Segerstrom et al. (2017) found that more repetitive thought (RT) was related to lower interleukin-6 (IL-6), in older adults at average IQ. This study aimed to replicate and extend this finding in midlife adults, with a daily measure of RT, and additional inflammatory biomarkers. 153 participants were drawn from the Midlife in the United States (MIDUS) Refresher project; ages 25-70 (M = 45.07, SD = 10.96), 50.3% female, and 83% Caucasian. Cognition was assessed via the Brief Test of Adult Cognition by Telephone, biological data via fasted blood draw, and RT data were collected as part of the National Study of Daily Experiences daily diary. Total RT (amount one engages in RT) and RT valence (positive vs. negative thought content) were analyzed. As IQ increased, more positive RT was associated with lover levels of IL-6 and CRP after adjusting for age, BMI, and statin use (β = -.161, p = .029; β = -.240, p = .002). Results did not replicate Segerstrom et al. (2017) but suggested that crystallized intelligence and RT total reflect a cognitive system different than that of fluid intelligence, executive functioning, and RT valence. Future studies should continue to investigate effects of RT on health outcomes.

By 2030 major depression is predicted to be the leading cause of disease burden in the world; as such, it is critical to understand factors that contribute to the development of depression. The social signal transduction theory of depression hypothesizes that adversity and social threat upregulate pro-inflammatory biomarkers leading to depression. The current study examined whether pro-inflammatory biomarkers (interleukin-6, interleukin-8, c-reactive protein, and tumor necrosis factor alpha) mediate the association between various types of childhood maltreatment (physical abuse, sexual abuse, emotional abuse, physical neglect, emotional neglect) and adult depression symptoms in a sample of 740 adults (372 female; Mage= 51.6 years, SD = 13.6) who provided retrospective report of childhood maltreatment as part of the Midlife in the United States (MIDUS) Refresher Biomarker study. Additionally, it explored whether these relations differ for males versus females. A series of linear regression analyses were run in SPSS; separate models were run for each form of childhood maltreatment and for interleukin-6, interleukin-8, c-reactive protein, and tumor necrosis factor-alpha. The results showed that childhood maltreatment is a robust predictor of adulthood depression; however, this association did not differ between biological sexes. In addition, only interleukin-6 was shown to partially mediate the association between childhood maltreatment and adulthood depression. These findings highlight the need to explore the use of interleukin-6 to screen for depression in youth. / M.S. / By 2030 major depression is predicted to be the leading cause of disease burden in the world; as such, it is critical to understand factors that contribute to the development of depression. It has been hypothesized that adversity and social threat activate pro-inflammatory biomarkers, which are proteins that can detect inflammation in the body, leading to depression. The current study examined whether several pro-inflammatory biomarkers explain the association between several types of childhood maltreatment (physical abuse, sexual abuse, emotional abuse, physical neglect, emotional neglect) and adult depression symptoms in a sample of 740 adults (372 female; Mage= 51.6 years, SD = 13.6) who provided report of past experiences of childhood maltreatment. Additionally, it explored whether these relations differ for males versus females. The results showed that childhood maltreatment is a robust predictor of adulthood depression for males and females. Of the inflammatory biomarkers examined, only interleukin-6 was shown to partially explain the association between childhood maltreatment and adulthood depression symptoms. These findings highlight the need to explore the use of interleukin-6 to screen for depression in youth.

Objective: To identify whether perceived stress is a risk-factor for higher cortisol levels and greater insulin resistance in Type 2 diabetic patients, using data from participants with and without diabetes in the National Survey of Midlife Development in the United States (MIDUS), specifically MIDUS II, Project 4. The following hypotheses were tested: (H1a) greater perceived stress would be associated with higher cortisol for Type 2 diabetic participants, (H1b) the perceived stress/cortisol relationship would be stronger for people with Type 2 diabetes than for those without it, (H2) greater perceived stress would be associated with higher Homeostatic Model Assessment-Insulin Resistance (HOMA-IR, insulin-resistance) for Type 2 diabetic participants, (H3a) subjective well-being would moderate the perceived stress/insulin resistance relationship for Type 2 diabetic participants, and (H3b) depression would moderate the perceived stress/insulin resistance relationship for Type 2 diabetic participants. Method: MIDUS, a longitudinal study of over 7,000 American adults, explores biopsychosocial factors that could contribute to variance in mental/physical health. Only complete data were utilized. Type 2 participants (n=115) consisted of 54 males and 62 females ranging in age from 36 to 81 years. Non-diabetic participants (n=1097) consisted of 470 males and 627 females ranging in age from 34 to 84 years. Results: None of the predicted relationships were statistically significant. Waist to hip ratio was significantly related to insulin resistance (r = .31, p = .001). Conclusions: Future studies should collect information about the type and duration of stressors in addition to perceptions about stress for those with Type 2 diabetes.

Affective intra-individual variability (IIV) and affective psychological flexibility (PF) are both types of within-person variability. Affective IIV is defined as the range of emotions experienced by an individual assessed at multiple time points. PF is defined as the ability to vary one’s responses in a contextually dependent manner in order to appropriately meet situational demands. Currently, there are no comparisons between affective IIV and PF demonstrating how these constructs might be uniquely different from each other. The current study proposed to examine affective IIV and PF in order to establish discriminant and convergent validity, and stability data for each construct. The National Study of Daily Experiences (NSDE) waves 1 and 2, an 8-day daily diary portion of the Midlife Development in the United States (MIDUS I) and MIDUS II surveys was used for this study (n =793 adults completed both waves of the NSDE). Affective IIV was related to higher mean NA and neuroticism, and lower perceived control. Affective PF was related to lower mean NA, neuroticism, and higher mean PA and perceived control. Higher affective IIV was associated with more psychological distress when assessed concurrently at both waves and predicted more psychological distress and physical ill-health 10 years later. Higher affective PF was related to less psychological distress and physical ill-health when assessed concurrently at wave 1 and less psychological distress and physical ill-health 10 years later. When situational context is included in the calculation of emotional variability, changes in emotional response may represent emotional complexity and increased control rather than emotional lability and are related to better psychological and physical outcomes.