Orientador: Tamara Beres Lederer Goldberg / Resumo: O termo qualidade de vida tem sido utilizado por todos os profissionais que lidam com o bem-estar das pessoas, estando freqüentemente associado a indicadores psicossociais. Este trabalho teve por objetivo identificar, descrever e avaliar a qualidade de vida verbalizada e percebida por adolescentes portadores de fissura labiopalatal e as de um grupo com características sociodemográficas próximas, utilizado como controle, e suas possíveis semelhanças e diferenças quanto à qualidade de vida. A amostra foi constituída por 67 adolescentes portadores de fissura labiopalatal (G1), matriculados no Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo, HRAC-USP, sendo os dados coletados no período de 16 de novembro a 22 de dezembro de 1999; e de 67 adolescentes estudantes sem fissuras (G2), no período entre 22 de agosto a 15 de setembro de 2000. Os grupos tinham representação de ambos os sexos, na faixa etária de 10 a 20 anos incompletos e residentes na cidade de Bauru. Com a intenção de verificar o cotidiano, foi aplicado um questionário de questões estruturadas e algumas questões abertas, enfocando as suas percepções. Apesar do estigma que a deformidade congênita representa, os adolescentes portadores de fissura labiopalatal superam os limites da deficiência, evento fundamental para que se integrem à sociedade, apresentando satisfação com a vida que levam, através da autorealização, saúde e bem-estar. / Abstract: The term quality of life has been employed by all professionals concerned with human welfare, which is often associated to psychosocial indicators. This study aimed at identifying, describing and evaluating the quality of life verbalized and noticed by teenagers with cleft lip and palate in relation to a control group presenting similar sociodemographic features, as well as the possible similarities and differences regarding quality of life. The sample comprised 67 teenagers with cleft lip and palate (G1) regularly enrolled for treatment at the Hospital for Rehabilitation of Craniofacial Anomalies of the University of São Paulo (HRAC/USP), the data of which were collected during the period November 16th to December 22nd, 1999. The control group consisted of 67 adolescent students without clefts (G2) who were surveyed in the period August 22nd up to September 15th, 2000. The groups included teenagers of both genders, aged 10 to 20 incomplete years old and living in the city of Bauru. A questionnaire comprising structured and some open questions was applied in an attempt to analyze the subjects' quotidian according to their perceptions. Despite of the stigma yielded by the congenital deformity, the teenagers with cleft lip and palate overcome the limits imposed by their deficiency, which is fundamental for their integration into society, and demonstrate satisfaction with the life they live, through self-realization, health and welfare. / Doutor

Diploma thesis presents the description of laser induced breakdown spectroscopy (LIBS) analytical method. The possibility to decrease LIBS detection limits using double pulse LIBS (DP-LIBS) is also detailed. Properties of laser induced plasma (LIP) are discussed. Thesis describes the optimisation process of DP-LIBS setup at laser spectroscopy laboratory of Faculty of Mechanical Engineering, Brno University of Technology. Optimisation was carried out for detection of chrome in steel with respect to detection limits and ablation crater size. Optimised DP-LIBS setup is appropriate for mapping chrome distribution in steel samples.

Clinical and epidemiologic studies of defined geographic populations can serve as a means of establishing data important for genetic counseling and as a first step in identifying strategies best suited for identification of causes. Under the sponsorship of Operation Smile International, clinical, genetic, and epidemiologic studies were carried out at six sites within the Philippines between 1989 and 1996. Patients who were being evaluated for surgical repair of craniofacial anomalies (primarily clefts of the lip and palate) were briefly examined for the presence of associated anomalies, and a family history was obtained to look for the frequency of cleft lip and palate in siblings. Birth records of 47,969 newborns born over an 8-year period at one hospital in Bacolod City in the province of Negros Occidental were reviewed. Medical records of infants born with clefts of the lip and/or palate and other major anomalies were reviewed and birth prevalence rates calculated. Findings include a birth prevalence of 1.94 per 1000 live births for cleft lip with/without palate in the Philippines. Recurrence rates in siblings for nonsyndromic clefts of the lip and palate were 23 per 1000 for cleft lip with or without cleft palate, and 14 per 1000 for cleft palate only. The percentage of clefts associated with multiple anomalies was 21% at birth and 6% for individuals examined during the screening process, providing evidence for a high postnatal death rate. These data provide groundwork for additional etiologic studies including segregation analysis and molecular genetic studies involving linkage or association, as well as for studies of environmental contributions to clefting such as vitamin deficiencies. Preliminary molecular analysis using an association approach is reported in a companion paper. The findings suggest a high incidence of cleft lip and palate in native-born Filipinos.

