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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
61

An examination of ionospheric plasma irregularities detected by the mid-latitude SuperDARN radars

Ribeiro, Alvaro John 06 May 2011 (has links)
The data from the new mid-latitude radars of the Super Dual Auroral Radar Network (SuperDARN) provide new types of challenges and observations. We have developed a method for identifying periods of ionospheric backscatter that increase the number of data and reduce the average velocity in agreement with previous incoherent scatter radar (ISR) studies. Analysis of the data identified by this method clearly shows that different types of ionospheric irregularities are being observed in the mid-latitude region. One type of irregularity is clearly subauroral and equatorward of the plasmapause. Fitting a convection pattern to the Doppler velocities associated with subauroral ionospheric scatter reveals some interesting features. Subauroral convection is shown to be westward thought most of the night, with an eastward turning near dawn. The rotation factor of the ionosphere relative to the rotation of the earth is shown to be ~0.95, which is in good agreement with previous studies of plasmaspheric corotation. / Master of Science
62

Tecnologia Analítica em processo (PAT): método espectroscópico como alternativa ao método clássico para uniformidade de conteúdo e doseamento de lamivudina e zidovudina em comprimidos revestidos / Process Analytical Technology (PAT): spectroscopic method as an alternative to the classical method for content uniformity and quantification of lamivudine and zidovudine in tablets.

Novaes, André Luís da Silva 12 August 2013 (has links)
A zidovudina, conhecida como AZT, é um inibidor da transcriptase reversa, enquanto que a lamivudina é um fármaco antirretroviral que atua na inibição da síntese de ácidos nucléicos. Estes são dois dos 21 fármacos componentes dos medicamentos distribuídas pelo Ministério da Saúde Brasileiro em programas de combate a Síndrome da imunodeficiência Adquirida (Acquired Immunodeficiency Syndrome - AIDS), configurando-se assim uma grande demanda de produção de medicamentos com estes fármacos. Programas de Tecnologia Analítica em Processo (Process Analytical techology - PAT), embasadas por avanços nos guias internacionais da Conferência Internacional sobre a Harmonização dos Requerimentos Técnicos para o Registro de Produtos Farmacêuticos para o uso Humano (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use - ICH) e pela agência norte-americana para a Administração de Alimentos e Medicamentos (Food and Drugs Administration - FDA), estão ganhando força como alternativas para aumentar a eficiência e a segurança na produção de medicamentos, tanto para aqueles já em processo produtivo como também para medicamentos em fase de desenvolvimento. Estes últimos são denominados desenvolvimento em programas de Qualidade por Design (QbD). Métodos de quantificação por espectroscopia (NIR, MID, RAMAM, entre outras) são reconhecidos como ferramentas para a PAT. Neste contexto propôs-se comparar objetivamente o método tradicional de quantificação destes dois fármacos frente a um método de quantificação desenvolvido utilizando-se a espectroscopia no infravermelho médio (MID). Prepararam-se assim 41 amostras de calibração e 23 amostras de validação, compostas por misturas de zidovudina, lamivudina e placebo (qs) em escala laboratorial, na faixa de 80 a 120% da concentração nominal de uma associação comercial dos dois fármacos. As concentrações de referência de todas as preparações foram determinadas empregando-se o método de referência por Cromatografia Líquida de Alta Eficiência (CLAE) da Farmacopeia Americana (United States Pharmacopeia - USP). Subsequentemente, obtiveram-se cinco espectros no infravermelho de cada uma das preparações, na faixa de 450 a 4000 cm-1. Os espectros foram então pré-processados e utilizados para a construção de um modelo de calibração multivariado por PLS (mínimo quadrados parciais), de acordo com a ASTM E1655-05. Adicionalmente, o método de CLAE foi transferido para um método de UPLC de acordo com o Capitulo Geral descrito no volume 37(3) do Fórum da USP (United States Pharmacopeia). O desempenho do método MID foi então comparado com o método tradicional, bem como com o novo método de quantificação por UPLC. Foram definidaLs assim regiões de confiança para embasar a utilização dos métodos desenvolvidos. O método de quantificação por MID apresentou uma grande variabilidade enquanto que o método por UPLC foi totalmente comparável com o método tradicional, reduzindo o tempo de corrida de 60 minutos para 12.55 minutos. / Zidovudine, also known as AZT is a reverse transcriptase inhibitor, whereas lamivudine is an antiretroviral drug that acts on the inhibition of nucleic acid synthesis. These are two of the 21 active ingredients components of medicines distributed by Brazilian Health Ministry in programs against the Acquired Immunodeficiency Syndrome (AIDS), becoming thus a great demand for production of these two drugs. Process Analytical Technology (PAT) programs, supported by advances in international guides from the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) and by the FDA (Food and Drugs Administration), are gaining momentum as alternatives to increase efficiency and safety in the production of medicines, both for those medicines already in the production process as well as to those medicines under development. The latter are called Quality by Design (QbD) programs. Spectroscopy quantification methodologies methodologies (NIR, MID, Ramam, among others) are recognized as PAT tools. In this context it was proposed to compare objectively the traditional method for quantification of these two drugs against a quantification method developed using the MID (middle infrared spectroscopy). Thus 41 calibration and 23 validation samples, comprising of laboratorial scale mixtures of lamivudine, zidovudine and placebo (qs), were prepared in the range equivalent to 80 to 120% of the nominal concentration of the commercial tablets product. The concentrations of all calibration and validation samples were determined using the HPLC reference method of USP (United States Pharmacopeia). Subsequently, there were obtained five infrared spectra of each of the preparations in the range 450-4000 cm-1. The spectra were then pre-processed and used to build a multivariate calibration model for PLS (Partial Least Squares) according to ASTM E1655-05. Additionally, the HPLC method was transferred to a UPLC method according to General Chapter described in volume 37 (3) Forum USP (United States Pharmacopeia). The performance of the method MID was then compared with the traditional method and with the new method of quantification by UPLC. Confidence regions were built to support the use of the methods developed. The MID quantification method presented considerable variability, while the method the UPLC method was fully comparable to the traditional method. Another advantage of the UPLC method was the reduction of running time from 60 minutes to 12:55 minutes.
63

