L'objectif de cette thèse est d'identifier et caractériser les boucles anatomiques et fonctionnelles cortico-sous-corticales chez l'Homme, à partir de données d'imagerie par résonance magnétique fonctionnelle (IRMf) au repos et de diffusion. Une boucle est un ensemble de régions corticales, sous-corticales et cérébelleuses, qui interagissent afin d'effectuer ou de préparer une tâche.Le premier axe de ce travail vise à identifier les réseaux fonctionnels cortico-sous-corticaux en IRMf au repos. Nous proposons une méthode statistique robuste séparant l'analyse corticale de l'analyse sous-corticale. Une analyse en composantes indépendantes spatiales est d'abord réalisée individuellement sur les régions corticales, et suivie d'une classification hiérarchique. Les régions sous-corticales associées sont ensuite extraites par un modèle linéaire général dont les régresseurs comportent la dynamique des régions corticales, suivi d'une analyse de groupe à effets aléatoires. La méthode est validée sur deux jeux de données différents. Un atlas immunohistochimique des structures sous-corticales permet ensuite de déterminer la fonction sensorimotrice, associative ou limbique des réseaux obtenus. Nous montrons enfin que l'anatomie est un support pour la fonction chez des sujets sains.Le dernier axe étudie le syndrome de Gilles de la Tourette, qu'on pense être dû à un dysfonctionnement des boucles cortico-sous-corticales. Nous caractérisons d'abord les boucles cortico-sous-corticales fonctionnelles grâce à des métriques d'intégration et de théorie des graphes, et des différences en termes de connectivité sont mises en évidence entre patients adultes et volontaires sains. Nous montrons également que les boucles cortico-sous-corticales fonctionnelles chez les patients sont soutenues par l'anatomie sous-jacente. / The objective of this thesis is to identify and characterize human anatomical and functional cortico-subcortical loops, using data from resting-state functional magnetic resonance imaging (fMRI) and diffusion MRI. A loop is a set of cortical, subcortical and cerebellar regions that interact to perform or prepare for a task.We first aim to identify cortico-subcortical functional networks from resting-state fMRI data. We propose a robust statistical method that separates the analysis of cortical regions from that of subcortical structures. A spatial independent component analysis is first performed on individual cortical regions, followed by a hierarchical classification. The associated subcortical regions are then extracted by using a general linear model, the regressors of which contain the dynamics of the cortical regions, followed by a random-effect group analysis. The proposed approach is assessed on two different data sets. An immunohistochemical subcortical atlas is then used to determine the sensorimotor, associative or limbic function of the resulting networks. We finally demonstrate that anatomy is a support for function in healthy subjects.The last part is devoted to the study of the Gilles de la Tourette syndrome, thought to be due to adysfunction of cortico-subcortical loops. Firstly, cortico-subcortical functional loops are characterized using metrics such as integration and graph theory measures, showing differences in terms of connectivity between adult patients and healthy volunteers. Secondly, we show that the cortico-subcortical functional loops in patients are supported by the underlying anatomy.

Este trabalho estuda o modelo de análise em componentes independentes (ICA) para misturas instantâneas, aplicado na separação de sinais de áudio. Três algoritmos de separação de misturas instantâneas são avaliados: FastICA, PP (Projection Pursuit) e PearsonICA; possuindo dois princípios básicos em comum: as fontes devem ser independentes estatisticamente e não-Gaussianas. Para analisar a capacidade de separação dos algoritmos foram realizados dois grupos de experimentos. No primeiro grupo foram geradas misturas instantâneas, sinteticamente, a partir de sinais de áudio pré-definidos. Além disso, foram geradas misturas instantâneas a partir de sinais com características específicas, também geradas sinteticamente, para avaliar o comportamento dos algoritmos em situações específicas. Para o segundo grupo foram geradas misturas convolutivas no laboratório de acústica do LPS. Foi proposto o algoritmo PP, baseado no método de Busca de Projeções comumente usado em sistemas de exploração e classificação, para separação de múltiplas fontes como alternativa ao modelo ICA. Embora o método PP proposto possa ser utilizado para separação de fontes, ele não pode ser considerado um método ICA e não é garantida a extração das fontes. Finalmente, os experimentos validam os algoritmos estudados. / This work studies Independent Component Analysis (ICA) for instantaneous mixtures, applied to audio signal (source) separation. Three instantaneous mixture separation algorithms are considered: FastICA, PP (Projection Pursuit) and PearsonICA, presenting two common basic principles: sources must be statistically independent and non-Gaussian. In order to analyze each algorithm separation capability, two groups of experiments were carried out. In the first group, instantaneous mixtures were generated synthetically from predefined audio signals. Moreover, instantaneous mixtures were generated from specific signal generated with special features, synthetically, enabling the behavior analysis of the algorithms. In the second group, convolutive mixtures were probed in the acoustics laboratory of LPS at EPUSP. The PP algorithm is proposed, based on the Projection Pursuit technique usually applied in exploratory and clustering environments, for separation of multiple sources as an alternative to conventional ICA. Although the PP algorithm proposed could be applied to separate sources, it couldnt be considered an ICA method, and source extraction is not guaranteed. Finally, experiments validate the studied algorithms.