Indiana University-Purdue University Indianapolis (IUPUI)

Indiana University-Purdue University Indianapolis (IUPUI) / This study investigated familial cases of cleft lip with or without cleft palate to determine whether the unaffected members of each family can be identified as gene carriers for the cleft trait. This research presumes that such carriers will have henotypic features identifiable by cephalometric analysis that are associated with an increased risk to cleft offspring. Using population genetics methodology, a pedigree analysis was made for each family member was assigned to one of four groups: (1) obligate normal, (2) affected, (3) carrier, and (4) unknown. LA and PA cephalographs were taken on each subject and a clinical oral-facial examination carried out on participating family members. Various anatomic landmarks located on the LA and PA films were digitized and from them, a total of 28 linear measurements were made. To eliminate the effect of sex and differential age responses, Z scores were calculated. Through univariate analysis, only one variable, NCR-MO, was shown to be significantly different between the two groups. This variable difference by itself is not adequate to differentiate those in the normal group from the carrier group. Even though only one variable was significant, other differences in the variables between these groups become obvious when the group variables were plotted as Z scores. Since Z scores are pure values with no limits (2--the number of standard deviations in a given variable differs from normal). Thereby, age-related growth differences were minimized. Further information is gained when these Z scores are plotted as pattern profiles, Figures 5-7. These profiles of mean Z scores for each variable pointed out areas of the face in which the differences were so great that specific anatomic areas appeared to be associated with one of the four groups. For example, gene carriers demonstrated specific alterations in facial height that might conceivably be used to discriminate that group from the other three groups. The family normals and carriers were then analyzed by using a stepwise multivariate analysis. By this approach, a discriminant function was generated consisting of six variables (three each from the lateral and frontal headplates), which proved to be significant in distinguishing an individual's phenotype. These variables define facial height, width and depth. The specific findings included a decrease in mid-facial height and depth along with an increased lower facial height and width in the gene carrier population as compared to the normals. The function then was used to predict group membership of the same two groups. Comparing this analytical prediction to that of the grouping system that resulted from the pedigree analysis, all but one individual was classified correctly in both the normal and carrier population. A discriminant score was also determined for the unknown population of family members which were defined as non-cleft blood relatives of cleft probands. Thus, they were a mixture of two types--those unaffected who carried a genetic liability for producing a cleft child and those unaffected who did not. A prediction of their placement into either the normal or carrier group was made with the discriminate function. One-third were classed in the normal group and two-thirds as gene carriers. The results of this study confirm that the phenotype of these unaffected family members designated as obligate gene carriers differs significantly from that of the family normals. This information is not only quite useful for genetic counselling but gives both a better understanding or the genetic control of clefting and can lead to molecular research to identify the specific gene in question.

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Min tanke med mitt arbete var att ta reda på om det fanns ett behov av att ta fram ett nytt åtgärdsprogram på skolan enligt mina kollegor och ledningen. Dessutom ville jag presentera ett alternativt åtgärdsprogram som jag kallar Handlingsprogram, helt i linje med Lösningsinriktad pedagogik. Jag har intervjuat tre av mina kollegor samt en person ur ledningen, jag har gjort en nulägesanalys och jag har sökt information runt den lösningsinriktade pedagogiken i böcker för att finna teorier om hur jag ska utforma mitt handlingsprogram. Resultatet blev att vi hade ett behov av ett nytt åtgärdsprogram och jag har skapat ett handlingsprogram som vi kommer att införa på skolan.

