This work presents the design and analysis of two Litz wire transformers for a 500 kHz, 18 kW input­parallel output­series partial power processing converter (IPOS PPP). Because the two power paths in the IPOS PPP operate as “dc transformers” (DCX), both transformers are designed with the goal of leakage inductance minimization in order to reduce gain variation around the resonant frequency. The selected winding topology with the lowest leakage inductance results in an impedance mismatch among parallel secondaries used in the majority power path transformer, resulting in poor current sharing. In order to balance the goals of leakage inductance minimization and even current sharing, a new winding technique called “intra­leaving” is presented which reduces current sharing error from 50%, to 5%. A design rule for “intra­leaving” is also established which extends the winding method to different winding configurations and higher numbers of parallel winding. A novel cooling duct designed with computational fluid dynamics is used for transformer thermal management. The cooling duct uses two 30 mm 7.7 CFM fans to cool the transformer winding and achieves a small height of 43 mm and only 6.8 W power consumption. Using the cooling duct, 106 °C peak winding temperature and 76 °C peak core temperature is achieved at 15 kW load, an ∼ 8% reduction compared to using a conventional 120 mm fan 41 CFM fan. The two transformers with the cooling system achieve 635 W/in3 power density, 1U height compliance, and 99.4% peak efficiency. / M.S. / As society moves towards the electric grid of the future, there have been increased calls for the research and development of resonant power converters due to their high efficiency, high power density, and low electromagnetic interference. The high frequency transformer is one of the main components of the resonant converter system as it contributes substantially to the converters volume, power loss, and thermal management risks. This work seeks to address the trade­offs between leakage inductance minimization and transformer current sharing and proposes a winding method called “intra­leaving” which achieves both. Using “intra­leaving” current sharing error was reduced from 50%, to 5%. Operating transformers at high frequency reduces their volume in accordance with Faraday’s law but also increases thermal risks due to decreased core surface area, higher winding fill factor, and higher loss per unit volume. A novel cooling duct designed using computational fluid dynamics is presented using two 30 mm 7.7 CFM fans and achieves a small height of 43 mm and only 6.8 W power consumption. Using the cooling duct, 106 °C peak winding temperature and 76 °C peak core temperature is achieved at 15 kW load, an ∼ 8% reduction compared to using a conventional 120 mm fan 41 CFM fan. The transformers with the cooling system designed in this work achieve 635 W/in³ power density, 1U height compliance, and 99.4% peak efficiency.

Glioblastoma multiforme (GBM) is the most common and lethal primary brain cancer with an average survival time of 15 months. GBM is considered incurable with even the most aggressive multimodal therapies and is characterized by near universal recurrence. Irreversible electroporation (IRE) is a cellular ablation method currently being investigated as a therapy for a variety of cancers. Application of IRE involves insertion of electrodes into tissue to deliver pulsed electric fields (PEFs), which destabilize the cell membrane past the point of recovery, thereby inducing cell death. While this treatment modality has numerous advantages, the lack of selectivity for malignant cells limits its application in the brain where damage to healthy tissue is especially deleterious. In this dissertation we hypothesize that a form of IRE therapy, high-frequency IRE (H-FIRE), may be able to act as a selective targeted therapy for GBM due to its ability to create an electric field inside a cell to interact with altered inner organelles. Through a comprehensive investigation involving experimental testing combined with numerical modeling, we have attained results in strong support of this hypothesis. Using tissue engineered hydrogels as our platform for therapy testing, we demonstrate selective ablation of GBM cells. We develop mathematical models that predict the majority of the electric field produced by H-FIRE pulses reach the inside of the cell. We demonstrate that the increased nuclear to cytoplasm ratio (NCR) of malignant GBM cells compared to healthy brain—evidenced in vivo and in in vitro tissue mimics—is correlated with greater ablation volumes and thus lower electric field thresholds for cell death when treated with H-FIRE. We enhance the selectivity