Um Sistema Elétrico de Potência (SEP) está susceptível à presença de diversas fontes de distúrbios que prejudicam a Qualidade da Energia Elétrica (QEE). Desta forma, as suas tensões e/ou correntes podem conter m´múltiplos distúrbios com ocorrência simultânea. Este trabalho apresenta uma metodologia para decomposição do sinal medido em componentes que estimem as formas de onda dos distúrbios individuais quando da ocorrência de m´múltiplos distúrbios, com o posterior reconhecimento de cada um deles. A Análise de Componentes Independentes (ICA) é utilizada como principal ferramenta na etapa de decomposição dos distúrbios. A ICA é originalmente uma t´técnica aplicada em análise multivariada de dados, o que significa que ela necessita de medições realizadas por múltiplos sensores dispostos em diferentes posições de um sistema. No entanto, este trabalho propõe a sua aplicação tendo disponível apenas um sinal medido. Para tanto, são propostos dois métodos para produzir a diversidade necessária para a t´técnica funcionar adequadamente. É demonstrado que ambos os métodos equivalem a um banco de filtros lineares adaptativos capaz de realizar a separação não-supervisionada de múltiplos distúrbios independentes e que sejam espectralmente disjuntos. Por fim, é proposto um sistema de classificação que utiliza Redes Neurais Artificiais (RNAs) para identificar os distúrbios decompostos pela etapa anterior. A metodologia completa é avaliada por meio de testes utilizando dados sintéticos e reais, alcançando resultados altamente satisfatórios para decomposição de sinais contendo múltiplos distúrbios e taxas de acerto globais dos classificadores superiores a 97% / The power system is susceptible to the presence of several sources of disturbances that harm the power quality. In this sense, its voltages and/or currents may contain multiple disturbances with simultaneous occurrence. This work presents a methodology that decomposes the measured signal in components which estimate the waveforms of the individual disturbances followed by their recognition when a multiple disturbance situation occurs. The Independent Component Analysis (ICA) is the main tool in the disturbance decomposition stage. The ICA is originally a technique applied in multivariate data analysis, which means that it requires measurements from multiple sensors allocated in different positions of the system. However, this work proposes its application for a single measured signal available. For this, two methods were developed in order to provide the required diversity to the ICA technique. It is demonstrated that both methods are equivalent to an adaptive linear filter bank capable to perform an unsupervised separation of multiple independent disturbances, if they are spectrally disjoint. A classification system based on artificial neural networks is proposed to identify the disturbances decomposed by the previous stage. The complete system is tested using synthetic and actual data, presenting highly satisfactory results for the decomposition of signals containing multiple disturbances, and precision for the classification task above 97%

CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior / Neste trabalho, à discutido o problema de reconhecimento de objetos utilizando imagens extraÃdas de um sensor industrial 3D. NÃs nos concentramos em 9 extratores de caracterÃsticas, dos quais 7 sÃo baseados nos momentos invariantes (Hu, Zernike, Legendre, Fourier-Mellin, Tchebichef, Bessel-Fourier e Gaussian-Hermite), um outro à baseado na Transformada de Hough e o Ãltimo na anÃlise de componentes independentes, e, 4 classificadores, Naive Bayes, k-Vizinhos mais PrÃximos, MÃquina de Vetor de Suporte e Rede Neural Artificial-Perceptron Multi-Camadas. Para a escolha do melhor extrator de caracterÃsticas, foram comparados os seus desempenhos de classificaÃÃo em termos de taxa de acerto e de tempo de extraÃÃo, atravÃs do classificador k-Vizinhos mais PrÃximos utilizando distÃncia euclidiana. O extrator de caracterÃsticas baseado nos momentos de Zernike obteve as melhores taxas de acerto, 98.00%, e tempo relativamente baixo de extraÃÃo de caracterÃsticas, 0.3910 segundos. Os dados gerados a partir deste, foram apresentados a diferentes heurÃsticas de classificaÃÃo. Dentre os classificadores testados, o classificador