Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-01-27T14:20:58Z No. of bitstreams: 1 FabienneLouiseJuvencioPaesDeAndrade_TESE.pdf: 1561318 bytes, checksum: 80c7dc22ce094332bc25950a71f37f1f (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-01-31T15:53:29Z (GMT) No. of bitstreams: 1 FabienneLouiseJuvencioPaesDeAndrade_TESE.pdf: 1561318 bytes, checksum: 80c7dc22ce094332bc25950a71f37f1f (MD5) / Made available in DSpace on 2017-01-31T15:53:29Z (GMT). No. of bitstreams: 1 FabienneLouiseJuvencioPaesDeAndrade_TESE.pdf: 1561318 bytes, checksum: 80c7dc22ce094332bc25950a71f37f1f (MD5) Previous issue date: 2016-07-01 / O acelerado processo de envelhecimento da popula??o brasileira est? associado ao incremento das doen?as cr?nicas n?o transmiss?veis, tornando cada vez maior a demanda por servi?os de sa?de. As taxas de interna??o hospitalar de idosos s?o mais elevadas do que as observadas em outros grupos et?rios, principalmente entre aqueles que residem em Institui??es de Longa Perman?ncia para Idosos (ILPI), devido ? maior vulnerabilidade e fragilidade destes. Nesse sentido, o objetivo do presente estudo foi verificar a incid?ncia e fatores de risco para hospitaliza??o em idosos institucionalizados da cidade do Natal/RN. Trata-se de estudo de coorte prospectivo, realizado entre outubro de 2013 a janeiro de 2015, com dura??o de 12 meses de acompanhamento, composto por idosos com 60 anos e que residiam nas 10 ILPI participantes do estudo. Na coleta dos dados inicial, foram obtidas informa??es sociodemogr?ficas, relacionadas ? institui??o e condi??es de sa?de. No per?odo do seguimento, foi observada a ocorr?ncia de hospitaliza??o, bem como a incid?ncia de quedas e fraturas, decl?nio da capacidade cognitiva, mobilidade, contin?ncia (urin?ria e/ou fecal) e informa??es referentes ? medica??o. Os dados foram coletados dos prontu?rios e diretamente com o idoso ou profissionais da sa?de. Foi realizada an?lise m?ltipla de regress?o log?stica, utilizando-se o m?todo Stepwise Forward, considerando o n?vel de signific?ncia de 5% e intervalo de confian?a (IC) de 95%. Dos 320 idosos participantes, houve predom?nio de idosos do sexo feminino (75,3%), com idade m?dia de 81,4 anos (DP: 9,0). Destes, 20,6% (IC 95%: 16,5-25,4) foram hospitalizados, com a perman?ncia m?dia de 16,1 dias (DP: 17,1). A principal causa da hospitaliza??o foram as doen?as pulmonares (30,3%). O modelo final mostrou que a presen?a de desnutri??o ou risco de desnutri??o (p=0,016) e fazer uso de medicamentos para o sistema cardiovascular (p=0,003) foram fatores de risco para a hospitaliza??o, ajustados pela idade, sexo e tipo de institui??o. Estes achados apontam uma alta incid?ncia de hospitaliza??o entre os idosos institucionalizados. Al?m disto, a desnutri??o ou risco de desnutri??o e o uso de medicamentos cardiovasculares foram considerados fatores de risco para a hospitaliza??o. Assim, h? a necessidade de maior aten??o na avalia??o multiprofissional, bem como nas interven??es e servi?os prestados aos idosos institucionalizados. / The accelerated aging process of the Brazilian population is associated with an increase in non-transmissible chronic diseases, which in turn increases the demands for health services. The hospitalization rates of older adults are higher than what is observed in other age groups, especially in those that reside in Long Term Institutions for the Elderly (LTIE), due to inherent vulnerability and frailty of these individuals. The objective of the work presented herein was to verify the incidence and risk factors associated with the hospitalization of institutionalized older adults in the city of Natal/RN, Brazil. A prospective cohort study, conducted from october 2013 to january 2015, was carried out throughout a monitoring period of 12 months, with older adults over the age of 60, who resided in the 10 LTIE that accepted to participate in the study. Initial data collection included sociodemographic information related to the institution and health conditions. In the period of follow-up, was observed the incidence of hospitalization, and the incidence of falls and fractures, decline in cognitive ability, mobility, continence (urinary and / or fecal) and information relating to the medication. Data were collected from medical records and directly with the elderly or health professionals. The Stepwise Forward method was utilized for