This thesis comprises, firstly, a careful and detailed description of the institutional workings of the Chinese stock market; secondly, a literature review of the Chinese segmented markets and dual-listed shares price premium; and thirdly, three evidence-based contributions designed to cast new light on the Chinese A-shares premium puzzle. Publicly-listed firms in China, under certain criteria, can issue two different types of shares, namely A-shares and B-shares, to local and foreign investors respectively. These shares carry the same rights and obligations, but are however priced differently due to market segmentation. After a review of the literature on determinants of the premium, the first contribution offers a complementary explanation. I propose that the premium reflects the difference in valuation preferences between the local and foreign investors, i.e., local investors pay more attention to stock liquidity, while foreign investors pay more attention to firm’s intrinsic value, and so firms having more favorable fundamentals tend to have lower premia. The second contribution involves the examination of a controversial question that which investor group is better informed about local assets, by testing the direction of information flows between the A- and B-shares markets. Both time series methods, and panel data techniques which are used for the first time in this context, are employed, in order to get a distinct and more insightful picture against the current literature. The third contribution compares and contrasts institutional settings of China, Singapore and Thailand which have similar market segmentation and dual-listing systems; examines whether or not the premia in the three countries are caused by same factors; and tries to answer why foreign investors in China pay less, rather than more, as commonly observed in other segmented markets, for identical assets. It provides the first cross-country comparison evidence after 1999 with updated data.

Le Syndrome de l’X Fragile (SXF) est la forme héréditaire de retard mental la plus fréquente et la cause la mieux caractérisée de troubles du spectre autistique (TSA). Elle est causée par une mutation causant l’inactivation du gène Fmr1 (codant pour la protéine FMRP). La sensibilité accrue aux stimuli sensoriels est une caractéristique importante du SXF et des TSA, mais les mécanismes sous-jacents sont encore mal compris. Nous avons constaté que la suppression du gène Fmr1 entrainait une hyperexcitabilité sensorielle dans le modèle murin du SXF. Les souris Fmr1KO nécessitaient significativement moins d'informations tactiles pour l'exploration haptique, et les représentations évoquées par les informations tactiles provenant des vibrisses dans le cortex somatosensoriel primaire (S1) se propageaient à une vitesse plus élevée chez les souris Fmr1KO par rapport aux souris témoins sauvages.Au niveau cellulaire, il a été montré que les ARNm de plusieurs sous-unités de canaux ioniques (par exemple HCN1, KCNMA1) jouant un rôle clé dans le traitement de l'information dendritique / neuronale étaient des cibles de la protéine FMRP (Liao et al, 2008; Darnell et al, 2011). Sur la base de ces observations, nous avons étudié les canalopathies comme une caractéristique importante du SXF. Nous avons testé de possibles dysfonctionnement des canaux ioniques, et leurs conséquences sur le traitement de l'information dendritique dans les neurones pyramidaux du néocortex de la couche 5 chez les souris Fmr1KO, en utilisant une combinaison d’approches électrophysiologiques et d’imagerie calcique bi-photonique. Nos résultats ont montré que les dendrites des neurones pyramidaux du S1 étaient hyperexcitables, facilitant ainsi le couplage des entrées d’information synaptique à la génération de potentiel d'action en sortie dans les neurones. Cette altération était, au moins en partie, attribuable à un dysfonctionnement des canaux Ih et BKCa et a été partiellement restaurée par l'activation pharmacologique des canaux BKCa. Ces résultats plaident en faveur d'un rôle nouveau et crucial des canalopathies dans l'expression de l'hyperexcitabilité sensorielle dans le SXF. / Fragile X Syndrome (FXS) is the most common form of inherited mental retardation syndrome and most well characterized cause of Autism Spectrum Disorders (ASD), and it is caused by a silencing mutation of the gene Fmr1 (encoding the protein FMRP). Increased sensitivity to sensory stimuli is a prominent feature of FXS and ASD, but its underlying mechanisms are poorly understood. We found that deletion of the Fmr1 gene results in somatosensory hyper-excitability in a mouse model for FXS. Fmr1 knockout (Fmr1KO) mice required significantly less tactile information for haptic exploration, and touch-evoked whisker representations in the primary somatosensory cortex (S1) spread with increased velocity in Fmr1KO mice compared to wild-type control. At the cellular level, it has been shown that the mRNAs of several ion channel subunits (e.g. HCN1, KCNMA1) playing key roles in dendritic/neuronal information processing are regulated by FMRP (Liao et al., 2008; Darnell et al., 2011). Based on these observations, we investigated channelopathies as a prominent feature of FXS. We probed ion channel dysfunction, and its consequence for dendritic information processing in neocortical pyramidal neurons of layer 5 in Fmr1KO mice, using a combination of electrophysiological and 2-photon calcium imaging approaches. Our results showed that dendrites of S1 pyramidal neurons were hyper-excitable, facilitating the coupling of synaptic input to the generation of action potential output in these neurons. This defect was, at least in part, attributable to a dysfunction of Ih channels and BKCa channels and was partially rescued by pharmacological activation of BKCa channels. These findings argue for a novel and critical role for channelopathies in the expression of sensory hyper-excitability in FXS.

