O problema de dimensionamento de lotes, objeto desse estudo, considera um ambiente composto por múltiplas plantas independentes, múltiplos itens e múltiplos períodos. O ambiente de produção tem capacidade limitada e as plantas podem produzir os mesmos itens. Cada planta tem uma demanda própria e é permitida a transferência de lotes entre as plantas, o que envolve um certo custo. Este problema tem como caso particular o de dimensionamento de lotes com máquinas paralelas. O objetivo desta dissertação é propor uma heurística baseada na meta-heurística GRASP (Greedy Randomized Adaptive Search Procedures). Além disso, uma estratégia path relinking foi incorporada ao GRASP como uma fase de melhoria do algoritmo. Para verificar a eficiência da heurística proposta, os seus resultados são comparados aos da literatura tanto no caso de máquinas paralelas quanto no de múltiplas plantas. Como resultado, o problema de múltiplas plantas obteve melhores resultados quando comparado aos da heurística da literatura. Com relação ao problema de máquinas paralelas, a heurística proposta se mostrou competitiva / The lot sizing problem, which is the aim of this study, considers an environment consisting of multiple independent plants, multiple items and multiple periods. The production environment has limited capacity and the plants can produce the same items. Each plant has its own demand and the lot transfers between the plants are permitted, which involves a certain cost. This problem has as a particular case the parallel machines lot sizing problem. The objective of this dissertation is to propose a heuristic based on the GRASP (Greedy Randomized Adaptive Search Procedures). Furthermore, a path relinking phase is embedded in the GRASP to obtain better performance. To verify the efficiency of the proposed heuristic, its results were compared with the literature as for the multi-plant as for parallel machines problem. Computational tests showed that the proposed heuristic performed better than other literature heuristic concerning the multiplant problem. Concerning the parallel machines, the heuristic is competitive

As decisões operacionais de produção em uma indústria de fiação são planejadas na prática determinando soluções dos sub-problemas de dimensionamento e sequenciamento de lotes e da mistura de fardos de algodão. As tarefas são: definir o tamanho, a sequência, o tempo e alocação de cada lote de produção e quais fardos de algodão devem ser utilizados na produção. Por si só, os sub-problemas representam grandes desafios no planejamento da produção. Entretanto, para melhor representar o ambiente produtivo e alcançar custos de produção mais baixos, indústrias de processo, como as de fiação, procuram integrar mais e mais seus sub-problemas de planejamento. O objetivo dessa tese é apresentar modelos matemáticos e métodos de solução para auxiliar a tomada de decisão no nível operacional do planejamento da produção. Três formulações matemáticas para o dimensionamento e sequenciamento de lotes em um sistema de dois estágios com produção sincronizada são propostas. Um novo método baseado em programação matemática e metaheurísticas e também desenvolvida para a solucão desse sub-problema. Além disso, a integração das decisões relativas a matéria-prima (fardos de algodão) ao dimensionamento e sequenciamento de lotes é analisada. As novas formulações propostas representam de forma mais realista o problema de dimensionamento e sequenciamento de lotes da indústria de fiação e de indústrias de processo com ambiente produtivo similares. O método de solução encontra boas soluções para o problema e supera outros méodos similares presentes em softwares comerciais. Além disso, o método é geral o suficiente para a solução de outros problemas de otimização. O problema integrado de dimensionamento e sequenciamento de lotes e mistura comprovou que restrições relativas à qualidade dos fios influenciam os custos e viabilidade do planejamento da produção. O planejamento integrado dessas óperações trata o sistema considerando restrições que se relacionam, definindo planos de produção mais realistas / In the practice of a spinning industry, the operational decisions of the production planning are determined by the hierarchical solution of the lot-sizing and scheduling problem and the blending problem of the cotton bales. The tasks are: to define the size, sequence, timing and allocation of each production lot and to select which cotton bales are used for production. Each of these problems represents a large challenge in planning the production. However, in order to better represent the production environment and to reach lower production costs, process industries (as the spinning industry) are integrating more and more of the production sub-problems into the planning. The aim of this thesis is to propose novel mathematical models and solution methods to assist the decision maker to plan the production at the operational level. Three formulations for the synchronized two-stage lot sizing and scheduling are proposed. A new method based