k-Vizinhos mais PrÃximos, obteve a melhor taxa mÃdia de acerto, 98.00% e, tempo mÃdio de classificaÃÃo relativamente baixo, 0.0040 segundos, tornando-se o classificador mais adequado para a aplicaÃÃo deste estudo. / In this work, the problem of recognition of objects using images extracted from a 3D industrial sensor is discussed. We focus in 9 feature extractors (where seven are based on invariant moments -Hu, Zernike, Legendre, Fourier-Mellin, Tchebichef, BesselâFourier and Gaussian-Hermite-, another is based on the Hough transform and the last one on independent component analysis), and 4 classifiers (Naive Bayes, k-Nearest Neighbor, Support Vector machines and Artificial Neural Network-Multi-Layer Perceptron). To choose the best feature extractor, their performance was compared in terms of classification accuracy rate and extraction time by the k-nearest neighbors classifier using euclidean distance. The feature extractor based on Zernike moments, got the best hit rates, 98.00 %, and relatively low time feature extraction, 0.3910 seconds. The data generated from this, were presented to different heuristic classification. Among the tested classifiers, the k-nearest neighbors classifier achieved the highest average hit rate, 98.00%, and average time of relatively low rank, 0.0040 seconds, thus making it the most suitable classifier for the implementation of this study.

Um Sistema Elétrico de Potência (SEP) está susceptível à presença de diversas fontes de distúrbios que prejudicam a Qualidade da Energia Elétrica (QEE). Desta forma, as suas tensões e/ou correntes podem conter m´múltiplos distúrbios com ocorrência simultânea. Este trabalho apresenta uma metodologia para decomposição do sinal medido em componentes que estimem as formas de onda dos distúrbios individuais quando da ocorrência de m´múltiplos distúrbios, com o posterior reconhecimento de cada um deles. A Análise de Componentes Independentes (ICA) é utilizada como principal ferramenta na etapa de decomposição dos distúrbios. A ICA é originalmente uma t´técnica aplicada em análise multivariada de dados, o que significa que ela necessita de medições realizadas por múltiplos sensores dispostos em diferentes posições de um sistema. No entanto, este trabalho propõe a sua aplicação tendo disponível apenas um sinal medido. Para tanto, são propostos dois métodos para produzir a diversidade necessária para a t´técnica funcionar adequadamente. É demonstrado que ambos os métodos equivalem a um banco de filtros lineares adaptativos capaz de realizar a separação não-supervisionada de múltiplos distúrbios independentes e que sejam espectralmente disjuntos. Por fim, é proposto um sistema de classificação que utiliza Redes Neurais Artificiais (RNAs) para identificar os distúrbios decompostos pela etapa anterior. A metodologia completa é avaliada por meio de testes utilizando dados sintéticos e reais, alcançando resultados altamente satisfatórios para decomposição de sinais contendo múltiplos distúrbios e taxas de acerto globais dos classificadores superiores a 97% / The power system is susceptible to the presence of several sources of disturbances that harm the power quality. In this sense, its voltages and/or currents may contain multiple disturbances with simultaneous occurrence. This work presents a methodology that decomposes the measured signal in components which estimate the waveforms of the individual disturbances followed by their recognition when a multiple disturbance situation occurs. The Independent Component Analysis (ICA) is the main tool in the disturbance decomposition stage. The ICA is originally a technique applied in multivariate data analysis, which means that it requires measurements from multiple sensors allocated in different positions of the system. However, this work proposes its application for a single measured signal available. For this, two methods were developed in order to provide the required diversity to the ICA technique. It is demonstrated that both methods are equivalent to an adaptive linear filter bank capable to perform an unsupervised separation of multiple independent disturbances, if they are spectrally disjoint. A classification system based on artificial neural networks is proposed to identify the disturbances decomposed by the previous stage. The complete system is tested using synthetic and actual data, presenting highly satisfactory results for the decomposition of signals containing multiple disturbances, and precision for the classification task above 97%

