Cross-linking in soy proteins is hypothesised to have an impact on the texture of tofu. In vitro incubation showed soy proteins and its two fractions, glycinin and β-conglycinin, were cross-linked using glutaraldehyde, formaldehyde, glyceraldehyde and transglutaminase (TGA). Increasing concentration of these carbonyl compounds and TGA, and temperature of the carbonyl compounds treatment, increased the reactivity of cross-linking. Glutaraldehyde was the most reactive in forming aggregated proteins, followed by formaldehyde and glyceraldehyde. Both carbonyl moieties of glutaraldehyde are believed to be essential for the rapid cross-linking reaction. In the unfractionated soy proteins, β-conglycinin had a higher reactivity than glycinin. In in vitro incubation using TGA, soy proteins served as good substrates for TGA, in which β-conglycinin was more susceptible to TGA than glycinin in the unfractionated soy proteins. The addition of TGA, and 1 and 2 mM glutaraldehyde prior to soymilk boiling in situ resulted in a small number of cross-linked proteins, which correspond to an increase in fracture force. The addition of glutaraldehyde after soymilk boiling resulted in a slight decrease in fracture force compared to the control. At higher concentrations of glutaraldehyde (15 and 30 mM), soy proteins were mostly cross-linked, regardless of addition before or after soymilk boiling. Highly cross-linked proteins resulted in a significant decrease in the fracture force. For TGA treatment, the fracture force was increased with increasing TGA concentration from 1000 to 5000 ppm, added either before or after soymilk boiling. However, the TGA treatment showed only a small quantity of cross-linking. It is hypothesised that TGA hydrolysed glutamine of proteins to glutamate and changed the functional properties of proteins. Upon examination of the microstructure, it was found that the TGA treatment resulted in a fine-stranded network, compact structure and less porosity. These characteristics resulted in a higher fracture force. In contrast, in the glutaraldehyde treatment, the network consisted of a higher porosity, loose network and diffuse structure, which gave lower fracture force. Thus, it appears that substrate modification to the structure of the soy proteins may have a greater impact than the number of cross-links. These findings are likely to have implications for production of soy products with a wide range of textures by manipulating the soy protein properties.

Thesis (Ph.D. (Biochemistry))--Mahidol University, 1984.

Along with the increasing development of language resources - i.e., new lexicons, lexical databases, corpora, treebanks - the need for their efficient interlinking is growing. With such a linking, one can easily benefit from all their properties and information. Considering the convergence of resources, universal lexicographic formats are frequently discussed. In the present thesis, we investigate and analyse methods of interlinking language resources automatically. We introduce a system for interlinking lexicons (such as VALLEX, PDT-Vallex, FrameNet or SemLex) that offer information on syntactic properties of their entries. The system is automated and can be used repeatedly with newer versions of lexicons under development. We also design a method for identification of multiword expressions in a parsed text based on syntactic information from the SemLex lexicon. An output that verifies feasibility of the used methods is, among others, the mapping between the VALLEX and the PDT-Vallex lexicons, resulting in tens of thousands of annotated treebank sentences from the PDT and the PCEDT treebanks added into VALLEX. Powered by TCPDF (www.tcpdf.org)

Tese (doutorado)—Universidade de Brasília, Instituto de Ciências Exatas, 2015. / Submitted by Fernanda Percia França (fernandafranca@bce.unb.br) on 2015-11-20T15:59:18Z No. of bitstreams: 1 2015_JoséCarlosdeOliveiraJunior.pdf: 585340 bytes, checksum: c3c6b263a9844a065ed6941adcc707b8 (MD5) / Approved for entry into archive by Raquel Viana(raquelviana@bce.unb.br) on 2016-05-12T21:17:39Z (GMT) No. of bitstreams: 1 2015_JoséCarlosdeOliveiraJunior.pdf: 585340 bytes, checksum: c3c6b263a9844a065ed6941adcc707b8 (MD5) / Made available in DSpace on 2016-05-12T21:17:39Z (GMT). No. of bitstreams: 1 2015_JoséCarlosdeOliveiraJunior.pdf: 585340 bytes, checksum: c3c6b263a9844a065ed6941adcc707b8 (MD5) / Neste trabalho, consideramos o problema autônomo {(-∆u+V(x)u=f(u) em R^N,@u∈H^1 (R^N)\\{0},)┤ em que N≥3, a função V é não periódica, radialmente simétrica e muda de sinal e a não linearidade f é assintoticamente linear. Além disso, impomos que V possui um limite positivo no infinito e que o espectro do operador L≔-∆+V tem ínfimo negativo. Sob essas condições, baseando-se em interações entre soluções transladadas do problema no infinito associado, é possível mostrar que tal problema satisfaz a geometria do teorema de linking clássico e garantir a existência de uma solução fraca não trivial. Em seguida, estabelecemos a existência de uma solução não trivial para o problema não autônomo {(-∆u+V(x)u=f(x,u) em R^N,@u∈H^1 (R^N)\\{0},)┤ sob hipóteses similares ao problema anterior, admitindo também que f(x,u)=f(|x|,u) dentre outras condições. Aplicamos novamente o teorema de linking para garantir que tal problema possui uma solução não trivial. Por fim, provamos que o problema quasilinear {(-∆u+V(x)u-u∆(u^2)=g(x,u) em R^3,@u∈H^1 (R^3)\\{0},)┤ em que o potencial V muda de sinal, podendo ser não limitado inferiormente, e a não linearidade g(x,u), quando |x|→∞, possui um certo tipo de monotonicidade, possui uma solução não trivial. A existência de tal solução é provada por meio de uma mudança de variável que transforma o problema num problema semilinear, nos permitindo, assim, empregar o teorema do passo da montanha combinado com o lema splitting. / In this work, we consider the autonomous problem {(-∆u+V(x)u=f(u) em R^N,@u∈H^1 (R^N)\\{0},)┤ where N≥3, V is a non-periodic radially symmetric function that changes sign and the nonlinearity f is asymptotically linear. Furthermore, we impose that V has a positive limit at infinity and the spectrum of the operator L≔-∆+V has negative infimum. Under these conditions, employing interaction between translated solutions of the problem at infinity, it is possible to show that such problem satisfies the geometry of the classical linking theorem and garantee the existence of a nontrivial weak solution. After that, we establish the existence of a nontrivial weak solution for the nonautonomous problem {(-∆u+V(x)u=f(x,u) em R^N,@u∈H^1 (R^N)\\{0},)┤ under similar hyphoteses to the previous problem, assuming also that f(x,u)=f(|x|,u) among others conditions. We apply again the classical linking theorem to ensure that such problem possesses a nontrivial weak solution. Finally, we prove that the quasilinear problem {(-∆u+V(x)u-u∆(u^2)=g(x,u) em R^3,@u∈H^1 (R^3)\\{0},)┤ where the potential V changes sign and may be unbounded from below and the nonlinearity g(x,u), as|x|→∞, has a kind of monotonicity, has a nontrivial weak solution. The existence of such solution is proved by means of a change of variables that makes the problem become a semilinear problem and hence allow us apply the mountain pass theorem combined with splitting lemma.

