Thesis (Ph. D.)--University of Oregon, 2005. / Includes bibliographical references (leaves 115-119)

Thesis (M.S.)--State University of New York at Binghamton, Department of Psychology, 2008. / Includes bibliographical references.

Orientadora: Roberta Gonçalves da Silva / Banca: Célia Maria Giacheti / Banca: Dionísia A. Lamônica / Resumo: Introdução: Pessoas com Paralisia Cerebral (PC) apresentam prognóstico e comorbidades diversificadas e suas manifestações estão relacionadas com limitações funcionais, tanto motoras globais como de controle neuromotor das funções orais, desencadeando dificuldades na comunicação, deglutição e saúde bucal. Objetivo: Este estudo teve por objetivo relacionar o risco de disfagia orofaríngea (DO) com o estado de saúde bucal na pessoa com Paralisia Cerebral. Método: Foram selecionados todos os prontuários com diagnóstico neurológico conforme CID 10, dentro da classificação de Paralisia Cerebral de distintos subtipos, do período de janeiro de 2011 a junho de 2017, do Centro de Assistência Odontológica à Pessoa com Deficiência (CAOE) da Universidade Estadual Paulista - Unesp - Campus de Araçatuba, perfazendo 1868 indivíduos. Foram incluídos nesse estudo 345 prontuários, 194 do gênero masculino e 151 do gênero feminino, faixa etária de 1 a 60 anos, com média de 13,9 anos, e função motora grossa (GMFCS) que variou de I a V. Elaborado e aplicado instrumento de rastreio para disfagia orofaríngea na PC e para a classificação da saúde bucal nessa população. Resultados: Das 345 (100%) pessoas com PC, 197 (57,1%) apresentaram risco para DO e 148 (42,9%) não apresentaram. A associação entre risco de DO e subtipo de PC foi significante na PC quadriplégica espástica e com maior razão de chance que nos demais subtipos. Houve associação entre disfagia orofaríngea e saúde bucal na PC considerando o... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Introduction: People with Cerebral Palsy (CP) have different prognoses and comorbidities and their manifestations are related to functional limitations, both global motor and neuromotor control of oral functions, with impairment in communication, swallowing and oral health. Purpose: This study aimed to relate the risk of oropharyngeal dysphagia (OD) with oral health status in people with CP. Methods: All neurological records according within the classification of CP of different subtypes, from January 2011 to June 2017, were selected from the Center for the Assistance to the Individuals with Disabilities (CAOE) of the Paulista State University- Unesp - Campus of Araçatuba, comprising 1868 individuals. The study included 345 medical records, 194 males and 151 females, ranging from 1 to 60 years old, mean age of 13.9 years, and gross motor function (GMFCS), ranging from I to V. Screening for oropharyngeal dysphagia on CP and the classification of oral health in this population were proposed and applied. Results: Of the 345 (100%) people with CP, 197 (57.1%) presented risk for OD and 148 (42.9%) did not present. The association between OD risk and PC subtype was significant in spastic quadriplegic CP and with a higher odds ratio than in the other subtypes. There was an association between oropharyngeal dysphagia and oral health in CP considering motor performance (p: 0.0485). Conclusion: The risk of oropharyngeal dysphagia was more frequent in spastic quadriplegic CP and present... (Complete abstract click electronic access below) / Mestre

Drug-induced tardive dyskinesia, an irreversible involuntary movement disorder caused by neuroleptic drugs, may reflect cholinergic hypofunction in the corpus striatum. Therapeutic results have been reported in trials of choline and lecithin, nutritional substrates which may enhance cholinergic neurotransmission. Lecithin's effects on dyskinetic symptoms were examined in 50 male patients in a double-blind, placebo-controlled trial. Patients were randomly assigned to treatment or control groups; 31 patients were retained in the analytic cohort. Experimental patients were treated with 60 gm/day lecithin (55% phosphatidyl choline) for 11 days. Symptom frequency was rated from videotapes made at baseline, 3 and 11 days of treatment, and 1 week follow-up.

O objetivo deste trabalho foi caracterizar as alterações de linguagem na doença de Huntington e correlacioná-las com os transtornos motores, cognitivos, psiquiátricos e, também, com o tempo de doença. Foram estudados 26 indivíduos, divididos em grupo leve (11 doentes) e moderado (15 doentes), comparados com dois grupos controle. Foram encontradas alterações em provas de compreensão e expressão da linguagem oral e gráfica para os dois grupos de doentes. Evidências sugerem que não há prejuízo nas representações semânticas, e que as dificuldades de linguagem estão relacionadas com o declínio cognitivo global e, especialmente, com o prejuízo das funções executivas. As alterações de linguagem se correlacionaram com o desempenho em tarefas cognitivas, mas não com as alterações motoras ou psiquiátricas da doença. Também não foi encontrada correlação entre o desempenho de linguagem e o tempo de doença / The objective of this study was to characterize the language alterations in Huntington's disease and how they relate to severity of motor, cognitive, psychiatric disturbances and also with the disease duration. Twenty-six (26) individuals were divided into groups characterized as lightly (11) and moderately ill (15) and compared with two control groups. Alterations in exams of language comprehension and expression were noticed for both groups of sick individuals. The result indicates no evident loss in semantic representation. The language difficulties are related to a global cognitive decline and, principally, to loss of executive functions. The language alterations were significantly correlated to performance in cognitive tasks, but not to the motor or psychiatric alterations of the disease. There was also no correlation observed between the language performance and duration of illness

