Philosophiae Doctor - PhD / This dissertation constructs a social history of African women in Cape Town from the vantage point of their varied attempts over the last five decades to map 'home' in the urban setting: in the physical structures of their homes; the character of their social and kinship networks; and in the ways a notion of 'place' was re-worked. An historiographical examination of existing research has shown that, especially in the South African context, much scope remains for a regionally specific historical analysis of the urbanisation process, and African women's unique role in it. The use of oral histories and the adoption of a trans-generational interviewing strategy have helped fashion a textured account of African women's settlement strategies, and the underlying social and personal transformations that their design and use suggested. 'First-generational' women, who entered Cape Town at mid-century, led an uncertain and highly regulated urban existence, by virtue of their enforced marginalisation under apartheid. Until the late-1980s, Cape Town retained a distinctive demographic composition, and an historical association as the 'home' of the Coloured population. This made state and local efforts to control the entry and residence of the minority African populace more coercive and successful, at least in the first two decades of apartheid rule. Despite these restrictions, African women constructed and managed a dense set of strategies which affirmed their material livelihoods in the city and increasingly enmeshed their identities in the workings of a modern and commoditised world. However, first-generational women also actively contested these developments to some extent, evident particularly in their efforts to regulate the movement of and compel financial support from their increasingly mobile daughters and granddaughters. Evidence from second and third-generational respondents show a growing reluctance to utilise first-generational women's settlement strategies and the conceptual frameworks which underpinned them. For instance, associational links were increasingly organised along non-racialised lines. Third-generational women's desire to establish residence in other areas of the city, or in other cities entirely, was indicative of a similar dynamic. This was also reflective of their embrace of mobility as an expression of greater economic and social freedoms possible in a post-apartheid world. This dissertation constructs a social history of African women in Cape Town from the vantage point of their varied attempts over the last five decades to locate 'home' in the urban setting. It charts the experiences of a group of women who first moved to Cape Town in the 1940s and 50s, and their children and grandchildren. My focus is on the way in which succeeding generations of women developed differing strategies of settlement, in the context of sometimes dramatic social and political change. The social as well as the physical elements of locating home are key elements in the analysis, including the redefinition of kinship and associational networks, as well as the re-casting of identities and a sense of place. Until the late 1980s, Cape Town retained a distinctive demographic composition, and an historical association as the 'home' of the Coloured- population. This made state and local efforts to control the entry and residence of the minority African populace more coercive and successful, at least in the first two decades of apartheid rule. Rather than painting a comprehensive portrait of urban African life in the apartheid era (1948- 1994), this dissertation hopes to map a few significant dynamics which were manifest in the encounters between a select group of African women and the distinctive terrain of this city during the apartheid years.

Previously, the bulk of the population lived in rural areas. The whole family lived there together in the family house on the same property. Young helped the elderly and old to their offspring, with households with children, with the economy. With the advent of industrialization and mobilization, many young people moved into the cities, to work, to the newly constructed blocks of residential houses, which were rather less than they could live with a large extended family. Mutual cooperation was suddenly far away. The town has more people, more jobs and more older people, which the state took care of them - homes for the elderly - retirees concentration in one place, without daily contact with young, with family. Thanks to good quality of health care older people is increasing and this problem is must be solved. The country has still semi-detached houses and multigenerational houses, where the family lived with grandparents, but in the city is hard to find to buy or rent two apartments near each other. The main concept of my work is to create a semi-detached flats, flats with common vestibule, which connects one smaller and one larger apartment. Use the castle for this principle is more than appropriate - will be returned the housing for the family and each of generation finds in the castle grounds space for their activities or employment. This area still remains open to inhabitant of the city and offer them new possibilities for leisure (restaurants and an amphitheater).

The subject of this masters thesis is preliminary design of III. phase connector road of D7 and D8 motorways near Kralupy nad Vltavou. The reason for this highway design is high traffic intensity. The highway is designed as a road type S9,5/90. Highway design includes two junctions. Junctions are designed in two variants, only one variant of each junction was finalized to more in-depth detail.

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No description available.

Diabetic ketoacidosis (DKA) is a life-threatening condition that can appear in patients with diabetes. High ketones in the blood lead to acidity of the blood. For DKA diagnosis and management, ketones such as hydroxybutyrate (HB) can be used to quantify the severity of the disease. The fabrication of electrochemical biosensors for the detection of HB is attractive since their capability to deliver fast response, high sensitivity, good selectivity and potential for miniaturisation. In this thesis, an integrated electrode system was prepared for the detection of HB. Laser-induced graphene (LIG) with a 3D porous structure was used as the flexible platform. Poly (toluidine blue O) (PTB) was electro-deposited on LIG (PTB/LIG) under the optimised conduction (pH of 9.7 and from 0.4 to an upper cyclic potential of 0.8 V). The single PTB/LIG working electrode demonstrated excellent performance towards the detection of NADH with a linear range of 6.7 M to 3 mM using chronoamperometry, high sensitivity of detecting NADH and excellent anti-fouling ability (94 % response current retained after 1500 s). Further integration of the 3-electrode system realised the static amperometric detection of NADH over the range of 78 M to 10 mM. Based on the excellent performance of PTB/LIG to NADH sensing, hydroxybutyrate dehydrogenase was immobilised via encapsulation with chitosan and polyvinyl butyral (PVB) which was used for HB biosensing over the linear range of 0.5 M to 1 mM with NAD+ dissolved in solution. In addition, the co-immobilisation of NAD+ and HBD on PTB/LIG was conducted by optimisation of enzyme and NAD+ amount per electrode, which shows excellent reproducibility and satisfactory HB biosensing performance. Further experiments to improve the long-term stability of the enzyme electrode is expected in the future. The proposed integrated electrode system also possesses the potential to extend to a multichannel sensor array for the detection of multiple biomarkers (e.g. pH and glucose) for diagnosis and management of DKA.

