African trypanosomes are protozoan parasites that cause African trypanosomiasis, diseases that affect humans and their livestock. Not only has trypanosomiasis had an overwhelming effect on the development of tropical Africa in the past, but it also constitutes one of the most significant present economic problems of the continent. Trypanosomes alternate between a mammalian host and a tsetse vector using a complex life cycle. In the mammalian host the trypanosomes live as bloodstream forms (BSFs) that are so proficient at antigenic variation, and thus host immune system evasion, that no suitable vaccine candidates have yet been identified. In contrast, the lifecycle stages that exist in the tsetse vector do not undergo antigenic variation. This potentially makes the vector-occupying trypanosomes much better targets for control if strategies can be devised to disrupt their lifecycle in the vector or to interfere with their transmission to mammalian hosts. The primary impediment to developing strategies for disruption of trypanosome life cycles in tsetse is a lack of understanding of the molecular basis of trypanosome-tsetse interactions. Although several major surface molecules have been identified on insect form trypanosomes, these have not been well studied due to a lack of appropriate antibody probes and to the difficulty in obtaining sufficient quantities of the different parasite life cycle stages required for such molecular studies. My thesis research was focused on developing and using monoclonal antibody probes for analysis of expression of major surface molecules of Trypanosoma congolense, a serious pathogen of cattle in Africa. I used this species of trypanosome since in addition to being a socioeconomically important parasite, all four of its major life cycle stages can be grown in vitro in amounts sufficient for immunochemical analysis. I successfully derived and characterized monoclonal antibodies that were useful for detecting the three major surface proteins of T. congolense insect forms: glutamic acid/alanine rich protein (GARP), the T. congolense heptapeptide repeat protein (TcHRP) and congolense epimastogote specific protein (CESP). Selected monoclonal antibody probes were then employed for expression analysis of these molecules throughout the parasite life cycle using in vitro grown trypanosomes and parasites taken directly from infected tsetse. In addition, I determined the peptide epitopes for two of my GARP-specific monoclonal antibodies and in collaboration with Dr. Martin Boulanger and Jeremy Mason was able to localize the epitopes on a high resolution three-dimensional structure obtained by X-ray crystallography. This allowed us to derive a model that describes the orientation of GARP in the trypanosome surface membrane and explains the possible structure-function relationships involved in replacement of the bloodstream form variant surface glycoprotein (VSG) by GARP as trypanosomes differentiate in the tsetse vector after a bloodmeal.

Zugl.: Berlin, Freie Univ., Diss., 2005 / Dateiformat: zip, Dateien im PDF-Format. - Erscheinungsjahr auf der Haupttitelstelle: 2005

In South Africa, trypanosomosis also known as Nagana, transmitted by Glossina brevipalpis and G. austeni, is the major cause of anaemia and chronic debilitating condition in cattle. There is a wealth of entomological information on the ecology of the two tsetse species generated following the devastating outbreak in cattle due to Nagana in 1990. However, it is unfortunate that these entomological data has not been supported by parallel studies on the epidemiology of the disease. Therefore, the present study presents the first intensive epidemiological investigations since 1990 to address the problem of animal trypanosomosis in South Africa. The relationship between trypanosomes herd average prevalence (HAP), herd average anaemia (HAA) and herd average