In this study, the relationship between maximal aerobic capacity (VO₂max) and left ventricular function was examined in two distinct age groups. A young group (20 - 30 years of age) and an elderly group (over 60 years of age) were compared. Left ventricular function was examined over wide variations in preload accomplished by 5º head-down tilt (TILT) for ninety minutes and lower body negative pressure (LBNP) to -40 mm Hg. with two-dimensional echocardiography. A greater response to an increase in preload (TILT) was related to high VO₂max levels in the young subjects but not in the elderly groups of subjects, suggesting that lower VO₂max levels of the elderly population affected the mechanism of response to the increased levels of preload. Additionally, in the elderly, greater reductions in ventricular volume reflected increased peripheral pooling due to decreased venous tone and/or increased venous compliance during LBNP and were related to increased VO₂max. In the young, VO₂max does not appear to affect the response to reduced preload.

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal.

The 19th century is recognised as a period of mass emigration from Cornwall, with a significant proportion of the male population leaving to work overseas, mainly in the mining industry. Less appreciated is that many of these migrants were married men who left wives and children behind in Cornwall. This study seeks to shed some light on the experiences of these women, known as 'married widows'. It adopts a multi-faceted approach, which draws upon crowd-sourcing and digital resources, in combination with more traditional methodologies. Scattered and fragmentary qualitative evidence (drawn from correspondence, newspapers, remittance and poor law records, supplemented by personal testimony recorded in family histories) is examined within a quantitative framework produced by an innovative database created from census records and a longitudinal study of outcomes. This thesis describes how tens of thousands of wives were 'left behind' in the mining communities of Cornwall, and the wide range of resources they drew upon in the absence of their husbands. It examines the interaction between the wives and the State in the form of the Poor Law and the Courts, identifying a pragmatic response to the needs of the emerging transnational nuclear family. Male migration from Cornwall is revealed to vary widely in type, intent and duration, leading to great diversity of experiences and outcomes for the wives 'left behind'. The establishment of temporary male labour emigration from the Cornish mining communities is shown to have occurred earlier than in many other emigration centres, creating greater potential for cultural acclimatisation to the challenges of spousal separation. The findings of this study challenge existing, generalised, perceptions of the wives as passive victims in the Cornish emigration story. Levels of destitution or desertion appear low compared to the scale of the phenomenon, and wives are shown as active participants and influential voices in family strategies. Nonetheless, this study highlights the vulnerability and greater risks faced by the wives 'left behind', and identifies financial and emotional insecurity as common elements of their experience. This thesis demonstrates a methodology and reveals insights that might be applied to the study of wives 'left behind' in other parts of the British Isles, and a comparator for existing studies of those elsewhere in the world.

There is a growing epidemic of chronic heart failure (CHF) in the developed world. The costs associated with providing care is profound and despite our best efforts, new, more effective treatments for CHF are needed; 50% of patients diagnosed with CHF are dead within 5 years. Current paradigms rely heavily on pharmacologic interventions, which merely help manage the disease. Surgical interventions may also be considered for late stage CHF patients such as heart transplant or left ventricular assist device (LVAD) but require burdensome and invasive surgical procedures. In addition they are costly, and require the need for life long immunosuppressive and anticoagulant therapies respectively. Despite our best intentions, the long-term prognosis for CHF patients remains poor. With over a decade of clinical investigation taken place, data from cell-based therapy trials remains inconsistent. While demonstrating safety, limited efficacy has been reported and to date, no stem cell therapy has been approved by the FDA. Despite these shortcomings important lessons have been learned that can be applied to future developments. Retrospective analysis of early cell-based clinical trial data has suggested that variations in isolated cell number, viability, and potency from donor to donor in autologous preparations yielded wide discrepancies in functional outcomes. In addition, sub culturing adult stem cells, even for short periods of time in 2D polystyrene environments void of complementary cell populations and extra cellular matrix protein interactions, may alter the therapeutic potential of a given cell. As a solution, allogeneic approaches where donor cell quality and potency can be assessed and optimized may help achieve functional benefits. Furthermore, co-dosing with multiple cell populations or developing 3D sub-culture environments that more closely mimic the in vivo milieu may ultimately yield more potent therapeutic cell populations. While these alterations may improve cell-based therapy outcomes, other solutions have been proposed such as tissue engineering. While the concept of tissue engineering is not new, advancements in biomaterials, bioreactor design and cell sources have greatly enhanced the reality of these preparations. Previously, one of the greatest limitations to tissue engineering is overcoming the cell requirements for developing and testing where millions if not billions of cells are required. Cell sourcing limitations appear to have been solved with the discovery and development of induced pluripotent stem cell (iPSC) derived cell populations. First reported in 2007, they have the ability to generate embryonic like pluripotent stem cells without the ethical concerns of embryonic stem cells. These iPSCs hold tremendous potential for drug toxicology / screening, personalized medicine and cell therapies. The body of work described in this dissertation looks at developing and testing a tissue engineered cardiac patch to treat heart failure. For which, an emphasis has been to provide 1) structural support for engrafted cells and 2) a rapidly inducible vascular supply once implanted in vivo. Biomaterials were sourced that facilitate infill by multiple cell populations in 3D culture and the establishment of extra cellular matrix deposits. Together, these patches enhanced cellular development in vitro and result in long term functional improvements in small animal models for CHF. Additional feasibility work was performed in large animal models to permit upscaling and development of surgical implantation techniques to demonstrate clinical applicability

