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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 11 to 16 of 16 (0.038 seconds)Spelling suggestions: "subject:"keimzellen"" "subject:"keimzelle""
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SCF-mediated degradation of the two translational regulators, CPB-3 and GLD-1, during oogenesis in C. elegansKisielnicka, Edyta 05 August 2017 (has links)
The development of an organism and its adult homeostasis rely on regulatory mechanisms that control the underlying gene expression programs. In certain biological contexts, such as germ cell development, gene expression regulation is largely executed at the post-‐transcriptional level. This relies on RNA-‐binding proteins (RBPs), whose activity and expression are also heavily controlled. While the RNA-‐binding potential of RBPs is currently of intense scrutiny, surprisingly little is known to date about the molecular mechanisms that control RNA-‐binding proteins abundance in the context of germ cell development.
This work identifies the molecular mechanisms that shape expression patterns of two evolutionarily conserved RNA-‐binding proteins, CPB-‐3 and GLD-‐ 1, which belong to CPEB and STAR protein family, respectively. By focusing on their regulation in the C. elegans germ line, this work reveals an involvement of the proteasome in reducing levels of CPB-‐3/CPEB and GLD-‐1/STAR at the pachytene-‐to-‐diplotene transition during meiotic prophase I. Furthermore, it documents that CPB-‐3 and GLD-‐1 are targeted to proteasomal degradation by a conserved SCF ubiquitin ligase complex that utilises SEL-‐10/Fbxw7 as a substrate recognition subunit. Importantly, destabilisation of both RBPs is likely triggered by their phosphorylation, which is regulated by the mitogen-‐activated protein kinase, MPK-‐1, and restricted to the meiotic timepoint of pachytene exit. Lastly, this work investigates the potential consequences of target mRNA regulation upon delayed RBP degradation. Altogether, the collected data characterise a molecular pathway of CPEB and STAR protein turnover, and suggest that MPK-‐1 signaling may couple RBP-‐mediated regulation of gene expression to progression through meiosis during oogenesis.
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Molecular mechanisms governing germ line development in zebrafish and the role of this lineage in sexual differentiation / Molekulare Mechanismen zur Steuerung der Keimzellentwicklung in Zebrafisch und die Rolle dieser Zelllinie in der GeschlechtsdifferenzierungSlanchev, Krasimir Ivanov 26 April 2005 (has links)
No description available.
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Topographie molekularer Faktoren der Keimzellentwicklung während der frühembryonalen Entwicklung des Kaninchens / Topography of molecular factors regulating primordial germ cell development in the early rabbit embryoHopf, Clas 20 April 2011 (has links)
No description available.
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Pluripotency of multipotent adult germ-line stem cells: analysis of apoptotic and epigenetic features / Pluripotenz der multipotenten adulten Keimstammzellen: Analyse der apoptotischer und epigenetischer MerkmaleKhromov, Tatjana 29 November 2011 (has links)
No description available.
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microRNA expression profile of undifferentiated and differentiating pluripotent cells / microRNA Expressionsprofile in nicht differenzierten und differenzierten pluripotenten ZelllinienPantazi, Angeliki 29 September 2009 (has links)
No description available.
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Stage-specific germ cell marker genes function in establishment and germ cell lineage commitment of pluripotent stem cells / Stadien-spezifische Keimzellmarker-Gene wirken in der Etablierung von pluripotenten Stammzellen und leisten einen Beitrag zu deren HerkunftXu, Xingbo 19 October 2012 (has links)
No description available.
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