achieved with H-FIRE using a molecularly targeted drug that induces an increase in NCR. We tune the treatment pulse parameters to increase selective malignant cell killing. Finally, we demonstrate the ability of H-FIRE to ablate therapy-resistant GBM cells which are a focus of many next-generation GBM therapies. We believe the evidence presented in this dissertation represents the beginning stages in the development of H-FIRE as a selective therapy to be used for treatment of human brain cancer. / Ph. D. / Glioblastoma multiforme (GBM) is the most common and lethal primary brain cancer with an average survival time of 15 months. GBM is considered incurable with even the most aggressive multimodal therapies and is characterized by near universal recurrence. Irreversible electroporation (IRE) is a therapy currently being developed for the treatment of a variety of cancers. Application of IRE involves the delivery of energy directly into the tumor tissue in the form of pulsed electric fields (PEFs). These PEFs destabilize the cell membrane past the point of recovery, thereby inducing cell death. Though this treatment modality has numerous advantages, the lack of selectivity for malignant cells limits its application in the brain where damage to healthy tissue is especially deleterious. In this dissertation we hypothesize that a form of IRE therapy, high-frequency IRE (H-FIRE), may be able to act as a selective targeted therapy for GBM due to its ability to create electric fields inside cells. Because cancer is characterized by alterations in inner organelles compared to healthy cells, electric fields inside the cell may be able to target these alterations resulting in selective malignant cell killing. Through a comprehensive investigation involving experimental testing combined with numerical modeling, we have attained results in strong support of this hypothesis. We have successfully demonstrated selective ablation of malignant GBM cells. We have shown that the increased nuclear to cytoplasm ratio (NCR) of malignant GBM cells compared to healthy brain—evidenced in vivo and in in vitro tissue mimics—is correlated with greater ablation volumes and thus lower electric field thresholds for cell death when treated with H-FIRE. We have enhanced the selectivity v achieved with H-FIRE using a molecularly targeted drug that induces an increase in NCR. We have tuned the treatment parameters to increase selective malignant cell killing. Finally, we have demonstrated the ability of H-FIRE to ablate therapy-resistant GBM cells which are a focus of many next-generation GBM therapies. We believe the evidence presented in this dissertation represents the beginning stages in the development of H-FIRE as a selective therapy to be used for treatment of human brain cancer.

Due to the concerns regarding increasing fuel cost and air pollution, plug-in electric vehicles (PEVs) are drawing more and more attention. PEVs have a rechargeable battery that can be restored to full charge by plugging to an external electrical source. However, the commercialization of the PEV is impeded by the demands of a lightweight, compact, yet efficient on-board charger system. Since the state-of-the-art Level 2 on-board charger products are largely silicon (Si)-based, they operate at less than 100 kHz switching frequency, resulting in a low power density at 3-12 W/in3, as well as an efficiency no more than 92 - 94% Advanced power semiconductor devices have consistently proven to be a major force in pushing the progressive development of power conversion technology. The emerging wide bandgap (WBG) material based power semiconductor devices are considered as game changing devices which can exceed the limit of Si and be used to pursue groundbreaking high frequency, high efficiency, and high power density power conversion. Using wide bandgap devices, a novel two-stage on-board charger system architecture is proposed at first. The first stage, employing an interleaved bridgeless totem-pole AC/DC in critical conduction mode (CRM) to realize zero voltage switching (ZVS), is operated at over 300 kHz. A bi-directional CLLC resonant converter operating at 500 kHz is chosen for the second stage. Instead of using the conventional fixed 400 V DC-link voltage, a variable DC-link voltage concept is proposed to improve the efficiency within the entire battery voltage range. 