This dissertation examines the various ways in which the experience of psychoactive drugs such as marijuana, LSD, and other substances influenced the development of psychedelic music on the West Coast during the Sixties. The first chapter of this work chronicles the evolution of mainstream America's understanding of psychoactive drugs. It focuses, in particular, on the role of mid-century figures such as Aldous Huxley, Ken Kesey, and Timothy Leary in disseminating the psychedelic paradigm, which held that certain psychoactive substances were capable of helping individuals gain a greater understanding of themselves, others, and the nature of existence. The second chapter of this work explores how the term "psychedelic," and the experiences the term espouses, came to be used as musical descriptors. It specifically details the various ways that amateur participation, musical eclecticism, and technological advances resulted in highly innovative works that provided surreal experiences similar to the drugs that shared their name. Chapter three explores self-report and laboratory research concerning the subjective effects of marijuana and LSD on the experience of sound, music, and creativity. It also presents new findings from a self-report study of 181 participants, which examined the various ways that marijuana affects the appreciation of specific musical sounds. The fourth and final chapter performs a psycho-aesthetic analysis of three examples of psychedelic music using the findings discussed in chapter three and theories from the field of music cognition. It posits various ways in which a direct relationship can be appreciated between the subjective effects of certain psychedelic substances and the experience of psychedelic music. In some instances, it asserts that psychedelic music can be understood to be emulating the effects of substances through its incorporation of sounds and musical structures that are emblematic of the specific effects of these drugs. In others, it suggests that these drugs enhance the experience of psychedelic music by playing upon the altered sensibilities of listeners who were experiencing its sounds under their effects. / 2017-05-01T00:00:00Z

Psychedelics are currently being researched due to their long-lasting antidepressant, anxiolytic and neuroplasticity inducing actions. The mechanism by which they induce these effects remains poorly understood. Here, we decided to investigate a relatively unexplored possibility. A potential interaction of psilocybin administration and sleep and their combined effects on memory consolidation. Memory formation in animals and humans is greatly influenced by sleep manipulation which led us to assess the possibility with spatial memory tasks. We hypothesized that acute psilocybin administration after learning may have a beneficial influence on memory consolidation in rats. To determine whether an interaction with sleep exists we also subjected the rats to combinations of psilocybin and control vehicle with normal sleep and sleep deprivation. Our data did not suggest such an interaction exists. Secondly, we tried to find out if psilocybin and sleep manipulation leads to changes in neuroplasticity-related events. A process that could very likely be the basis of such a proposed beneficial effect. For this purpose, we analysed the expression of the immediate-early gene Arc and the immature neuron marker doublecortin in the rat hippocampus. Doublecortin's expression was not influenced by any of the factors....

Depois de apresentar as origens históricas da contracultura, no Brasil e nos Estados Unidos, e contextualizar um pouco das relações entre os integrantes destes movimentos e o uso de drogas, sobretudo maconha e ácido lisérgico, esse trabalho traça, através principalmente da análise de trajetórias individuais que se cruzam de uma forma ou de outra, uma história social da chegada do LSD ao Brasil. O trabalho investiga, com profundidade, o primeiro processo judicial por tráfico e porte da substância, iniciado em janeiro de 1970, em São Paulo, estudando a trajetória dos principais réus, a repercussão midiática, os relatos feitos a posteriori e as formas de ação da polícia e da justiça, em um momento em que não só a ditadura militar vivia sua fase mais violenta, após o AI-5, como também vigorava a lei de drogas mais dura que o país já teve. Analisando os autos de dito processo, e também uma ampla variedade de outras fontes, orais e documentais, apresenta-se como se desenrolou o começo da repressão ao LSD no Brasil, e recupera-se também como foi a chegada da substância ao país, que se deu pela via medicinal na virada dos anos 1950 para os 1960. / After presenting the historical origins of the counterculture in Brazil and in the United States, and also after contextualizing some of the relations between the members of these movements and the use of drugs, especially marijuana and lysergic acid, this work traces, mainly through the analysis of individual trajectories which intersect in one way or another, a social history of the arrival of LSD in Brazil. This thesis investigates in depth the first judicial process for trafficking and possession of the substance, begun in January 1970, in São Paulo, studying the trajectory of the main defendants, the media repercussion, the reports made a posteriori and the forms of action of the police and the justice system, at a time when not only the military dictatorship was experiencing its most violent phase, after the \"AI-5\", but the hardest drug law in the country\'s history was also in force.By analyzing the files of this process, as well as a wide variety of other sources, both oral and documentary, the beginning of the repression of LSD in Brazil is described, as well as the medical origins of the substance\'s arrival in the country.