Multiple Logistic Regression Analysis, with a 5% significance level and confidence interval (CI) 95%. Of the participating 320 elderly, there was a predominance of females (75.3%), average age 81.4 years (Standard Deviation, SD: 9.0). Of these, 20.6% (CI 95%: 16,5-25,4) were hospitalized, with an average permanence time of 16,1 days (SD: 17.1). The main hospitalization cause was pulmonary disease (30.3%). The final model showed that malnutrition or risk of malnutrition (p=0.016) and the use of medication for the cardiovascular system (p=0.003) were risk factors for hospitalization, adjusted by age, sex and type of institution. These findings indicate a high incidence of hospitalization in institutionalized elderly. Malnutrition or risk of malnutrition and the use of cardiovascular medication were considered to be risk factors for hospitalization. There is a clear need for increased attention in multiprofessional evaluation, as well in interventions and services rendered to institutionalized elderly.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-02-10T16:52:35Z No. of bitstreams: 1 JavierJerezRoig_TESE.pdf: 3511641 bytes, checksum: 4ae07f46d035d68bf8ef148cfa29afe2 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-02-10T22:20:22Z (GMT) No. of bitstreams: 1 JavierJerezRoig_TESE.pdf: 3511641 bytes, checksum: 4ae07f46d035d68bf8ef148cfa29afe2 (MD5) / Made available in DSpace on 2017-02-10T22:20:22Z (GMT). No. of bitstreams: 1 JavierJerezRoig_TESE.pdf: 3511641 bytes, checksum: 4ae07f46d035d68bf8ef148cfa29afe2 (MD5) Previous issue date: 2016-08-23 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / O presente trabalho teve como objetivos principais: verificar a preval?ncia de incapacidade funcional (IF) para as atividades b?sicas da vida di?ria (ABVD) e os fatores associados (Estudo 1), assim como verificar a incid?ncia de decl?nio funcional e os fatores progn?sticos de decl?nio funcional (Estudo 2) em idosos institucionalizados. A amostra do trabalho foi formada por indiv?duos de 60 anos ou mais pertencentes a 10 institui??es de longa perman?ncia para idosos (ILPI) da cidade do Natal/RN, sendo exclu?dos os hospitalizados ou em processo de cuidados paliativos. O Estudo 1 ? de tipo transversal (Outubro e Dezembro de 2013) e foi avaliada a IF mediante a escala de Katz e caracterizada quando houve limita??o em uma ou mais ABVD (alimenta??o, controle de esf?ncteres, transfer?ncias posturais, higiene pessoal, capacidade para se vestir e tomar banho). Como vari?veis independentes foram consideradas as sociodemogr?ficas, as relacionadas ? institui??o e ?s condi??es de sa?de. Usaram-se o teste qui-quadrado, teste de Fisher ou teste qui-quadrado de tend?ncia linear para a an?lise bivariada, assim como a regress?o log?stica para a multivariada. A amostra foi de 321 idosos e a preval?ncia de IF de 72,9% (IC 95%: 67,8-77,5%). A tarefa mais afetada foi o ?banho?, seguido por ?vestir-se? e ?ir ao banheiro?. O modelo final constatou associa??o com a institui??o de tipo privado (RP=1,33, p<0,001), idade igual ou superior a 83 anos (RP=1,26, p=0,003), ser institucionalizado por n?o ter cuidador (RP=1,17, p=0,033) e osteoporose (OR=1,23, p=0,045), ajustado por sexo. O Estudo 2 ? longitudinal de 24 meses de acompanhamento com intervalos de follow-up de 6 meses (5 ondas). Al?m dos crit?rios aplicados no Estudo 1, foram exclu?dos aqueles que apresentavam IF para todas as ABVD (banho, higiene pessoal, vestir-se, ir ao banheiro, caminhar, transfer?ncias posturais e comer) no in?cio do estudo. Foi considerada a presen?a de decl?nio funcional quando houve redu??o na pontua??o total das ABVD, as quais foram avaliadas mediante uma escala tipo Likert de 5 pontos. Foram analisadas todas as vari?veis independentes do Estudo 1, mais o estado de mobilidade, cognitivo (teste de Pfeiffer), h?bitos t?xicos e atividade f?sica, al?m de vari?veis dependentes do tempo. Para a an?lise estat?stica, foi utilizado o m?todo atuarial, o teste log-rank, a an?lise univariada de Cox e a regress?o de Cox. A coorte esteve composta por 280 idosos: 140, 50,0% (IC 95%: 44,2-55,8%), sofreram decl?nio funcional, 94, 33,6% (IC 95%: 28,3-39,3%) mantiveram a capacidade funcional, e 40, 14,3% (IC 95%: 10,7-18,9%), apresentaram melhora funcional em uma ou mais avalia??es. A probabilidade acumulada de manuten??o funcional foi de 44,0% (IC 95%: 37,7-50,2%) aos 24 