1.2 kV SiC devices are adopted for the AC/DC stage and the primary side of DC/DC stage while 650 V GaN devices are used for the secondary side of the DC/DC stage. In addition, a two-stage combined control strategy is adopted to eliminate the double line frequency ripple generated by the AC/DC stage. The much higher operating frequency of wide bandgap devices also provides us the opportunity to use PCB winding based magnetics due to the reduced voltage-second. Compared with conventional litz-wire based transformer. The manufacture process is greatly simplified and the parasitic is much easier to control. In addition, the resonant inductors are integrated into the PCB transformer so that the total number of magnetic components is reduced. A transformer loss model based on finite element analysis is built and used to optimize the transformer loss and volume to get the best performance under high frequency operation. Due to the larger inter-winding capacitor of PCB winding transformer, common mode noise becomes a severe issue. A symmetrical resonant converter structure as well as a symmetrical transformer structure is proposed. By utilizing the two transformer cells, the common mode current is cancelled within the transformers and the total system common mode noise can be suppressed. In order to charge the battery faster, the single-phase on-board charger concept is extended to a higher power level. By using the three-phase interleaved CLLC resonant converter, the charging power is pushed to 12.5 kW. In addition, the integrated PCB winding transformer in single phase is also extended to the three phase. Due to the interleaving between each phase, further integration is achieved and the transformer size is further reduced. / PHD / Plug-in electric vehicles (PEVs) are drawing more and more attention due to the advantages of energy saving, low CO₂ emission and cost effective in the long run. The power source of PEVs is a high voltage DC rechargeable battery that can be restored to full charge by plugging to an external electrical source, during which the battery charger plays an essential role by converting the grid AC voltage to the required battery DC voltage. Silicon based power semiconductor devices have been dominating the market over the past several decades and achieved numerous outstanding performances. As they almost reach their theatrical limit, the progress to purse the high-efficiency, high-density and high-reliability power conversion also slows down. On this avenue, the emerging wide bandgap (WBG) material based power semiconductor devices are envisioned as the game changer: they can help increase the switching frequency by a factor of ten compared with their silicon counterparts while keeping the same efficiency, resulting in a small size, lightweight yet high efficiency power converter. With WBG devices, magnetics benefit the most from the high switching frequency. Higher switching speed means less energy to store during one switching cycle. Consequently, the size of the magnetic component can be greatly reduced. In addition, the reduced number of turns provides the opportunity to adopt print circuit board as windings. Compared with the conventional litz-wire based magnetics, planar magnetics not only can effectively reduce the converter size, but also offer improved reliability through automated manufacturing process with repeatable parasitics. This dissertation is dedicated to address the key high-frequency oriented challenges of adopting WBG devices (including both SiC and GaN) and integrated PCB winding magnetics in the battery charger applications. First, a novel two-stage on-board charger system architecture is proposed. The first stage employs an interleaved bridgeless totem-pole AC/DC with zero voltage switching, and a bi-directional CLLC resonant converter is chosen for the second stage. Second, a PCB winding based transformer with integrated resonant inductors is designed, so that the total number of magnetic components is reduced and the manufacturability is greatly improved. A transformer loss model based on finite element analysis is built and employed to optimize the transformer loss and volume to get the best performance under high frequency operations. In addition, a symmetrical resonant converter structure as well as a symmetrical transformer structure is proposed to solve the common noise issue brought by the large parasitic capacitance in PCB winding magnetics. By utilizing the two transformer cells, the common mode current is cancelled within the transformers, and the total system common mode noise can be suppressed. Finally, the single-phase on-board charger concept is extended to a higher power level to charge the battery faster. By utilizing the three-phase interleaved CLLC resonant converter as DC/DC stage, the charging power is pushed to 12.5 kW. In addition, the integrated PCB winding magnetic in single phase is also extended to the three phase. Due to the interleaving between the three phase, further integration is achieved and the transformer size is further reduced.