on mathematical programming and metaheuristics is also developed to solve this sub-problem. In addition, the integration of the lot sizing and scheduling with decisions related to the raw materials (cotton bales) is analyzed. The novel models represent a more realistic lot sizing and scheduling for the spinning industry and process industries of similar production environment. The solution method finds good solutions to the mentioned problem and outperforms other state-of-the-art methods incorporated in commercial softwares. Moreover, the method is general enough to solve other optimization problems. The integrated lot-sizing, scheduling and blending prove that constraints related to the yarn quality influence the costs and the feasibility of the production planning. The integrated planning of these operations approaches the system considering the constraint relationship and defines more realistic production plans

Nesta tese é abordado o problema da mochila compartimentada e o problema de corte de estoque unidimensional acoplado ao problema dimensionamento de lotes. Para o problema da mochila compartimentada é apresentada a versão unidimensional e proposta a versão bidimensional, denominados como problema da mochila compartimentada unidimensional e problema da mochila compartimentada bidimensional, respectivamente. Para o problema de corte de estoque acoplado ao dimensionamento de lotes são apresentadas três variações: uma máquina para produzir um tipo de objeto; uma máquina para produzir vários tipos de objetos; múltiplas máquinas para produzir vários tipos de objetos. Algumas formulações matemáticas de programação inteira e inteira-mista, decomposições dos problemas em problema mestre e subproblemas e heurísticas baseadas no método geração de colunas são propostas para os problemas da mochila compartimenta e o problema acoplado. Em específico, para o problema acoplado são aplicadas decomposições Dantzig-Wolfe, que podem ser por período, por máquina ou por período e máquina. Além disso, uma heurística baseada em grafo E/OU é proposta para o problema da mochila compartimentada bidimensional / In this thesis we present the constrained compartmentalized knapsack problem and the one dimensional cutting stock problem integrated with the capacitated lot sizing problem. For the constrained compartmentalized knapsack problem, the one dimensional version is presented and the two dimensional version is proposed, called one-dimensional compartmentalized knapsack problem and two-dimensional compartmentalized knapsack problem, respectively. For the cutting stock problem integrated with the capacitated lot sizing problem three variations are considered: one machine to produce one type of object; one machine to produce multiple types of objects; multiple machines to produce multiple types of objects. Some integer and mixed programming formulations, decompositions of the problems in master problem and subproblems and heuristics based on column generation method are proposed for the compartmentalized knapsack problem and the cutting stock problem integrated with the capacitated lot sizing problem. In particular, the period, the machine, and the period and machine Dantzig- Wolfe decompositions are applied for the integrated problem. Moreover, a heuristic based on the graph AND/OR is proposed for the two-dimensional compartmentalized knapsack problem. Computational results show that these mathematical formulations and methods provide good solutions

O problema de dimensionamento de lotes com restrições de capacidade (CLSP) consiste em determinar um plano de produção que satisfaça a demanda requerida, respeitando as limitações de capacidade, com o menor custo possível, ou seja, minimizando os custos de produção, estocagem e preparação de máquina. Encontrar uma solução factível para o CLSP, considerando tempo de preparação de máquina, é NP-completo. Nesta dissertação, para a resolução do CLSP, utiliza-se a decomposição de Dantzig-Wolfe e o procedimento de geração de colunas, encontrando bons limitantes inferiores. Duas diferentes estratégias de decomposição são exploradas, decomposição por itens e períodos. Para a obtenção de uma solução inteira para o problema (limitante superior) foram exploradas heurísticas lagrangianas, onde a solução inicial para as heurísticas provém da geração de colunas. Os limitantes obtidos podem ser utilizados em métodos exatos, como por exemplo, em algoritmos do tipo branch-and-price. Experimentos computacionais, baseados em exemplares gerados aleatoriamente, foram realizados e os resultados analisados, as variações dos parâmetros das instâncias foram sugeridas na literatura / The Capacitated Lot Sizing Problem (CLSP) consists in determining a production plan such that all demands are met and the total costs of production, inventory and setup are minimized. Since the problem to find a feasible solution to the CLSP with setup times is NP-complete, large problem instances have been solved by heuristic methods. In this dissertation, we are particularly concerned in using the methodology of Dantzig-Wolfe decomposition and column generation to generate good bounds to the CLSP with setup times and costs. Here, we analyse two types of decomposition which are based on items and time periods (lower bound) and some lagrangian-based heuristics (upper bound). Numerical results based on randomly generated intances suggest that highquality lower bounds are obtained by column generation algorithms, such as well as upper bounds by heuristics. These bounds are useful in exact solution methods, such as branch-and-price algorithms