Depois de apresentar as origens históricas da contracultura, no Brasil e nos Estados Unidos, e contextualizar um pouco das relações entre os integrantes destes movimentos e o uso de drogas, sobretudo maconha e ácido lisérgico, esse trabalho traça, através principalmente da análise de trajetórias individuais que se cruzam de uma forma ou de outra, uma história social da chegada do LSD ao Brasil. O trabalho investiga, com profundidade, o primeiro processo judicial por tráfico e porte da substância, iniciado em janeiro de 1970, em São Paulo, estudando a trajetória dos principais réus, a repercussão midiática, os relatos feitos a posteriori e as formas de ação da polícia e da justiça, em um momento em que não só a ditadura militar vivia sua fase mais violenta, após o AI-5, como também vigorava a lei de drogas mais dura que o país já teve. Analisando os autos de dito processo, e também uma ampla variedade de outras fontes, orais e documentais, apresenta-se como se desenrolou o começo da repressão ao LSD no Brasil, e recupera-se também como foi a chegada da substância ao país, que se deu pela via medicinal na virada dos anos 1950 para os 1960. / After presenting the historical origins of the counterculture in Brazil and in the United States, and also after contextualizing some of the relations between the members of these movements and the use of drugs, especially marijuana and lysergic acid, this work traces, mainly through the analysis of individual trajectories which intersect in one way or another, a social history of the arrival of LSD in Brazil. This thesis investigates in depth the first judicial process for trafficking and possession of the substance, begun in January 1970, in São Paulo, studying the trajectory of the main defendants, the media repercussion, the reports made a posteriori and the forms of action of the police and the justice system, at a time when not only the military dictatorship was experiencing its most violent phase, after the \"AI-5\", but the hardest drug law in the country\'s history was also in force.By analyzing the files of this process, as well as a wide variety of other sources, both oral and documentary, the beginning of the repression of LSD in Brazil is described, as well as the medical origins of the substance\'s arrival in the country.

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The consumption of LSD and similar psychedelic drugs in New York City led to a great deal of cultural innovations that formed a unique psychedelic subculture from the early 1960s onwards. Historians and other commentators have offered conflicting views on this phenomenon by using either an epidemiological approach or by giving drug users more agency. The present study sides with the latter category to offer a new social history of LSD, but problematizes this topic in a sophisticated way by understanding psychedelic drug use as a social fact that in turn produces meaning for its consumers. It analyses the multiple cultural features of psychedelia through the lenses of politics, science, religion, and art, but also looks at the utopian and radical off-shoots of that subculture. To balance this thematic approach, it historicises the subculture by analysing its early days and discussing its origins, and then by pointing to the factors that led to its metamorphosis towards the end of the 1960s. In order to give LSD consumers a clearer voice, this dissertation is based on memoirs, correspondence and interviews that are used to balance press coverage gleaned from archival collections. With this wide array of primary sources supplemented by up-to-date secondary literature, it argues that the use of LSD and psychedelics led to a rich subculture that can be explained by the inherent complexity of the psychedelic experience. In turn, the plurality of opinions regarding the meaning and purposes of the experience led to tensions and polarisations within the large subculture, as well as with other drug subcultures and outsiders leery of illicit drug use. In doing so, this dissertation contributes to the social history of illicit substance consumption and adds to the fields of urban history and the history of subcultures, and makes a case for understanding LSD and psychedelics as a unique category of forbidden drugs that differ vastly in their cultural meaning from other drugs.