This work investigates the use of irreversible electroporation (IRE) for tissue engineering applications and as a cancer ablation therapy. IRE uses short, high-intensity electric pulses to create pores in a cell's membrane and disrupt its stability. At a certain energy level, damage to the cell becomes too great and it leads to cell death. The particular mechanisms that drive this response are still not completely understood. Thus, further characterization of this behavior for cell death induced by pulsed electric fields (PEFs) will advance the understanding of these types of therapies and encourage their use to treat unresectable tumors that can benefit from the non-thermal mechanism of action which spares critical blood vessels and nerves in the surrounding area. We evaluate the response to PEFs by different cell types through experimental testing combined with computer simulations of these treatments. We show that IRE can be used to kill a specific type of bacteria that produce cellulose which can be used as an implantable material to repair damaged tissues. By killing these bacteria at particular times and locations during their cellulose production, we can create conduits in the overall structure of this material for the transport of oxygen and nutrients to the cells within the area after implantation. The use of tissue models also plays a key role in the investigation of various cancer treatments by providing a controlled environment which can mimic the state of cells within a tumor. We use tumor models comprised of a mix of collagen and cancer cells to evaluate their response to IRE based on the parameters that induce cell death and the time it takes for this process to occur. The treatment of prostate and pancreatic cancer cells with standard monopolar (only positive polarity) IRE pulses resulted in different time points for a full lesion (area of cell death) to develop for each cell type. These results indicate the presence of secondary processes within a cell that induce further cell death in the border of the lesion and cause the lesion to increase in size several hours after treatment. The use of high-frequency irreversible electroporation (H-FIRE)--comprised of short bursts of high-intensity, bipolar (both positive and negative polarity) pulses--can selectively treat cancer cells while keeping healthy cells in the neighboring areas alive. We show that H-FIRE pulses can target tumor-initiating cells (TICs) and late-stage, malignant cancer cells over non-malignant cells using a mouse ovarian cancer model representative of different stages of disease progression. To further explore the mechanisms that drive this difference in response to IRE and H-FIRE, we used more complex tumor models. Spheroids are a type of 3D cell culture model characterized by the aggregation of one or more types of cells within a single compact structure; when embedded in collagen gels, these provide cell-to-cell contact and cell-to-matrix adhesion by interactions of cells with the collagen fibers (closely mimicking the tumor microenvironment). The parameters for successful ablation with IRE and H-FIRE can be further optimized with the use of these models and the underlying mechanisms driving the response to PEFs at the cellular level can be revealed. / Ph. D. / This work investigates the use of irreversible electroporation (IRE) for tissue engineering applications and as a cancer ablation therapy. IRE uses short, high-intensity electric pulses to create pores in a cell’s membrane and disrupt its stability. At a certain energy level, damage to the cell becomes too great and it leads to cell death. The particular mechanisms that drive this response are still not completely understood. Thus, further characterization of this behavior for cell death induced by pulsed electric fields (PEFs) will advance the understanding of these types of therapies and encourage their use to treat unresectable tumors that can benefit from the non-thermal mechanism of action which spares critical blood vessels and nerves in the surrounding area. We evaluate the response to PEFs by different cell types through experimental testing combined with computer simulations of these treatments. We show that IRE can be used to kill a specific type of bacteria that produce cellulose which can be used as an implantable material to repair damaged tissues. By killing these bacteria at particular times and locations during their cellulose production, we can create conduits in the overall structure of this material for the transport of oxygen and nutrients to the cells within the area after implantation. The use of tissue models also plays a key role in the investigation of various cancer treatments by providing a controlled environment which can mimic the state of cells within a tumor. We use tumor models comprised of a mix of collagen and cancer cells to evaluate their response to IRE based on the parameters that induce cell death and the time it takes for this process to occur. The treatment of prostate and pancreatic cancer cells with standard monopolar (only positive polarity) IRE pulses resulted in different time points for a full lesion (area of cell death) to develop for each cell type. These results indicate the presence of secondary processes within a cell that induce further cell death in the border of the lesion and cause the lesion to increase in size several hours after treatment. The use of high-frequency irreversible electroporation (H-FIRE)—comprised of short bursts of high-intensity, bipolar (both positive and negative polarity) pulses—can selectively treat cancer cells while keeping healthy cells in the neighboring areas alive. We show that H-FIRE pulses can target tumor-initiating cells (TICs) and late-stage, malignant cancer cells over non-malignant cells using a mouse ovarian cancer model representative of different stages of disease progression. To further explore the mechanisms that drive this difference in response to IRE and H-FIRE, we used more complex tumor models. Spheroids are a type of 3D cell culture model characterized by the aggregation of one or more types of cells within a single compact structure; when embedded in collagen gels, these provide cell-to-cell contact and cell-to-matrix adhesion by interactions of cells with the collagen fibers (closely mimicking the tumor microenvironment). The parameters for successful ablation with IRE and H-FIRE can be further optimized with the use of these models and the underlying mechanisms driving the response to PEFs at the cellular level can be revealed.