This dissertation is devoted to the modeling, analysis and development of solution approaches for some optimization-related problems encountered in industrial and manufacturing settings. We begin by introducing a special type of traveling salesman problem called "High Multiplicity Asymmetric Traveling Salesman Problem" (HMATSP). We propose a new formulation for this problem, which embraces a flow-based subtour elimination structure, and establish its validity for this problem. The model is, then, incorporated as a substructure in our formulation for a lot-sizing problem involving parallel machines and sequence-dependent setup costs, also known as the "Chesapeake Problem". Computational results are presented to demonstrate the efficacy of our modeling approach for both the generic HMATSP and its application within the context of the Chesapeake Problem. Next, we investigate an integrated lot-sizing and scheduling problem that is encountered in the primary manufacturing facility of pharmaceutical manufacturing. This problem entails determination of production lot sizes of multiple products and sequence in which to process the products on machines, which can process lots (batches) of a fixed size (due to limited capacity of containers) in the presence of sequence-dependent setup times/costs. We approach this problem via a two-stage optimization procedure. The lot-sizing decision is considered at stage 1 followed by the sequencing of production lots at stage 2. Our aim for the stage 1 problem is to allocate batches of products to time-periods in order to minimize the sum of the inventory and backordering costs subject to the available capacity in each period. The consideration of batches of final products, in addition to those for intermediate products, which comprise a final product, further complicates the lot-sizing problem. The objective for the stage 2 problem is to minimize sequence-dependent setup costs. We present a novel unifying model and a column generation-based optimization approach for this class of lot-sizing and sequencing problems. Computational experience is first provided by using randomly generated data sets to test the performances of several variants of our proposed approach. The efficacy of the best of these variants is further demonstrated by applying it to the real-life data collected with the collaboration of a pharmaceutical manufacturing company. Then, we address a single-lot, lot streaming problem for a two-stage assembly system. This assembly system is different from the traditional flow shop configuration. It consists of m parallel subassembly machines at stage 1, each of which is devoted to the production of a component. A single assembly machine at stage 2, then, assembles products after components (one each from the subassembly machines at the first stage) have been completed. Lot-detached setups are encountered on the machines at the first and second stages. Given a fixed number of transfer batches (or sublots) from each of the subassembly machines at stage 1 to the assembly machine at stage 2, our problem is to find sublot sizes so as to minimize the makespan. We develop optimality conditions to determine sublot sizes for the general problem, and present polynomial-time algorithms to determine optimal sublot sizes for the assembly system with two and three subassembly machines at stage 1. Finally, we extend the above single-lot, lot streaming problem for the two-stage assembly system to multiple lots, but still, for the objective of minimizing the makespan. Due to the presence of multiple lots, we need to address the issue of the sequencing of the lots along with lot-splitting, a fact which adds complexity to the problem. Some results derived for the single-lot version of this problem have successfully been generalized for this case. We develop a branch-and-bound-based methodology for this problem. It relies on effective lower bounds and dominance properties, which are also derived. Finally, we present results of computational experimentation to demonstrate the effectiveness of our branch-and-bound-based methodology. Because of the tightness of our upper and lower bounds, a vast majority of the problems can be solved to optimality at root node itself, while for others, the average gap between the upper and lower bounds computed at node zero is within 0.0001%. For a majority of these problems, our dominance properties, then, effectively truncate the branch-and-bound tree, and obtain optimal solution within 500 seconds. / Ph. D.

