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Alzheimer's disease is the most common dementia disease and the main cause of death. The hallmark is neurofibrillary tangles (abnormal aggregates of tau protein) and beta-amyloid (Aβ) neuritic plaques that leads to impaired cognitive function such as memory loss and learning difficulties. Researchers have discovered that intermittent fasting improves these cognitive abilities, even though eating regularly is recommended for good cognition. This systematic review aims to investigate further if intermittent fasting improves cognitive function in Alzheimer’s disease and if levels of Aβ and tau pathology explain these changes in cognitive function. The research question is: does intermittent fasting improve cognitive abilities in Alzheimer’s disease and does the levels of Aβ and tau pathology explain these cognitive changes? A literature search for articles was performed on three electronic databases: Pubmed, Web of Science, and WorldCat which gave n=744 articles. The cognitive tests showed a trend toward improved memory, learning, and exploratory behavior in Alzheimer’s disease from intermittent fasting. However, the effects on the levels of Aβ and tau pathology were inconsistent, which invites the possibility of a more prominent, underlying issue of Alzheimer's disease.

Objective: to compare dietary treatments and their effectiveness in reducing seizures through a systematic review and meta-analysis of clinical trials Methods: Using the PRISMA Method, the Primo database was searched to find peer-reviewed articles where researchers compared one treatment against another. The treatments of choice present in all studies are the Ketogenic Diet and the Modified Atkins Diet. Due to the nature of the experiments, the Ketogenic Diet was considered the control, as it was coined first. Results: Of the 450 articles identified, 378 met the primary peer review threshold and 190 were classified as Open Access. Eight met eligibility and were included in this review. 443 patients across all studies were assigned either a Ketogenic Diet or a Modified Atkins Diet for a median period of 3 months. 48.17% of MAD patients had a significant decrease in seizure frequency, compared to 61.11% of patients under KD. As much as the ketogenic diet showed better results overall, there was no statistical difference in the odds of achieving a significant reduction in seizures using either diet. Significance: Trials suggest that while there was not a significant difference in this study between the ketogenic diet and the modified Atkins diet, there was a trend for ketogenic diets to be more effective than the more recent Modified Atkins diet for drug-resistant epileptics. However, the sample size needs to be increased before a more accurate determination can be made.

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Sammanfattning   Bakgrund: Övervikt och fetma har blivit en hälsofarlig nödsituation i västvärlden, i synnerhet bukfetma som är en av de viktigaste riskfaktorerna för kardiovaskulära sjukdomar. Den västerländska dieten domineras av högt förädlade livsmedel till låg kostnad vilket snabbt har utvecklat övervikt och överviktsrelaterade sjukdomar. Det finns olika behandlingsmetoder för att minska övervikt och fetma, där kost är en viktig komponent. Lågkolhydratkost kommer alltmer i fokus, som ett alternativ till de rådande näringsrekommendationerna. För att stödja och motivera personer med övervikt och fetma kan sjuksköterskan förmedla en personcentrerad egenvård enligt Orem. Sjuksköterskan skall enligt lag arbeta evidensbaserat och det krävs ständig uppdatering av forskningsläget. Syfte: Syftet var att studera effekten av lågkolhydratkost hos personer med övervikt och fetma. Metod: Litteraturöversikten är av kvantitativ metod och innehåller 15 vetenskapliga artiklar. Analysmodellen som användes var Fribergs analys. Resultat: Effekter av lågkolhydratkost visar signifikanta förbättringar i framförallt viktnedgång men även i blodtryck, blodfetter och blodsocker. De största effekterna av de olika variablerna sågs efter sex månader. Dessa effekter gav ofta en minskad användning av antidiabetika som följd. Slutsats: Då lågkolhydratkost har gynnsamma effekter på viktnedgång, blodfetter och blodsocker är behovet stort av långtidsstudier. Sjuksköterskan har en viktig roll att stödja och motivera personer med övervikt och fetma till livsstilsförändringar. Nyckelord: Viktnedgång, ketogen kost, lågkolhydratkost, egenvård / Summary Low-carbohydrate diets for overweight and obesity - A literature review   Background: Overweight and obesity has become a health hazard emergency in the western world, especially abdominal obesity which is one of the major risk factors for cardiovascular diseases. The Western diet is dominated by highly processed food at low cost, which has rapidly developed obesity and obesity related diseases. There are various treatment methods to reduce overweight and obesity by diet which is an important component. Low-carbohydrate diet comes increasingly into focus, as an alternative to the current nutritional recommendations. To support and motivate people with overweight and obesity, the nurse can convey a person-centered self-care according to Orem. The nurse should, by law, set their work based on evidence and that requires a continuous update of available research. Objective: The objective was to study the effect of low-carbohydrate diet in people with overweight and obesity. Method: The literature review is the quantitative method and contains 15 scientific articles. The analysis model used was Friberg analysis. an important role to support and motivate people with overweight Result: Effects of low-carbohydrate show significant improvements especially in weight loss but also in blood pressure, blood fats and blood sugar. The main effects of the different variables were observed after six months. These effects often gave a reduced use of antidiabetic drugs as a result. Conclusion: Since low-carbohydrate proven to have beneficial effects on weight loss, blood fat and blood sugar there is a great need for long-term studies. The nurse has and obesity to lifestyle changes. Keywords: Weight loss, ketogenic diet, low-carbohydrate diet, self-care