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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

The Vertical Integration of Mechatronics at Virginia Tech

Grove, Donald E. 06 April 2001 (has links)
The focus of this thesis is on the vertical integration of mechatronics in the mechanical engineering curriculum at Virginia Tech. It reports the details of an experimental strategy to integrate mechatronics at an early level in the education of engineers. A proposal was submitted to and accepted by the NSF/SUCCEED coalition to fund this experiment. Through this assistance, the experiment of vertically integrating mechatronics was initiated. The methodology in which it was integrated is presented -- through optional participation in a sophomore design class and a required design project in a junior system dynamics course. The material developed for the vertical integration of mechatronics is in the appendices. This material is appropriate for other institutions to use to vertically integrate mechatronics into their curriculums, which is part of the NSF/SUCCEED coalition's initiative. For the sophomore class, ME 2024, Introduction to Engineering Design and Economics, selected sections were exposed to the concepts of mechatronic design, along with the normal course material. Students in the mechatronic sections were given an opportunity to incorporate the use of a custom-built VT Project Box and the PIC Visual Development (PVD) software, both of which were created specifically for the task of vertical integration of mechatronics. Throughout the semester, the students were given several demonstrations of mechatronic systems through the use of the project box and software. Many students decided to implement mechatronic concepts in their final design projects. A smaller number of students made a decision to use the project box and software to develop a prototype of their final design project. Candid remarks about the students experiences, obtained from a survey at the semester's end, indicated that the vertical integration of mechatronics was a motivational feature in the second-year curriculum. For the junior class, ME 3514, System Dynamics, all sections were exposed to the concepts of mechatronics, along with the normal course material. The students were required to acquire steady-state velocity data from a DC motor and create an analytical model of the motor to predict the steady-state velocity for a given duty cycle of a pulse-width modulated controller. After the collection of the data and the creation of the analytical model, the students compared the results of simulations to the actual data collected, and report the comparison to the instructor in a memorandum. The collection of the steady-state velocity data was accomplished using the PVD software and the VT Project Box. The essentials of mechatronics was communicated to the students in two lectures, and the students gained hands-on experience with mechatronics through the use of the project box and the software. The lecture material covered the basics of mechatronics, the Mechatronics course at Virginia Tech, and detailed information about the design project. The assessment of the vertical integration of mechatronics into this junior course was accomplished by surveying all of the students in the course. The results of the survey indicated that the inclusion of mechatronics material increased the students understanding of the course material and also increased their interest in mechatronics. / Master of Science
2

Involvement of mTOR pathway in neurodegeneration in NSF-related developmental and epileptic encephalopathy / NSF関連発達性てんかん性脳症の神経変性におけるmTOR経路の関与

Hayashi, Takahiro 25 March 2024 (has links)
京都大学 / 新制・課程博士 / 博士(医学) / 甲第25162号 / 医博第5048号 / 京都大学大学院医学研究科医学専攻 / (主査)教授 林 康紀, 教授 髙橋 良輔, 教授 井上 治久 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
3

LIFE AFTER NATIONAL SCIENCE FOUNDATION FELLOWSHIPS: THE IMPLICATIONS FOR A GRADUATE STUDENT'S PROFESSIONAL ENDEAVORS

OBARSKI, KELLY JOSEPHINE 05 October 2007 (has links)
No description available.
4

Lead and Copper Corrosion Control in New Construction: Shock Chlorination, Flushing to Remove Debris & In-line Device Product Testing

Raetz, Meredith Ann 27 August 2010 (has links)
Several aesthetic, health, and plumbing quality issues can arise during new construction or renovation of premise plumbing. There has been little research done on many of these concerns and therefore few guidelines or regulations are in place to protect the health of the consumer or the integrity of the plumbing infrastructure. This work examines common construction practices including: 1) effect of residual construction debris, 2) shock chlorination of new plumbing lines, and 3) lead leaching propensity of new brass ball valves. During installation of plumbing systems, residual chemicals and debris including copper brass particles and flux, can be left in plumbing lines following construction and installation. This debris is considered undesirable from health, aesthetic, and corrosion perspectives. Soldering flux is of particular concern due to its corrosive nature. Experiments were conducted to determine the effects of residual solder flux, PVC glue, and metallic debris and to quantify flushing velocities and durations to effectively remove them from a new plumbing system. A flushing velocity of 3 fps for 30 minutes is needed to remove water soluble flux, while petroleum based flux still persists after extensive flushing at 7 fps. Currently a practice known as shock chlorination, whereby super chlorinated water is used for disinfection, is used in water mains after installation or repair as specified in the ANSI/AWWA C651 Standard. This practice is now starting to be required by some building codes in premise plumbing for new construction. Water mains are typically made of concrete where as premise plumbing using copper or PVC piping. Copper pipe is susceptible to attack by high chlorine, and this reaction will also remove the chlorine residual. There is concern about potential damage to copper from free chlorine and that in some systems targeted residuals of chlorine might not be obtained. Experiments did not detect serious damage to copper pipe, but in some waters it was not possible to meet targeted residual levels of chlorine. The addition of orthophosphate corrosion inhibitor or adjustment of pH can sometimes reduce the chlorine decay rate. Extremely high and persistent lead leaching in a brand new building at the University of North Carolina (UNC) traced to leaded bronze ball valves, prompted an extensive forensic evaluation how existing standards (National Sanitation Foundation Section 8) could allow for installation of products that could create a human health hazard due to high lead. Diffusion of lead from within the device to water in the pipe, high velocity, microbial activity and other factors caused more leaching in practice than would be expected based on NSF testing and normalization factors applied to certify a valve as safe. Moreover, use of flux during soldering of joints, increased lead leaching by orders of magnitude relative to results of NSF testing without flux. / Master of Science
5

