This thesis is concentrated to problems anti-corruption education. The notion of corruption, its causes and sorts, norms of corruption, the relation of corruption with ethics, sociology, economics and law. The place is given also to important differences between the situation in countries with an unbroken continuity of democracy. The sociological research was conducted to determine the attitudes of students to corruption. On the basis of defined sets of problems which should be the focus of anti-corruption education and formulated recommendations based on the requirements of pro-social education. Key words: sociological research, analysis, corruption, importance of anti-corruption education, teacher, student

Seventy years ago Erikson proposed successful identity formation in adolescence was the foundation for successful intimacy formation in young adulthood. With the extended period of identity exploration in emerging adulthood, it is unclear if intimacy formation continues to be connected to identity. The purpose of this study was to determine the relationship between identity in three domains of love, work, and worldview with long term views of intimacy using Marital Horizons Theory. Results from a sample of 777 college students in the Project READY dataset indicated that identity formation in love is positively associated with views of marriage, identity formation in work has no significant association with views of marriage, and identity formation in worldview is negatively associated with views of marriage. Implications for the transition into marriage and further identity research are discussed.

Australia�s policy on Quality Use of Medicines (QUM) aims to achieve appropriate use of medicines and improved health outcomes. Drug and Therapeutics Committees (DTCs) are educators, policy makers as well as financial gatekeepers in matters relating to medicine use. Increasingly, DTCs are also involved in risk management and clinical governance. As such, DTCs could be considered to be QUM advocates in the institutions in which they function. In a health care arena where there are escalating demands on high standards of clinical practice, quality assessment and improvement is essential in ensuring safe and effective patient care. Given the role DTCs play in safeguarding the interests of the stakeholders of the health care system, research into ways in which DTC performance could be enhanced is required. Although indicators specific to DTCs exist, the literature does not seem to provide straightforward answers to the question of what is currently being done in terms of quality assessment and quality improvement of DTCs. In the absence of such data, an opportunity for research is clearly identified. The first aim of this research project was to gain insight into the current activities undertaken by, and challenges facing Australian DTCs. Following this, the second aim was to explore ways in which DTC performance could be augmented. In addressing the first aim of this project, a national survey of Australian DTCs was conducted. These findings reinforce the evidence in the literature about the roles, structure and stakeholder expectations of DTCs. Our research also documents DTCs� quality improvement initiatives and barriers to DTC activities. It appears that there is little support available to Australian DTCs. Further, a case study was undertaken in order to gain an understanding of the depth and detail of DTC operations. An audit of a DTC in an Australian hospital was conducted. This study revealed that DTC decisions are being implemented in an ad hoc manner. In fact, there were no strategies (or action) planned to implement the majority of their decisions. This could have an impact on DTC performance. In view of this finding, qualitative methods were used to explore stakeholder opinions regarding the implementation of DTC decisions and policies. Stakeholders believed that strategies used to implement DTC policies should be targeted (to the audience as well as the type of decision/policy being implemented), timely, and delivered at the point of care. Face-to-face strategies were perceived to be more effective than printed materials, particularly when an influence on clinical practice was desired. Stakeholders also felt that the lack of resources was a significant barrier to DTC performance augmentation. This probably contributed to a lack of follow-up (or review) of implemented policies. According to stakeholders, other barriers to policy implementation include a lack of ownership of policies, low DTC profile, and an over-reliance on pharmacy to implement DTC decisions. Stakeholders felt one of the ways in which DTC performance could be improved was to prioritise DTC decisions for implementation. In pursuit of a method to prioritise DTC decisions, a survey was conducted. Stakeholders identified patient safety, cost, and the practice of evidence-based medicine as domains of important DTC decisions. The results also suggest that stakeholders recognise the need for the prioritisation of DTC decisions for implementation. Stakeholders implied that higher priority would be assigned to DTC decisions considered to be important. In a follow-up survey, stakeholders (including doctors, nurses, pharmacists, and DTC members) seemed to have agreement of the primary domains of DTC decisions. Higher levels of importance and higher priority were assigned to decisions involving the primary domains of patient safety and cost. However, level of importance and priority assignment were not consistently correlated. The work presented in this thesis suggests that there are ways to improve DTC performance. Although conducted primarily on hospital-based DTCs, it is anticipated that the lessons learnt could be applied to state-based, or even, Area Health-based DTCs. In conclusion, this research found that there was a range of views regarding �importance� and prioritisation for implementation. Social, organisational, as well as environmental factors may contribute to this. Future research should examine other possible factors contributing to the importance and priority of DTC decisions, so that DTC policy could be appropriately implemented into practice.