In this dissertation, we develop novel approaches to independently address two issues that are commonly encountered in machine scheduling problems: uncertainty of problem parameters (in particular, due to job processing times), and batching of jobs for processing on capacitated machines. Our approach to address the uncertainty issue regards the indeterminate parameters as random variables, and explicitly considers the resulting variability of a performance measure. To incorporate variability into the schedule selection process, we develop a method to evaluate both the expectation and variance of various performance measures for a given schedule. Our method is based on the use of mixture models to approximate a variety of distribution types. The Expectation-Maximization algorithm of Dempster et al. (1977) is applied to derive mixture models of processing time distributions. Our method, then, utilizes these mixture models to calculate the distributions of other random variables in order to derive the expectation and variance of various scheduling performance measures, assuming that the job sequencing decisions are known a priori. To make our method more computationally efficient, we adapt a mixture reduction method to control the number of mixture components used in the intermediate steps. We apply our method to two different scheduling problems: the job shop makespan scheduling problem and the single machine total weighted tardiness scheduling problem, and compare its performance with that of Monte-Carlo method. The results show the efficacy of our mixture approximation method. It generates fairly accurate results while requiring significantly less CPU times. The proposed method offers a good compromise between the Monte Carlo method, which requires extensive effort, and use of simple normal approximation, which produces lower-quality results. Next, we introduce and demonstrate for the first time in the literature the use of conditional-value-at-risk (CVaR) as a criterion for stochastic scheduling problems in order to obtain risk-averse solutions. This criterion has the tendency of minimizing both the expectation and variance of a performance measure simultaneously, which is an attractive feature in the scheduling area as most of the literature in this area considers the expectation and variance of a performance measure separately. Also, the CVaR has an added advantage of maintaining a linear objective function. We develop a scenario-based mixed integer programming formulation to minimize CVaR for the general scheduling problem involving various performance measures, and employ a decomposition-based approach for its solution. Furthermore, a set of valid inequalities are incorporated to strengthen the relaxed master problem of this decomposition scheme. The proposed approach is demonstrated on the single machine total weighted tardiness scheduling problem. Our computational investigation reveals the efficacy of the proposed decomposition approach and the effectiveness of using the CVaR as an optimization criterion for scheduling problems. Besides providing an exact approach to solve our stochastic scheduling problem, we also develop an efficient heuristic method to enable the use of CVaR for large-sized problems. To that end, we modify the Dynasearch method of Grosso et al. (2004) to minimize CVaR for a stochastic scheduling problem. Furthermore, we extend the application of CVaR to a parallel-machine total weighted tardiness problem. The use of CVaR appears to be quite promising for simultaneously controlling both the expected value and variability of a performance measure in a stochastic scheduling environment. Scenario-based formulations have frequently been used for stochastic scheduling problems. However, the determination of a lower bound can be a time-consuming task for this approach. Next, we develop a new method for scenario generation that is computationally competitive and that assures attainment of an exact lower bound. Our approach is based on discretization of random parameter distributions of job processing times. We use the idea of Recursive Stratified Sampling to partition the probability space, so that the conditional expectations in each region yield scenario-wise parameter values. These scenarios are, then, used to formulate a two-stage stochastic program, which yields a lower bound for the original stochastic problem. We provide theoretical basis of our bounding approach for both the expectation and CVaR objectives. Our discrete bounding method generates exact lower bounds, as against the probabilistic bounds generated by Sample Average Approximation. We also present results of our numerical experimentation to compare the performances of these two approaches in terms of the bound value obtained and the CPU time required. The problem pertaining to integrated batching and scheduling of jobs on capacitated parallel machines that we consider arises in the primary manufacturing sector of a pharmaceutical supply chain. We, first, develop a comprehensive mathematical programming model that can accommodate various realistic features of this problem. These features include batch production, sequence-dependent setup time/cost, and inter-period carryover of setup status. We further derive several valid inequalities that are based on the embedded subproblem structure. We also consider an alternative formulation (termed the Plant Location model) based on the lot-sizing perspective of the problem. Noting the resemblance of the campaign sequencing subproblem to the high multiplicity asymmetric traveling salesman problem (HMATSP), we adapt various ideas from the HMATSP to enforce the connectivity of the sequencing graph. Due to the complexity of this problem, we also explore the possibility of applying column generation technique for its solution. Various schemes of problem decomposition are considered, along with the use of dual stabilization technique to improve the convergence of the column generation procedure. We also develop heuristic methods to generate initial feasible solutions that further enhance the performance of the column generation method. A computational experimentation has been conducted on a data set that mimics real-life problem instances. It illustrates the effectiveness of using the proposed column generation method. / Ph. D.