packed cell volume (HA-PVC) were investigated in cattle in three communal diptanks located by the Hluhluwe-uMfolozi Game Reserve by regular monthly sampling for 15 months. The tsetse challenge with G. brevipalpis in two of the diptanks, Mvutshini and Ekuphindisweni, was high but low in the third (Ocilwane). In addition, G. brevipaplis and G. austeni coexist in Mvutshini diptank. This high and low tsetse challenge presented different disease scenarios. Cattle at Mvutshini and Ekuphindisweni diptanks had the highest HAP of 12.3% and 8.9%, respectively, which is significantly different (p = 0.001) from the HAP obtained from cattle at Ocilane (2.9%). Both cattle herds at Mvutshini and Ekuphindisweni diptanks also had the highest HAA, 27.7 and 33.4%, respectively, while cattle at Ocilwane had the lowest, 11.1% (statistically different; p = 0.001). Conversely, cattle at Ocilwane diptank had the highest HA-PCV, ranging between 29-32% while cattle at Mvutshini and Ekuphindisweni diptanks had the lowest HA-PCV (24-29%). The interaction between HAP and HAA is significant (p = 0.021). The overall effect of HAP on the animal health condition is clearly demonstrated when comparing the anaemia in trypanosomes infected and uninfected cattle at the 3 diptanks. Fifty percent, 63% and 100% of trypanosomes infected cattle were anaemic at Mvutshini, Ekuphindisweni and Ocilwane diptanks, respectively. In comparison, the prevalence of anaemia in uninfected cattle in the 3 diptanks was 20, 30 and 10% at Mvutshini, Ekuphindisweni and Ocilwane diptanks, respectively. By combining the data from the 3 diptanks (1,800 observations), the overall HAA in infected and uninfected cattle was 62 and 20%, respectively The results of trypanosomes seasonal surveys conducted at 7 communal diptanks in tsetse infested areas, showed that all cattle at the diptanks were infected with trypanosomes with mean HAP and HAA of 10.3 and 35.3%, respectively. The highest HAP (range 15-31%, n=4) was recorded in Ngwenyambili diptank. This high infection in the cattle herds produced high values of HAA (50%; range 40-60). The infection rate with trypanosomes in G. brevipalpis caught from the field showed immature infections in the midgut of 3.5% (16/458) while only one fly was found with mature infection in the proboscis (1/458, 0.22%). Very few G. austeni were collected (total of 9) during the same period and dissected. The infection rate with trypanosomes immature and mature infections was found to be very high; 5/9 (55.5%). Blood samples were collected from a total of 132 buffaloes randomly immobilized for tuberculosis testing by the Hluhluwe-uMfolozi Game Reserve Authority. Two buffaloes were found to have T. congolense infection by the buffy coat technique. The presence of trypanosomes infected buffaloes in this study confirms the occurrence of sylvatic cycle at the tsetse/livestock/Hluhluwe-uMfolozi Game Reserve, thus, presenting a high risk of serious disease to cattle. The objective of the study on the strategic treatment of trypanosomosis conducted on one farm in endemic area was to treat adult cows and calves at an arbitrary HAP threshold before the disease produces any clinical symptoms or production losses. The strategic use of ethidium bromide and novidium chloride produced attractive results whereby cattle were protected for an extended period of 3 to 6 months with no development of anaemia during this period. Therefore, two to four treatments per year may be sufficient to keep cattle productivity on the farm under the tsetse challenge Copyright / Dissertation (MSc)--University of Pretoria, 2012. / Veterinary Tropical Diseases / unrestricted