Informe de memoria radial para optar al título de Periodista / El programa radial “Psicodelia, ecos de un pasado” es un aporte al rescate de las historias tras una época de la cultura chilena. Desde la llegada del rock a Chile, pasando por el revolucionado momento que vivía el mundo entero en los años 60, hasta indagar en el fondo de las motivaciones y sustento de la naciente cultura hippie, el programa hace un recorrido por el fenómeno psicodélico y el impacto que tuvo en los potentes cambios culturales vividos en la segunda mitad del siglo XX en Chile. La investigación nace del interés por rescatar el rico patrimonio musical y sonoro de un momento que definimos como clave en la posterior construcción de una escena cultural en el país, a pesar del quiebre que supone el golpe de estado en 1973. ¿Hubo psicodelia en Chile? ¿Cómo vivieron los jóvenes la experimentación con drogas y la búsqueda de la libertad? ¿Cómo se viven hoy estas manifestaciones? Son algunas de las preguntas que se ponen en diálogo en este espacio radial, una invitación a revivir una época y su rico patrimonio musical.

Lumpy skin disease (LSD) is a disease of significant economic importance in Africa. It causes considerable production losses and its presence in semen is a constraint to international trade. Recent findings that LSDV viral DNA can be found in the semen of artificially infected bulls for up to five months, while viable virus could be isolated 42 days after infection, indicated the need for studies into the mechanism by which this protracted shedding occurs. Six healthy, seronegative, postpubertal Dexter bulls were housed in vector-free stables and challenged with LSD virus by intravenous injection. Sheath washes, vesicular fluid and semen collection was performed every other day and subjected to PCR. On these days, blood was collected for serum neutralization tests and virus isolation, and ultrasonography of the reproductive tracts performed. Semen was centrifuged to separate cell-rich and seminal plasma fractions, and tested by PCR. Clinical parameters were recorded twice daily. Bulls shedding viral DNA 28 days after challenge were slaughtered, their reproductive tracts were harvested and diagnostic post mortem was performed. Histopathology, immunoperoxidase staining, electron microscopy, virus isolation and PCR were done on tissue samples. Of the six bulls, two showed no clinical signs, two showed mild and two showed severe clinical signs. Fever appeared five to seven days and lesions eight to ten days post challenge. Bulls were viraemic and febrile during the same time. Viral DNA was detected in all semen fractions of all bulls, but mostly from the cell-rich fraction and from the bulls showing the most severe clinical signs. Ultrasonography showed infarction in the testes and epididymides of the two bulls that were most severely affected. Necropsy of the two bulls that were still shedding after 28 days showed testicular degeneration and infarction, as well as epididymal granuloma formation. None of the accessory sex organs showed significant pathology. Histopathological changes seen were necrogranulomata in testes and peididymides. IMP staining of reproductive tissues showed that staining was restricted to areas in the testes and epididymides that were associated with necrosis. Virus could be seen on negative staining EM of sections of the testes. Our results show that LSDV is not limited to specific fractions of the ejaculate and that the testes and epididymides are most profoundly affected. Blood contamination is not responsible for the presence of viral DNA in semen, and it is unlikely that the virus is sperm-associated. Results suggest that the ejaculate is contaminated with viral DNA as it is shed from necrotic lesions in the genital tract. Further research is indicated into the ability of infected semen to produce disease as well as treatment protocols that could render semen free of viral DNA. / Dissertation (MMedVet (Theriogenology))--University of Pretoria, 2006. / Production Animal Studies / unrestricted