Submitted by Rosivalda Pereira (mrs.pereira@ufma.br) on 2017-08-14T18:15:08Z No. of bitstreams: 1 DanielCosta.pdf: 1087754 bytes, checksum: ada5f863f42efd8298fff788c37bded3 (MD5) / Made available in DSpace on 2017-08-14T18:15:08Z (GMT). No. of bitstreams: 1 DanielCosta.pdf: 1087754 bytes, checksum: ada5f863f42efd8298fff788c37bded3 (MD5) Previous issue date: 2008-02-25 / Female breast cancer is the major cause of death in western countries. Efforts in Computer Vision have been made in order to add improve the diagnostic accuracy by radiologists. In this work, we present a methodology that uses independent component analysis (ICA) along with support vector machine (SVM) and linear discriminant analysis (LDA) to distinguish between mass or non-mass and benign or malign tissues from mammograms. As a result, it was found that: LDA reaches 90,11% of accuracy to discriminante between mass or non-mass and 95,38% to discriminate between benign or malignant tissues in DDSM database and in mini-MIAS database we obtained 85% to discriminate between mass or non-mass and 92% of accuracy to discriminate between benign or malignant tissues; SVM reaches 99,55% of accuracy to discriminate between mass or non-mass and the same percentage to discriminate between benign or malignat tissues in DDSM database whereas, and in MIAS database it was obtained 98% to discriminate between mass or non-mass and 100% to discriminate between benign or malignant tissues. / Câncer de mama feminino é o câncer que mais causa morte nos países ocidentais. Esforços em processamento de imagens foram feitos para melhorar a precisão dos diagnósticos por radiologistas. Neste trabalho, nós apresentamos uma metodologia que usa análise de componentes independentes (ICA) junto com análise discriminante linear (LDA) e máquina de vetor de suporte (SVM) para distinguir as imagens entre nódulos ou não-nódulos e os tecidos em benignos ou malignos. Como resultado, obteve-se com LDA 90,11% de acurácia na discriminação entre nódulo ou não-nódulo e 95,38% na discriminação de tecidos benignos ou malignos na base de dados DDSM. Na base de dados mini- MIAS, obteve-se 85% e 92% na discriminação entre nódulos ou não-nódulos e tecidos benignos ou malignos respectivamente. Com SVM, alcançou-se uma taxa de até 99,55% na discriminação de nódulos ou não-nódulos e a mesma porcentagem na discriminação entre tecidos benignos ou malignos na base de dados DDSM enquanto que na base de dados mini-MIAS, obteve-se 98% e até 100% na discriminação de nódulos ou não-nódulos e tecidos benignos ou malignos, respectivamente.

Cette thèse développe des méthodes de diagonalisation conjointe de matrices et de tenseurs d’ordre trois, et son application à la séparation MIMO de sources de télécommunications numériques. Après un état, les motivations et objectifs de la thèse sont présentés. Les problèmes de la diagonalisation conjointe et de la séparation de sources sont définis et un lien entre ces deux domaines est établi. Par la suite, plusieurs algorithmes itératifs de type Jacobi reposant sur une paramétrisation LU sont développés. Pour chacun des algorithmes, on propose de déterminer les matrices permettant de diagonaliser l’ensemble considéré par l’optimisation d’un critère inverse. On envisage la minimisation du critère selon deux approches : la première, de manière directe, et la seconde, en supposant que les éléments de l’ensemble considéré sont quasiment diagonaux. En ce qui concerne l’estimation des différents paramètres du problème, deux stratégies sont mises en œuvre : l’une consistant à estimer tous les paramètres indépendamment et l’autre reposant sur l’estimation indépendante de couples de paramètres spécifiquement choisis. Ainsi, nous proposons trois algorithmes pour la diagonalisation conjointe de matrices complexes symétriques ou hermitiennes et deux algorithmes pour la diagonalisation conjointe d’ensembles de tenseurs symétriques ou non-symétriques ou admettant une décomposition INDSCAL. Nous montrons aussi le lien existant entre la diagonalisation conjointe de tenseurs d’ordre trois et la décomposition canonique