By 2030, it is expected that 80% of all electric power will flow through power electronics systems. Wide bandgap power modules that can tolerate higher voltages and currents than silicon-based modules are the most promising solution to reducing the size and weight of power electronics systems. These wide-bandgap power modules constitute powerful building blocks for power electronics systems, and wide bandgap-based converter/power electronics building blocks are envisaged to be widely used in power grids in low- and medium-voltage applications and possibly in high-voltage applications for high-voltage direct current and flexible alternating current transmission systems. One of the merits of wide bandgap devices is that their slew rates and switching frequencies are much higher than silicon-based devices. However, from the insulation side, frequency and slew rate are two of the most critical factors of a voltage pulse, influencing the level of degradation of the insulation systems that are exposed to such voltage pulses. The shorter the rise time, the shorter the lifetime. Furthermore, lifetime dramatically decreases with increasing frequency. Thus, although wide bandgap devices are revolutionizing power electronics, electrical insulating systems are not prepared for such a revolution; without addressing insulation issues, the electronic power revolution will fail due to dramatically increased failure rates of electrification components. In this regard, internal partial discharges (PDs) have the most effect on insulation degradation. Internal PDs which occur in air-filled cavities or voids are localized electrical discharges that only partially bridge the insulation between conductors. Voids in solid or gel dielectrics are challenging to eliminate entirely and may result simply during manufacturing process. The objective of this study is to develop a Finite-Element Analysis (FEA) PD model under fast, repetitive voltage pulses, which has been done for the first time. The model is coded and implemented in COMSOL Multiphysics linked with MATLAB, and its simulation results are validated with experimental tests. Using the model, the influence of different parameters including void shape, void size, and void air pressure on PD parameters are studied. / M.S. / To decarbonize and reduce energy consumption for commercial aviation, the development of lightweight and ultra-efficient all-electric powertrain including electric motors, drives, and associated thermal management systems has been targeted. Using wide bandgap (WBG) power modules that can tolerate high voltages and currents can reduce the size and weight of the drive. However, the operation of WBG-based power converter can endanger the reliability of the electrified systems, most importantly, the insulation system. In this study, it is attempted to model the impact of such threats to the insulation system using numerical models.

We introduce a financial model for limit order book with two main features: First, the limit orders and market orders for the given asset both appear and interact with each other. Second, the high frequency trading (HFT, for short) activities are allowed and described by the scaling limit of nearly-unstable multi-dimensional Hawkes processes with power law decay. The model eventually becomes a stochastic partial differential equation (SPDE, for short) with the diffusion coefficient determined by a Volterra integral equation governed by a Hawkes process, whose Hurst exponent is less than 1/2, which makes the volatility path of the stochastic PDE rougher than that driven by a Brownian motion. We have further established the well-posedness of such a system so that a foundation is laid down for further studies in this direction.

Brain tumors are among the most devastating types of solid tumors to treat. Standard of care for glioblastoma (GBMs), the most aggressive form of primary brain tumors, has failed to improve the current survival rates in the past decades. Despite many other solid tumors, recent advances in cancer immunotherapies have also shown disappointing outcomes in GBMs. The heterogenous nature of GBMs, the immunosuppressive tumor microenvironment and the restrictive role of blood brain barrier (BBB) are some of the main challenges faced for treating GBMs. Electroporation-based treatments have demonstrated promising results, treating preclinical models of GBMs. It has been shown that low and high frequency irreversible electroporation treatments shift the immunosuppressive tumor microenvironment and reversibly open large areas of blood brain barrier (BBB). In this dissertation, in vitro cell culture models are utilized to study electroporation-based treatments for achieving a more optimized treatment for glioblastoma. We are proposing to utilize the immunomodulatory effects of electroporation treatments to improve the outcomes of immunotherapies in the brain. / Doctor of Philosophy / Despite the current advancements in treating solid tumors, brain tumors remain among the most difficult cancers to treat. The special structure of the brain as an organ as well as tumor complexity can lead to treatment failure. It is also known that infiltration of the immune cells within the tumor mass is limited due to the tumor's immunosuppressive nature. Hence, the use of newly advancing immunotherapy techniques is limited in the brain. Local treatments have become one of the most promising tools against brain tumors. Such treatments include methods that use excessive heating of the tissue to kill the tumors. Relying on heat for tissue destruction could damage the critical structures near the tumor and will reduce the favorable immune response after the treatment. A new treatment modality known as electroporation has been introduced for non-thermal treatment of brain tumors. Due to its non-thermal nature, electroporation treatments will allow for sparing of critical structures and can lead to a more robust immune response comparing to thermal treatment modalities. In this dissertation, we utilize electroporation-based treatments to try to overcome some of the challenges associated with treating brain tumors such as tumor heterogeneity and immune suppression.