Objective: The aim of this study was to evaluate the dentoalveolar effects of rapid maxillary expansion in children with unilateral complete cleft lip and palate in comparison with non-cleft patients. Methods: The experimental group (EG) was composed of 25 patients with unilateral and complete cleft lip and palate (9 males and 15 females) with a mean age of 10.6 years. The control group (CG) comprised of 27 patients without cleft lip and palate (14 males and 13 females) with a mean age of 9.1 years. Dental models of the maxillary dental arch were obtained immediately preexpansion (T1) and 6 months post-expansion (T2) at the time of appliance removal. Digital dental models were obtained using the 3Shape R700 3D laser scanner (3Shape A/S, Copenhagen, Denmark). Transversal widths, arch perimeter, arch length, palatal depth, palatal volume, canine and posterior tooth inclination were digitally measured. Paired t-test was used to perform interphase comparisons and independent t-test to perform intergroup comparisons (p<0.05). Results: In the experimental group, the expansion produced a ignificant increase of all maxillary transverse measurements, palatal volume, arch perimeter and palatal depth while decreased the arch length. RME caused a buccal tip of posterior teeth in patients with UCLP. No differences were observed between experimental and control groups for all the measurements performed except for the intermolar distance (6-6), which showed a greater increase in patients with cleft. Conclusion: Rapid maxillary expansion showed similar dentoalveolar effects in children with UCLP and without oral clefts. / Objective: The aim of this study was to evaluate the dentoalveolar effects of rapid maxillary expansion in children with unilateral complete cleft lip and palate in comparison with non-cleft patients. Methods: The experimental group (EG) was composed of 25 patients with unilateral and complete cleft lip and palate (9 males and 15 females) with a mean age of 10.6 years. The control group (CG) comprised of 27 patients without cleft lip and palate (14 males and 13 females) with a mean age of 9.1 years. Dental models of the maxillary dental arch were obtained immediately preexpansion (T1) and 6 months post-expansion (T2) at the time of appliance removal. Digital dental models were obtained using the 3Shape R700 3D laser scanner (3Shape A/S, Copenhagen, Denmark). Transversal widths, arch perimeter, arch length, palatal depth, palatal volume, canine and posterior tooth inclination were digitally measured. Paired t-test was used to perform interphase comparisons and independent t-test to perform intergroup comparisons (p<0.05). Results: In the experimental group, the expansion produced a ignificant increase of all maxillary transverse measurements, palatal volume, arch perimeter and palatal depth while decreased the arch length. RME caused a buccal tip of posterior teeth in patients with UCLP. No differences were observed between experimental and control groups for all the measurements performed except for the intermolar distance (6-6), which showed a greater increase in patients with cleft. Conclusion: Rapid maxillary expansion showed similar dentoalveolar effects in children with UCLP and without oral clefts.

Novas interfaces homem-computador têm sido pesquisadas a fim de se tornarem mais naturais e flexíveis. O rastreamento labial, foco deste trabalho, é parte deste contexto, podendo ser utilizado na detecção de emoções, bem como no auxílio ao reconhecimento de voz. Pode assim tornar-se um módulo inicial para a leitura labial, na criação de interfaces voltadas a deficientes auditivos. Os algoritmos disponíveis na literatura foram analisados e comparados, mostrando os prós e contras de cada método. Finalmente foi escolhido desenvolver uma técnica baseada em Active Appearance Model (AAM). O AAM gera um modelo a partir de um conjunto de imagens de treinamento, que pode ser utilizado no rastreamento labial de novas imagens. A técnica proposta baseia-se no uso de algoritmos genéticos para o ajuste do modelo, diferente, portanto, da técnica proposta originalmente pelo AAM. A convergência da técnica proposta foi extensivamente analisada, com a variação de parâmetros, buscando a análise de erro residual da função custo e sua relação com o tempo de convergência e erro de posição. / New human-computer interfaces have been researched to make them more natural and flexible. The lip tracking, emphasis of this work, is part of this setting it can be used for detecting emotions and to aid the speech recognition. It may well become an initial module for lip-reading, in the creation of interfaces directed to hearing impaired people. Algorithms available on literature are analyzed and compared, explaining the upsides and downsides of each method. Finally was chose to develop a technique based on Active Appearance Model (AAM). The AAM generates a model from a set of training images, which can be used in tracking of new lip images. The proposed technique is based on the use of genetic algorithms for fitting the model, different therefore of the technique originally proposed by AAM. The convergence of the proposed technique has been extensively analyzed with the variation of parameters, searching the error analysis of the cost function residual error and its relation to the execution time and position error.