polyadique d’un tenseur d’ordre quatre, puis nous comparons les algorithmes développés à différentes méthodes de la littérature. Le bon comportement des algorithmes proposés est illustré au moyen de simulations numériques. Puis, ils sont validés dans le cadre de la séparation de sources de télécommunications numériques. / This thesis develops joint diagonalization of matrices and third-order tensors methods for MIMO source separation in the field of digital telecommunications. After a state of the art, the motivations and the objectives are presented. Then the joint diagonalisation and the blind source separation issues are defined and a link between both fields is established. Thereafter, five Jacobi-like iterative algorithms based on an LU parameterization are developed. For each of them, we propose to derive the diagonalization matrix by optimizing an inverse criterion. Two ways are investigated : minimizing the criterion in a direct way or assuming that the elements from the considered set are almost diagonal. Regarding the parameters derivation, two strategies are implemented : one consists in estimating each parameter independently, the other consists in the independent derivation of couple of well-chosen parameters. Hence, we propose three algorithms for the joint diagonalization of symmetric complex matrices or hermitian ones. The first one relies on searching for the roots of the criterion derivative, the second one relies on a minor eigenvector research and the last one relies on a gradient descent method enhanced by computation of the optimal adaptation step. In the framework of joint diagonalization of symmetric, INDSCAL or non symmetric third-order tensors, we have developed two algorithms. For each of them, the parameters derivation is done by computing the roots of the considered criterion derivative. We also show the link between the joint diagonalization of a third-order tensor set and the canonical polyadic decomposition of a fourth-order tensor. We confront both methods through numerical simulations. The good behavior of the proposed algorithms is illustrated by means of computing simulations. Finally, they are applied to the source separation of digital telecommunication signals.

In this thesis, improving the performance of the automatic recognition of the Doppler radar targets is studied. The radar used in this study is a ground-surveillance doppler radar. Target types are car, truck, bus, tank, helicopter, moving man and running man. The input of this thesis is the output of the real doppler radar signals which are normalized and preprocessed (TRP vectors: Target Recognition Pattern vectors) in the doctorate thesis by Erdogan (2002). TRP vectors are normalized and homogenized doppler radar target signals with respect to target speed, target aspect angle and target range. Some target classes have repetitions in time in their TRPs. By the use of these repetitions, improvement of the target type classification performance is studied. K-Nearest Neighbor (KNN) and Support Vector Machine (SVM) algorithms are used for doppler radar target classification and the results are evaluated. Before classification PCA (Principal Component Analysis), LDA (Linear Discriminant Analysis), NMF (Nonnegative Matrix Factorization) and ICA (Independent Component Analysis) are implemented and applied to normalized doppler radar signals for feature extraction and dimension reduction in an efficient way. These techniques transform the input vectors, which are the normalized doppler radar signals, to another space. The effects of the implementation of these feature extraction algoritms and the use of the repetitions in doppler radar target signals on the doppler radar target classification performance are studied.

