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Moral Foundations Theory (MFT) suggests there are five distinct moral dimensions, which define morality as a whole. MFT can be broken down into two groups binding: in group/loyalty, authority/respect, and purity/sanctity-which encompass group morality. Harm/Care, fairness/reciprocity are individualizing dimensions, which highlight individual morality. Recent work has found MFT predicts sociopolitical ideologies, as well as sociopolitical attitudes. In an effort to better understand the existing relationships we investigate MFT as a predictor of sociopolitical parties, and attitudes Right-Wing Authoritarianism (RWA) and Social Dominance Orientation (SDO). We also draw on similarities between Individualism/Collectivism and MFT. Specifically we demonstrate individualizing foundations, and dimensions of individualism predict SDO, where as Binding dimensions and dimensions of Collectivism relate to RWA.

The mitochondrial folate transport protein (MFT) functions to transport folates into the mitochondrial matrix. The MFT is a member of a mitochondrial carrier family (MCF) of proteins that have a high degree of sequence and structural similarities, yet they transport vastly different substrates at high specificities. In this dissertation research, the folate-specific transport mechanism of the MFT was explored using experimental and computational techniques. MFT residues that differed from MCF consensus residues in conserved PxD/ExxK/R motifs and at a predicted substrate-binding site common to all MCF proteins were investigated. Site-directed mutagenesis of these anomalous residues in the MFT revealed that these residues were adapted for optimal folate transport, and that the MCF consensus residues at these positions were incompatible with folate transport. The structure of the MFT was predicted by homology modeling using the solved crystallographic structure of the ADP/ATP carrier as a template and this model was subjected to ~75 ns of molecular dynamics simulations. These simulations predicted a stepwise descent for the folate substrate into the MFT transport cavity and implicated several aromatic and basic residues in folate recognition and orientation. A predicted set of interactions at the base of the transport cavity between the MCF PxD/ExxK/R conserved motif residues did not appear static as previously hypothesized; these interactions appeared to be induced in the presence of the folate substrate. Therefore, we believe it is unlikely that these interactions form a barrier at the base of the transport cavity. We also investigated the role of the MFT in the compartmentalization of folate metabolism. Cell lines were created that could be induced with doxycycline to express either the cytosolic or mitochondrial isoform of the enzyme folylpoly-γ-glutamate synthetase (FPGS). The constructed cell lines were used to study the flux of folylpolyglutamates across the mitochondrial membrane. It appeared that cellular folylpolyglutamates are not transported across the mitochondrial membrane in either direction. We also demonstrated that many antifolates, including methotrexate and pemetrexed, impaired mitochondrial folate uptake. We believe that these folate analogs competitively inhibit the MFT and have purified the MFT protein for future analysis in reconstituted transport systems.

This master thesis presents an approach on how to design moral behaviour in a scenario with een. een is an iteration of emobn which is based on bn, an action selection system with activation dynamics among modules, goal oriented and capable of prediction and planing. The design is based on current research from prominent psychologist like Haidt and uses Mikhial’s umg framework for causal and intentional validation. Also Roseman’s appraisal model and Haidt’s mft is used for determining moral emotions in a moral context. The design is tested against empirical results from philosophical experiment know as the trol- ley problem, a well known moral dilemma.