meses. A capacidade de se alimentar foi a que apresentou maior decl?nio durante o per?odo (-0,54 pontos), seguido por deambula??o (-0,43), vestir-se (-0,35), transfer?ncias posturais (-0,31), banho (-0,29), higiene pessoal (-0,24) e ir ao banheiro (-0,22). O modelo multivariado mostrou que os fatores predictores de decl?nio funcional foram a incapacidade cognitiva grave (HR=1,98; p=0,003), decl?nio da contin?ncia (HR=1,70; p=0,013) e incid?ncia de hospitaliza??es (HR=1,65; p=0,023). / The main objectives of this work were: to verify the prevalence of functionaldisability (FD) inthe basic activities of daily living (BADL) and its associated factors (Study 1) and verify the incidence of functional decline and predictor factors of functional decline (Study 2) in institutionalized older people. The sample of the study was formed by individuals aged 60 years and over belonging to 10 nursing homes (NH) in Natal/RN, being excluded hospitalized or palliative care residents. The Study 1 is a cross-sectional study (October-December 2013) and FD was evaluated by Katz scale and characterized when there was limitation in one or more BADL (eating, sphincter control, transferring, personal hygiene, dressing and bathing). As independent variables sociodemographic, instituition-related health-related variables were considered. The Chi-square test, Fisher's exact test or the linear Chi-square test for the bivariate analysis and logistic regression for multivariate analysis were applied. The sample consisted of 321 individuals and the prevalence of FD was 72.9% (95% CI: 67.8-77.5%). The most affected task was 'bathing', followed by 'dressing' and 'toileting.' The final model found association with private NH (PR=1.33, p<0.001), age 83 and over (RP=1.26, p=0.003), reason for institutionalization ?lack of caregiver? (RP=1.17, p=0.033) and osteoporosis (RP=1.23, p=0.045), adjusted by sex. The Study 2 is a 24-months longitudinal study with follow-up every 6 months (5 waves). Apart from the criteria considered in the Study 1, residents with FD for all BADL (bathing, personal hygiene, dressing, toileting, walking, transferring and eating) at baseline were excluded. The presence of functional decline was defined when there was a reduction the total score of BADL, which were assessed by a 5-point Likert scale. All independent variables of the Study 1 were considered, as well asthe mobility status, cognitive status (Pfeiffer test), toxic habits, physical activity and time-dependent variables. Statistical analysis was performed using the actuarial method, log-rank test, Cox univariate analysis and Cox regression. The cohort was composed of 280 individuals: 140, 50.0% (95% CI: 44.2-55.8%) experienced functional decline; 94, 33.6% (95% CI: 28.3-39.3%), maintained their functional capacity, and; 40, 14.3% (95% CI: 10.7-18.9%), showed functional improvement at one or more waves. The cumulative probability of functional maintenance was 44.0% (95% CI: 37.7-50.2%) at 24 months. The ability to eat showed the largest decline during the period (-0.54 points), followed by walking (-0.43), dressing (-0.35), transferring (-0.31), bathing (-0.29), personal hygiene (-0.24) and toileting (-0.22). The final model showed that the predictors factors of functional decline were severe cognitive impairment (HR=1.96, p=0.001), continence decline (HR=1.85, p=0.002) and incidence of hospitalizations (HR=1.62, p=0.020).

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-08-10T11:59:48Z No. of bitstreams: 1 LeonidasDeOliveiraNeto_TESE.pdf: 1668906 bytes, checksum: 3fa7c80c1f7980340ddded1cd5fc5726 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-08-11T15:48:54Z (GMT) No. of bitstreams: 1 LeonidasDeOliveiraNeto_TESE.pdf: 1668906 bytes, checksum: 3fa7c80c1f7980340ddded1cd5fc5726 (MD5) / Made available in DSpace on 2017-08-11T15:48:54Z (GMT). No. of bitstreams: 1 LeonidasDeOliveiraNeto_TESE.pdf: 1668906 bytes, checksum: 3fa7c80c1f7980340ddded1cd5fc5726 (MD5) Previous issue date: 2017-06-05 / Introdu??o: O diagn?stico da sarcopenia ? restrito aqueles com boa capacidade f?sica e cognitiva, n?o sendo adaptado ?s condi??es dos idosos institucionalizados. Al?m disso, apesar da perda de massa muscular ser determinante para seu diagn?stico, redu??o associada de massa gorda tem sido observada na sarcopenia. Ademais, embora o estado inflamat?rio seja considerado um