<p>The aim of this thesis is to assess the strategic importance of Central Asia as a whole and interests of great powers in the region in particular within the theoretical framework chosen. The work shows Central Asia as an area of the New Great Game, analogue of the original Great Game which was played out between the British Empire and Tsarist Russia in XIX century. The parallels between the original Great Game and the New Great Game are drawn in order to understand the scope and the true intentions of the players of the latter one. Also, the security issues in the contemporary Central Asia are explored and analyzed to provide with the background for future predictions. Furthermore, the indirect purpose of the thesis is to examine whether the international system has changed from that of two centuries ago by comparing the structure of the international systems at the time of two Games. </p><p>Different theories are gathered into one system theory which serves as a framework for analytical elaboration. The theories used are - the theory of offensive realism, regional security complex theory, strategic theory and the concept of strategic geography, where the applicable essence is withdrawn for analysis of the processes in the contemporary Central Asia. The strategic interests of the regional powers in Central Asia are described and analyzed with the significant help of the theoretical part. </p><p>In order to reach the aim of the research the historical concept of the Great Game is chosen as a method. By comparison of the location, players, means and goals with the New Great Game the validity of concept is verified and, consequently, applied to the Central Asian case. </p><p>On the basis of theoretical and methodological parts the empirical findings are withdrawn and analyzed in turn providing us with the reasonable conclusions on the issue. The perspectives of the two key players - the US and Russia - are analyzed and the possible predictions are made. In a similar way, certain scenarios are provided to Central Asian states, depending on the development of the New Great Game. Finally, the recommendations for further research are given. </p><p>Last but not least, this work is a study of one part of geopolitics in one region at one time, thereby the conclusion drawn is actual only for one region, but not for the discipline as a whole.</p>

<p>The overall aim of this thesis is to investigate health-related quality of life (HRQoL), anxiety and depression in patients with endocrine gastrointestinal (GI) tumours. Patient as well as staff perceptions were assessed. HRQoL was studied with the EORTC QLQ-C30, and anxiety and depression with the Hospital Anxiety and Depression Scale. In addition, patient perceptions of the importance of and satisfaction with selected HRQoL aspects were investigated. Semi-structured interviews with open-ended questions were conducted to identify disease- and treatment-related distress, what constitutes a good quality of life and strategies to "keep a good mood" among these patients. Patients reported a relatively good HRQoL and low levels of anxiety and depression. However, they reported a lower HRQoL than could be expected for healthy people of similar age and gender. Staff gave a more pessimistic view of patient satisfaction with HRQoL aspects than did patients, and staff did not accurately judge individual patients' levels of anxiety and depression. Importance>satisfaction discrepancies for HRQoL aspects may identify patients with a low quality of life. HRQoL, anxiety and depression did not change substantially during the first year of treatment. Categories identified through content analysis of interview data concerning distress and quality of life were referred to physical, emotional or social dimensions. Identified strategies to "keep a good mood" were classified as Internal or External. Most categories of distress that were identified are covered by the EORTC QLQ-C30 and/or the HADS, but some additional emotional and social aspects of distress emerged from the interview data. Receiving good care was identified as a strategy to "keep a good mood". This result indicates a possible and potentially important relation between the quality of care and patient HRQoL.</p>