<p>QC 20170306</p>

Thesis advisor: Marilyn Cochran-Smith / This practitioner research longitudinal study examines the effects of the No Child Left Behind (NCLB) law and the Race To The Top (RTTT) initiative on a high performing middle school in Massachusetts between 2003 and 2013. Utilizing a theoretical framework that combines Cochran-Smith and Lytles (2009) "inquiry as stance" and Ball's concept of (1990b) "policy cycles," the study analyzes the programmatic and structural changes enacted in response to NCLB, RTTT and their effects on special education and low income students, their teachers, parents, and the principal. The study's findings show that federal mandates and related state regulations placed unrealistic, unfair and unreasonable demands on students, teachers and the school. Staff often felt as if we were riding on a rollercoaster. Massachusetts' rating of "High" and "Very High" performance on the state test contrasted with the NCLB school report cards that labeled the school as in need of "improvement," "corrective action," and eventually "restructuring" because of the failure of special education or low income students to meet constantly rising targets. NCLB's and RTTT's requirements caused the school to prioritize courses providing remediation in tested subjects--English language arts and mathematics--reducing the availability of related arts classes and thereby narrowing the curriculum. The school's obsessive focus on the annual state tests produced an atmosphere of anxiety for all stakeholders. Unwanted changes in the school culture eventually generated a schoolwide movement to resist the obsession with testing, reduce anxiety and expand interdisciplinary learning. The study concludes with recommendations for further research of the effects of federal mandates on "good" schools across the US. It recommends that policymakers recognize that "one size fits all" school reform is detrimental to public schools and calls for the recognition of local knowledge in the making of policy. A further recommendation encourages school leaders to study their own practice, becoming practitioner researchers for the benefit of their schools. / Thesis (PhD) — Boston College, 2014. / Submitted to: Boston College. Lynch School of Education. / Discipline: Teacher Education, Special Education, Curriculum and Instruction.

This thesis has dealt with the thought of the German legal and political theorist Carl Schmitt and with the reception of his work by the intellectual Left. The main goals of the thesis were to find out which aspects of Schmitt's work are the most popular among left-wing authors and to search for the causes of this inspiration. Thus, it was necessary to reconstruct the historical context in which such a conservative thinker becomes a frequently quoted author within various branches of leftist thought. In Carl Schmitt's case, because of his shift towards Nazism in the 1930s, there is also a methodological problem of the possible separation of his work from his career and personality, the separation of a particular theoretical approach from the motives which led to this approach. Therefore, the attempt to use Schmitt's thought for progressive left-wing goals is not easily compatible with strictly contextual reading of his work. Schmitt's work itself is described and analyzed especially in the first half of this thesis. The first chapter describes, in the historical context, some basic concepts which Schmitt deals with. The chapter is structured according to main targets of his critique: legal positivism; liberal democracy; quantitative total state, which is able to intervene in every part of society,...