Movement disorders are a group of syndromes that often arise due to neurological abnormalities. Approximately 40 million Americans are affected by some form of movement disorder, significantly impacting patients’ quality of life and their ability to live independently. Deep brain stimulation (DBS) is one treatment that has shown promising results in the past couple decades, however, the currently used open-loop system has several drawbacks. By implementing a closed-loop or adaptive DBS (aDBS) system, the need for expensive parameter reprogramming sessions would be reduced, side-effects may be relieved, and habituation could be avoided. Several biomarkers, for example signals or activity derived from electroencephalogram (EEG), could potentially be used as a feedback source for aDBS. Here, we attempted to characterize cortical EEG potentials in healthy subjects performing six tasks that are difficult for those with movement disorders. Using a 32-channel EEG cap with an amplifier sampling at 500 Hz, we performed our protocol on 11 college-aged volunteers lacking any known movement disorder. For each task, we analyzed task-related power (TRP) changes, spectrograms, and topographical maps. In a finger movement exercise, we found task-related depression (TRD) in the delta band at the F4 electrode, as well as TRD at the C3 electrode in the alpha band during a pencil-pickup task, and TRD at the F3 electrode in the beta band during voluntary swallowing. While delta-ERD in the finger movement exercise was likely due to ocular artifact, the other significant results were in line with what relevant literature would predict. The findings from the work, in conjunction with a future study involving movement disorder patients, can provide insight into the use of EEG as a feedback source for aDBS. Keywords: EEG, electroencephalography, neurostimulation, deep brain stimulation, movement disorders, closed-loop DBS, adaptive DBS, aDBS

Summary: Movement disorders are caused by impairment of the basal ganglia and extrapyramidal connections. The most common is Parkinson's disease (PD), characterised by hypokinesia together with resting tremor and / or rigidity, which may be influenced by dopaminergic therapy or invasive methods, including deep brain stimulation (DBS). Gait and balance disorders are part of the Parkinson's syndrome, progress during the disease course and limit daily activities, quality of life, may lead to falls and contribute to higher mortality of the patients in the late stages. Therapy is difficult. Gait disorders and parkinsonism may occur also in other diseases, including intoxications which may also lead to basal ganglia impairment. The theoretical part include the physiology of gait, gait disorders and examination. The section devoted to movement disorders focuses on Parkinson's disease and methanol intoxication. The practical part consists of 3 studies evaluating gait disorder in patients with advanced PD and possibilities of the treatment, the 4th study documents gait disorder in survivors after mass methanol poisoning with outbreak between 2012 and 2014 in the Czech Republic. The result confirm the effect of DBS in step length prolongation and gait speed increment in patients with PD. Compensation strategies using...

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No description available.

Currently a lack of guidelines for Criterion B of the DSM-IV-TR (American Psychiatric Association, 2000) hampers diagnosis of children with developmental coordination disorder (DCD). The Performance of Activities of Daily Living Questionnaire (PADL-Q; Dewey, Larkin & Summers, 2004) is a new parent-reported instrument developed to quantify the level of interference in activities of daily living (ADL) experienced by children with DCD and was tested for its efficacy in addressing Criterion B. Thirty-two children aged between 5 and 10 years comprising two matched groups, 16 with DCD (8 boys and 8 girls) and 16 without DCD (8 boys and 8 girls) participated in the study. The aim of the research was to investigate the ability of the PADL-Q to identify differences between children with and without DCD. A further 5 children, in the same age range, who did not have DCD added data that was used to ascertain relationships between the constituent assessments. All children were tested using the MAND (McCarron, 1982) whilst their parents completed the PADL-Q. A set of Tests of Activities of Daily Living (TADL) tasks were devised for the children to perform that further validated parents ratings of children?s ADL performance. A Group x Gender MANCOVA, controlled for age, of the PADL-Q total scores demonstrated that there was a significant difference between the children with and without DCD (F(3,25) = 9.44, p < .001; Wilks' lambda = 0.47). Follow-up univariate tests showed a Group x Gender interaction and simple main effects of this interaction indicated that the PADL-Q did not discriminate between the DCD and non-DCD boys. The ability of the PADL-Q to identify DCD was explored in the concurrent validity against the MAND when using a diagnostic cut-off point. The PADL-Q demonstrated 100% specificity and positive predictive values but only 19% sensitivity and 62% negative predictive values. There was a moderately strong relationship (r = .71), between the PADL-Q total score, considered a measure of Criterion B, and the MAND, a measure of Criterion A (DSMIV- TR, 2000). A two factor (Group x Gender) ANCOVA, controlled for age, of the TADL items revealed a statistically significant effect for DCD only (F(1,19) = 34.65, p < .001). There was a moderate correlation (r = -.64) between the PADL-Q total score and the TADL tasks, indicating that parent-reports are supported by their child?s performance. The PADL-Q appears to have potential as part of the DCD diagnostic process; however, further refinement on a larger sample is necessary before it can be used as an easily-administered guide to ADL performance levels in children.