La RMN est un outil analytique extrêmement puissant pour l’analyse quantitative et structurale, et est très utilisée en biologie structurale. C’est dans ce contexte que nous avons choisi d’étudier les interactions par RMN. Le premier système choisi est un système de polymères, les PEO. Ils sont caractérisés par plusieurs grandeurs physiques dont l’indice de polydispersité. Cet indice représente la distribution de taille d’une population de polymères. Nous avons développé une nouvelle méthode de diffusion par RMN, la DOSY afin d’accéder à cet indice : J. Viéville et al. / Journal of Magnetic Resonance 212 (2011)169–173 Le deuxième système complexe étudié est un type de molécules chimiques mimétiques de l’ADN, les PNA, acides nucléiques peptidiques. Les PNA possèdent des bases nucléiques leur permettant de former des liaisons avec l’ADN ou l’ARN. Nous avons montré par des analyses de RMN que les PNA en solution peuvent former des complexes très stables avec des températures de fusion élevées. Ces analyses RMN sont complétées par des analyses de dichroïsme circulaire.Afin de compléter notre panel d’études sur les interactions moléculaires par RMN, nous avons étudié les interactions protéine-ligand avec greffage de la protéine sur phase solide : J.M.P. Viéville et al. / Journal of Pharmaceutical and Biomedical Analysis 89 (2014) 18–23 / NMR is a powerfull technique we decided to extend to follow interactions in complex mixtures. First part is about polydispersity index of polymer which is an important physical parameter when working with polymers. We developed here a new method, based on PEO analysis, using diffusion experiments (DOSY) by NMR to assess the polydispersity index: J. Viéville et al. / Journal of Magnetic Resonance 212 (2011) 169–173. In a second time, we worked on peptidic nucleic acids, PNA. These chemicals molecules are designed to bind DNA or RNA for clinical studies. We studied PNA in solution, by NMR to showwhich kind of interactions they form on themselves. We found very stable complexes with high fusion temperatures. Circular dichroism measurements were helpful for fusion temperature determination and structural studies. To complete this panel, we were interested in the study of protein-ligand interaction. We developed a new way to follow them, using a grafted protein on a solid phase based on HR-MAS NMR technology: J.M.P. Viéville et al. / Journal of Pharmaceutical and Biomedical Analysis 89 (2014) 18–23

Multi-agent Systems (MAS) provide an increasingly relevant field of research due to their many applications to modelling real world situations where the behaviour of many individual, self-motivated, agents must be reasoned about and controlled. The problem of agent social reasoning is central to MAS, where an agent reasons about its actions and interactions with other agents. This is the most important component of MAS, as it is the interactions, cooperation and competition between agents that make MAS a powerful approach suited for tackling many complex problems. Existing work focuses either on specific types of social reasoning or general purpose agent practical reasoning - reasoning directed toward actions. This thesis argues that social reasoning should be considered separately from practical reasoning. There are many possible benefits to this separation compared to existing approaches. Principally, it can allow general algorithms for agent implementation, analysis and bounded reasoning. This viewpoint is motivated by the desire to implement social reasoning agents and allow for a more general theory of social reasoning in agents. This thesis presents the novel Expectation- Strategy-Behaviour (ESB) framework for social reasoning, which provides a generic way to specify and execute agent reasoning approaches. ESB is a powerful tool, allowing an agent designer to write expressive social reasoning specifications and have a computational model generated automatically. Through a formalism and description of an implemented reasoner based on this theory it is shown that it is possible and beneficial to implement a social reasoning engine as a complementary component to practical reasoning. By using ESB to specify, and then implement, existing social reasoning schemes for joint commitment and normative reasoning, the framework is shown to be a suitable general reasoner. Examples are provided of how reasoning can be bounded in an ESB agent and the mechanism to allow analysis of agent designs is discussed. Finally, there is discussion on the merits of the ESB solution and possible future work.

The current study was designed to evaluate the utility of progressing sequentially from multiple-respondent anecdotal assessments through test-control treatment analysis as an effective and efficient method of identifying the environmental determinants of problem behavior. the goal of the study was to evaluate overall agreement among multiple respondents on the primary function of aberrant behavior using the Motivation Assessment Scale (MAS) and Questions About Behavioral Function (QABF) and, if agreement was obtained, conduct a test-control evaluation to confirm anecdotal assessment findings while simultaneously evaluating the effects of function-based treatment. for 4 individuals, at least 4 of 5 respondents to the anecdotal assessments agreed (both within and across assessments) on the probable maintaining consequence for their problem behaviors. Test-control multielement evaluations were then conducted in which baseline sessions, corresponding to the suspected operant function of each individual’s problem behavior, were alternated with sessions in which the identified contingency was arranged for alternative behavior. Each evaluation showed substantial decreases in problem behavior and maintenance of alternative responses.

