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Metallodendrimers as catalysts for C-C coupling reactionsMapolie, S. F. January 2011 (has links)
>Magister Scientiae - MSc / In this work, we describe the synthesis of ferrocenylimine and G1 dendrimeric N,N′ ligands, and their palladium(II) complexes. The ligands L1 – L4 were synthesized following Schiff base condensation reactions. The ferrocenylimine ligands L1 and L2 were prepared from ferrocenecarboxaldehyde and 1,3-diaminopropane or DAB-4-(NH2)4, while the G1 dendrimeric N,N′ ligands L3 and L4 were prepared from DAB-4-amine and 2- pyridinecarboxaldehyde or 2-quinolinecarboxaldehyde.
The air and moisture stable ligands were obtained in fairly good yields of over 65 %. All the ligands were observed to be soluble in common organic solvents. They were characterized by FTIR spectroscopy, 1H-NMR spectroscopy, 13C-NMR spectroscopy, micro-analysis and ESImass spectrometry.A reaction of the ligands with PdCl2(COD) or PdCl2(MeCN)2 gave palladium(II) complexes C1 – C4 in good yields of over 70%. The complexes were observed to be stable. However,the complexes did not dissolve in common organic solvents. These were characterized by FTIR spectroscopy and 1H-NMR and 13C-NMR spectroscopy.All the complexes were screened for activity towards Heck coupling model reaction of iodobenzene with styrene. The complexes catalyzed the coupling of styrene with iodobenzene, giving over 60 % conversions. However, complex C3 was found to be the most
active catalyst, yielding 75% conversion without formation of palladium black.
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Metal complex catalysed C-X (X = S, O and N) bond formationVuong, Khuong Quoc, Chemistry, Faculty of Science, UNSW January 2006 (has links)
This thesis describes the catalysed addition of X-H bonds (X = S, O and N) to alkynes using a range of novel rhodium(I) and iridium(I) complexes containing hybrid bidentate phosphine-pyrazolyl, phosphine-imidazolyl and phosphine-N heterocyclic carbene (NHC) donor ligands. The synthesis of novel bidentate phosphine-pyrazolyl, phosphine-imidazolyl (P-N) and phosphine-NHC (PC) donor ligands and their cationic and neutral rhodium(I) and iridium(I) complexes [M(P N)(COD)]BPh4, [M(PC)(COD)]BPh4, [Ir(P-N)(CO)2]BPh4 and [M(P-N)(CO)Cl] were successfully performed. An unusual five coordinate iridium complex with phosphine-NHC ligands [Ir(PC)(COD)(CO)]BPh4 was also obtained. Seventeen single crystal X-ray structures of these new complexes were determined. A range of these novel rhodium and iridium complexes were effective as catalysts for the addition of thiophenol to a variety of alkynes. Iridium complexes were more effective than rhodium analogues. Cationic complexes were more effective than neutral complexes. Complexes with hybrid phosphine-nitrogen donor were more effective than complexes containing bidentate nitrogen donor ligands. An atom-economical, efficient method for the synthesis of cyclic acetals and bicyclic O,O-acetals was successfully developed based on the catalysed hydroalkoxylation. Readily prepared terminal and non-terminal alkyne diols were cyclised into bicyclic O,O-acetals in quantitative conversions in most cases. The efficiency of a range of rhodium and iridium complexes containing bidentate P-N and PC donor ligands as catalysts for the cyclisation of 4-pentyn-1-amine to 2-methyl-1-pyrroline varied significantly. The cationic iridium complexes with the bidentate phosphine-pyrazolyl ligands, [Ir(R2PyP)(COD)]BPh4 (2.39-2.42) were extremely efficient as catalysts for this transformation. Increasing the size of the substituent on or adjacent to the donor led to improvement in catalytic activity of the corresponding metal complexes. The mechanism of the catalysed hydroalkoxylation was proposed to proceed by the initial activation of the alkyne via ?? coordination to the metal centre. The ?? binding of both aliphatic and aromatic alkynes to [Ir(PyP)(CO)2]BPh4 (2.44) was observed by low temperature NMR and no reaction between 2.44 and alcohols was observed. In contrast, the facility in which thiol and amine oxidatively added to 2.44 led the proposal that in the hydrothiolation and hydroamination reaction, the catalytic cycle commences with the activation of the X-H bond (X = S, N) by an oxidative addition process.