Recent research in experimental and computational biology has revealed the necessity of using stochastic modeling and simulation to investigate the functionality and dynamics of gene networks. However, there is no sophisticated stochastic modeling techniques and efficient stochastic simulation algorithms (SSA) for analyzing and simulating gene networks. Therefore, the objective of this research is to design highly efficient and accurate SSAs, to develop stochastic models for certain real gene networks and to apply stochastic simulation to investigate such gene networks. To achieve this objective, we developed several novel efficient and accurate SSAs. We also proposed two stochastic models for the circadian system of Drosophila and simulated the dynamics of the system. The K-leap method constrains the total number of reactions in one leap to a properly chosen number thereby improving simulation accuracy. Since the exact SSA is a special case of the K-leap method when K=1, the K-leap method can naturally change from the exact SSA to an approximate leap method during simulation if necessary. The hybrid tau/K-leap and the modified K-leap methods are particularly suitable for simulating gene networks where certain reactant molecular species have a small number of molecules. Although the existing tau-leap methods can significantly speed up stochastic simulation of certain gene networks, the mean of the number of firings of each reaction channel is not equal to the true mean. Therefore, all existing tau-leap methods produce biased results, which limit simulation accuracy and speed. Our unbiased tau-leap methods remove the bias in simulation results that exist in all current leap SSAs and therefore significantly improve simulation accuracy without sacrificing speed. In order to efficiently estimate the probability of rare events in gene networks, we applied the importance sampling technique to the next reaction method (NRM) of the SSA and developed a weighted NRM (wNRM). We further developed a systematic method for selecting the values of importance sampling parameters. Applying our parameter selection method to the wSSA and the wNRM, we get an improved wSSA (iwSSA) and an improved wNRM (iwNRM), which can provide substantial improvement over the wSSA in terms of simulation efficiency and accuracy. We also develop a detailed and a reduced stochastic model for circadian rhythm in Drosophila and employ our SSA to simulate circadian oscillations. Our simulations showed that both models could produce sustained oscillations and that the oscillation is robust to noise in the sense that there is very little variability in oscillation period although there are significant random fluctuations in oscillation peeks. Moreover, although average time delays are essential to simulation of oscillation, random changes in time delays within certain range around fixed average time delay cause little variability in the oscillation period. Our simulation results also showed that both models are robust to parameter variations and that oscillation can be entrained by light/dark circles.

The Birnbaum importance (BI) is a well-known measure that evaluates the relative contribution of components to system reliability. It has been successfully applied to tackling some reliability problems. This dissertation investigates two topics related to the BI in the reliability field: the patterns of component BIs and the BI-based heuristics and meta-heuristics for solving the component assignment problem (CAP).There exist certain patterns of component BIs (i.e., the relative order of the BI values to the individual components) for linear consecutive-k-out-of-n (Lin/Con/k/n) systems when all components have the same reliability p. This study summarizes and annotates the existing BI patterns for Lin/Con/k/n systems, proves new BI patterns conditioned on the value of p, disproves some patterns that were conjectured or claimed in the literature, and makes new conjectures based on comprehensive computational tests and analysis. More importantly, this study defines a concept of segment in Lin/Con/k/n systems for analyzing the BI patterns, and investigates the relationship between the BI and the common component reliability p and the relationship between the BI and the system size n. One can then use these relationships to further understand the proved, disproved, and conjectured BI patterns.The CAP is to find the optimal assignment of n available components to n positions in a system such that the system reliability is maximized. The ordering of component BIs has been successfully used to design heuristics for the CAP. This study proposes five new BI-based heuristics and discusses their corresponding properties. Based on comprehensive numerical experiments, a BI-based two-stage approach (BITA) is proposed for solving the CAP with each stage using different BI-based heuristics. The two-stage approach is much more efficient and capable to generate solutions of higher quality than the GAMS/CoinBonmin solver and a randomization method.This dissertation then presents a meta-heuristic, i.e., a BI-based genetic local search (BIGLS) algorithm, for the CAP in which a BI-based local search is embedded into the genetic algorithm. Comprehensive numerical experiments show the robustness and effectiveness of the BIGLS algorithm and especially its advantages over the BITA in terms of solution quality.