Reconsidering Lead Corrosion in Drinking Water: Product Testing, Direct Chloramine Attack and Galvanic Corrosion

Dudi, Abhijeet 26 October 2004 (has links)
The ban on lead plumbing materials in the Safe Drinking Water Act (1986) and the EPA Lead and Copper Rule (1991) have successfully reduced lead contamination of potable water supplies. The success of these regulations gave rise to a belief that serious lead contamination was an important past problem that had been solved, and that additional fundamental research was therefore unnecessary. This work carefully re-examined the lead contamination issue from the perspective of 1) new regulations causing a shift from chlorine to chloramine disinfectant, 2) assumptions guiding sampling strategies, 3) existing performance standards for brass, and 4) galvanically driven corrosion of lead bearing plumbing materials. The results were instrumental in uncovering and understanding a serious problem with lead contamination in Washington, D.C. A critical reading of the literature indicates that chloramines can accelerate corrosion of lead bearing materials and increase lead contamination of water. When a new sampling protocol was conceived and used in Washington homes to assess the nature of the problem, hazardous levels of lead were found to be present in some drinking water samples. Contrary to the conventional wisdom, lead was not always highest in first draw samples, but often increased with flushing. This has several important implications for monitoring and public health. For instance, well-intentioned public education materials were causing consumers to drink water containing very high levels of lead in some circumstances. Laboratory and field-testing proved that chloramines were causing serious lead corrosion problems. That testing also discovered that, unbeknownst to scientists and utilities, free chlorine itself can act as a corrosion inhibitor, reducing lead solubility and contamination of water. The net result is that changing disinfectant from free chlorine to chloramine can sometimes trigger serious lead contamination of water. While the worst problems with lead in Washington, D.C. came from the lead services, significant levels of lead were occasionally sampled from homes with solders or brass as the lead source. This prompted re-evaluation of the ANSI/NSF 61, Section 8 standard, which is relied on to protect public health from in-line brass plumbing devices that might leach excessive lead to potable water. In-depth study of the standard revealed serious flaws arising from use of a phosphate buffer in the test waters and a failure to control carbonate dissolution from the atmosphere. Due to these deficiencies, small devices made of pure lead could actually pass the performance test. The public therefore has no assurance that devices passing NSF Section 8 testing are safe and reforms to the standard are obviously needed. Other problems arise from connecting copper pipe to lead bearing plumbing in practice. The copper is cathodic and dramatically accelerates corrosion of the lead anode via a galvanic current. Corrosion and hydrolysis of released Pb²⁺ can lower pH near the surface of the lead and increase its solubility. A similar galvanic effect can arise from cupric ions present in the water via deposition corrosion mechanism. In cases where part of a lead service line is replaced by copper pipe, the galvanic corrosion effect can create a serious long-term problem with lead contamination. Such partial lead service line replacements are occurring in many US cities and the practice should be stopped. Lead contamination of potable water is not only a problem of the past but also of the present. While additional research is necessary before regulators, utilities and homeowners can anticipate and mitigate such problems with confidence, this work provides sound fundamental basis for future progress. / Master of Science
6

Biophysical Characterization of SNARE Complex Disassembly Catalyzed by NSF and alphaSNAP

Winter, Ulrike 03 July 2008 (has links)
No description available.
7

The Role of alpha- and beta-SNAP in Synaptic Vesicle Exocytosis / Die Rolle von alpha- und beta-SNAP bei der Exozytose Synaptischer Vesikel

Burgalossi, Andrea 13 May 2008 (has links)
No description available.
8

Nouveaux mécanismes de régulation des récepteurs couplés aux protéines G : lien entre complexes protéiques, localisation et signalisation

Pontier, Stéphanie M. January 2005 (has links)
Thèse diffusée initialement dans le cadre d'un projet pilote des Presses de l'Université de Montréal/Centre d'édition numérique UdeM (1997-2008) avec l'autorisation de l'auteur.
9

Nouveaux mécanismes de régulation des récepteurs couplés aux protéines G : lien entre complexes protéiques, localisation et signalisation

Pontier, Stéphanie M. January 2005 (has links)
Thèse diffusée initialement dans le cadre d'un projet pilote des Presses de l'Université de Montréal/Centre d'édition numérique UdeM (1997-2008) avec l'autorisation de l'auteur.
10

Selection of disposal method for nuclear spent fuel: a plan for the application of the systems engineering process

Min, Bryan B. 16 February 2010 (has links)
Master of Science

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