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Metal complex catalysed C-X (X = S, O and N) bond formationVuong, Khuong Quoc, Chemistry, Faculty of Science, UNSW January 2006 (has links)
This thesis describes the catalysed addition of X-H bonds (X = S, O and N) to alkynes using a range of novel rhodium(I) and iridium(I) complexes containing hybrid bidentate phosphine-pyrazolyl, phosphine-imidazolyl and phosphine-N heterocyclic carbene (NHC) donor ligands. The synthesis of novel bidentate phosphine-pyrazolyl, phosphine-imidazolyl (P-N) and phosphine-NHC (PC) donor ligands and their cationic and neutral rhodium(I) and iridium(I) complexes [M(P N)(COD)]BPh4, [M(PC)(COD)]BPh4, [Ir(P-N)(CO)2]BPh4 and [M(P-N)(CO)Cl] were successfully performed. An unusual five coordinate iridium complex with phosphine-NHC ligands [Ir(PC)(COD)(CO)]BPh4 was also obtained. Seventeen single crystal X-ray structures of these new complexes were determined. A range of these novel rhodium and iridium complexes were effective as catalysts for the addition of thiophenol to a variety of alkynes. Iridium complexes were more effective than rhodium analogues. Cationic complexes were more effective than neutral complexes. Complexes with hybrid phosphine-nitrogen donor were more effective than complexes containing bidentate nitrogen donor ligands. An atom-economical, efficient method for the synthesis of cyclic acetals and bicyclic O,O-acetals was successfully developed based on the catalysed hydroalkoxylation. Readily prepared terminal and non-terminal alkyne diols were cyclised into bicyclic O,O-acetals in quantitative conversions in most cases. The efficiency of a range of rhodium and iridium complexes containing bidentate P-N and PC donor ligands as catalysts for the cyclisation of 4-pentyn-1-amine to 2-methyl-1-pyrroline varied significantly. The cationic iridium complexes with the bidentate phosphine-pyrazolyl ligands, [Ir(R2PyP)(COD)]BPh4 (2.39-2.42) were extremely efficient as catalysts for this transformation. Increasing the size of the substituent on or adjacent to the donor led to improvement in catalytic activity of the corresponding metal complexes. The mechanism of the catalysed hydroalkoxylation was proposed to proceed by the initial activation of the alkyne via ?? coordination to the metal centre. The ?? binding of both aliphatic and aromatic alkynes to [Ir(PyP)(CO)2]BPh4 (2.44) was observed by low temperature NMR and no reaction between 2.44 and alcohols was observed. In contrast, the facility in which thiol and amine oxidatively added to 2.44 led the proposal that in the hydrothiolation and hydroamination reaction, the catalytic cycle commences with the activation of the X-H bond (X = S, N) by an oxidative addition process.
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N3, N4/(N3S, N3O) and N6 Phenanthroline Bases and their Spin Crossover Iron(II) ComplexesDjomgoue, Paul 05 August 2016 (has links) (PDF)
The present dissertation focuses on the synthesis of iron(II) complexes and the study of their SCO behavior. The equilibrium between the HS and the LS states gives to the SCO systems large potential applications for molecular electronics. However, today there is not a single molecular device from SCO compounds in the market. This is due to the fact that the SCO systems discovered up to now were unable (e.g. TLIESST « 300 K) for these applications. The aim of this thesis is to synthesize new SCO compounds with sustainable properties for applications.