The most common and aggressive malignant brain tumor, glioblastoma (GBM), demonstrates on average a 5-year survival rate of only 6.8%. Difficulties arising in the treatment of GBM include the inability of large molecular agents to permeate through the blood-brain barrier (BBB); migration of highly invasive GBM cells beyond the solid tumor margin; and gross, macroscopic intratumor heterogeneity. These characteristics complicate treatment of GBM with standard of care, resulting in abysmal prognosis. Electroporation-based therapies have emerged as attractive alternates to standard of care, demonstrating favorable outcomes in a variety of tumors. Notably, irreversible electroporation (IRE) has been used for BBB disruption and nonthermal ablation of intracranial tumor tissues. Despite promising results, IRE can cause unintended muscle contractions and is susceptible to electrical heterogeneities. Second generation High-frequency IRE (H-FIRE) utilizes bursts of bipolar pulsed electric fields on the order of the cell charging time constant (~1 μs) to ablate tissue while reducing nerve excitation, muscle contraction, and is far less prone to differences in electrical heterogeneities. Throughout my dissertation, I discuss investigations of H-FIRE for the treatment of malignant gliomas and other intracranial disorders. To advance the versatility, usability, and understanding of H-FIRE for intracranial applications, my PhD thesis focuses on: (1) characterizing H-FIRE-mediated BBB disruption effects in an in vivo healthy rodent model; (2) the creation of a novel, real-time impedance spectroscopy technique (Fourier Analysis SpecTroscopy, FAST) using waveforms compatible with existing H-FIRE pulse generators; (3) development of FAST as an in situ technique to monitor ablation growth and to determine patient-specific ablation endpoints; (4) conducting a preliminary efficacy study of H-FIRE ablation in an orthotopic F98 rodent glioma model; and (5) establishing the feasibility of MRI-guided H-FIRE for the ablation malignant gliomas in a spontaneous canine glioma model. The culmination of this thesis advances our understanding of H-FIRE in intracranial tissues, as well as develops a novel, intraoperative impedance spectroscopy technique towards determining patient-specific ablation endpoints for intracranial H-FIRE procedures. / Doctor of Philosophy / The most aggressive malignant brain tumor, glioblastoma (GBM), demonstrates on average a 5-year survival rate of only 6.8%. Difficulties arising in the treatment of GBM include the inability of chemotherapy agents to diffuse into brain tumor tissue as these molecular are unable to pass the so-called blood-brain barrier (BBB). This tumor tissue also presents with cells with the propensity to invade healthy tissue, to the point where diagnostic scans are unable to capture this migration. These characteristics complicate treatment of GBM with standard of care, resulting in abysmal prognosis. Electroporation-based therapies have emerged as attractive alternates to standard of care, demonstrating favorable outcomes in a variety of tumors. For instance, irreversible electroporation (IRE) has been used to successfully treat tumors in the prostate, liver, kidney, and pancreas. Second generation High-frequency IRE (H-FIRE) may possess even greater antitumor qualities and this is the focus of my dissertation. Throughout my dissertation, I discuss investigations of H-FIRE with applications to treat malignant gliomas and other intracranial disorders. My PhD thesis focuses on: (1) characterizing H-FIRE effects for enhanced drug delivery to the brain; (2) the creation of a new, real-time electrical impedance spectroscopy technique (Fourier Analysis SpecTroscopy, FAST) using waveforms compatible with existing H-FIRE pulse generators; (3) development of FAST as a technique to determine H-FIRE treatment endpoints; (4) conducting a preliminary efficacy study of H-FIRE to ablate rodent glioma tumors; and (5) establishing the feasibility of MRI-guided H-FIRE for the ablation malignant gliomas in a spontaneous canine glioma model. The culmination of this thesis advances our understanding of H-FIRE in intracranial tissues, as well as develops a new impedance spectroscopy technique to be used in determining patient-specific ablation endpoints for intracranial H-FIRE procedures.

