se considera a heterogeneidade das variâncias foram encontradas diferentes estimativas. As herdabilidades encontradas para os modelos tradicionais foram de 0,22(sem genômica) e 0,23(com genômica) para PL, 0,32(sem genômica) e 0,30(com genômica) para PGOR e 0,27(sem genômica) e 0,34(com genômica) para PPRO. Ao se considerar heterogeneidade residual, as herdabilidades para os níveis alto e baixo de produção foram, respectivamente: 0,28 e 0,17 para PL, 0,28 e 0,35 para PGOR e 0,30 e 0,42 para PPRO. Quando também se considerou a heterogeneidade aditiva, as herdabilidades para os níveis alto e baixo de produção, respectivamente, foram de: 0,38 e 0,25 para PL, 0,29 e 0,31 para PGORD e 0,33 e ... / Is extreme important knowing the variability natures and how those affect production characteristics and population estimations like heritability and correlations. It was used in this research proximally 3500 buffaloes in lactation, most being murrah, genotyped with IlluminaInfiniumbovineHDbeadChip, taken from the database of Jaboticabal Campus, UNESP for the evaluation of milk yield at 305 days(MY), protein yield(PY) and fat yield(F), estimating heritability and variances effects on it. It was used a mixed model with two different approaches, one where doesn’t account the heterogeneity of variances, and another where is accounted these variances, both residual and additive, splitting the animals in two groups for production levels. In both models were included genomic informations. And by replacing the relationship matrix with matrix H, including genomic informations, the same results were studied but in models accounting genomic information. The heritability found, all of them, were moderate and between the intervals estimated in other studies. However in the models where different variances are in consideration, were found different heritabilitys for all characteristics. For the tradicional models the heritabilities found, without and with genomic information, were: 0.22 and 0.23 for MY, 0.32 and 0.30 for FY and 0.27 and 0.34 for PY. When take in account only the residual heterogeneity, the heritability for high and low level of production, were: 0.28 and 0.17 for MY, 0.28 and 0.35 for FY and 0.30 and 0.42 for PY. When the additive heterogeneity was also taken in account, the heritabilitys for high and low level of production were: 0.28 and 0.17 for MY, 0.29 and 0.31 for FY and 0.33 and 0.37 for PY. By the results of this studies is possible to concluded that taking in account ...

As the leading cause of bacterial gastroenteritis, Campylobacter represents a significant public health burden; however, our knowledge of its epidemiology in low- and middle-income countries remains limited. Recent studies have demonstrated the power of whole-genome sequencing (WGS) for public health microbiology. The primary aim of this thesis was to exploit WGS to improve our understanding of the epidemiology of Campylobacter from the Republic of South Africa, a middle-income country. In the first half of this thesis, in silico approaches were developed to evaluate diagnostic assays and methods of species identification. Large-scale analyses of publicly available WGS data identified a robust real-time PCR assay for the detection of Campylobacter jejuni and Campylobacter coli, the primary causes of human campylobacteriosis. Evaluation of in silico speciation methods demonstrated that the atpA gene and ribosomal multilocus sequence typing can be used to identify Campylobacter from WGS data. The second half of this thesis extended concepts developed in the first half to investigate the epidemiology of Campylobacter from animals and humans from South Africa. Isolates from a study of Campylobacter from free-range broiler carcasses belonged to the agriculture-associated ST-828 lineage, but were atypically homogenous and differed at only 46/1,513 (3%) loci, providing novel insights into clonal infections in chickens. Analyses of human disease isolates collected in Cape Town in 1991, 2011, and 2012 confirmed that the local epidemiology of Campylobacter is distinct from that of high-income countries: in addition to major agriculture-associated C. jejuni and C. coli lineages, a putative novel C. jejuni subsp. jejuni/C. jejuni subsp. doylei hybrid clade and genetically diverse C. jejuni subsp. doylei and C. upsaliensis isolates were identified. This work delivers further evidence of the utility of WGS for clinical microbiology, presents approaches that address general problems in Campylobacter diagnostics and public health microbiology, and provides insights into the epidemiology of this important group of pathogens in South Africa.