The importance of philosophy and the philosophical is not on the lips of many library and information science practitioners and scholars, even though pervasive in information science theory and practice. This investigation focusses on the relationship between information science, philosophy and the philosophical thinking attitude revealed through theoretical and practical concerns. This includes theory generation arising from the philosophical in exploring the role of philosophy and the philosophical. It takes into account perceived problems in recognising, accepting and rejecting the role of philosophical approaches and the impact in determining the nature and the theoretical and practical aspects of information science. The problem posed by not recognising philosophical approaches, is that the benefits of philosophical thought cannot be drawn on to understand how knowledge, information and its communication manifest through language and language expression. Three pathways are used in order to reveal philosophy and the philosophical in information science, the connection between information retrieval and language, and philosophical thinking attitudes at theoretical and practical levels. The value of the study lies in contributing towards knowledge and awareness of the effect of philosophical theories on problems seen as central research areas in information science and its domains. The methodological approach gives preference to the comparative and pluralistic epistemology of a journey. The study examines Peter Ingwersen’s cognitive perspective and information retrieval interaction, David Blair’s treatment of information retrieval with natural language as primary concern, and Fanie de Beer’s contribution on the inventive act of reading and knowledge organisation, as representative figures. It is argued that information science cannot avoid philosophy in its different manifestations. By understanding how philosophy manifests in information science, such as the role of philosophy revealed through language and information retrieval, an opportunity is offered to reconsider the discipline’s interdisciplinary nature in the existing scholarly and societal environment, and the contribution of its historical development to the assumptions and philosophies underlying the discipline. A further empirical study on how philosophy and the philosophical are embedded in information science research is recommended. It could investigate the influence of philosophy on decisions made by South African universities to redesign information science research and study programmes. / Biblioteek- en inligtingkundige praktisyns praat nie dikwels oor die belangrikheid van filosofie en die filosofiese nie, hoewel dit algemeen in die teorie en praktyk van inligtingkunde voorkom. Hierdie ondersoek fokus op die verband tussen inligtingkunde, filosofie en die filosofiese denkhouding wat deur teoretiese en praktiese aspekte blootgelê word. Dit sluit die skepping in van teorieë wat uit die filosofiese voortspruit met die ondersoek na die rol van filosofie en die filosofiese. Dit neem kennis van vermeende probleme met herkenning, aanvaarding en verwerping van die rol van filosofiese benaderings en die impak op bepaling van die aard en die teoretiese en praktiese aspekte van inligtingkunde. Die probleem wat veroorsaak word deur nie die filosofiese benaderings te erken nie, is dat die voordele van filosofiese denke nie gebruik kan word om te verstaan hoe kennis, inligting en die kommunikasie daarvan in taal- en taaluitdrukking manifesteer nie. Drie weë word gevolg om die filosofie en die filosofiese in inligtingkunde, die verband tussen inligtingontsluiting en taal, en filosofiese denkhouding op teoretiese en praktiese vlak aan te toon. Die waarde van die studie lê daarin dat dit bydra tot kennis en bewustheid van die uitwerking van filosofiese teorieë op probleme wat as sentrale navorsingsgebiede in inligtingkunde en sy domeine beskou word. Die metodologiese benadering gee voorkeur aan die vergelykende en pluralistiese epistemologie van 'n reis. Die studie ondersoek Peter Ingwersen se kognitiewe perspektief en interaksie