Magister Educationis - MEd / The central aim of this study was to examine the Western Cape Education Department's restructuring process, which entails changing the centralised support service to a more decentralized one through the newly constituted Education Management and Development Centres (EMDCs), in particular, the aim of the study was to explore how one Multi-Functional Team (MFT) in an EMDC structure is attempting to provide more holistic and co-ordinated support to schools. Chapter 1 briefly discusses the South African context, providing a brief historical overview and description of education relevant policy challenges. This chapter also outlines and provides details of the decentralisation process, the challenges of developing an holistic and co-ordinated approach to support, and the research aims, questions and research methodology. In Chapter 2 a literature inter-sectoral collaboration in relation challenges of inter-sectoral to explore the concept of inter This includes an overview of the Chapter 3 provides an overview of the researcn approach,· research design, data collection methods, data processing methods and an ethics methods Chapter 4 provides an analysis and interpretation of data obtained under the categories of analysis provided by the research questions. Chapter 5 provides a summary of the findings as well as recommendations for the improvement of inter-sectoral collaboration within the EMDCs. It also includes a reflection on the research process. The study showed that there is a growing realisation in the EMDCs that services cannot be carried out in isolation and that collaboration, co-operation and co-ordination are necessary for more effective and holistic service delivery. Most of the participants in this study emphasized that services need to be better coordinated and that there was a need for better communication and leadership within the MFT. When asking the question about the difficulties experienced in trying to co-ordinate support services, they said that there is little co-ordination and management within the MFT. Some of the participants said that there is no time for reporting, recording or planning, and most of the time all the role players are not available to attend meetings or discussions. The primary reason given for poor co-ordination was that there was a lack of overall co-ordination in planning projects being run in the EMDC . This study should make a contribution to an understanding of how the EMDC can provide more coordinated and holistic support to schools. It should, among other things, give insight into the challenges of inter-sectoral collaboration and how to address these challenges.

The purpose of this study is to examine the attitudes and beliefs of art therapists towards Evidence-Based Practices (EBP). EBP is a rising trend in healthcare that refers to the process of using empirically validated research to make clinical decisions that best meet the needs of each client (Patterson, Miller, Carnes & Wilson, 2004).The investigators used a mixed methods approach to the research topic. Part A consists of a survey distributed to graduates of the Department of Marital and Family Therapy (MFT) at Loyola Marymount University (LMU). In addition to answering questions, survey participants were asked to create an art response depicting their perspective on the relationship between art therapy and EBP. In the second phase (Part B), the researchers used an arts-based methodology to further explore the findings from Part A. Part B involved the creation of key idea cards pulled from the literature review and the findings, individual art responses by each investigator, and verbal and written analyses of the content and process. The idea that art therapists are already integrating EBP and art therapy in their practices emerged as the major finding of the research. This realization that clinicians are already at the intersection of EBP and art therapy was a contrast to the cautious divided attitudes that were discovered in the literature review. Further research could not only strengthen the evidence base of art therapy, but also illuminate how exactly therapists have managed to bridge the gap between EBP and art therapy.

Poor settling of solids increases land requirement for tailings containment and imposes severe constraints on the water balance. Consequent to these considerations, the alternating current electrocoagulation (AC/EC) technique emerged as a candidate for enhancing the settling behaviour of suspensions in the mineral, coal and oil sands industries. Hence, a fundamental study of AC/EC was undertaken with aluminum electrodes. Ground silica (d50 = 20 m), which formed a stable suspension, served as the model tailings solid at 5.0 wt % in water. The AC/EC process consisted of two developmental stages: coagulation, marked by pH decrease in the silica suspension; and floc growth, characterized by pH increase from the minimum (i.e., the end of coagulation). AC/EC enhanced the initial settling rate of silica by over three orders of magnitude, and exhibited remarkable flexibility by virtue of the wide range of process parameters that could be optimized. For example, AC/EC can be operated in either the indirect or direct mode. The settling behaviour of bentonite (estimated d50 < 1 m) was more enhanced by indirect AC/EC, while that of silica benefited more from direct AC/EC. Any condition that increased aluminum dosage (e.g., current, retention time), increased the initial settling rate of silica. Over the feed water pH range of 3.0 to 9.1, AC/EC was effective in enhancing the settling behaviour of silica. AC/EC was also effective over a wide range of temperatures (23 to 85C). High electrical energy demand by AC/EC was observed throughout this study. Its optimization was beyond the scope of this work. Dilution of a sample of Syncrude mature fine tailings (MFT) to 4.6 wt % solids sustained a stable suspension. Settling occurred after AC/EC treatment, a crystal-clear supernatant resulted and bitumen was recovered as froth. Entrained solids were easily spray-washed from the froth with water. The settling behaviour of a Luscar Sterco fine coal tailings sample was not augmented by AC/EC, possibly due to contamination by the companys own electrocoagulation operation. After having been stored dry for more than a year, electrocoagulated silica was an effective coagulant for as-received silica and Syncrude MFT. / Chemical Engineering

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