Land use and soil associations in western County Victoria, South Australia

Matheson, W. E. January 1967 (has links) (PDF)
Includes Dept. of Agriculture leaflet no. 3706 : "Standing oat crops." Includes tables. Two col. maps in pocket. Bibliography : leaves 81-85.
64

Loss of the Dream: Stories of Mid-Life Divorce

Leighman, Marilyn Rust 2009 December 1900 (has links)
The divorce experiences of seven mid-life women were investigated using Bohannan's (1970) and Hagemeyer's (1986) divorce theories as a framework to guide the research. In-depth interviews and visual interpretation were used: (a) to determine the greatest challenges and losses experienced by mid-life women after divorce; (b) to identify factors which contribute to resilience and determine coping mechanisms used by mid-life women following divorce; and (c) to assess long-term effects of divorce on midlife women several years after the event. The results of this study included the following findings: The women in the study had been divorced from 7 to 18 years and all agreed that losing the dream of the "happily ever after marriage" and the loss of the family unit were the most difficult losses they experienced. Other losses included the loss of identity as a married person, loss of home and assets, loss of income, and loss of relationship with children. Factors affecting resilience and coping mechanisms included working at a job or profession, support of family and friends, faith and spirituality and social activities and dating. These were unanimous choices among the participants. Long-term effects were both positive and negative. Negative effects included continued feelings of loss concerning the family unit, lingering anger, and lack of forgiveness toward the former spouse. Positive aspects included increased resilience, autonomy, personal achievement, and spiritual growth.
65

A review of density control system in Hong Kong : a case study of Mid-level West /