Large interruptions of power supply in the transmission system have considerable impact on modern society. The goal for the transmission system operator (TSO) is to prevent and mitigate such events with optimal decisions in design, planning, operation and maintenance. Identifying critical power components for system reliability provides one important input to this decision-making. This thesis develops quantitative component reliability importance indices applicable for identifying critical components in real transmission systems. Probabilistic models with component failure statistics are combined with detailed power system models evaluated with the AC power flow technique. In the presented method each system component is assigned three importance indices based on outage events expected probability and consequence to (i) reduced system security margin, (ii) interrupted load supply and (iii) disconnected generation units. By ranking components by each of the three interests, a more complete view of the risks to system reliability can be assessed than if, as traditionally, only (ii) is modelled. The impact on security margin is studied in well established critical transfer sections (CTS) supervised by the TSO. TSOs set the CTSs limits [MW] based on deterministic security criteria, with regard to thermal, voltage level, and system stability limits, and the CTSs' condition at post-contingency state is in the method used as an indicator of the system security margin. The methodology is extended with three indices modified to quantify the component importance for common-cause events initiated by acts of sabotage. The developed methods are applied on a significant part of the Great Britain transmission system, modelling 7000 components and 107 substation layouts. The study includes several load demand scenarios, 200 million initiating outage events and non-functioning protection equipment. The resulting component ranking provides an important input to the TSO's decision-making, and could be implemented as a complement to the existing deterministic N-1 criterion. With the methods applied a TSO can perform further and more detailed assessments on a few critical components in order to enhance system reliability for equipment failures and strengthen the system vulnerability against sabotage. / QC 20110920

The aim of this thesis is to assess the strategic importance of Central Asia as a whole and interests of great powers in the region in particular within the theoretical framework chosen. The work shows Central Asia as an area of the New Great Game, analogue of the original Great Game which was played out between the British Empire and Tsarist Russia in XIX century. The parallels between the original Great Game and the New Great Game are drawn in order to understand the scope and the true intentions of the players of the latter one. Also, the security issues in the contemporary Central Asia are explored and analyzed to provide with the background for future predictions. Furthermore, the indirect purpose of the thesis is to examine whether the international system has changed from that of two centuries ago by comparing the structure of the international systems at the time of two Games. Different theories are gathered into one system theory which serves as a framework for analytical elaboration. The theories used are - the theory of offensive realism, regional security complex theory, strategic theory and the concept of strategic geography, where the applicable essence is withdrawn for analysis of the processes in the contemporary Central Asia. The strategic interests of the regional powers in Central Asia are described and analyzed with the significant help of the theoretical part. In order to reach the aim of the research the historical concept of the Great Game is chosen as a method. By comparison of the location, players, means and goals with the New Great Game the validity of concept is verified and, consequently, applied to the Central Asian case. On the basis of theoretical and methodological parts the empirical findings are withdrawn and analyzed in turn providing us with the reasonable conclusions on the issue. The perspectives of the two key players - the US and Russia - are analyzed and the possible predictions are made. In a similar way, certain scenarios are provided to Central Asian states, depending on the development of the New Great Game. Finally, the recommendations for further research are given. Last but not least, this work is a study of one part of geopolitics in one region at one time, thereby the conclusion drawn is actual only for one region, but not for the discipline as a whole.

The overall aim of this thesis is to investigate health-related quality of life (HRQoL), anxiety and depression in patients with endocrine gastrointestinal (GI) tumours. Patient as well as staff perceptions were assessed. HRQoL was studied with the EORTC QLQ-C30, and anxiety and depression with the Hospital Anxiety and Depression Scale. In addition, patient perceptions of the importance of and satisfaction with selected HRQoL aspects were investigated. Semi-structured interviews with open-ended questions were conducted to identify disease- and treatment-related distress, what constitutes a good quality of life and strategies to "keep a good mood" among these patients. Patients reported a relatively good HRQoL and low levels of anxiety and depression. However, they reported a lower HRQoL than could be expected for healthy people of similar age and gender. Staff gave a more pessimistic view of patient satisfaction with HRQoL aspects than did patients, and staff did not accurately judge individual patients' levels of anxiety and depression. Importance&gt;satisfaction discrepancies for HRQoL aspects may identify patients with a low quality of life. HRQoL, anxiety and depression did not change substantially during the first year of treatment. Categories identified through content analysis of interview data concerning distress and quality of life were referred to physical, emotional or social dimensions. Identified strategies to "keep a good mood" were classified as Internal or External. Most categories of distress that were identified are covered by the EORTC QLQ-C30 and/or the HADS, but some additional emotional and social aspects of distress emerged from the interview data. Receiving good care was identified as a strategy to "keep a good mood". This result indicates a possible and potentially important relation between the quality of care and patient HRQoL.