Nous nous intéressons au Problème de Dimensionnement de Lots mono-produit (PDL) dans une chaîne logistique composée d'un détaillant et d'un fournisseur en y intégrant le contrat buyback et l'approvisionnement par batch. L'objectif est de déterminer un plan d'approvisionnement pour le détaillant pour satisfaire ses demandes déterministes sur un horizon fini, tout en minimisant ses coûts d'approvisionnement et de stockage. Concernant le coût d'approvisionnement, nous supposons deux structures différentes : FTL (Full Truck Load) et OFB (Only Full Batch). Trois types de contrat buyback sont étudiés : avec des périodes de retour fixes, avec une limite de temps sur les retours, et avec des retours uniquement dans les périodes d'approvisionnement. Chaque contrat est caractérisé par un pourcentage de retour maximal qui peut être égal à 100% (retour total) ou inférieur à 100% (retour partiel). Pour le PDL sous le contrat buyback avec des périodes de retour fixes, nous supposons le cas de ventes perdues (lost sales). En outre, un autre concept ajouté dans les PDL sous les trois types de contrat buyback réside dans le fait que le détaillant peut jeter la quantité invendue et non retournée au fournisseur, appelé mise au rebut (disposal). Nous avons modélisé ces différentes extensions du PDL par des Programmes Linéaires en Nombres Entiers (PLNE). Nous avons ensuite développé des algorithmes exacts polynomiaux de programmation dynamique pour certaines extensions, et montré la NP-difficulté pour d'autres. Pour chaque problème résolu en temps polynomial, nous avons comparé l'efficacité et les limites de l'algorithme proposé avec celles des quatre formulations en PLNE. Nous avons également proposé des modèles mathématiques pour les PDL sous d'autres types de contrats de réservation de capacité dans le cas déterministe à multi-périodes. / We study the single-item Lot Sizing Problem (LSP) in a supply chain composed of a retailer and a supplier by integrating the buyback contract and the batch ordering. The purpose is to determine a replenishment planning for the retailer to satisfy his deterministic demands over a finite horizon, while minimizing the procurement and inventory costs. Regarding the procurement cost, we assume two different structures: FTL (Full Truck Load) and OFB (Only Full Batch). We consider three types of buyback contract: with fixed return periods, with a time limit on returns, and with returns permitted only in procurement periods. Each contract is characterized by the maximum return percentage being either equal to 100% (full return) or less than 100% (partial return). For the LSP under the buyback contract with fixed return periods, we assume the concept of lost sales. Another concept considered in the LSP's under the three types of buyback contract is the disposal of the unsold and unreturned quantities. We model these different LSP extensions as a Mixed Integer Linear Program (MILP). Thereafter, we develop exact polynomial time dynamic programming algorithms for some extensions and show the NP-hardness of others. For each problem solved in polynomial time, we compare the efficiency and the limits of the proposed algorithm with those of four MILP formulations by performing different tests. Finally, we propose mathematical models for the LSP's under other types of the capacity reservation contract in the deterministic and multi-period case.