met inligtingontsluiting, David Blair se hantering van inligtingontsluiting met natuurlike taal as primêre belang, en Fanie de Beer se bydrae oor die vindingryke handeling van lees- en kennisorganisasie, as verteenwoordigende figure. Daar word aangevoer dat inligtingkunde nie filosofie in sy verskillende manifestasies kan vermy nie. Deur te verstaan hoe filosofie in inligtingkunde manifesteer, soos die rol van filosofie wat deur taal- en inligtingontsluiting openbaar word, word die geleentheid gebied om die dissipline se interdissiplinêre aard in die bestaande wetenskaplike en samelewingsomgewing en die bydrae van die historiese ontwikkeling daarvan tot die aannames en filosofieë onderliggend aan die dissipline te heroorweeg. 'n Verdere empiriese studie oor hoe filosofie en die filosofiese in inligtingkundige navorsing vervat is, word aanbeveel. Dit kan die invloed van filosofie op besluite wat Suid-Afrikaanse universiteite neem om navorsings- en studieprogramme vir inligtingkunde te herontwerp, ondersoek. / Bohlokwa bja filosofi le bja tiriso ya filosofi bo bolelwa kudu ke basomi ba bantsi ba dithutamahlale tsa bokgobapuku le tshedimoso le dirutegi, le ge e le gore di tletse kudu ka go teori le tiriso ya dithutamahlale tsa tshedimoso. Dinyakisiso tse di nepisitse go kamano magareng ga dithutamahlale tsa tshedimoso, filosofi le maikutlo a go nagana ka filosofi ao a utollotswego ka dipelaelo mabapi le teori le tiriso. Se se akaretsa moloko wo o dirisago teori e lego seo se bakilwego ke tiriso ya filosofi go utolla mosomo wa filosofi le wa tiriso ya filosofi. Di hlokometse kudu mathata ao a bonwago ka go lekodisisa, go amogela le go gana mosomo wa mekgwa ya filosofi le seabe sa go tseba mokgwa le dilo tsa teori le tsa tiriso ya dithutamahlale tsa tshedimoso. Bothata bjo bo laeditswego bja go se lemoge mekgwa ya filosofi, ke gore mehola ya kgopolo ya filosofi e ka se diriswe gore re kwesise ka fao tsebo, tshedimoso le poledisano ka ga yona di ka phethagatswago ka polelo le tlhagiso ya polelo. Ditsela tse tharo di a diriswa ka nepo ya go utolla filosofi le tiriso ya filosofi ka go dithutamahlale tsa tshedimoso, kamano magareng ga go hwetsa tshedimoso le polelo, le mekgwa ya go nagana ka filosofi maemong a teori le a tiriso. Boleng bja dinyakisiso tse ke go ba le seabe go tsebo le go temoso ka ga seabe sa diteori tsa filosofi go mathata ao a bonwego bjalo ka dinyakisiso tse bohlokwa ka go dithutamahlale tsa tshedimoso le go makala a tsona. Tsela ye ya go dirisa mekgwa e rata kudu mokgwa wa papetso le wa go tseba dilo ka tsela ye e fapafapanego mo leetong. Dinyakisiso tse di lekodisisa mokgwa wa kwesiso le kamano ya go hwetsa tshedimoso tsa Peter Ingwersen, kwesiso ya David Blair ya go hwetsa tshedimoso le polelo ya tlhago bjalo ka selo seo se tlisago tlhobaelo ya mathomo, le seabe sa Fanie de Beer ka ga tiro ya boitlhamelo ya go bala le go beakanya tsebo, bjalo ka dilo tseo di tlisago kemelo. Go bolelwa gore dithutamahlale tsa tshedimoso di ka se kgone go efoga filosofi ka tirisong ya tsona ye e fapafapanego. Ka go kwesisa ka fao filosofi e diriswago ka gona ka go dithutamahlale tsa tshedimoso, go swana le ge mosomo wa filosofi o utollotswe ka polelo le ka go utolla tshedimoso, sebaka se a fiwa go lebeledisisa leswa seemo sa thuto ye sa kamano le dithuto tse dingwe ka seemong sa bjale sa dirutegi le ka setshabeng, le seabe sa tlhabollo ya yona mo nakong ye e fetilego go ditshisinyo le go difilosofi tseo di thekgago thuto ye. Dinyakisiso tse dingwe tseo di theilwego go boitemogelo ka ga ka fao filosofi le tiriso ya filosofi di tsentswego ka go dithutamahlale tsa tshedimoso di a sisinywa. Di ka nyakisisa khuetso ya filosofi go diphetho tseo di dirilwego ke diyunibesithi tsa Afrika Borwa go hlama leswa dinyakisiso tsa dithutamahlale tsa tshedimoso le go mananeo a dithuto. / Information Science / Ph. D. (Information Science)