L'asma és una malaltia d'etiologia complexa, formada per factors genètics i ambientals, on la interrelació de ambdós factors mitjançant interaccions gen-ambient juga un paper clau. L'objectiu d'aquesta tesi ha sigut aprofundir en el coneixement del paper dels polimorfismes genètics, i la seva interacció amb factors ambientals, en la ocurrència d'asma, atòpia i hiperreactivitat bronquial. Aquest objectiu ha estat desenvolupat a través de la replicació de variants genètiques prèviament identificades, l'avaluació d'interaccions gen-ambient i la identificació de nous gens de susceptibilitat mitjançant un disseny basat en el genotipatge de variants genètiques all llarg del genoma en pools d'ADN. La tesi ha estat majoritàriament duta a terme dins l'estudi European Community Respiratory Health Survey (ECRHS) que està comprès per 5.000 individus seguits durant 9 anys, pels quals es disposa d'un qüestionari complet sobre símptomes respiratoris, avaluacions clíniques, informació sobre exposicions ambientals i mostres de ADN. Aquesta tesi a replicat l'associació del polimorfismes dels gens TNFA i NPSR1 amb asma. A més s'han establert les interaccions entre TNFA i obesitat, NQO1 i contaminació atmosfèrica, i NPSR1 i edat d'inici d'asma. L'anàlisi de pools d' ADN ha permès associar la regió on es situa el gen SGK493 amb atòpia. Aquesta tesi contribueix al coneixement de l'etiologia d'asma amb la identificació i replicació d'associacions genètiques i interaccions gen-ambient. / Asthma is a disease with a complex etiology, involving multiple genetic and environmental factors, and with an important role of the interplay of these factors through gene-environment interactions. In this thesis I aimed to advance our knowledge on the importance of genetic polymorphisms and their interaction with environmental data for the occurrence of asthma and related phenotypes (atopy and bronchial hyperreactivity). This objective was developed through the replication of genetic associations previously reported, the assessment of gene-environment interactions and the identification of new susceptibility genes using genome-wide analysis based on a pooling DNA strategy. The thesis was, mostly, performed within the European Community Respiratory Health Survey (ECRHS). This cohort has information and DNA samples from approximately 5,000 adult subjects followed-up for 9 years, with extensive questionnaires on respiratory symptoms, clinical evaluations and information on environmental exposures. This thesis replicates previous effects on asthma of polymorphisms in TNFA and NPSR1 genes. In addition, interactions have been established between TNFA and obesity, NQO1 and air-pollution, and NPSR1 and age at onset of asthma. The approach based on genome-wide analysis of DNA pools identified the SGK493 region being associated with atopy. This thesis contributes to the understanding of the etiology of asthma through the identification and replication of genetic associations and gene-environment interactions.

The Abstract This diploma thesis discusses three lawsuits at the period of normalization, when participants were sued and later sentenced for provocation and denigration of the Czechoslovak Socialistic Republic and its representatives during their theatre activity or improvisation with theatrical elements. The first from three lawsuits had been taking place during 1971 and 1972 in Ostrava. There was a parody of the novel called Son polka by Valentin Katajev put on stage in the Waterloo Theatre in 1969. The production was banned after several repetitions. Some participants were involved in producing the Tramp magazine which was unwanted and watched by the state authority. There was and editorial board organized by this magazine like a tramp party where besides other songs Son polka's songs were sung. Shortly after those events the members from the Waterloo Theatre: Petr Podhrázký, Ivan Binar, Josef Frais, Petr Ullmann, Edvard Schiffauer a Tomáš Sláma were arrested and sentenced to jail. The second case took place in Kroměříž in 1974. A group of friends led by an amateur puppeteer Emil Hauptmann had staged an improvised presentation during the Hostýn pilgrimage. Playing the puppets Emil Hauptmann committed lots of utterances which were considered as provocations according to an actual penal code and that is...

Design, exoskeleton, overhead work, fatigue, human body, musculoskeletal disorder

Diploma thesis "School media - press, radio, television, internet: on example of regions of Olomouc and Ústí nad Labem" deals with school media production of pupils and students of primary and secondary education focusing on the Czech environment. The whole issue is framed within media literacy, media education. Moreover, the interpretation accents with its direction of production. The most important chapters of historical-theoretical part introduce the outline of the school media development from the beginning till nowadays. Practical part characterizes school media in the regions of Olomouc and Ústí nad Labem. The research survey is mainly focused on the occurrence of school media production, forms of their outputs and characteristics of individual types of school media. What is more, the survey is also interested in current trends in publishing of school and class magazines and their theme and genre profile. Survey summarizes reasons, which impedes realization of school media production. Finally, on account of compile findings and data, it deduces a school media typology, criteria of their possible categorisation and includes them into the media system. As a result, the diploma thesis is a contribution to a study of school media and presents the platform from which it is possible to stem from during...