<p>This thesis is concerned with the solution of the blind source separation problem (BSS). The BSS problem occurs frequently in various scientific and technical applications. In essence, it consists in separating meaningful underlying components out of a mixture of a multitude of superimposed signals.</p> <P> In the recent research literature there are two related approaches to the BSS problem: The first is known as Independent Component Analysis (ICA), where the goal is to transform the data such that the components become as independent as possible. The second is based on the notion of diagonality of certain characteristic matrices derived from the data. Here the goal is to transform the matrices such that they become as diagonal as possible. In this thesis we study the latter method of approximate joint diagonalization (AJD) to achieve a solution of the BSS problem. After an introduction to the general setting, the thesis provides an overview on particular choices for the set of target matrices that can be used for BSS by joint diagonalization.</p> <P> As the main contribution of the thesis, new algorithms for approximate joint diagonalization of several matrices with non-orthogonal transformations are developed.</p> <P> These newly developed algorithms will be tested on synthetic benchmark datasets and compared to other previous diagonalization algorithms.</p> <P> Applications of the BSS methods to biomedical signal processing are discussed and exemplified with real-life data sets of multi-channel biomagnetic recordings.</p> / <p>Diese Arbeit befasst sich mit der Lösung des Problems der blinden Signalquellentrennung (BSS). Das BSS Problem tritt häufig in vielen wissenschaftlichen und technischen Anwendungen auf. Im Kern besteht das Problem darin, aus einem Gemisch von überlagerten Signalen die zugrundeliegenden Quellsignale zu extrahieren.</p> <P> In wissenschaftlichen Publikationen zu diesem Thema werden hauptsächlich zwei Lösungsansätze verfolgt:</p> <P> Ein Ansatz ist die sogenannte "Analyse der unabhängigen Komponenten", die zum Ziel hat, eine lineare Transformation <B>V</B> der Daten <B>X</B> zu finden, sodass die Komponenten U_n der transformierten Daten <B>U</B> = <B> V X</B> (die sogenannten "independent components") so unabhängig wie möglich sind. Ein anderer Ansatz beruht auf einer simultanen Diagonalisierung mehrerer spezieller Matrizen, die aus den Daten gebildet werden. Diese Möglichkeit der Lösung des Problems der blinden Signalquellentrennung bildet den Schwerpunkt dieser Arbeit.</p> <P> Als Hauptbeitrag der vorliegenden Arbeit präsentieren wir neue Algorithmen zur simultanen Diagonalisierung mehrerer Matrizen mit Hilfe einer nicht-orthogonalen Transformation.</p> <P> Die neu entwickelten Algorithmen werden anhand von numerischen Simulationen getestet und mit bereits bestehenden Diagonalisierungsalgorithmen verglichen. Es zeigt sich, dass unser neues Verfahren sehr effizient und leistungsfähig ist. Schließlich werden Anwendungen der BSS Methoden auf Probleme der biomedizinischen Signalverarbeitung erläutert und anhand von realistischen biomagnetischen Messdaten wird die Nützlichkeit in der explorativen Datenanalyse unter Beweis gestellt.</p>

The last twenty years presented increased interest for the study of cerebral processes caused by external events (stimuli). One of the most significant endogenous components of Evoked Potentials is the P600 component. The P600 component may be defined as the most positive peak in the time window between 500 and 800 msec after an eliciting stimulus. This component is thought to reflect the response selection stage of information processing. P600 component is usually less pronounced compared to other components, such as the N100 or the P300. Frequently the P600 component appears as a not-easily discernible secondary peak overlying the ascending negative-going slope of the P300 waveform. In our study we used ERP data from various groups of patients and healthy controls. Patients were recruited from the outpatient university clinic of Eginition Hospital of the University of Athens. The controls were recruited from hospital staff and local volunteer groups. The aim of the study is the implementation of classification systems for these groups, using P600 features. This is usually not achieved well using as features the ERPs amplitude and latency. So for that reason, in our study, we want to extract new features using advanced techniques for processing the original ERPs, such as the Independent Component Analysis (ICA) method. However as a precursor of ICA, is considered the Principal Component Analysis (PCA) method, which we used for comparison reasons to ICA. In the application of ICA we achieve the decomposition of the recorded signals in ICs, supposing temporally independent components and propose ICs selection techniques in order to