Abstracts in English, Xhosa and Sotho / The purpose of this study was to analyse the role of critical thinking in the teaching and learning of History in three selected secondary schools in Masvingo urban area, Zimbabwe. The study focused on the challenges Form III learners faced regarding critical thinking. The findings of the research could assist to reveal the role of critical thinking in the secondary education system of Zimbabwe and other countries. A qualitative study method adopting the interpretive phenomenological approach was employed for the purpose of discovering participants’ experiences. The method was the most appropriate for the study since it enabled the researcher to assess the attitudes of teachers and learners to critical thinking. It also assessed their experiences with the development of critical thinking in the History learners in secondary schools. The study used semi-structured interviews, focus group interviews, lesson observations and document analysis to generate data. The study’s main findings reflected a lack of critical thinking among learners in secondary schools in Masvingo urban area in Zimbabwe. The development of critical thinking was negatively affected by three major categories of factors. These are: (a) the characteristics of the teaching and learning environment such as deficiency in teaching and learning resources, inadequate infrastructure and poor learning and teaching routines; (b) personal factors connected to the negative attitudes and lack of motivation of teachers and learners to critical thinking; and (c) policyrelated matters being an obstacle to learners’ development of critical thinking such as policies that embrace enrolment of learners, the History syllabus, the system of public examinations and the creation of the examination-oriented education system. The study revealed that several approaches such as the provision of essential learning resources and the improvement of teacher motivation could enhance effective implementation of critical thinking in the curriculum of Zimbabwe’s secondary schools. The study also revealed that including critical thinking in the curriculum could contribute positively to the improvement of the Zimbabwean education system. The study recommends that the Zimbabwean government, Ministry of Primary and Secondary Education, the secondary school authorities, universities and teachers’ training colleges and Zimbabwe’s Schools’ Examination Council work together to develop critical thinking among learners in Zimbabwean secondary schools. / Xikongomelo xa ndzavisiso lowu i ku xopaxopa hi ndzima ya ku ehleketa hi vuenti eka ku dyondzisa na ku dyondza Matimu eswikolweni swa sekondari swinharhu leswi nga hlawuriwa endhawini ya doroba eMasvingo eZimbabwe. Ndzavisiso wu tshikilela eka mintlhontlho leyi vadyondzi va Form III va langutanaku na yona ya ku ehleketa hi vuenti. Leswi kumekaku eka ndzavisiso swi nga pfuneta ku kombisa ndzima ya ku ehleketa hi vuenti eka dyondzo ya sekondari eZimbabwe na matiko man'wana. Methodi wa ndzavisiso wa qualitative lowu tekelaku eka interpretive phenomenological approach ku tirhisiwe wona hi xikongomelo xa ku kuma mintokoto ya vakhomaxiavo. Methodi a wu fanele swinene eka ndzavisiso hikuva wu kotise muendli wa ndzavisiso ku kambela mavonelo ya mathichara na vadyondzi eka ku ehleketa hi vuenti. Wu tlhele wu kambela mintokoto ya vona hi nhluvuko wa ku ehleketa hi vuenti eka vadyondzi va Matimu eswikolweni swa sekondari. Ndzavisiso wu tirhise ti-semistructured interview, wu tshikilela na le ka ti-interview ta ntlawa, ku langutisa kunene leswi endlekeka eka tidyondzo na ku dokumenta vuxopaxopi ku endla vutivi. Swikulukumba leswi kumiweke eka ndzavisiso swi kombise ku pfumaleka ka ku ehleketa hi vuenti exikarhi ka vadyodnzi eswikolweni swa sekondari endhawini ya doroba ra Masvingo eZimbabwe. Ku hluvukisa ku ehleketa hi vuenti swi khumbeke hi ndlela yo biha hikokwalaho