Orientador: Fátima Cabral / Banca: Marcos Tadeu Del Roio / Banca: Maria ribeiro do Valle / Resumo: O presente trabalho tem por objetivo analisar a reflexão empreendida por Hannah Arendt (1906-1975) acerca dos fenômenos do poder e da violência, bem como sua crítica à Nova Esquerda , crítica essa que se apresenta de forma sistematizada em seu ensaio Sobre a violência, de 1969. A distinção entre poder e violência constitui-se, pois, em tema central do pensamento político da autora, que teve como motivação para sua reflexão a Rebelião Estudantil de 1968, a guerra do Vietnã e o papel da violência no âmbito da Nova Esquerda. Com efeito, o poder, para Arendt, é inerente a toda comunidade política e resulta da capacidade de agir conjuntamente. Por outro lado, a violência, que é instrumental, se funda na categoria meio-fim, e quando recobrada no âmbito do político é responsável por fazer desaparecer o poder. Portanto, poder e violência são assuntos opostos: quando um se afirma absoluto, o outro desaparece. Do contato com o pensamento de Arendt, percebemos que seu conceito de poder foi forjado tendo como referência a tradição da polis grega, a qual, no entendimento de Arendt, lança luzes sobre a derrocada dos valores da política moderna, bem como sobre a necessidade de resgatar a diferença entre as esferas pública e privada para fazer emergir o fenômeno originariamente político. Confrontando suas idéias com as de outros autores, consideramos que a análise de Arendt sobre o poder transcende completamente as relações conflituosas constitutivas da vida política e suas instituições tradicionais. Além disso, a rejeição da ação radical da Nova Esquerda, por esta autora, em grande medida parece engrossar o coro que recusa e rechaça a utopia, que significa, no contexto do "fim da ideologia", a negação da perspectiva socialista em favor, mais uma vez, da "democracia" e do "pluralismo" norte-americanos. / Abstract: The aim of this paper is to analyze the reflexion undertaken by Hannah Arendt (1906-1975) on the phenomena of power and violence as well as her critique of the New Left, which is presented systematically in her essay On Violence (1969). The distinction between power and violence thus comprises a central theme in her political thought, which has had as a motivation for her reflexion the Student Rebellion of 1968, the Vietnam war and the role of violence within the New Left. Indeed, the power, on Arendt's account, is inherent to every political community and it is a result of the ability to act jointly. Furthermore, the violence, that is instrumental, is based upon the means-end category and whenever stablished within the political sphere becomes responsible for causing the power to vanish. Therefore, power and violence are opposite subjects: as one becomes absolute, the other vanishes. By being in touch with Arendt's thinking we come to realize that her innovative concept of power has been forged having as reference the tradition of Greek polis, which, from Arendt's understanding, casts light on the defeat of the values of the modern Politics, as well as on the need of restoring the difference between public and private spheres to cause the originally political phenomenom to emerge. By putting her thoughts with those of other authors, we consider that Arednt's analysis of power goes completely beyond the conflicting constituents of political life and its traditional institutions. Moreover, the rejection of the extreme action of the New Left, by the author, largely seems to reinforce the chorus that refuses and rejects the utopia, which means, in the "end of ideology" context, the negation of the socialist perspective in behalf, once again, of the American "democracy" and "pluralism". / Mestre

O impacto da desnutrição não se processa da mesma maneira nos diversos órgãos e tecidos do organismo, promovendo alterações na estrutura corpórea geral. O coração não é isento das consequências catabólicas da desnutrição. Em Maputo (capital de Moçambique), comprova um aumento na incidência de desnutrição grave, o que faz com que proporcione uma das maiores taxas de mortalidade, chegando a 20%. O objetivo deste trabalho foi avaliar possíveis repercussões morfofuncionais nos cardiomiócitos constituintes dos ventrículos esquerdos de ratos Wistar. Para tanto, foram utilizadas as dietas hipoprotéica (contendo 5% de caseína, e que caracteriza estado de subnutrição - grupo S); padrão de Moçambique (cujo conteúdo proteico vegetal é extraído do amendoim grupo M) e protéica (com 20% de caseína, caracterizando o grupo nutrido ou controle - grupo N). Os animais S, M e N constituíram dois grupos de estudo, sendo avaliados aos 21 dias de vida (época do desmame), e aos 42 dias. Após o desmame, foram mensurados os parâmetros metabólicos de ingestão de água e alimentar, bem como os de excreção de fezes e urina. As amostras dos corações foram processadas com técnicas rotineiras de histologia e submetidas a colorações que permitiram evidenciar o colágeno. Os aspectos ultraestruturais do ventrículo esquerdo também foram analisados. Para as avaliações, os dados foram submetidos a uma Análise de Variância (ANOVA) com dois fatores (idade e dieta) e quando necessário aplicou-se pós-teste de Bonferroni ou Tukey. Os nossos resultados mostram que a subnutrição é capaz de modificar as propriedades biomecânicas do miocárdio, causando atraso no seu desenvolvimento. Quanto às dietas aqui empregadas, mostram que a dieta padrão de Moçambique não atende uma nutrição adequada em comparação ao grupo nutrido, dentro dos parâmetros analisados. Conclui-se que a dieta padrão de Moçambique tem seus efeitos deletérios da subnutrição, nos aspectos metabólicos, estruturais e ultraestruturais do ventrículo esquerdo / The impact of malnutrition is not processed in the same way in various organs and tissues of the body, promoting changes in the general body structure. The heart is not exempt from the catabolic effects of malnutrition. In Maputo (Mozambique&#39;s capital), proves an increased incidence of severe malnutrition, providing one of the highest mortality rates, reaching 20%. The aim of this study was to evaluate possible morphological and functional repercussions of the cardiomyocytes of left ventricles from Wistar rats. Therefore, low protein diets were used (containing 5% casein, malnutrition group - S group); standard diet from Mozambique (the vegetable protein content was extracted from the peanut - group M) and protein diet (with 20% casein - fed/control group - N group). Animals S, M and N constituted two study groups and were evaluated at 21 days of life (time of weaning), and at 42 days. After weaning, the metabolic parameters of ingestion of water and food and the excretion of faeces and urine were measured. The samples of hearts were processed and subjected to histological techniques which emphasize collagen. Ultrastructural aspects of the left ventricle were analyzed. Data were subjected to analysis of variance (ANOVA) with two factors (age and diet) and when required Bonferroni or Tukey post-test were applied. Our results show that malnutrition is capable of modifying the biomechanical properties of the myocardium, causing delay in its development. As for diets employed here, show that the standard diet from Mozambique does not provide adequate nutrition when compared to control group within the parameters analyzed. It concludes that the standard diet from Mozambique has its deleterious effects of malnutrition, metabolic, structural and ultrastructural aspects of the left ventricle