Irreversible electroporation has recently emerged as an effective focal ablation technique. When performed clinically, the procedure involves placing electrodes into, or around, a target tissue and applying a series of short, but intense, pulsed electric fields. Oftentimes, patient specific treatment plans are employed to guide procedures by merging medical imaging with algorithms for determining the electric field distribution in the tissue. The electric field dictates treatment outcomes by increasing a cell's transmembrane potential to levels where it becomes energetically favorable for the membrane to shift to a state of enhanced permeability. If the membrane remains permeabilized long enough to disrupt homeostasis, cells eventually die. By utilizing this phenomenon, irreversible electroporation has had success in killing cancer cells and treating localized tumors. Additionally, if the pulse parameters are chosen to limit Joule heating, irreversible electroporation can be performed safely on surgically inoperable tumors located next to major blood vessels and nerves. As with all technologies, there is room for improvement. One drawback associated with therapeutic irreversible electroporation is that patients must be temporarily paralyzed and maintained under general anesthesia to prevent intense muscle contractions occurring in response to pulsing. The muscle contractions may be painful and can dislodge the electrodes. To overcome this limitation, we have developed a system capable of achieving non-thermal irreversible electroporation without causing muscle contractions. This progress is the main focus of this dissertation. We describe the theoretical basis for how this new system utilizes alterations in pulse polarity and duration to induce electroporation with little associated excitation of muscle and nerves. Additionally, the system is shown to have the theoretical potential to improve lesion predictability, especially in regions containing multiple tissue types. We perform experiments on three-dimensional in vitro tumor constructs and in vivo on healthy rat brain tissue and implanted tumors in mice. The tumor constructs offer a new way to rapidly characterize the cellular response and optimize pulse parameters, and the tests conducted on live tissue confirm the ability of this new ablation system to be used without general anesthesia and a neuromuscular blockade. Situations can arise in which it is challenging to design an electroporation protocol that simultaneously covers the targeted tissue with a sufficient electric field and avoids unwanted thermal effects. For instance, thermal damage can occur unintentionally if the applied voltage or number of pulses are raised to ablate a large volume in a single treatment. Additionally, the new system for inducing ablation without muscle contractions actually requires an elevated electric field. To ensure that these procedures can continue to be performed safely next to major blood vessels and nerves, we have developed new electrode devices that absorb heat out of the tissue during treatment. These devices incorporate phase change materials that, in the past, have been reserved for industrial applications. We describe an experimentally validated numerical model of tissue electroporation with phase change electrodes that illustrates their ability to reduce the probability for thermal damage. Additionally, a parametric study is conducted on various electrode properties to narrow in on the ideal design. / Ph. D.

With the fast development of information technology (IT) industry, the demand and market volume for off-line power supplies keeps increasing, especially those for desktop, flat-panel TV, telecommunication, computer server and datacenter. An off-line power supply normally consists of electromagnetic interference (EMI) filter, power factor correction (PFC) circuit and isolated DC/DC converter. Isolated DC/DC converter occupies more than half of the volume in an off-line power supply and takes the most control responsibilities, so isolated DC/DC converter is the key aspect to improve the overall performance and reduce the total cost for off-line power supply. On the other hand, of all the power supplies for industrial applications, those for the data center servers are the most performance driven, energy and cost conscious due to the large electricity consumption. The total power consumption of today's data centers is becoming noticeable. Moreover, with the increase in cloud computing and big data, energy use of data centers is expected to continue rapidly increasing in the near future. It is very challenging to design isolated DC/DC converters for datacenters since they are required to provide low-voltage high-current output and fast transient response. The LLC resonant converters have been widely used as the DC-DC converter in off-line power supplies and datacenters due to its high efficiency and hold-up capability. Using LLC converters can minimize switching losses and reduce electromagnetic interference. Almost all the high-end offline power supplies employs LLC converters as the DC/DC converter. But there are three major challenges in LLC converters. Firstly, the control characteristics of the LLC resonant converters are very complex due to the dynamics of the resonant tank. This dissertation proposes to implement a special LLC control method, state-trajectory control, with a low-cost microcontroller (MCU). And further efforts have been made to