O presente trabalho trata do problema integrado de dimensionamento e sequenciamento de lotes de produção. O processo de dimensionar e sequenciar lotes de produção consiste em determinar quanto produzir de cada produto e a sequência de produção desses lotes em cada máquina a cada período a fim de atender a uma demanda prevista sob as condições e capacidades operacionais existentes. O caso estudado nesse trabalho aborda o cenário de uma empresa de grande porte da indústria de bens de consumo de higiene pessoal, um mercado bastante concorrido no qual o bom nível de serviço de atendimento e a gestão de custos mostram-se essenciais na competição pelos clientes. Nessa empresa, existe um ambiente operacional complexo, composto por máquinas distintas em paralelo com capacidade limitada de produção cujos tempos de preparação (setup) são dependentes da sequência de produção, além de uma restrição de capacidade de armazenagem dos produtos fabricados, característica não encontrada na literatura existente. Os clientes permitem que ocorram atrasos de atendimento da demanda, porém isso é extremamente indesejável. Esse tipo de problema é NP-difícil, sendo geralmente tratado na literatura por heurísticas. Nesse trabalho, elaboramos nove diferentes estratégias de resolução baseadas na heurística relax-and-fix. O objetivo é, não somente resolver um problema real complexo, como também avaliar se o modo de articionamento e a sequência de resolução dos subproblemas influencia no desempenho da heurística. Os testes computacionais foram conduzidos em instâncias geradas aleatoriamente e em casos reais. Os resultados mostraram um bom desempenho e robustez da abordagem proposta. Técnicas alternativas foram aplicadas na estratégia com os melhores resultados para potencializar seu desempenho. / This work adresses the integrated lot sizing and scheduling problem. The process of lot sizing and scheduling consists of determining how much to produce of each product and the scheduling of these lots in each machine in order to meet the demand under existing restrictions and operational capabilities. The case studied in this work describes the scenario of a big company in the industry of consumer goods for personal hygiene, a very competitive market in which the good service level for customers and the cost management show up in the competition for the clients. In this company, there is a complex operational environment, composed of distinct parallel machines with limited production capacity and sequence dependente setup times. There is also a limited finished goods storage capacity, a characteristic not found in the existing literature. Backordering is allowed but it is extremely undesirable. This problem is NP-hard and it has been treated by heuristics in the literature. In this work, we developed nine different solving strategies based on the relax-and-fix heuristics. The aim of this approach is not only to solve a complex real problem but also assess whether the form of partitioning and the sequence of solving the subproblems influences the performance of the relax-and-fix heuristics. The computational experiments were conducted on ramdomly generated instances and real problems. The results showed the good performance and the robustness of the proposed approach. Alternative techniques were applied in the strategy with the best results in the previous tests to enhance its performance.

Este trabalho aborda o problema multiestágio de planejamento e programação da produção em indústrias cervejeiras. O processo de fabricação de cerveja pode ser dividido em duas etapas principais: preparação do líquido e envase. A primeira etapa ocorre, na maior parte do tempo, dentro de tanques de fermentação e maturação. A segunda ocorre nas linhas de envase, podendo ter início assim que o líquido estiver pronto nos tanques. O tempo de preparação do líquido demora vários dias, enquanto que na maioria das indústrias de bebidas carbonatadas este tempo é de no máximo algumas horas. O objetivo deste estudo é obter planos de produção viáveis que visam otimizar as decisões de programação envolvidas nestes processos. Visitas a cervejarias no Brasil e em Portugal foram realizadas para uma maior familiaridade do processo de produção e dados foram coletados. Modelos de programação inteira mista para representar o problema foram desenvolvidos, baseados em abordagens CSLP (The Continuous Setup Lot-Sizing Problem), GLSP (General Lot Sizing and Scheduling Problem), SPL (Simple Plant Location Problem) e ATSP (Asymmetric Travelling Salesman Problem). Os resultados mostram que os modelos são coerentes e representam adequadamente o problema, entretanto, mostram-se difíceis de serem resolvidos na otimalidade. Esta dificuldade de resolução dos modelos motivou o desenvolvimento de procedimentos MIP-heurísticos, como também de uma metaheurística GRASP (Greedy Randomized Adaptive Search Procedure). As soluções obtidas pelos procedimentos heurísticos são de boa qualidade, quando comparadas ao melhor limitante inferior encontrado por meio da resolução dos modelos matemáticos. Os testes computacionais foram realizados utilizando instâncias geradas com base em dados reais. / This study deals with the multistage lot-sizing and scheduling problem in breweries. The brewing process can be divided into two main stages: preparation and filling of the liquid. The first stage occurs most of the time in fermentation and maturation tanks. The second stage occurs in the filling lines and it can start as soon as the liquid gets ready. The preparation time of the liquid takes several days, while in the carbonated beverage industries this time is at most a few hours. The purpose of this study is to obtain feasible production plans aimed at optimizing the decisions involved in these processes. Visits to brewery industries in Brazil and Portugal were held to a greater familiarity of the production process and data were collected. Mixed integer programming models have been developed to represent the problem, based on approaches for the CSLP (The Continuous Setup Lot-Sizing Problem), GLSP (General Lot Sizing and Scheduling Problem), SPL (Simple Plant Location Problem) and ATSP (Asymmetric Travelling Salesman Problem). The results show that the models are consistent and adequately represent the problem; however, they are difficult to be solved at optimality. This motivated the development of MIP-heuristic procedures, as well as a meta-heuristic GRASP (Greedy Randomized Adaptive Search Procedure). The obtained solutions by the heuristics are of good quality, when compared to the best lower bound found by solving the mathematical models. The tests were conducted using generated instances based on real data.

