Thesis (Ph.D.)--McMaster University (Canada), 1996. / Source: Dissertation Abstracts International, Volume: 57-10, Section: B, page: 6325. Adviser: D. A. Thompson.

Thesis (Ph.D.)--McMaster University (Canada), 1996. / Source: Dissertation Abstracts International, Volume: 58-06, Section: B, page: 3263. Adviser: G. C. Weatherly.

Thesis (M.S.)--Oregon State University, 2009. / Printout. Includes bibliographical references (leaves 145-153). Also available on the World Wide Web.

Thesis (M.Mat.S.E.)--University of Delaware, 2007. / Principal faculty advisor: Robert L. Opila, Dept. of Materials Science & Engineering. Includes bibliographical references.

Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (p. 69-75).

Dissertation (Ph.D.)--University of Toledo, 2009. / Typescript. "Submitted as partial fulfillment of the requirements for the Doctor of Philosophy in Physics." Bibliography: leaves 132-148.

Thesis (M.S. in Physics)--Naval Postgraduate School, January 1964. / Thesis Advisor(s): Hawns, William W. "January 1964." Description based on title screen as viewed on June 2, 2010 DTIC Descriptor(s): (Neutron Flux), (Research Reactors, Measurement, Neutron Activation, Reactor Lattice Parameters, Reactor Control, Power, Reactor Operation, Reactor Power Density, Scintillation Counters, Foils (Materials), Gold, Gamma Rays, Nuclear Radiation Spectrometers, Indium, Monitors, Errors, Probability, Statistical Analysis. DTIC Identifier(s): AGN-201 Reactors. Includes bibliographical references (p. 20). Also available in print.

Thesis (M.S.)--Florida State University, 2006. / Advisor: Peter Kalu, Florida State University, College of Engineering, Dept. of Mechanical Engineering. Title and description from dissertation home page (viewed Sept. 22, 2006). Document formatted into pages; contains x, 77 pages. Includes bibliographical references.

Receptores para o peptídeo liberador de gastrina (GRPr) são super expressos em vários tipos de células cancerígenas, incluindo câncer de mama e próstata. A Bombesina é um análogo do peptídeo GRP de mamíferos que se liga com alta especificidade e afinidade aos receptores do peptídeo liberador de gastrina (GRPr). Significantes pesquisas têm sido realizadas para desenvolver e radiomarcar um análogo da bombesina para diagnóstico de tumores de próstata e mama, utilizando-se técnicas de SPECT e PET, com radionuclídeos como 111In e 68Ga. O objetivo deste trabalho foi estudar a marcação com 111In de uma série inédita de peptídeos derivados de bombesina e determinar o potencial de aplicação no diagnóstico de tumores de próstata em modelos animais. Vários estudos foram realizados para padronizar o procedimento de marcação, variando-se temperatura, tempo de marcação, massa do peptídeo e atividade do radionuclídeo. Os resultados demonstraram que os análogos da bombesina estudados podem ser marcados com índio-111 com alto rendimento de marcação e alta atividade específica. Os estudos de biodistribuição em animais normais demonstraram que o derivado de BBN com espaçador aminoacídico Gly5 apresentou captação pancreática e intestinal expressiva, sugerindo ser o melhor derivado. Dois derivados DOTA- conjugados, com espaçador Gly5 foram radiomarcados com gálio-68 e investigados em modelo animal com tumor de próstata humano, indicando o potencial para aplicação do peptídeo radiomarcado no diagnóstico por PET. / Gastrin releasing peptide receptors (GRPRs) are over expressed in various types of cancer cells including prostate and breast cancer. Bombesin is an analogue of the mammalian GRP that binds with high specificity and affinity to GRPRs. Significant research efforts have been devoted to the design and radiolabel bombesin peptides for the diagnostic of prostatic and breast cancer using SPECT e PET, with radionuclides like 111In e 68Ga. The objective of this work was to study the labeling with 111In of a new bombesin series and evaluate the potential for diagnostic application using animal model. Several studies were evaluated to optimize the labelling conditions of BBN derivatives with 111In using different temperature, time, mass of peptide and radionuclide activity. High radiochemical purity and high specific activity were obtained for all the peptides labeled with 111-indium. Biodistribution studies in normal mices showed that the BBN derivative with Gly5 as aminoacidic spacer presented high uptake on pancreas and intestines that suggests that is the best peptide. Two DOTA-derivatives with Gly5 as spacer were radiolabelled with 68-gallium and evaluated in tumor model animals of human prostatic cancer and showed high potential for clinical application in diagnostic procedures with PET.

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