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1	Terrane accretion and translation on the western margin of Gondwana Webber, Patricia Marie 01 May 2018 (has links) The timing and kinematics of terrane accretion and translation on the Paleozoic margin of Gondwana remains contentious. Multiple models exist for the accretion of the MARA and Precordillera terranes, but deviate in timing and kinematics of accretion, the nature of involved terranes, Laurentian versus Gondwanan origin, and the extent of translation along the margin. The Valle Fertil Fault Zone (VFFZ) marks the suture zone between the Pampean margin and the MARA terrane, which was accreted and translated via thrusting or transpression between 515-400 Ma. The VFFZ projects northward to the Sierra de Maz region, which is transected by ductile shear zones that lie along strike with the boundary and separate assemblages with varied magmatic and metamorphic history. Sierra de Maz is underlain by Mesoproterozoic-Neoproterozoic igneous and metamorphic units assigned to the MARA terrane, known as the Maz and El Taco Complexes, which are juxtaposed with El Zaino Complex, a clastic assemblage that has a simple metamorphic history. Ramaditas lies to the east of the main sierra, and is comprised of granulite facies units with poorly constrained origin. Characterization of Sierra de Maz and Ramaditas involved U/Pb analysis of 17 igneous zircon and 2 in-situ titanite samples by SHRIMP-RG methods, 6 igneous zircon and 8 detrital zircon samples by LA-ICP-MS methods, and trace element analyses of selected samples. Microstructural analyses and Ti-in-Zr geothermometry were used to analyze the timing of metamorphic conditions and kinematics. This collaborative study was performed in conjunction with petrologic analysis, geochronologic analyses of Lu/Hf garnet and Ar/Ar suites, and detailed structural analyses executed by two M.S. students from Western Washington University and University of California-Davis. The U/Pb data suggests that the Proterozoic basement and Maz Shear Zone experienced widespread metamorphism and deformation from ca. 430 to 420 Ma in the Maz and El Zaino Complexes, and from ca. 430-460 Ma in the Taco Complex and Ramaditas. Metamorphic assemblages and kinematic indicators suggest this took place at granulite to greenschist facies conditions in a sinistral transpressional regime, with localized dextral slip. The magmatic and metamorphic history is similar to that observed west of the VFFZ to the south, suggesting that Sierra de Maz records a complex late Ordovician to early Devonian history of convergence and translation of the MARA terrane along the Pampean margin. Famatina MARA terrane Sierra de Maz transpression Valle Fertil Western Sierras Pampeanas Geology
2	Antioxidant Liposomes Protect Against CEES-Induced Lung Injury by Decreasing SAF-1/MAZ-Mediated Inflammation in the Guinea Pig Lung Mukhopadhyay, Sutapa, Mukherjee, Shyamali, Ray, Bimal K., Ray, Alpana, Stone, William L., Das, Salil K. 01 January 2010 (has links) We reported earlier in a guinea pig model that exposure of 2-chloroethyl ethyl sulfide (CEES), a mustard gas analog, causes lung injury associated with the activation of tumor necrosis factor alpha (TNF-α), mitogen activated protein kinases (MAPK) signaling, and activator protein-1 (AP-1) transcription factor. Our earlier studies also revealed that antioxidant liposomes can be used as antidotes. Proinflammatory cytokines IL-1, IL-6, and TNF-α, either alone or in combination, can induce the activation of another group of transcription factors, namely SAF-1 (serum accelerator factor-1)/MAZ (Myc-associated zinc finger protein). Phosphorylation of SAF-1 via MAPK markedly increases its DNA-binding and transactivational potential. The objective of the present study was to investigate whether CEES exposure causes activation of IL-1β, IL-6, and SAF-1/MAZ and whether these effects can be prevented by antioxidant liposomes. A single dose (200 μL) of the antioxidant liposome mixture was administered intratracheally after 5 min of exposure of CEES (0.5 mg/kg). The animals were sacrificed either 1 h or 30 days after CEES exposure. CEES exposure caused an upregulation of proinflammatory cytokines IL-6 and IL-1β in the lung along with an increase in the activation of transcription factor SAF-1/MAZ. The antioxidant liposomes treatment significantly blocked the CEES-induced activation of IL-6, IL-1β, and SAF-1/MAZ. This might suggest that antioxidant liposomes might offer a potential therapeutic strategy against inflammatory diseases associated with activation of these bioactive molecules. antioxidant liposome CEES IL-1β IL-6 lung injury SAF-1/MAZ Pediatrics
3	Konsequenzen der Expression des Ether à go-go Kaliumkanals / Consequences of the ether à go-go potassium channel expression Weber, Claudia 06 July 2006 (has links) No description available. 500 Naturwissenschaften allgemein Mathematics and Computer Science Onkogen Krebs Kaliumkanal EAG MAZ c-MYC hTERT spezifischer Inhibitor RNAi Proliferation cDNA-Array subtraktive Hybridisierung differentielle Expression LPS Mutation oncogene cancer potassium channel EAG MAZ c-MYC hTERT specific inhibitor RNAi proliferation cDNA array subtractive hybridization differential expression LPS mutation 42 42.13 42.15 44.81 WA WHF500 WF200 MED424
4	Developing Variation and Melodic Contour Analysis: A New Look at the Music of Max Reger McConnell, Sarah E. 08 1900 (has links) Max Reger was a prolific composer on the threshold of modernism. The style of his extensive musical output was polarizing among his contemporaries. A criticism of Reger's music is its complex and dense musical structure. Despite writing tonal music, Reger often pushes the boundaries of tonality so far that all sense of formal organization is seemingly imperceptible. In this dissertation, I offer what I observed to be a new way of discerning Reger's motivic relationships and formal structures within and between movements. There are three primary tools and methods I incorporated to make these observations: Schoenberg's developing variation; melodic contour analysis as discussed by Elizabeth West-Marvin and Diana Deutsch; and Janet Schmalfeldt's motivic cyclicism stemming from internal themes. In this dissertation I examine five different musical works by Reger: D minor Piano Quartet, Clarinet Quintet, Piano Concerto, String Quartet, op. 121 and E minor Piano Trio, op. 102. My analysis shows how Reger relies on melodic contours of his motives to connect musical moments across entire movements and entire works with multiple movements. These motives are developed and often mark structurally significant moments providing the organization often perceived as missing in Reger's music. Max Reger Arnold Schoenberg Elizabeth West-Marvin Diana Deutsch Janet Schmalfeldt Piano quartet Clarinet quintet Piano concerto String quartet Piano trio Musical analysis Reger, Maz, 1873-1916. Musical analysis. Musical form. Melodic analysis. Academic theses

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