abstract: Web applications are ubiquitous. Accessible from almost anywhere, web applications support multiple platforms and can be easily customized. Most people interact with web applications daily for social media, communication, research, purchases, etc. Node.js has gained popularity as a programming language for web applications. A server-side JavaScript implementation, Node.js, allows both the front-end and back-end to be coded in JavaScript. Node.js contains many features such as dynamic inclusion of other modules using a built-in function named require which dynamically locates and loads code. To be effective, web applications must perform actions quickly while avoiding unexpected interruptions. However, dynamically linked libraries can cause delays and thus downtime, because dynamically linked code must load multiple files, often from disk. As loading is one of the slowest operations a computer performs, seeking from disk can have a negative impact on performance which causes the server to feel less responsive for users. Dynamically linked code can also break when the underlying library is updated. Normally, when trying to update a server, developers will use test servers. However, if the developer accidentally updates a library in a dynamically linked system, it may be incompatible with another portion of the program. Statically linking code makes it more reliable and faster (to load) than dynamically linking code. The static linking process varies by programming language. Therefore, different static linkers need to be developed for different languages. This thesis describes the creation of a static linker, called FrozenNode, for the popular back-end web application language, Node.js. FrozenNode resolves Node.js applications into a single file that does not rely on dynamic libraries. FrozenNode was built on top of Closure Compiler to accurately process JavaScript. We found that the resolved application was faster and self-contained yielding significant advantages over the dynamically loaded application. Furthermore, both had the same output. Vulnerabilities in web applications can be found using static analysis tools, however static analysis tools must reason about dynamically linked application. FrozenNode can be used to statically link a Node.js application before being used by a JavaScript static analysis tool. / Dissertation/Thesis / Masters Thesis Computer Science 2018

Made available in DSpace on 2014-10-09T12:29:52Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:00:23Z (GMT). No. of bitstreams: 1 00437.pdf: 935313 bytes, checksum: 06cabc4489d4233743e8951ec8c442ed (MD5) / Dissertacao (Mestrado) / IEA/D / Instituto de Energia Atomica - IEA

Made available in DSpace on 2014-10-09T12:55:24Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:04:56Z (GMT). No. of bitstreams: 0 / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Dissertação (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP / FAPESP:06/53634-3

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Made available in DSpace on 2014-06-12T16:24:05Z (GMT). No. of bitstreams: 2 arquivo1334_1.pdf: 2233146 bytes, checksum: 44ea069ca199552779b8f3fb08d87782 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2010 / Objetivo: Avaliar o efeito do cross-linking corneal (CCL) nos portadores de ceratopatia bolhosa sintomática, e seu impacto na acuidade visual, espessura corneal e sintomatologia dolorosa. Métodos: Doze pacientes com ceratopatia bolhosa sintomática foram incluídos. Exame clínico com questionário específico para a pesquisa com escala de dor (escala visual analógica numérica), acuidade visual e mensuração da espessura corneal foi realizada pré CCL, 7, 30, 60, 180 e 365 dias após. Em todos os pacientes o tratamento com UVA-crosslinking foi realizado após abrasão do epitélio corneal em lâmpada de fenda e instilação de solução de riboflavina 0,1% a cada cinco minutos por 30 minutos. Após esse período, o paciente foi submetido à exposição à luz UVA, utilizando riboflavina e anestesia tópica a cada cinco minutos por 30 minutos. Os pacientes utilizaram colírios de ofloxacina 0,3% e lágrima artificial até completa reepitelização. O teste de Friedman foi usado para comparar as médias das freqüências da acuidade visual, sintomatologia dolorosa e espessura central da córnea. p <0.05 foi utilizado para rejeitar a hipótese nula. Resultados: Doze olhos de 12 pacientes com erosões epiteliais recorrentes foram tratados. O tempo de seguimento foi de um ano. Foi observada redução significante da dor (p<0,001). As medidas de espessura corneal e da acuidade visual não sofreram alterações estatisticamente significantes. Conclusâo: Foi constatado o potencial de aplicação do cross-linking corneal no tratamento de pacientes com dor causada por ceratopatia bolhosa