In the beginning of the thesis, [Fe(rac-22a))]2+∙2[BF4]- and [Fe(rac-22b)]2+∙2[BF4]- employing rigid hexadentate ligands were described. In contrast to the expectation, the N-methylation of the amines shifts the equilibrium towards the LS state. [Fe(rac-22b)2+∙2[BF4]- shows a T1/2 higher at 74 K and 52 K than the non methylated [Fe(rac-22a)2+∙2[BF4]- respectively in nitrobenzene and acetonitrile. The T1/2 are solvent-dependent for these complexes. After that, ligand series 9-R2-2-(6-R1-pyridin-2-yl)-1,10-phenanthroline 25b (R2 = Me), 25f (R2 = Ph), 25d (R2 = C(O)H), 25c (R1 = Ph), 25l (R1 = oxylphenyl-4-oxymethylene), 25m (R1 = oxymesitylene) and 25j (R1 = pyrol-1-yl) were synthesized. It was observed that the size of the substituent influences the SCO properties (T1/2). In addition, the influence of the counterion was shown with [Fe(25c)2]2+∙2[BF4]- and [Fe(25c)2]2+∙2[B(Ph)4]-. The B(Ph)4- conterions bring π∙∙∙π interactions in the molecular cell which shift the T1/2 parameter to a high temperature (200 K) compared to the complex with BF4- ions (175 K). Moreover the substituents R1 on the terminal position of the pyridine effect on T1/2 more than the substituents R2 on the terminal position of the phenanthroline. For example, [Fe(25f)]2+∙2[BF4]- (R1 = Ph) is a pure HS complex while the complex [Fe(25c)]2+∙2[BF4]- (R2 = Ph) is a SCO system (T1/2 = 175 K). The expansion of the coordination mode from N6 to N8 was investigated by the synthesis of the tetradentate ligands. This expansion shows an unexpected coordination mode, [Fe(25i)2]2+∙2[BF4]- (R2 = pyrazol-1-yl) forms a distorted square antiprism coordination geometry (HS iron(II)-complex) and does not show any Fe-N bond breaking over the application of the temperature as expected. / Die vorliegende Dissertation behandelt die Synthese von Eisen(II)-Komplexen und ihr spin crossover (SCO)-Verhalten. Das Gleichgewicht zwischen high-spin (HS)- und low-spin (LS)-Zustand verleiht den SCO-Systemen eine großes Anwendungspotential im Bereich der molekularen Elektronik. Dennoch existiert bis heute kein SCO-basiertes molekulares Bauteil auf dem Markt. Hauptgrund hierfür ist, dass die bislang bekannten SCO-Systeme keine hinreichenden Eigenschaften (z.B. TLIESST « 300 K) aufweisen. Das Ziel der vorliegenden Arbeit ist die Synthese neuer SCO-Verbindungen mit geeigneten Eigenschaften für die Anwendung.
Zu Beginn der Arbeit werden die Komplexe [Fe(rac-22a)]2+∙2[BF4]– und [Fe(rac-22b)]2+ ∙2[BF4]– mit starren hexadentaten Liganden beschrieben. Entgegen der Erwartung verschiebt die N-Methylierung der Amine das Gleichgewicht in Richtung des LS-Zustandes. Verglichen mit dem nicht-methylierten Komplex Fe(rac-22b)]2+∙2[BF4]– zeigt Fe(rac-22a)]2+∙2[BF4]– eine höhere Übergangstemperatur T1/2, welche in Nitrobenzen 74 K und in Acetonitril 52 K beträgt. Für die Komplexe ist T1/2 lösungsmittelabhängig. Im Folgenden wurde die Ligandenserie 9-R2-2-(6-R1-pyridin-2-yl)-1,10-phenanthrolin mit den Vertretern 25b (R2= Me), 25f (R2 = Ph), 25d (R2 = C(O)H, 25c (R1 = Ph), 25l (R1 = oxyphenyl-4-oxymethylen), 25m (R1 = oxymesitylen) und 25j (R1 = pyrol-1-yl) hergestellt. Es wurde beobachtet, dass die Größe des Substituenten das SCO-Verhalten (T1/2) beeinflusst. Ergänzend wurde der Einfluss des Gegenions anhand der Komplexe [Fe(25c)]2+∙2[BF4]– und [Fe(25c)]2+∙2[B(Ph)4]– untersucht. Das Gegenion B(Ph)4– ermöglicht intra- und intermolekulare π···π-Wechselwirkungen in der Zelle, welche die Übergangstemperature T1/2 (200 K) gegenüber dem BF4–-Komplex (175 K) erhöhen. Des Weiteren beeinflussen die Substituenten R1 an der Pyridin-Einheit die ubergangskomplexes T1/2 stärker als die Substituenten R2 an der Phenanthrolin-Einheit. So ist [Fe(25f)]2+∙2[BF4]– (R1 = Ph) ein reiner HS-Komplex, während der Komplex [Fe(25c)]2+∙2[BF4]– (R2 = Ph) ein SCO-System ist (T1/2 = 175 K). Die Erhöhung der Koordinationszahl von N6 auf N8 wurde über die Synthese von tetradentaten Liganden untersucht. Diese Erhöhung führt zu einem unerwarteten Koordinationsmodus. So bildet [Fe(25i)]2+∙2[BF4]– (R2 = pyrazol-1-yl) eine quadratisch-antiprismatische Koordinationssphäre (HS Eisen(II)-Komplex) und zeigt, wie erwartet, über den untersuchten Temperaturbereich keine Fe–N-Bindungsspaltung.