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This thesis explores James Macpherson’s The Highlander (1758) in relation to originality, Scottish identity and historiography. It also situates the Ossianic Collections in the context of Macpherson’s earlier poetical and later historical works. There are three parts to it: a biographical sketch of Macpherson’s early life, the annotated edition of The Highlander, and discursive commentary chapters. By examining The Highlander in detail this thesis questions the emphasis of other Macpherson criticism on the Ossianic Collections, and allows us to see him as a writer who is historically minded, very aware of sources, well versed in established forms of poetry and thoroughly, and positively, British. The Highlander stands out among the corpus of his works not because it can give us insights into the Ossianic Collections, which is its usual function in Macpherson criticism, but because it can help us understand what it is that connects Macpherson’s earlier and later works with the Ossianic Collections: history, Britishness, tradition. Macpherson’s poetical works are united by a desire to translate Scotland’s factual past into sentimental British poetry. In the Ossianic Collections he does so without particular faithfulness to his sources, but in The Highlander he converts historical sources directly into neo-classic verse. This is where Macpherson’s originality lies: his ability to adapt history. In different styles and genres, and based on different sources, Macpherson’s works are early examples of Scotland’s great literary achievement: historical fiction. Instead of accusing him of forgery or trying to trace his knowledge of Gaelic ballads, this thesis presents Macpherson as a genuine historian who happened to write in a variety of genres.

The L5 signal of the Global Positioning System (GPS) is becoming available on an increasing number of Block IIF satellites. As the third civilian signal, L5 is superior in signal design to the L1 C/A and L2C civilian signals. This new signal has been marked healthy for use on selected satellites since 2010, yet the hardware capable of tracking the L5 signal is still in the early stages of development. This work investigates the characteristics of the new signal and the quality of data produced by L5-tracking receivers. Commonly used receiver models chosen for this study are the Leica GRX1200+GNSS, the Trimble NetR8, and the Javad Delta TRE-G3TH. The metrics used in this analysis to assess the quality of data produced by these receivers are signal strength, receiver phase noise, receiver code noise, and multipath. The data used in these analyses were obtained from the International GNSS Service for the days of the year 275 to 281 in 2011. Metrics averaged over the GPS week 1656 provide a good indication of the overall performance of the receivers. / text