integrate all the state-trajectory control function into one MCU for high-frequency LLC converters, including start-up and short-circuit protection, fast transient response, light load efficiency improvement and SR driving. Secondly, the transformer in power supplies for IT industry is very bulky and it is very challenging to design. By pushing switching frequency up to MHz with gallium nitride (GaN) devices, the magnetics can be integrated into printed circuit board (PCB) windings. This dissertation proposes a novel matrix transformer structure and its design methodology. On the other hand, shielding technique can be employed to suppress the CM noise for PCB winding transformer. This dissertation proposes a novel shielding technique, which not only suppresses CM noise, but also improves the efficiency. The proposed transformer design and shielding technique is applied to an 800W 400V/12V LLC converter design. Thirdly, the LLC converters have sinusoidal current shape due to the nature of resonance, which has larger root mean square (RMS) of current, as well as larger conduction loss, compared to pulse width modulation (PWM) converter. This dissertation employs three-phase interleaved LLC converters to reduce the circulating energy by inter-connecting the three phases in certain way, and proposed a novel magnetic structure to integrated three inductors and three transformers into one magnetic core. By pushing switching frequency up to 1MHz, all the magnetics can be implemented with 4-layer PCB winding. Additional 2-layer shielding can be integrated to reduce CM noise. The proposed magnetic structure is applied to a 3kW 400V/12V LLC converter. This dissertation solves the challenges in analysis, digital control, magnetic design and EMI in high-frequency DC/DC converters in off-line power supplies. With the academic contribution in this dissertation, GaN devices can be successfully applied to high-frequency DC/DC converters with MHz switching frequency to achieve high efficiency, high power density, simplified but high-performance digital control and automatic manufacturing. The cost will be reduced and the performance will be improved significantly. / Ph. D. / With the fast development of information technology (IT) industry, the demand and market volume for off-line power supplies keeps increasing, especially those for desktop, flat-panel TV, telecommunication, computer server and datacenter. The total power consumption of today’s data centers is becoming noticeable. Moreover, with the increase in cloud computing and big data, energy use of data centers is expected to continue rapidly increasing in the near future. The efficiency of off-line power supplies is very critical for the whole human society in order to reduce the total electricity consumption. And the cost is also a key driving force for the development of novel technology in off-line power supplies due to the large market volume. An off-line power supply normally consists of electromagnetic interference (EMI) filter, power factor correction (PFC) circuit and isolated DC/DC converter. Isolated DC/DC converter occupies more than half of the volume in an off-line power supply and takes the most control responsibilities, so isolated DC/DC converter is the key aspect to improve the overall performance and reduce the total cost for off-line power supply. Among all the DC/DC converter topologies, the LLC resonant converters have been most widely used as the DC/DC converter due to its high efficiency and hold-up capability. But there are three major challenges in LLC converters. Firstly, the control characteristics are very complex due to the dynamics of the resonant tank. To achieve good control performance, very complex and expensive digital controller has to be employed. Secondly, the magnetic components are very bulky, and it is expensive to manufacture them. Thirdly, there is circulating energy in LLC converters due to the nature of resonance, which increases the total loss. To solve these challenges, this dissertation proposes to implement a special control method, state-trajectory control, with a low-cost microcontroller (MCU). All the control functions can be integrated into one simple, low-cost MCU to replace the previous complex and expensive controller. By pushing switching frequency up to MHz with next generation power devices, this dissertation proposes a novel magnetics structure that can be integrated into printed circuit board (PCB) windings to achieve low-cost and automatic manufacturing. Furthermore, this dissertation employs three-phase interleaved LLC converters topology to reduce the circulating energy, and proposed a novel magnetic structure to integrated three inductors and three transformers into one magnetic core with simple 4-layer PCB winding. All the proposed technologies have been verified on hardware prototypes, and significant improvements over industrial state-of-art designs have been demonstrated. To sum up, this dissertation solves the challenges in analysis, digital control, magnetic design and EMI in DC/DC converters for off-line power supplies. With the academic contribution in this dissertation, the cost can be reduced due to the simplified control and automatic manufactured magnetics, and the efficiency can be improved with proper utilization of next generation power devices. This dissertation will improve future DC/DC converter for IT industrial in the three most important aspects of efficiency, power density and cost.