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Synthesis, Structure and Reactivity of Manganese Complexes Supported by Carbon or Nitrogen Donor Ligands / Synthese, Struktur und Reaktivität von Mangan-Komplexen mit Carben oder Nitrogen Donor LigandenChai, Jianfang 03 November 2004 (has links)
No description available.
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Biomimetic Copper(I)-Mediated Activation of Dioxygen and Redox Non-Innocence in Copper(II) Complexes of Bis(oxazoline)sWalli, Adam 13 October 2014 (has links)
No description available.
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Pyrazolliganden mit Imin-Seitenarmen und ihre zweikernigen Palladium(II)- und Nickel(II)-Komplexe: neue bimetallische Katalysatoren für die Olefinpolymerisation / Pyrazolligands with imine sidearms and their dinuclear palladium(II)- and nickel(II)-complexes: new dinuclear catalysts for olefinpolymerizationNoël, Gilles Louis Lucien 03 November 2005 (has links)
No description available.
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Synthèse stéréospécifique et chimie de coordination de ligands hétérobifonctionnels P-stéréogènes : vers le développement de méthodologies de couplages C-C palladocatalysés / Stereospecific synthesis and coordination chemistry of P-stereogenic heterobidentate ligands : towards the development of palladium-catalyzed C-C couplingsLemouzy, Sébastien 29 November 2016 (has links)
La première partie de ce manuscrit traite de la synthèse de phosphine-boranes P-stéréogènes énantioenrichis à partir d’un précurseur développé par notre laboratoire : le H-phénylphosphinate d’adamantyle. Grâce au développement d’une séquence monotope, une variété d’oxydes de phosphine P-stéréogènes de haute pureté optique a pu être synthétisée. Ces composés comportant une attache hydroxyle ont ensuite été réduits de façon stéréospécifique en présence de borane pour générer les précurseurs phosphine-boranes correspondants. Lors de cette étape de réduction, l’importance de la fonction hydroxyle a été mise en évidence, et un mécanisme basé sur la formation d’une espèce phosphaboracyclique intermédiaire a été proposé, sur la base de l’isolement d’intermédiaires réactionnels O-borés. Les trois rôles du borane (activation, réduction, protection de la phosphine) ont été clairement identifiés dans ce processus. Dans un second temps, nous avons pu mettre à profit la rétroaddition du groupement hydroxyalkyle en milieu basique lors de l’alkylation stéréospécifique chimiodivergente de phosphure-boranes masqués. Cette rétroaddition a permis de contourner l’instabilité chimique et configurationnelle des phosphures générés in situ, permettant l’accès à des phosphine-boranes fonctionnalisés de manière énantiospécifique. Ces ligands P,N ont été ensuite complexés au palladium et les complexes ont pu être testés comme catalyseurs de couplages C-C énantiosélectifs. Lors de ces couplages, l’angle de morsure du ligand s’est révélé crucial pour la réactivité du système catalytique. / The first part of this manuscript deals with the synthesis of enantioenriched P-stereogenic phosphine-boranes from a chiral precursor developed in our laboratory: H-adamantyl phenylphosphinate. Through the design of a one-pot procedure, the synthesis of a wide array of highly enantioenriched phosphine oxides has been achieved. These hydroxy-functionalised compounds were reduced stereospecifically under borane conditions to yield the corresponding hydroxyalkylphosphine-boranes. During the study of this reaction, the importance of hydroxy group has been highlighted, and a mechanism relying on the formation of transient phosphaboracyclic intermediate could be proposed, on the basis of kinetic observation and isolation