Psychedelics—also known as hallucinogens and entheogens—comprise a family of psychoactive molecules that are both found in nature and synthetically engineered in the lab. As a class, psychedelic compounds produce phenomenologically complex and novel experiences that have recently captured the attention of mental health clinicians and researchers. However, psychedelic clinical research and treatment remain limited, with most studies exploring the efficacy and safety of protocols for individuals with anxiety, depression, substance use, and posttraumatic stress disorder (PTSD), while individuals with personal or familial histories of psychosis, psychotic disorders, and bipolar disorder are mostly excluded from treatment and research. The overarching objectives of this thesis included determining 1) whether excluding this group from psychedelic clinical research is justified, 2) when psychedelic drug administration and psychedelic-assisted psychotherapy (PAP) may be contraindicated for this group, 3) if people with a history of psychosis or a psychotic disorder may be able to treat their psychotic symptoms with PAP, 4) if people with a history of psychosis or psychotic disorder may be able to treat their co-morbid conditions like anxiety, depression, substance use, or PTSD with PAP, 5) what a PAP treatment protocol for this group could look like 6) how individuals with reported histories of psychosis and psychotic disorders describe their experiences of psychedelic drug use and 7) whether naturalistic psychedelic use has an overall positive or negative effect on emotional well-being and psychological functioning for this group. Results from the first study—a qualitative study with experts in medicine, mental health, and psychedelics—suggest that certain individuals with histories of psychosis and psychotic disorders may benefit from PAP under the right conditions, such as when psychosis is etiologically connected to traumatic events, when the protocol offers extensive support for the patient, and when psychosis is not the result of amphetamine use or medical conditions such as epilepsy. Moreover, results suggest that the effects of the specific psychedelic that is administered must be carefully considered and support outside of therapy must also be assessed. Other factors such as personality traits, ability to form rapport with a guide or sitter, symptom severity, specific symptom endorsement, symptom duration, age, the presence of physiopathology and more must also be taken into consideration. For the second study, a cross-sectional, retrospective, phenomenological survey report was administered to individuals who reported a history of one or more psychotic experiences and/or diagnosis of a psychotic condition who also had at least one psychedelic drug experience in their lifetime. The survey asked participants to describe one memorable instance of psychedelic drug use and found that in a sample of 100, most individuals (n=88) describe some degree of personal growth resulting from their experience. Many also describe mystical-type experiences, gaining insight or awareness during their experience, heightened appreciation for life, and improved mental health and emotional well-being. Descriptions of symptomatic relief included reduced paranoid thinking, changes in relationships with symptoms, and decreased suicidal ideation. Approximately 11% of the sample described negative experiences including perseverating psychological impairment, symptom exacerbation, and psychedelic-induced suicidality. A slightly larger portion of the sample described mixed-type experiences, i.e., experiencing positive and negative effects alongside each other. The findings of these studies fill a major gap in the literature by suggesting that individuals with histories of psychotic symptoms and disorders may be able to partake in psychedelic studies and treatment under certain circumstances. This is because experts have explicitly stated that psychedelic use is not necessarily contraindicated for everyone with psychotic conditions and symptoms, but rather that most PAP protocols for anxiety, depression and other conditions do not offer enough support. At the same time, exclusion criteria are required by the FDA. Additionally, survey reports from individuals with lived experiences of psychosis further back the position that PAP could be a viable treatment option for this group through their survey reports. Specifically, the high prevalence of positive and therapeutic experiences with psychedelics in naturalistic settings suggests that clinically supervised psychedelic drug use may generate similar or even better outcomes for this population. Although a minority had adverse experiences, it remains to be studied as to whether similar effects might be experienced at a similar rate or similar degree of frequency in clinical studies, which utilize harm reduction strategies, maximize safety, and implement preparatory and integration sessions, elements which were notably absent from reports of adverse experiences in the survey. Results also shed light on what a psychedelic treatment protocol could look like for this group, and how individuals with histories of psychotic experiences and diagnosed psychotic conditions describe their experiences of psychedelic use and the effects of psychedelic drugs on their emotional and psychological functioning.

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