Bilayer embedded proteins are affected by stress. This general affirmation is, in this thesis, embodied by two types of proteins: membrane spandex and voltage-gated sodium channels. In this work, we essentially explore, using methods from physics, the theoretical consequences of ideas drawn from experimental biology. Membrane spandex was postulated to exist and we study the theoretical implications and possible benefits for a cell to have such proteins embedded in its bilayer. There are no specific membrane spandex proteins, rather any protein with a transition involving a large enough area change between two non-conducting states could act as spandex. Bacterial cells have osmovalve channels which open at near-lytic tensions to protect themselves against rupture. Spandex expanding at tensions just below the osmovalves’ opening tension could relieve tension enough as to avoid costly accidental osmovalve opening due to transient bilayer tension excursions. Another possible role for spandex is a tension-damper: spandex could be used to maintain bilayer tension at a fixed level. This would be useful as many bilayer embedded channels are known to be modulated by tension. The Stress/shear experienced in traumatic brain injury cause an immediate (< 2 min) and irreversible TTX-sensitive rise in axonal calcium. In situ, this underlies an untreatable condition, diffuse axonal injury. TTX sensitivity indicates that leaky voltage-gated sodium (Nav) channels mediate the calcium increase. Wang et al. showed that the mammalian adult CNS Nav isoform, Nav1.6, expressed in Xenopus oocytes becomes “leaky” when subjected to bleb-inducing pipette aspiration. This “leaky” condition is caused by a hyperpolarized-shift (left-shift or towards lower potentials, typically 20 mV) of the kinetically coupled processes of activation and inactivation thus effectively degrading a well-confined window conductance into a TTX-sensitive Na leak. We propose experimental protocols to determine whether this left-shift is the result of an all-or-none or graded process and whether persistent Na currents are also left-shifted by trauma. We also use modeling to assess whether left-shifted Nav channel kinetics could lead to Na+ (and hence Ca2+ ) loading of axons and to study saltatory propagation after traumatizing a single node of Ranvier.

The subject of this thesis is Microsoft Dynamics NAV 2013 ERP system implementation in functionally driven organization. The goal is to identify eventual problems, which can occur during the implementation of this system, and based on the findings deliver recommendations for the future projects to eliminate or minimize these problems. The scope of the theoretical section is the analysis of ERP market, specifications of ERP implementation projects, available methodologies, ERP system implementation strategies and finally the analysis of Microsoft Dynamics NAV 2013 implementation in specific company. During the research I managed to identify the most critical problems across the stages of ERP system Microsoft Dynamics NAV 2013 implementation. The results provide advice on how to choose suitable tools and procedures to minimize these problems.

This diploma thesis focuses on the design and development of the software tool using C# programming language and his subsequent implementation into the Microsoft Dynamics NAV information system. The task of this tool is to analyze the development of selected indicators using statistical methods and to predict their future development. On the basis of these predicted data, is created an indicative budget to support decision making on the determination of key accounting parameters and coefficients for the next accounting period in the company Vodovody a kanalizace Hodonín, a.s.

This diploma project is about the assessment of the information system of the Czech branch of the American company Sherwin-Williams, which is the world's leading supplier of paints, colours, varnishes, stains and mastics. In the Czech Republic, production is concentrated on the wood surface treatment and other related materials for industrial production. In this work, the analysis of the current Microsoft Dynamics NAV Information System in version 5.0 is performed. The main objective of this analysis is to optimize important processes and to eliminate system weaknesses.

This master’s thesis deals with jet streams. The exploration part describes conditions of jet stream formation, its characteristics, classification on the geographical basis and phenomena attendant on the jet streams. It also contains a description of jet stream measurement methods and methods of its interpretation in aeronautical meteorological charts. Organization of aeronautical traffic in the north Atlantic region within reach of the jet streams is further described. Practical part of this thesis contains author’s own research which compares time and economical profitability of transatlantic flights planned according to the jet streams. The principle of this evaluation was based on assessment of real flights and flights via shortest possible routes. It was proven, that profits mentioned above are gained only in the oceanic parts of flights.

Ce travail de thèse s'inscrit dans le contexte des drones vise à réaliser à terme un Nano-dispositif volant (Nano Aerial Vehicle) capable d'imiter le vol des insectes. Ce mode de locomotion est privilégié car il présente des caractéristiques très adaptées au vol en milieu confiné. La solution proposée consiste à développer un drone de la taille d'un insecte s'appuyant sur des ailes vibrantes pour se mouvoir et à utiliser les technologies MEMS pour répondre aux problématiques de fabrication et de réduction d'échelle. La réussite d'un tel projet soulève néanmoins de nombreux défis scientifiques et technologiques, en particulier, les aspects aéro-élastiques des ailes et l'autonomie du drone. Pour répondre à ces défis, nous proposons dans un premier temps de mettre en œuvre des concepts comme la résonance et la torsion passive sur des prototypes en polymère (SU-8) réalisés par photolithographie. Dans un second temps, les différents composants de la chaîne de puissance sont optimisés, notamment l'actionneur électromagnétique, la liaison et les ailes de manière à maximiser la force de portance générée. Suite à ces améliorations, nous démontrons de façon expérimentale que le prototype était capable non seulement de reproduire une cinématique complexe mais également de compenser 75% de son poids. / This manuscript reports a work which aims to develop a tiny flying robots inspired by natural flyers. Our main objective is to devise a flying robot mimicking insects in terms of kinematics and scale using MEMS technologies in order to answer the scale challenges: the large-scale manufacturing and the system's small scale. The success this project faces different challenges such as aeroelastic aspects of wings and drone autonomy.In this work we propose the use of original concepts like resonance and passive torsion of the wings which are implemented on all-polymer prototypes obtained using a micromachining SU-8 photoresist process. In order to achieve a better efficiency of the prototype, each element of the energy transduction has been carefully examined and optimized. Especially, the actuation, the transmission and the wings in order to increase the lift. These improvements demonstrate experimentally that the prototype is able to produce a complex kinematic and compensate 75 % of its weight.