Chan, Kwai-chau, Carrie. January 1993 (has links)
Thesis (M. Sc.)--University of Hong Kong, 1993. / Includes bibliographical references.
66

Convection and melting processes in a mantle plume under a spreading ridge, with application to the Iceland plume

Ruedas, Thomas. January 1900 (has links)
Thesis (doctoral)--Johann Wolfgang Goethe Universität, 2004. / Includes bibliographical references (p. [270]-299).
67

Mantle melting and heterogeneity along mid-ocean ridges : insight from basalt geochemistry along axial depth and morphologic gradients for intermediate spreading rate systems /

Russo, Christopher J. January 1900 (has links)
Thesis (Ph. D.)--Oregon State University, 2008. / Printout. Includes bibliographical references (leaves 171-186). Also available on the World Wide Web.
68

Tecnologia Analítica em processo (PAT): método espectroscópico como alternativa ao método clássico para uniformidade de conteúdo e doseamento de lamivudina e zidovudina em comprimidos revestidos / Process Analytical Technology (PAT): spectroscopic method as an alternative to the classical method for content uniformity and quantification of lamivudine and zidovudine in tablets.

André Luís da Silva Novaes 12 August 2013 (has links)
A zidovudina, conhecida como AZT, é um inibidor da transcriptase reversa, enquanto que a lamivudina é um fármaco antirretroviral que atua na inibição da síntese de ácidos nucléicos. Estes são dois dos 21 fármacos componentes dos medicamentos distribuídas pelo Ministério da Saúde Brasileiro em programas de combate a Síndrome da imunodeficiência Adquirida (Acquired Immunodeficiency Syndrome - AIDS), configurando-se assim uma grande demanda de produção de medicamentos com estes fármacos. Programas de Tecnologia Analítica em Processo (Process Analytical techology - PAT), embasadas por avanços nos guias internacionais da Conferência Internacional sobre a Harmonização dos Requerimentos Técnicos para o Registro de Produtos Farmacêuticos para o uso Humano (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use - ICH) e pela agência norte-americana para a Administração de Alimentos e Medicamentos (Food and Drugs Administration - FDA), estão ganhando força como alternativas para aumentar a eficiência e a segurança na produção de medicamentos, tanto para aqueles já em processo produtivo como também para medicamentos em fase de desenvolvimento. Estes últimos são denominados desenvolvimento em programas de Qualidade por Design (QbD). Métodos de quantificação por espectroscopia (NIR, MID, RAMAM, entre outras) são reconhecidos como ferramentas para a PAT. Neste contexto propôs-se comparar objetivamente o método tradicional de quantificação destes dois fármacos frente a um método de quantificação desenvolvido utilizando-se a espectroscopia no infravermelho médio (MID). Prepararam-se assim 41 amostras de calibração e 23 amostras de validação, compostas por misturas de zidovudina, lamivudina e placebo (qs) em escala laboratorial, na faixa de 80 a 120% da concentração nominal de uma associação comercial dos dois fármacos. As concentrações de referência de todas as preparações foram determinadas empregando-se o método de referência por Cromatografia Líquida de Alta Eficiência (CLAE) da Farmacopeia Americana (United States Pharmacopeia - USP). Subsequentemente, obtiveram-se cinco espectros no infravermelho de cada uma das preparações, na faixa de 450 a 4000 cm-1. Os espectros foram então pré-processados e utilizados para a construção de um modelo de calibração multivariado por PLS (mínimo quadrados parciais), de acordo com a ASTM E1655-05. Adicionalmente, o método de CLAE foi transferido para um método de UPLC de acordo com o Capitulo Geral descrito no volume 37(3) do Fórum da USP (United States Pharmacopeia). O desempenho do método MID foi então comparado com o método tradicional, bem como com o novo método de quantificação por UPLC. Foram definidaLs assim regiões de confiança para embasar a utilização dos métodos desenvolvidos. O método de quantificação por MID apresentou uma grande variabilidade enquanto que o método por UPLC foi totalmente comparável com o método tradicional, reduzindo o tempo de corrida de 60 minutos para 12.55 minutos. / Zidovudine, also known as AZT is a reverse transcriptase inhibitor, whereas lamivudine is an antiretroviral drug that acts on the inhibition of nucleic acid synthesis. These are two of the 21 active ingredients components of medicines distributed by Brazilian Health Ministry in programs against the Acquired Immunodeficiency Syndrome (AIDS), becoming thus a great demand for production of these two drugs. Process Analytical Technology (PAT) programs, supported by advances in international guides from the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) and by the FDA (Food and Drugs Administration), are gaining momentum as alternatives to increase efficiency and safety in the production of medicines, both for those medicines already in the production process as well as to those medicines under development. The latter are called Quality by Design (QbD) programs. Spectroscopy quantification methodologies methodologies (NIR, MID, Ramam, among others) are recognized as PAT tools. In this context it was proposed to compare objectively the traditional method for quantification of these two drugs against a quantification method developed using the MID (middle infrared spectroscopy). Thus 41 calibration and 23 validation samples, comprising of laboratorial scale mixtures of lamivudine, zidovudine and placebo (qs), were prepared in the range equivalent to 80 to 120% of the nominal concentration of the commercial tablets product. The concentrations of all calibration and validation samples were determined using the HPLC reference method of USP (United States Pharmacopeia). Subsequently, there were obtained five infrared spectra of each of the preparations in the range 450-4000 cm-1. The spectra were then pre-processed and used to build a multivariate calibration model for PLS (Partial Least Squares) according to ASTM E1655-05. Additionally, the HPLC method was transferred to a UPLC method according to General Chapter described in volume 37 (3) Forum USP (United States Pharmacopeia). The performance of the method MID was then compared with the traditional method and with the new method of quantification by UPLC. Confidence regions were built to support the use of the methods developed. The MID quantification method presented considerable variability, while the method the UPLC method was fully comparable to the traditional method. Another advantage of the UPLC method was the reduction of running time from 60 minutes to 12:55 minutes.
69

