Under item response theory, three types of limited information goodness-of-fit test statistics – M2, Mord, and C2 – have been proposed to assess model-data fit when data are sparse. However, the evaluation of the performance of these GOF statistics under multidimensional item response theory (MIRT) models with polytomous data is limited. The current study showed that M2 and C2 were well-calibrated under true model conditions and were powerful under misspecified model conditions. Mord were not well-calibrated when the number of response categories was more than three. RMSEA2 and RMSEAC2 are good tools to evaluate approximate fit. The second study aimed to evaluate the psychometric properties of the Religious Commitment Inventory-10 (RCI-10; Worthington et al., 2003) within the IRT framework and estimate C2 and its RMSEA to assess global model-fit. Results showed that the RCI-10 was best represented by a bifactor model. The scores from the RCI-10 could be scored as unidimensional notwithstanding the presence of multidimensionality. Two-factor correlational solution should not be used. Study two also showed that religious commitment is a risk factor of intimate partner violence, whereas spirituality was a protecting factor from the violence. More alcohol was related with more abusive behaviors. Implications of the two studies were discussed.

本研究探討台灣債券型基金的發展歷程、相關問題、及主管機關的因應措施，並介紹全球債券型基金資產規模前二大之美國及盧森堡的基金發展經驗，作為台灣債券型基金發展及監理的參考。此外，迴歸分析債券型基金資產規模的影響因素及基金資產規模對金融市場、貨幣總計數M2的影響。本研究實證結果顯示:（1）債券型基金資產規模分別與6個月期美元LIBOR及我國金融同業隔夜拆款利率，呈現顯著負相關；（2）債券型基金持有公司債及金融債與該等債券發行市場的榮枯，呈現顯著正相關；及（3）債券型基金資產規模分別與銀行定期存款、中長期放款、及貨幣總計數M2的成長，呈現顯著負相關。根據本研究的結果，對於健全我國債券型基金的發展，我們建議主管機關細分基金類型、強制投信公司設立獨立董事、強化基金市場機能的發揮等；建議投信投顧公會公布之資訊宜涵蓋銀行所募集的貨幣市場基金；建議投信公司加強風險管理並檢討基金經理人紅利給付方式；及建議中央銀行增列「M2+準貨幣市場基金」的成長目標區。 / The purpose of this paper is to study the development of bond funds in Taiwan. Besides, we introduce the development of bond funds in the United States and Luxemburg. Furthermore, we analyze the determinants of the bond fund assets, and effect of the bond funds on the financial market and monetary aggregate M2 in Taiwan. The main findings of empirical study are: （1）the bond fund assets has a significant negative relationship with 6-month USD LIBOR, Taiwan interbank oversight call-loan rate, respectively； （2）the bond fund’s investment of corporate bonds has a significant positive relationship with the prosperity of corporate bond’s issuance market； and（3）the bond fund assets has a significant negative relationship with the time deposits, long-term loans, and M2, respectively. According to the results of this study, we have the following suggestions. To the supervisory authority: subdivide the type of bond fund, investment trust CO. should establish independent directors compulsorily, reinforce funds market mechanism；to the Securities Investment Trust and Consulting Association of the ROC: fund information release should include money market funds raised by bank； to the investment trust CO.: strengthen risk management and review the bonus payment； to the central bank: set up the target zone of M2 plus quasi money market funds grew.

This thesis develops a critique of the methodology of mainstream academic moral philosophy, based on insights from feminist and more generally anti-oppressive political thought. The thesis consists of two parts. In the first, I loosely characterise a certain dominant methodology of philosophy, one based on giving an important epistemological role to existing, 'pre-theoretical' moral attitudes, such as intuitions. I then argue that such methodologies may be critiqued on the basis of theories that identify these moral attitudes as problematically rooted in oppressive social institutions, such as patriarchy and white supremacy; that is, I identify these attitudes as ideological, and so a poor guide to moral reality. In the second part, I identify and explore of a number of themes and tendencies from feminist, anti-racist, and other anti-oppressive traditions of research and activism, in order to draw out the implications of these themes for the methodology of moral philosophy. The first issue I examine is that of how, and how much, moral philosophers should use abstraction; I eventually use the concept of intersectionality to argue for the position that philosophers need to use less, and a different type of, abstraction. The second major theme I examine is that of ignorance, in the context of alternative epistemologies: standpoint epistemology and epistemologies of ignorance. I argue that philosophers must not take themselves to be well placed to understand, using solitary methodologies, any topic of moral interest. Finally, I examine the theme of transformation in moral philosophy. I argue that experiencing certain kinds of personal transformation may be an essential part of developing accurate ethical views, and I draw out the political implications of this position for the methodology of moral philosophy.