of O-borylated intermediates. In this transformation, borane seems to display three roles: activating, reducing and protecting agent. Next, we were able to take advantage of the retroaddition of hydroxyalkyl moiety under basic conditions to develop a new approach for the stereospecific and chemodivergent alkylation of masked secondary phosphine-boranes. This unusual reactivity allowed us to circumvent the relative chemical and configurational instability of such in situ generated phosphido-boranes intermediate, thus enabling the stereospecific synthesis of functionalised tertiary phosphine-boranes. These P-N ligands have been complexed to palladium, and the catalytic activity of these complexes in enantioselective C-C couplings has been studied. During the catalytic process, it appears that the ligand bite angle plays an important role in the catalyst activity.
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N3, N4/(N3S, N3O) and N6 Phenanthroline Bases and their Spin Crossover Iron(II) ComplexesDjomgoue, Paul 13 May 2016 (has links)
The present dissertation focuses on the synthesis of iron(II) complexes and the study of their SCO behavior. The equilibrium between the HS and the LS states gives to the SCO systems large potential applications for molecular electronics. However, today there is not a single molecular device from SCO compounds in the market. This is due to the fact that the SCO systems discovered up to now were unable (e.g. TLIESST « 300 K) for these applications. The aim of this thesis is to synthesize new SCO compounds with sustainable properties for applications.
In the beginning of the thesis, [Fe(rac-22a))]2+∙2[BF4]- and [Fe(rac-22b)]2+∙2[BF4]- employing rigid hexadentate ligands were described. In contrast to the expectation, the N-methylation of the amines shifts the equilibrium towards the LS state. [Fe(rac-22b)2+∙2[BF4]- shows a T1/2 higher at 74 K and 52 K than the non methylated [Fe(rac-22a)2+∙2[BF4]- respectively in nitrobenzene and acetonitrile. The T1/2 are solvent-dependent for these complexes. After that, ligand series 9-R2-2-(6-R1-pyridin-2-yl)-1,10-phenanthroline 25b (R2 = Me), 25f (R2 = Ph), 25d (R2 = C(O)H), 25c (R1 = Ph), 25l (R1 = oxylphenyl-4-oxymethylene), 25m (R1 = oxymesitylene) and 25j (R1 = pyrol-1-yl) were synthesized. It was observed that the size of the substituent influences the SCO properties (T1/2). In addition, the influence of the counterion was shown with [Fe(25c)2]2+∙2[BF4]- and [Fe(25c)2]2+∙2[B(Ph)4]-. The B(Ph)4- conterions bring π∙∙∙π interactions in the molecular cell which shift the T1/2 parameter to a high temperature (200 K) compared to the complex with BF4- ions (175 K). Moreover the substituents R1 on the terminal position of the pyridine effect on T1/2 more than the substituents R2 on the terminal position of the phenanthroline. For example, [Fe(25f)]2+∙2[BF4]- (R1 = Ph) is a pure HS complex while the complex [Fe(25c)]2+∙2[BF4]- (R2 = Ph) is a SCO system (T1/2 = 175 K). The expansion of the coordination mode from N6 to N8 was investigated by the synthesis of the tetradentate ligands. This expansion shows an unexpected coordination mode, [Fe(25i)2]2+∙2[BF4]- (R2 = pyrazol-1-yl) forms a distorted square antiprism coordination geometry (HS iron(II)-complex) and does not show any Fe-N bond breaking over the application of the temperature as expected. / Die vorliegende Dissertation behandelt die Synthese von Eisen(II)-Komplexen und ihr spin crossover (SCO)-Verhalten. Das Gleichgewicht zwischen high-spin (HS)- und low-spin (LS)-Zustand verleiht den SCO-Systemen eine großes Anwendungspotential im Bereich der molekularen Elektronik. Dennoch existiert bis heute kein SCO-basiertes molekulares Bauteil auf dem Markt. Hauptgrund hierfür ist, dass die bislang bekannten SCO-Systeme keine hinreichenden Eigenschaften (z.B. TLIESST « 300 K) aufweisen. Das Ziel der vorliegenden Arbeit ist die Synthese neuer SCO-Verbindungen mit geeigneten Eigenschaften für die Anwendung.