Enquadradas arbitrariamente no mesmo termo generalizante drogas, diversas substâncias psicoativas de diferentes efeitos e tradições foram proibidas a partir do começo do século XX por conta de interesses morais, econômicos e políticos justificados por um questionável discurso defensor da saúde pública. A proibição destas substâncias não incidiu sobre seus possíveis efeitos danosos e trouxe consigo uma série de outrosproblemas, como violência do crime e do Estado, corrupção, criminalização da pobreza,encarceramento em massa,ingerência imperial sobre territórios desejados e ingerência estatal sobre a vida privada dos cidadãos. Mesmo assim, com algumas exceções, a questão não ocupou lugar de destaque nos programas e na atuação das organizações de esquerda no Brasil, que invariavelmente ignoraram esta questão, quando não se posicionaram favoravelmente ao proibicionismo. Inspiradas em ideais de hierarquia, disciplina e sacrifício militante,e considerando o uso depsicoativosmajoritariamentepela chave explicativa da fuga da realidade, estas organizações tiveram pouca sensibilidade para propor outros meios que não o repressivo e o penal para se lidar com problemas decorrentes do abuso no uso de drogas, e menos vezes ainda para lidar com formas alternativas de exploração das tecnologias de si, como definiu Michel Foucault. Além de traçar um panorama das origens da proibição das drogas e seus efeitos, este trabalho investiga que tipo de tratamento foi dado pela esquerda à questão das drogas após 1961 ano tanto da aprovação da Convenção Única sobre Narcóticos, da ONU, quanto dos primeiros rompimentos com o PCB, processo que representou uma reconfiguração na esquerda brasileira. / Arbitrarily framed in the same generalizing term \"drugs\", several different psychoactive substances, with different traditions and effects were prohibited in the early twentieth century -because of moral, economic and political interests, justified by a questionable speech defender of \"public health.\" The prohi bition of these substances did not influence in their possible harmful effects and brought with it a lot of other problems, such as crime and violence of the State, corruption, criminalization of poverty, mass incarceration, imperial interference on desired territories and state interference on the citizens private lives. Yet, with few exceptions, the subject did not occupy a prominent place in programs and activities of leftist organizations in Brazil, which most of the time ignored this question. Inspired by the ideals of hierarchy, discipline and militant sacrifice, and considering the use of psychoactive drugs mostly by the explication of \"escape from reality\", these organizations have had little sensitivity to propose other means than the repressive and penal to deal with problems arising from drug abuse, and even less often to deal with alternative ways of operating \"technologies of the self,\" as defined by Michel Foucault. Besides from giving an overview of the origins of drug prohibition and its effects, this study investigates what kind of treatment was given to the issue of drugs by the brasilian left after 1961 -the year of the adoption of the Single Convention on Narcotic Drugs of the United Nations, and also of the first splits in the brasilian comunist party (PCB), which represented a reconfiguration process in the brazilian left.