recompose the P600 component. The next stage was the use of a classification method based on the features extracted using the original data, data extracted through PCA processing and ICA-processed data. First we applied Kolmogorov-Smirnov test to check the normality of the distribution of the features, then we used the Logistic Regression method for classification and finally we have done two implementations of classification using Probabilistic Neural Networks. The first implementation was done with the creation of 15 features from the P600 peak amplitudes from the subjects’ data and the second implementation was done with the creation of four meta-features from the subjects’ P600 amplitude data. The results show that the application of ICA, combined with the logistic regression classification technique, provides notable improvement, compared to the classification performance based on the original ERPs. The main merit of the application is that classification is based on single parameters, i.e. amplitude of the P600 component, or its latency or its termination latency, which are directly related to the brain mechanisms related to ERP generation and pathological processes. / Τα τελευταία 20 χρόνια παρουσιάζεται αυξημένο ενδιαφέρον για την μελέτη εγκεφαλικών επεξεργασιών που προκλήθηκαν από εξωτερικά γεγονότα (ερέθισμα). Ένα από τα πιο σημαντικά ενδογενή συστατικά των Προκλητών Δυναμικών είναι το συστατικό P600. Το συστατικό P600 μπορεί να οριστεί σαν η πιο θετική αιχμή στο χρονικό διάστημα μεταξύ 500 και 800 msec μετά από ένα εκλυτικό ερέθισμα. Το συστατικό αυτό θεωρείται ότι απεικονίζει το στάδιο επιλογής απόκρισης της επεξεργασίας πληροφορίας. Το συστατικό P600 είναι συνήθως λιγότερο έντονο συγκρίνοντας το με άλλα συστατικά, όπως το N100 ή το P300. Συχνά το συστατικό P600 εμφανίζεται ως μια δυσδιάκριτη δεύτερη αιχμή, επικαλύπτοντας την ανοδική αρνητική κλίση της κυματομορφής του P300. Στη μελέτη μας χρησιμοποιήσαμε δεδομένα ΠΔ από ποικίλες ομάδες ασθενών και υγιών μαρτύρων. Οι ασθενείς συλλέχθησαν από τη πανεπιστημιακή κλινική του Αιγηνήτειου Νοσοκομείου του Πανεπιστημίου Αθηνών. Οι υγιείς συλλέχθησαν από το προσωπικό του νοσοκομείου και ομάδες εθελοντών. Ο σκοπός της μελέτης είναι η εφαρμογή συστημάτων ταξινόμησης για αυτές τις ομάδες, χρησιμοποιώντας χαρακτηριστικά του P600. Αυτό συνήθως δεν επιτυγχάνεται καλά χρησιμοποιώντας σαν χαρακτηριστικά το πλάτος και τον λανθάνοντα χρόνο των ΠΔ. Για αυτό το λόγο, στην μελέτη μας, θέλουμε να εξάγουμε νέα χαρακτηριστικά χρησιμοποιώντας προηγμένες τεχνικές για επεξεργασία των αρχικών ΠΔ, όπως τη μέθοδο Ανάλυσης Ανεξαρτήτων Συνιστωσών (ICA). Εντούτοις ως πρόδρομο της ICA, θεωρείται η μέθοδος Ανάλυσης Κύριων Συνιστωσών (PCA), την οποία χρησιμοποιήσαμε για συγκριτικούς λόγους με την ICA. Στην εφαρμογή της ICA προχωρήσαμε στην αποσύνθεση των καταγραφόμενων σημάτων σε Ανεξάρτητες Συνιστώσες και διερευνήσαμε τρεις τεχνικές επιλογής ανεξαρτήτων συνιστωσών μέσω των οποίων επανασυνθέσαμε το συστατικό P600. Το επόμενο βήμα ήταν η χρήση μεθόδου ταξινόμησης βασισμένης στα χαρακτηριστικά που εξάχθηκαν χρησιμοποιώντας τα αρχικά δεδομένα, τα δεδομένα με επεξεργασία PCA και τα δεδομένα με επεξεργασία ICA. Πρώτα εφαρμόσαμε το τεστ Kolmogorov-Smirnov για τον έλεγχο της κανονικότητας της κατανομής των χαρακτηριστικών, μετά χρησιμοποιήσαμε τη μέθοδο Λογαριθμικής Παλινδρόμησης (Logistic Regression) για ταξινόμηση και τελικά πραγματοποιήσαμε δύο εφαρμογές ταξινόμησης χρησιμοποιώντας Πιθανοκρατικά Νευρωνικά Δίκτυα (Probabilistic Neural Networks). Η πρώτη εφαρμογή έγινε με την δημιουργία 15 χαρακτηριστικών από τα πλάτη των αιχμών του P600 από τα δεδομένα των ομάδων και η δεύτερη εφαρμογή έγινε με την δημιουργία τεσσάρων μετά-χαρακτηριστικών από τα δεδομένα των πλατών των ομάδων. Τα αποτελέσματα δείχνουν ότι η εφαρμογή της ICA, συνδυασμένη με την τεχνική ταξινόμησης λογαριθμικής παλινδρόμησης, παρέχει αξιοσημείωτη βελτίωση, συγκριτικά με την απόδοση ταξινόμησης βάση των αρχικών ΠΔ. Η κύρια αξία της εφαρμογής είναι ότι η ταξινόμηση πετυχαίνει ποσοστά μεγαλύτερα του 80% βασιζόμενη σε μία μόνο κάθε φορά παράμετρο, π.χ. το πλάτος του συστατικού P600, ή τον λανθάνοντα χρόνο του ή τον λανθάνοντα χρόνο τερματισμού του, οι οποίες σχετίζονται άμεσα με τους μηχανισμούς του εγκεφάλου σχετικούς με την παραγωγή ΠΔ και τις παθολογικές διαδικασίες.