- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 731 to 740 of 1477 (0.018 seconds)| 731 |
Effect of Corrosion Inhibitor on Water Wetting and Carbon Dioxide Corrosion in Oil-Water Two-Phase FlowLi, Chong 10 August 2009 (has links)
No description available.
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| 732 |
Inhibitors of Basal Glucose Transport and Their Anticancer Activities and MechanismLiu, Yi 25 July 2012 (has links)
No description available.
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| 733 |
Mechanism, function, and inhibition of peptide deformylaseNguyen, Kiet T. 09 March 2005 (has links)
No description available.
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| 734 |
Development of neutral phosphotyrosine memetics as a protein tyrosine phosphatase inhibitor and studies on its inhibition mechanismPark, Junguk 02 December 2005 (has links)
No description available.
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| 735 |
Molecularly targeted therapy for ovarian cancerYang, Ya-Ting 21 September 2006 (has links)
No description available.
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| 736 |
Evaluation of peptide based vaccines and inhibitors to prevent the onset of HTLV-1 associated diseasesLynch, Marcus Phillip 30 November 2006 (has links)
No description available.
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| 737 |
The world according to mast cells – the role of Kit in normal and neoplastic canine mast cellsLin, Tzu-Yin 20 September 2007 (has links)
No description available.
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| 738 |
Targeting the phosphoinositide-dependent protein kinase-2 for anticancer drug discoveryLee, Su-Lin 25 June 2012 (has links)
No description available.
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| 739 |
Mechanistic Validation of Potential Anti-Breast Cancer TherapeuticsChuang, Hsiao-Ching 27 June 2012 (has links)
No description available.
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| 740 |
Investigation of endogenous p21 expression and its correlation to therapy resistance in high-risk neuroblastomaSorteberg, Agnes January 2021 (has links)
Neuroblastoma (NB) is a childhood cancer with a highly complex nature. High-risk NB patients undergo intensive treatment regimens that are often followed by long-term side effects. This, in addition to the emergence of resistant cancer cells, highlights a need for novel therapeutic targets and treatment strategies to improve outcome in NB. P21 is a cyclin-dependent kinase inhibitor considered to play a role in tumor resistance and aggressiveness due to its involvement in cell cycle and/or apoptosis. This project aimed to explore the expression of endogenous p21 in high-risk NB cell lines and whether p21 could be a therapeutic target for high-risk NB. Endogenous p21 levels were investigated using RT-qPCR and quantitative immunocytochemistry in eight high-risk NB cell lines. A small molecular inhibitor of p21, UC2288, was used in these cell lines to investigate tumour cell viability following p21 inhibition. In addition, combination treatment with UC2288 and the chemotherapy drug cisplatin was performed on resistant NB cell lines. Our results show variable expression of p21, where cell lines with high endogenous p21 expression showed sensitivity to single agent treatment with cisplatin or UC2288. Moreover, resistant NB cell lines showed lower endogenous p21 expression, however, combination treatment with UC2288 and cisplatin showed reduced viability, indicating sensitivity to combination treatment. This project highlights the potential of using p21 as a therapeutic target as well as a predictive biomarker in high-risk NB.
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