ka swilo swinharhu swa nkoka. Swona hi leswi: (a) swihlawulekisi swa mbangu wa ku dyondzisa na ku dyondza swo fana na nkalo wa swihlovo swa swipfuneto eka ku dyondzisa na ku dyondza, ku kala ka infrastrakchara na matirhiselo ya le hansi ya maendlelo ya ku dyondza na ku dyondzisa; (b) swilo swa vanhu xiviri leswi khumbanaka na mavonelo yo ka ya nga ri lamanene, na ku pfumaleka ka nsusumeto wa nhlohlotelo eka mathicara na vadyondzi eka ku ehleketa hi vuenti; na (c) swilo leswi fambelanaka na swa pholisi leswi swi nga swihingakanyi eka nhluvukiso wa vadyondzi eka ku ehleketa hi vuenti swo fana na tipholisi leti ti angarhelaka ku tsarisa ka vadyondzi, silabasi ya Matimu, sisteme ya makambelelo ya vadyondzi va mfumo, na ku endliwa ka sisteme leyi fambelanaka na nkambelo eka sisteme ya dyondzo. Ndzavisiso wu paluxe leswo matirhelo yo hambana yo fana no nyiketa swihlovo swa swipfuneto eka ku dyondza na ku antswisa nsusumeto wa nhlohlotelo eka mathicara swi nga antswisa tirhelo lerinene eka ku ehleketa hi vuenti eka kharikhyulamu ya swikolo swa sekondari eZimbabwe. Ndzavisiso wu tlhele wu paluxa leswo ku katsa ku ehleketa hi vuenti eka kharikhyulamu swi nga pfuneta hi vuyelo byo antswa eka sisteme ya dyondzo ya Zimbabwe. Ndzavisiso wu bumabumela leswo mfumo wa Zimbabwe, va vulobye bya Dyondzo ya Prayimari na Sekondari, vafumi wa swikolo swa sekondari, tiyunivhesiti na tikholichi ta ku letela mathicara na huvo ya Zimbabwe ya vukamberi bya swikolo swa sekondari ku nga Zimbabwe's Schools Examination Council, va fanele ku tirhisana eka ku hluvukisa ku ehleketa hi vuenti eka vadyondzi va swikolo swa sekondari eZimbabwe. / Maikemišetšo a dinyakišišo tše ebile go sekaseka tema ye e kgathwago ke go nagana ka tsinkelo ka go ruteng le go ithuta thuto ya Histori ka dikolong tše tharo tšeo di kgethilwego ka lefelong la motsesetoropo la Masvingo, ka Zimbabwe. Dinyakišišo di nepišitše kudu ditlhohlo tšeo baithuti ba Foromo ya III ba ilego ba lebana le tšona mabapi le go nagana ka tsinkelo. Dikutollo tša dinyakišišo di ka thuša go utolla tema ye e kgathwago ke go nagana ka tsinkelo ka lenaneo la thuto ya dikolo tše di phagamego tša Zimbabwe le ka dinageng tše dingwe. Mokgwa wa dinyakišišo wa boleng wo o dirišago mokgwa wa go hlatholla seemo o šomišitšwe ka maikemišetšo a go utolla maikutlo a bakgathatema. Mokgwa wo o bile maleba kudu go dinyakišišo tše ka ge o kgontšhitše monyakišiši go sekaseka maikutlo a barutiši le a baithuti mabapi le go nagana ka tsinkelo. O sekasekile gape maitemogelo a bona mabapi le go tšweletša go nagana ka tsinkelo ga baithuti ba thuto ya Histori ka dikolong tšeo di phagamego. Dinyakišišo di šomišitše dipoledišano tšeo dipotšišo tša gona di nyakago gore baarabi ba fe mabaka, dipoledišano le dihlophanepišo, ka ditekodišišo tša thutišo le tshekatsheko ya dingwalwa ka nepo ya go tšweletša tshedimošo. Dikutollokgolo tša dinyakišišo di laeditše tlhokego ya go nagana ka tsinkelo magareng ga baithuti ka dikolong tšeo di phagamego ka lefelong la metsesetoropo la Masvingo ka Zimbabwe. Go tšweletša go nagana ka tsinkelo go amilwe gampe ke mabaka a mararo a magolo. Wona ke: (a) dikokwane tša seemo sa go ruta le go ithuta tša go swana le tlhaelelo ya methopo ya go ruta le ya go ithuta, tlhokego ya mananeokgoparara le mekgwa ye e fokolago ya go ithuta le ya go ruta; (b) mabaka a seng ao a amanago le maikutlo a go se loke le tlhokego ya tlhohleletšo ya barutiši le baithuti go nagana ka tsinkelo; le (c) mabaka a go amana le melawana ao a fetogago ditšhitišo go tšweletšo ya go nagana ka tsinkelo go baithuti go swana le melawana yeo e amogelago go ngwadišwa ga baithuti, lenaneothuto la Histori, tshepedišo ya ditlhahlobo tša dikolo tša mmušo le go hlama ga lenaneothuto leo le theilwego go ditlhahlobo. Dinyakišišo di utollotše gore mekgwa ye mmalwa ya go swana le kabo ya methopo ya go ithuta ye bohlokwa le kaonafatšo ya tlhohleletšo ya barutiši di ka