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1	ACID-SENSING ION CHANNELS: TARGETS FOR NEUROPEPTIDE MODULATION AND NEURONAL DAMAGE Frey, Erin N. 23 July 2013 (has links) No description available. Biomedical Research Neurosciences acid sensing ion channels acidosis ischemia dynorphin opioid peptides RFamides ASICs
2	Generierung und Analyse EMA/E2F-6-defizienter Mäuse Pohlers, Michael 12 December 2005 (has links) The present study focuses on the biological functions of the transcription factor EMA/E2F-6, a member of the E2F-family of transcription factors that play an import role in cell cycle progression, differentiation and apoptosis. EMA/E2F-6 functions as a transcriptional repressor by recruiting a large protein complex, that includes polycomb group proteins, to specific target genes in order to silence their expression. To identify the biological functions of EMA/E2F-6 mice lacking this factor were developed and subsequently analysed. EMA/E2F6-/- mice are born with the expected frequency, are fertile and develop normally up to 18 months of age. Then about 25 % of these mice develop a paralysis of the hind limbs and present with a severe primary myelination defect of the spinal cord (and in part of peripheral nerves, too) that is accompanied by a massive infiltration of macrophages. Importantly, the histological findings were also detected in EMA/E2F-6-/- mice lacking clinical symptoms albeit to a lesser extend. With respect to EMA/E2F-6 association with polycomb group (Pc-G) proteins there were no significant findings such as skeletal transformations. In addition, only a mild proliferation defect of T-lymphocytes was observed that, in a more severe form, is typical for Pc-G mutations in the mice. Surprisingly, embryonic fibroblasts from EMA/E2F-6-/- mice have no obvious cell cycle defects. Accordingly, gene expression profiles showed that classical E2F target genes were normally regulated in these cells. However, EMA/E2F-6-/- fibroblasts ubiquitously express genes like alpha-tubulin-3 and -7 that are normally expressed in a strictly testis-specific manner. All EMA/E2F-6-dependent target genes identified contain a conserved E2F-binding site in their promoters that is required both for EMA/E2F-6 binding and regulation. Zellzyklus Demyelinisierungen Gehirnveränderungen Geninaktivierung Gewebsspezifische Genexpression Lähmungen Makrophageninfiltration Mäuse/Nullmutanten Neuronenuntergang Oligodendrozytenreduktion Polycomb-Gruppe-Proteine Proliferation von T-Lymphozyten Regulation der Genexpression Rückenmarksveränderungen Skeletttransformationen Transkriptionsfaktoren Brain/Abnormalities Cell Cycle Demyelinisations Gene Targeting Infiltration of Makrophages Mice/Knockout Neuron Death Paralyses Polycomb-Group Proteins Proliferation of T-Lymphocytes Reduktion of Oligodendrocytes Regulation of Gene Expression Skeletal Transformations Spinal Cord/Abnormalities Tissue-specific Gene Expression Transkription Factors 570 Biowissenschaften, Biologie 32 Biologie WG 3580 WG 3700 ddc:570

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ACID-SENSING ION CHANNELS: TARGETS FOR NEUROPEPTIDE MODULATION AND NEURONAL DAMAGE

Generierung und Analyse EMA/E2F-6-defizienter Mäuse