Part I of this thesis describes the development of bioactive small molecules of relevance to the study of the apicomlexan parasite Toxoplasma gondii into useful chemical tools. The research includes the target identification and validation studies, using both chemical and biological methods. Chapter 1 provides an overview of chemical genetics with a particular emphasis on methods for the identification of the protein targets of bioactive small molecules. The concept of biochemical protein target identification techniques was introduced with a detailed discussion of interesting applications from the literature. Chapter 2 focuses on the development of a tetrahydro-β-carboline based lead molecule into a chemical tool through target identification studies. The structure activity relationship (SAR) data associated with this core structure, the design of a chemical inducer of dimerisation (CID) and the synthesis of this CID are discussed in detail. Chapter 3 described work done to identify the potential protein target(s) of Conoidin A. Experiments to assess whether Conoidin A can inhibit a proposed target in vitro are also included. Further optimisation of this structural class to develop more potent inhibitors is discussed in the second part of this chapter. Part II of this thesis describes the development of methods for the synthesis of medium-sized ring containing compounds using oxidative fragmentation and rearrangement strategies. Chapter 5 provides an overview of the existing oxidative fragmentation methodology, with an emphasis on the use of oxidative fragmentation reactions for the synthesis of medium-sized ring systems (8-11 ring atoms). Chapter 6 focuses on using the established oxidative fragmentation method in the oxizino carbazolone system to investigate the diasteroselectivity of this reaction. Possible mechanisms for this transformation are investigated and discussed using both chemical and computational methods. An interesting rearrangement reaction has also been observed during this study. Chapter 7 focuses on developing an asymmetric oxidative fragmentation method, for use in the diazabenz[e]aceathrylenes system. Asymmetric oxidative fragmentation reactions using [Ru(pybox)(pydic)] catalysts are discussed. Attempts to optimise the enantiomeric excesses of the reaction by varying reaction conditions and substituents in the substrate are also included.

Scintillation of Global Positioning Systems (GPS) signals have been extensively studied at low and high latitude regions of the Earth. It has been shown in past studies that amplitude scintillation is severe at low latitudes and phase scintillation is severe at high latitudes. Unlike low and high latitude regions, mid-latitude scintillation has not been extensively studied. Further, it has been suggested that mid-latitude scintillation is negligible. The purpose of this research is to challenge this belief. A multi-constellation and multi-frequency receiver, that tracks American, Russian, and European satellites, was used to monitor scintillation activity at the Virginia Tech Space Center. Analysis was performed on collected data from various days and compared to past research done at high, mid, and low latitudes. The results are discussed in this thesis. / Master of Science

This short paper considers all possible stakeholders in different stages of a sustainability transition and matches their behavioral features and diversity to policies. This will involve an assessment of potential or expected responses of stakeholders to a range of policy instruments. Following the Multi-Level Perspective framework to conceptualize sustainability transitions, we classify the various transition policies at niche, regime and landscape levels. Next, we offer a complementary classification of policies based on a distinction between social preferences and bounded rationality. The paper identifies many barriers to making a sustainability transition and how to respond to them. In addition, lessons are drawn from the case of Denmark. The detailed framework and associated literature for the analysis was discussed in Milestone 31 of the WWWforEurope project (Gazheli et al., 2012). / Series: WWWforEurope

Furniture history is often considered a niche subject removed from the main discipline of art history, and one that has little to do with the output of painters, sculptors and architects. This thesis, however, connects the key intellectual, artistic and architectural debates surfacing in 'the arts' between 1740 and 1840 with the design of British furniture. Despite the expanding corpus of scholarly monographs and articles dealing with individual cabinet-makers, furniture making in geographic areas and periods of time, little attention has been paid to exploring Gothic furniture made between 1740 and 1840. Indeed, no body of research on 'mainstream' Gothic furniture made at this time has been published. No sustained attempt has been made to trace its stylistic evolution, establish stylistic phases, or to place this development within the context of contemporary architectural practice and historiography — except for the study of A.W.N. Pugin's 'Reformed Gothic'. Neither have furniture historians been willing to explore the aesthetic's connection with the intellectual and sentimental position of 'the Gothic' in the period. This thesis addresses these shortcomings and is the first to bridge the historiographic, cultural and architectural concerns of the time with the stylistic, constructional and material characteristics of Gothic furniture. It argues that it, like architecture, was charged with social and political meanings that included national identity in the eighteenth century — around a century before Charles Barry and A.W.N. Pugin designed the Palace of Westminster and prominently associated the Gothic legacy with Britishness.