Thesis. 1976. M.ArchAS--Massachusetts Institute of Technology. Dept. of Architecture. / Microfiche copy available in Archives and Rotch. / Bibliography: leaves 94-97. / M.ArchAS

Spiritual, mystic and natural boundaries haunt the writings of Henri Bosco. Critics such as Bachelard have studied Bosco's interpretation of the natural elements and noted his sensitive portrayal of the protagonists with a focus on their unconscious desires by the use of this device. In Le Mas Theotime Bosco has unleashed his artistic and poetic creativity in addition to his passion for nature. Indeed, of all of Bosco's novels, perhaps this one exemplifies the quintessential harmony of man with nature. As suggested by Jean-Claude Godin: " ... il n'y a que dans Le Mas Theotime oil elles soient veritablement au coeur du recit ... La reverie de la terre debouche alors sur toutes les images de l'intimite heureuse." (Godin 176) It is also the essence of Provence, its legends and its natural beauty that plays an integral role in this novel. Not only does Bosco explore the natural elements, but he also explores the religious myths that so influence our society. This thesis will explore, through a symbolic and religious interpretation, the boundaries which prevail throughout. Le Mas Theotime incorporates Bosco's true genius as a writer who brings to his reader the possibility of a personal rendition and view of the story. His is not a straightforward and evident recollection of events, but rather a voyage through and involvement in the lives and minds of the characters.

This thesis examines the origins, nature, and characteristics of the Subud mystical order which is an expression of Javanese Red (abangan) Muslim mysticism. It presents material on the life of the founder, on the religious background of the order) and presents the doctrines, practices, and forms of organizatiori peculiar to the order.

Thesis (D.M.A.)--University of North Texas, 2008. / System requirements: Adobe Acrobat Reader. Accompanied by 4 recitals, recorded Sept. 24, 2007. Includes bibliographical references (p. 107-108).

Orientador: Antonio Carlos Cicogna / Resumo: Introdução: Nos últimos anos, investigadores têm demonstrado que há a possibilidade de estimular a proliferação de cardiomiócitos adultos. Atualmente, a comunidade científica está voltada para três principais estratégias para a regeneração cardíaca: uso de células tronco, inibição de genes que regulam o sistema de controle do ciclo celular e o aperfeiçoamento de mecanismos endógenos. Um exemplo de mecanismo endógeno é a estimulação de vias de sinalização que permite a reentrada dos miócitos no ciclo celular e sua posterior divisão. O treinamento físico (TF) é um fator estimulatório para a proliferação das células cardíacas por meio da angiotensina-(1-7) (Ang-(1-7)) via receptor Mas. Além disso, o TF promove cardioproteção e aumenta os níveis deste peptídeo em animais com sobrecarga pressórica. Existem evidências, recentes, que o TF promove proliferação de miócitos em diferentes modelos experimentais e atua sobre os níveis de Ang-(1-7) em corações disfuncionantes. Entretanto, não foram encontrados estudos que avaliaram, concomitantemente, os efeitos do TF sobre a função, níveis de Ang-(1-7) e receptor Mas miocárdicos e proliferação de cardiomiócitos em modelo de sobrecarga pressórica e deterioração da função cardíaca. Objetivo: Testar a hipótese que o TF atenua a queda do desempenho cardíaco, acarreta proliferação de cardiomiócitos e eleva os níveis de Ang-(1-7) e do receptor Mas miocárdicos em ratos com estenose aórtica supravalvar (EAo) e disfunção ventricular esquerda. Méto... (Resumo completo, clicar acesso eletrônico abaixo) / Mestre

The main purpose of dissertation was to be formed economic characteristics district Tabor with appreciation status of the small and middle companies in a given district and possibility their next development. The partial purpose was activity analysis to the local action groups, their comparison and meaning for the development of the small and middle companies. The first step in the processing of the thesis was the study of literature. For the diploma thesis was the method of comparison, the questionnaire and the method of SWOT analysis.

The thesis contains an evaluation of LAG as a tool for development of the rural region. The default hypothesis is that the LAG Říčansko has of its region and the influence of this effect can be evaluated positively. It followed the trends and developments in the field of rural development with a focus on the LEADER approach. Furthermore, for the final evaluation analyzes the structure of the LAG, the selection of supported projects and the implementation of cooperation projects. Part of the work is devoted to the characteristics and the current situation in the region LAG Říčansko. As a basis for the design of projects in problematic areas include a description of activities of some foreign LAG in Germany and Austria. The aim is achieved through interviews with workers LAG Říčansko and compares its structure and focus of the recommended and mandatory requirement for LAG. It was also the focus of supported projects compared with regard to problem areas in the region. The main part of the job evaluation LAG was a questionnaire survey among inhabitants of the region, partners and holders LAG regional brand Zápraží original product, which was focused on knowledge of the activities of the LAG and satisfaction with the treatment. Economic efficiency projects LAG was assessed using a cost-benefit analysis (CBA) of the selected project. Due to the nature of the project, its methodology was amended and as a result of its work is proposed for evaluating the effectiveness of cooperative projects using space CBA cost utility analysis (CUA). Knowledge about the work of LAG Říčansko are summarized in the conclusion that the MAS Říčansko has on the region a positive effect. Conclusion also includes the realization that this fact is only sustainable if the LAG will respond to changes in the region and its activities will involve local stakeholders in all sectors in sufficient representation.