gatilho da perda de massa muscular, a redu??o no tecido adiposo tem sido associado ? redu??o do estado inflamat?rio, concorrendo no constructo te?rico da associa??o entre inflamm-aging e sarcopenia. Objetivo: Discutir o diagn?stico para sarcopenia em idosos institucionalizados e verificar a associa??o entre inflamm-aging e sarcopenia, assim como analisar seus fatores associados. Metodologia: Tr?s estudos foram conduzidos em idosos de ambos os sexos, residentes em institui??es de longa perman?ncia na cidade do Natal/RN. No estudo 1 (n=219) foi realizado uma adapta??o do Consenso Europeu para Diagn?stico da Sarcopenia (2010) agregando idosos com baixa capacidade f?sica e cognitiva. No estudo 2 (n=219) foi verificado quais os fatores est?o associados ? sarcopenia. No estudo 3 (n=187) foi realizado an?lise de conglomerados de idosos segundo seu estado inflamat?rio e verificado os fatores associados ? esta condi??o. Resultados: Inclus?o de idosos com baixa condi??o f?sica e cognitiva (estudo 1) acresceu em 32,2% a preval?ncia de sarcopenia. No estudo 2, os fatores associados ? sarcopenia foram altura do joelho, eutrofia e excesso de peso (segundo IMC) e capacidade de deambular. No estudo 3 foi poss?vel verificar que aumento de 1 unidade ?g/dL no LDL, HDL e triglicer?deos apresentaram aumento de 1,5%, 4,1% e 0,9% a chance de inflamm-aging e idosos longevos (?80 anos) possu?ram 84,9% mais de chance de inflamm-aging. Conclus?o: Inclus?o de idosos com baixa capacidade f?sica e cognitiva para c?lculo de sarcopenia ? valida e representa de modo mais adequado os idosos institucionalizados, apresentando o aspectos antropom?tricos e f?sicos como seus principais fatores associados. Ademais, os indicadores bioqu?micos e antropom?tricos demonstraram rela??o da sarcopenia com desnutri??o. Al?m disso, n?o foi observado associa??o do inflamm-aging com sarcopenia, corroborando o constructo de que na sarcopenia n?o ocorre perda seletiva da massa muscular. / Introduction: The diagnosis of sarcopenia is restricted to those with good physical and cognitive capacity, not being adapted to the conditions of the institutionalized elderly. In addition, dispite the loss of muscle mass is determinant for its diagnosis, associated reduction of fat mass has been observed in sarcopenia. Although the inflammatory state is considered a trigger to loss of muscle mass, reduction in adipose tissue has been associated with the reduction of the inflammatory state, competing in the theoretical construct of the association between inflammation and sarcopenia. Objective: To discuss the diagnosis of sarcopenia in institutionalized elderly patients and to verify the association between inflammation and sarcopenia, as well as to analyze their associated factors. Methodology: Three studies were conducted in elderly people of both sexes, living in nursing homes in the city of Natal / RN. In study 1 (n = 219) an adaptation of the European Consensus for Diagnosis of Sarcopenia (2010) was carried out, adding elderly people with low physical and cognitive capacity. In study 2 (n = 219) it was verified which factors are associated with sarcopenia. In study 3 (n = 187), the analysis of elderly conglomerates according to their inflammatory state was performed and the factors associated with this condition were verified. Results: Inclusion of elderly people with low physical and cognitive status (study 1) increased the prevalence of sarcopenia by 32.2%. In study 2, the factors associated with sarcopenia were knee height, eutrophy and excess weight (according to BMI) and the ability to ambulate. In study 3 it was possible to verify that increase of 1 unit ?g / dL in LDL, HDL and triglycerides presented a 1.5%, 4.1% and 0.9% increase in the chance of inflamm-aging and elderly individuals (?80 years ) had an 84.9% greater chance of inflammation. Conclusion: Inclusion of elderly with low physical and cognitive capacity to calculate sarcopenia is valid and represents more appropriately the institutionalized elderly, presenting the anthropometric and physical aspects as their main associated factors. In addition, the biochemical and anthropometric indicators demonstrated a relationship of sarcopenia with malnutrition. In addition, no association of inflammation with sarcopenia was observed, corroborating the construct that in sarcopenia there is no selective muscle mass loss.