The thesis analyses in detail the relationship between the money stock defined by money aggregates M1 and M2 and the real GDP in the Czech Republic for period between 1996 and 2015. A long-term relationship between the real GDP and the money aggregate is not found using quarterly time series data. These conclusions are in accordance with the economic theory which does not confirm that money affects level of the real GDP in the long run. Short-term relationship between given variables is also analysed. Results indicate that the growth rate of the money aggregate M1 statistically significantly affects the growth rate of the real GDP in the same direction which is in line with monetary theories of business cycle. On the other hand, any statistically significant relationship for the money aggregate M2 is not found which speaks in favour of the Real Business Cycle theory. The Policy Ineffectiveness Proposition accepted by New Classical Macroeconomists is also tested in the thesis. The issue is investigated for the whole period and subsequently for shorter time from 2000 to 2015 where the uniform monetary policy is applied. Results for the money aggregate M1 imply that expected changes in the growth rate of M1 play important role in the money-output relationship which is consistent with the New Keynesian Macroeconomic theory. Considering the shorter period of time, Lucas' theory seems to be more appropriate explanation. Outcomes for the aggregate M2 provide mixed conclusions which support rather the Real Business Cycle theory. At the end of the thesis, there is a section devoted to the quasi money (one of M2 aggregate components) as a possible source of mixed results.

Chronic inflammation is essential mechanism during the development of cardiovascular and metabolic diseases. The outcome of diseases depends on the balance between the migration/accumulation of pro-inflammatory (M1) and anti-inflammatory (M2) macrophages in damaged tissue. The mechanism of macrophage migration and subsequent accumulation is still not fully understood. Currently, the amoeboid adhesion-independent motility is considered essential for leukocyte migration in the three-dimensional environment. We challenge this hypothesis by studying the contribution of leukocyte adhesive receptors, integrins αMβ2, and αDβ2, to three-dimensional migration of M1-polarized, M2-polarized, and resident macrophages. Both integrins have a moderate expression on M2 macrophages, while αDβ2 is upregulated on M1 and αMβ2 demonstrates high expression on resident macrophages. The level of integrin expression determines its contribution to macrophage migration. Namely, intermediate expression supports macrophage migration, while a high integrin density inhibits it. Using in vitro three-dimensional migration and in vivo tracking of adoptively-transferred fluorescently-labeled macrophages during the resolution of inflammation, we found that strong adhesion of M1-activated macrophages translates to weak 3D migration, while moderate adhesion of M2-activated macrophages generates dynamic motility. Reduced migration of M1 macrophages depends on the high expression of αDβ2, since αD-deficiency decreased M1 macrophage adhesion and improved migration in fibrin matrix and peritoneal tissue. Similarly, the high expression of αMβ2 on resident macrophages prevents their amoeboid migration, which is markedly increased in αM-deficient macrophages. In contrast, αD- and αM-knockouts decrease the migration of M2 macrophages, demonstrating that moderate integrin expression supports cell motility. The results were confirmed in a diet-induced diabetes model. αD deficiency prevents the retention of inflammatory macrophages in adipose tissue and improves metabolic parameters, while αM deficiency does not affect macrophage accumulation. Summarizing, β2 integrin-mediated adhesion may inhibit amoeboid and mesenchymal macrophage migration or support mesenchymal migration in tissue, and, therefore, represents an important target to control inflammation.

京都大学 / 0048 / 新制・課程博士 / 博士(薬学) / 甲第18208号 / 薬博第798号 / 新制||薬||237(附属図書館) / 31066 / 京都大学大学院薬学研究科創薬科学専攻 / (主査)教授 松﨑 勝巳, 教授 加藤 博章, 教授 石濱 泰 / 学位規則第4条第1項該当 / Doctor of Pharmaceutical Sciences / Kyoto University / DGAM

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Multipurpose hall Brno- Arena is situated in Brno- Bosonohy with capacity 12.000 visitors and 20.000m2. retail. Composition of all area is contained the Mulltipurpose hall, the Training hall, one floor garage and parking. Walkable roof of garage and the Training hall serve as a dispersion area as well as a relaxation zone.

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