The main objective of this paper is to discuss a platform which can provide accurate information to moving objects like a car in poor environmental conditions where the use of signals of GPS is not possible. This approach is going to integrate imaging sensor data into an inertial navigation system. Navigation systems are getting smart and accurate but still, an error occurs at long distances causing a failure to find out accurate location. In order to increase the accuracy front camera in a car is proposed as a sensor for the navigation system. Before this problem is solved with the help of extended Kalmanfilter but still, the small error occurs. In order to find out, accurate location landmarks will be detected from the real-time environment and will be matched with the landmarks which are already stored database. Detection is the challenge in an open environment in which object must be illumination invariant, pose invariant and scale invariant. Selection between algorithms according to the requirement is important. SIFT is a feature descriptor which creates the description of features in an image and known as the more accurate algorithm. Speeded up robust features (SURF) is another algorithm in computer considered as fast and less accurate than SIFT. Most of the time it is not a problem with given algorithms but the feature is not detected or matched because of illumination, scale, and pose. In this condition use of filters and other techniques is important for better results. Better results mean required information from images must extract easily, this part is obtained with the help of computer vision and image processing. After creating matched images data, this data is given to navigation data calculation so that it can produce an exact location based on matched images and time calculation. Navigation data calculation unit has the connection with Landmark Database so navigation system can compute that at this point landmark is present and it is matched and assure that given location is accurate. In this way accuracy, safety and security can be assured.

Listed property companies trading at a discount or premium to their Net Asset Value (NAV) is a widely recognized phenomenon. Previous research within this field has primarily applied OLS-regressions and is mainly focused on U.K. and U.S. markets. This study is the first to empirically assess discounts and premiums in Swedish-listed property companies. By applying a fixed effect model controlling for panel data, this study also expands previous work and contributes to more knowledge about company-specific effects. The study covers 14 Swedish-listed property companies between the years of 2008 to 2015. Two OLS regression models and one fixed effect model were applied on cross-sectional data. Overall, the results show that the size, reputation, portfolio concentration and debt to asset ratio of a firm are negatively correlated with discount to NAV. The overall market sentiment and stock volatility are positively correlated with discount to NAV. Moreover, the overall market sentiment in tandem with firm-specific factors is believed to significantly impact discounts and premiums. Board size, insider ownership, administration costs and cross-border investments were found to not have a significant impact on discounts and premiums. Last it was also found that discounts and premiums are not determined by within variations in the subject companies, rather it is determined by across variations in the firm-specific variables. / Noterade fastighetsbolag som handlas till rabatt eller premium av sitt substansvärde är ett känt fenomen. Tidigare studier har huvudsakligen fokuserat på data från Storbritannien och USA. De studier som gjorts har primärt varit regressionsmodeller av typen OLS. Den här studien är den första som kvantitativt undersöker substansrabatt och substanspremier i svenska fastighetsbolag. Vi applicerar också en regressionsmodell av typen fixed effect, där vi kontrollerar för paneldata. Därför kan denna studie ses som en utökning gentemot tidigare studier. Denna studie omfattas av 14 noterade fastighetsbolag. Datan som används sträcker sig mellan perioden 2008 till 2015. Generellt kan sägas att storlek, rykte, portföljfokus och skulder i förhållande till totala tillgångar hos ett företag är negativt korrelerade med substansrabatt. Vidare så visar resultaten tydligt på att aktuellt marknadsförhållande tillsammans med bolagsspecifika faktorer, spelar en stor roll för skillnaden mellan aktiekurs och substansvärde. Volatilititen i en aktie och det aktuella marknadsförhållandet är båda positivt korrelerade med substansrabatt. Styrelsens storlek, insiderägande, kostnad för administration och internationella investeringar har däremot inte någon statistiskt signifikant påverkan på rabatter och premier i svenska noterade fastighetsbolag. Slutligen kan sägas att nästan inga företagsspecifika effekter hittades. De faktorer vi konstaterar ha en påverkan på substansrabatter och substanspremier varierar över hela datasetet.

博士(理学) / Doctor of Philosophy in Science / 同志社大学 / Doshisha University

<p>There are several standards for wireless communication. People that are involved in computers and networking recognize names like Bluetooth, HiperLAN and IEEE 802.11. The last one was standardized in 1997 [2,6]and has begun to reach acceptance as a solid ground for wireless networking. A fundamental part of an IEEE 802.11 node is the Medium Access Controller, or MAC. It establishes and controls communication with other nodes, using a physical layer unit. </p><p>The work has been carried out as final project at Linkopings Universitet, it has been about the improvement of the functions of MAC layer. I have developed some of the required functions that PUM uses to interact with the MAC layer. Because of that, I have implemented the Reception functions of MAC layer, having the possibility of using short control frames RTS/CTS to minimize collision.</p>