Late-early to middle pleistocene vegetation and climate history of the Highland Valley, British Columbia, Canada

Jonsson, Carl H. W. 22 December 2017 (has links)
The climate and vegetation history of the Middle Pleistocene transition in the interior of British Columbia (BC) is poorly understood due largely to the lack of records. Sediments from the overburden of the Teck Highland Valley Copper mine (HVC) of British Columbia straddle the Brunhes-Matuyama paleomagnetic transition, providing a opportunity to study this critical Pleistocene interval. The stratigraphy was described and sampled for paleomagnetic and pollen/spore analysis at reconnaissance scale. The HVC sediments consist mainly of (from bottom to top) a lower glacial drift, >50 m of lakebed sediments, ~50 m of gravel fan deposits, and a >60 m thick drift of mostly glacial till. These units were deposited by a valley glacier, lake, fluvial/debris flow events, and an ice sheet, respectively. Pollen and spore analyses, reveal at least 11 climate-vegetation intervals (9 zones, 2 more possible ones). These are broadly classified as either warm Pinus-Picea parkland and forest, cold Selaginella-rich steppe or arid Artemisia-Poaceae steppe. These intervals suggest a long paleo-environmental record at HVC and indicate fluctuations between glacial and interglacial climates which can tentatively be placed with Marine Isotope Stages 23 through 16 and younger. The HVC record is a unique sequence with the potential to reveal a much more detailed history of this critical time in Earth’s past. Implications of these findings are discussed. / Graduate / 2018-12-06
70

Chancen und Möglichkeiten des Duroplast für MID-Anwendungen

Scheffler, Thomas January 2014 (has links)
Chancen und Möglichkeiten des Duroplast für MID-Anwendungen

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