O setor industrial produtor de papel e celulose tem aumentado sua relevância comercial nas últimas décadas devido à demanda constantemente crescente. O aumento na competitividade do setor gerado pela economia globalizada e a dificuldade de desenvolvimento de bons planos de produção em ambientes produtivos cada vez mais complexos têm motivado a pesquisa por novas e efetivas ferramentas de auxílio à tomada de decisão. Considerando estas dificuldades, abordamos neste trabalho o problema de dimensionamento e sequenciamento de lotes com foco em empresas com processo integrado de produção de celulose e de papel. Trata-se de um problema de planejamento de médio a curto prazo, geralmente com maior enfoque no curto prazo por considerar o planejamento detalhado da produção em horizontes de planejamento que não superam 30 dias. No processo integrado de celulose e papel, foram consideradas as decisões de produção do digestor, evaporador, caldeira de recuperação e de múltiplas máquinas produtoras de papel, além do controle de estoque de produtos intermediários e finais. Modelos matemáticos da literatura foram modificados e estendidos para incorporar características adicionais do problema como, por exemplo, processos com múltiplas máquinas de papel. Além disso, foram desenvolvidas heurísticas construtivas, heurísticas de melhoria, abordagens de solução híbridas baseadas em algoritmos genéticos combinadas com ferramentas comerciais de solução exata, além de combinações entre os métodos. As abordagens desenvolvidas foram testadas computacionalmente e as melhores combinações de métodos foram definidas. De forma geral, os resultados dessas abordagens foram superiores aos obtidos por ferramentas de solução comerciais puras. Ademais, a variação proposta da heurística de melhoria fixe-e-otimize com mudanças na função objetivo se destacou com relação aos demais métodos, obtendo os melhores resultados, independentemente da qualidade da solução inicial utilizada. As principais contribuições desta tese são a apresentação de modelos matemáticos para representar apropriadamente o problema estudado, e o desenvolvimento de métodos de solução efetivos para resolver o problema. / The pulp and paper industry has been increasing the commercial importance in recent decades due to the constant growing demand. The increasing competitiveness of this sector generated by the globalized economy and the difficulty to develop good production plans in complex production environments have motivated the search for new and effective decision support systems. Given these difficulties, in this thesis we address the lot sizing and scheduling problem focused on integrated pulp and paper mills. This is a problem of medium to short term planning, generally more focused on the short term as it covers detailed production schedules in planning horizons which do not exceed 30 days. In these integrated pulp and paper process the production decisions of digester, evaporator, recovery boiler and multiple paper machines are considered, apart from the inventory control of intermediate and final products. Mathematical models known in the literature were modified and extended to incorporate additional features of the problem, such as processes with multiple paper machines. In addition, constructive and improvement heuristics, and hybrid methods based on genetic algorithms combined with a commercial solver were developed, as well as combinations of these solution approaches. The methods developed were computationally tested and the best combinations of methods were defined. Overall, the results of these methods were superior to the solutions obtained by pure commercial solvers. Moreover, the alternative variation proposed of the improvement heuristic fix-and-optimize with exchanges in the objective function surpassed the other methods, obtaining the best results, regardless of the quality of the initial solution used. The main contribution of this thesis are the presentation of mathematical models that appropriately represents the problem under study, and the development of effective solution methods to deal with the problem.