thuša phethagatšo ye e šomago gabotse ya go nagana ka tsinkelo ka go lenaneothuto la dikolo tšeo di phagamego tša ka Zimbabwe. Dinyakišišo di utollotše gape gore go akaretšwa go nagana ka tsinkelo ka go lenaneothuto go ka ba le seabe se sekaone go kaonafatšo ya lenaneothuto la Zimbabwe. Dinyakišišo di šišinya gore mmušo wa Zimbabwe, Kgoro ya Thuto ya Dikolo tša Phoraemari le ya Dikolo tše di Phagamego, bolaodi bja dikolo tše di phagamego, diyunibesithi le dikholetše tša go ruta barutiši le Lekgotla la Ditlhahlobo tša Dikolo tša Zimbabwe di swanetše go šomišana mmogo ka nepo ya go tšweletša go nagana ka tsinkelo gareng ga baithuti ka dikolong tše di phagamego tša Zimbabwe. / Educational Foundations / D. Ed. (Philosophy of Education)

Abstracts in English and Southern Ndebele / “We tend to think of the mind of an organisation residing in the … top management …but… [strategic] intelligence is not organised in a centralised structure but much more like a beehive of small simple components… ” Kevin Kelly, (1994: 166283). From the quote above, it is implied that the strategising practices of, among others, top managers, are the ‘small simple components’ that build towards the overall strategy of an organisation. The overall strategy of any organisation directly influences the performance thereof. As strategists, top managers use their thinking styles to influence the new strategic practices they endorse and those that are discarded, thereby impacting the competitive strategy employed by the organisation and ultimately organisational performance. This study investigated the rapport between the strategising practices used by top managers and their thinking styles. Based on a single illustrative case, this study utilised mixed data obtained from of 33 interviews and 79 questionnaires to describe the possible relationship between thinking styles and strategising practises. The results show that at the case organisation, thinking styles of top managers differ depending on the situation in which they find themselves. A possible relationship between thinking styles and strategising practises, at the case organisation, is further implied. / “Se taele go nagana ge monagano we mokhadlo lo o hlala e tulu, mara lehlelo le go hlaganepha le ga bekwa ge Ndlela le ngore esekhathi, mara kgulu go fana ne lekhaya le tenosi le le le gase bodese le lengane.” Kevin Kelly, (1994:166283). Go leso setsopolwe e tulu, era gore tedlela te go hlela, go leto te khona, baphathi ba se tulu, geto tedo te tengane leto te gase bodese le to te akha lehlelo gemoga le mokhadlo. Lehlelo gemoga le mokhadlo o monye na o monye le dlolela e go etene ge tedo. Jene ge bahleli, baphathi ba setulu ba beregesa tedlela tabo te go nagana, go tshwaetja tedlela te tetsha leto ba te vumelago na leto ba te kganago. Ge go eta jalo te thella lehlelo lelo le phalesanago lelo lele beregeswe mokhadlo, e maphellweni na leso mokhadlo o se yetago. Go bala lokhu, go ete gore go be ne go vesesana e khathe ge tedlela te go hlela leto te beregeswa mbaphathi ba setulu ne Ndlela leyo ba nagana gayo. Go beka nnye ye tedlela leto ba te beregeselego, go beregeswe tedaba leto te phoma go 33 ye bado labo be ba butiswa go kereya leso be ba fona go seva ne mebotiso e 79 leyo e hlalosa nkgonagalo ye go talana e khathe ge mehuda ye go nagana ne ndlela leyo go hlelwa gayo. Mephomela e bonesa gore lapho e mekhadlweni, Ndlela ye go nagana ge baphathi ba setulu e ya phabana go ya ge gore ba te kereya ba se sejamweni se se jane. Nkgonagalo ye bodlelwano e khathe ge Ndlela ye go nagana ne lenaneo le le le ladelwago e tedweni te nhlagano, te beregeselwe. Mave e bohlogwa: Bophathi ba setulu, bakgoni be go hlela, baberegi be go hlela, tedlela leto go hlelwa gato, Ndlela leyo go naganwa gayo; go khetha, mekgwa ye go nagana ge botalo, tedlela te go suga endabeni ennye goya go ennye. / Business Management / M. Com. (Business Management)