Zu Beginn der Arbeit werden die Komplexe [Fe(rac-22a)]2+∙2[BF4]– und [Fe(rac-22b)]2+ ∙2[BF4]– mit starren hexadentaten Liganden beschrieben. Entgegen der Erwartung verschiebt die N-Methylierung der Amine das Gleichgewicht in Richtung des LS-Zustandes. Verglichen mit dem nicht-methylierten Komplex Fe(rac-22b)]2+∙2[BF4]– zeigt Fe(rac-22a)]2+∙2[BF4]– eine höhere Übergangstemperatur T1/2, welche in Nitrobenzen 74 K und in Acetonitril 52 K beträgt. Für die Komplexe ist T1/2 lösungsmittelabhängig. Im Folgenden wurde die Ligandenserie 9-R2-2-(6-R1-pyridin-2-yl)-1,10-phenanthrolin mit den Vertretern 25b (R2= Me), 25f (R2 = Ph), 25d (R2 = C(O)H, 25c (R1 = Ph), 25l (R1 = oxyphenyl-4-oxymethylen), 25m (R1 = oxymesitylen) und 25j (R1 = pyrol-1-yl) hergestellt. Es wurde beobachtet, dass die Größe des Substituenten das SCO-Verhalten (T1/2) beeinflusst. Ergänzend wurde der Einfluss des Gegenions anhand der Komplexe [Fe(25c)]2+∙2[BF4]– und [Fe(25c)]2+∙2[B(Ph)4]– untersucht. Das Gegenion B(Ph)4– ermöglicht intra- und intermolekulare π···π-Wechselwirkungen in der Zelle, welche die Übergangstemperature T1/2 (200 K) gegenüber dem BF4–-Komplex (175 K) erhöhen. Des Weiteren beeinflussen die Substituenten R1 an der Pyridin-Einheit die ubergangskomplexes T1/2 stärker als die Substituenten R2 an der Phenanthrolin-Einheit. So ist [Fe(25f)]2+∙2[BF4]– (R1 = Ph) ein reiner HS-Komplex, während der Komplex [Fe(25c)]2+∙2[BF4]– (R2 = Ph) ein SCO-System ist (T1/2 = 175 K). Die Erhöhung der Koordinationszahl von N6 auf N8 wurde über die Synthese von tetradentaten Liganden untersucht. Diese Erhöhung führt zu einem unerwarteten Koordinationsmodus. So bildet [Fe(25i)]2+∙2[BF4]– (R2 = pyrazol-1-yl) eine quadratisch-antiprismatische Koordinationssphäre (HS Eisen(II)-Komplex) und zeigt, wie erwartet, über den untersuchten Temperaturbereich keine Fe–N-Bindungsspaltung.
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Preparation and Reactions of Compounds with Heavier Group 14 Elements in Low Oxidation States / Synthese und Reaktionen von Verbindungen der Schweren Elemente der 14. Gruppe in niedrigen OxidationsstufenSen, Sakya Singha 04 October 2010 (has links)
No description available.
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