This study was to explore the relationships between personal exposure to 10 volatile organic compounds (VOCs) and biochemical liver tests with the application of canonical correlation analysis. Data from a subsample of the 1999-2000 National Health and Nutrition Examination Survey were used. Serum albumin, total bilirubin (TB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and γ-glutamyl transferase (GGT) served as the outcome variables. Personal exposures to benzene, chloroform, ethylbenzene, tetrachloroethene, toluene, trichloroethene, o-xylene, m-,p-xylene, 1,4-dichlorobenzene, and methyl tert-butyl ether (MTBE) were assessed through the use of passive exposure monitors worn by study participants. The first two canonical correlations were 0.3218 and 0.2575, suggesting a positive correlation mainly between the six VOCs (benzene, ethylbenzene, toluene, o-xylene, m-,p-xylene, and MTBE) and the three biochemical liver tests (albumin, ALP, and GGT) and a positive correlation mainly between the two VOCs (1,4-dichlorobenzene and tetrachloroethene) and the two biochemical liver tests (LDH and TB). Subsequent multiple linear regressions show that exposure to benzene, toluene, or MTBE was associated with serum albumin, while exposure to tetrachloroethene was associated with LDH and total bilirubin. In conclusion, exposure to certain VOCs as a group or individually may influence certain biochemical liver test results in the general population.

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第20753号 / 理博第4329号 / 新制||理||1622(附属図書館) / 京都大学大学院理学研究科数学・数理解析専攻 / (主査)教授 森脇 淳, 教授 雪江 明彦, 教授 並河 良典 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

An examination of scholarly perspectives on the ethicality of Joseph's enslavement of the Egyptians in Gen 47:13-26 reveals a debate over whether Joseph's actions were benevolent or oppressive. The majority of scholars who evaluate Joseph negatively simply ignore the relevant historical data, and Brueggemann's case for its dismissal is unconvincing. However, one area of contention that has gone relatively unexamined is the relevance and implications of later canonical materials relating to slavery. Childs' Canonical Approach is employed in a modified form to honor the canon as the larger context in which a passage should be read. I argue that when examined in light of relevant slavery texts across the Tanakh, Joseph's actions in Gen 47:13-26 are not culpable on the basis of his employment of debt slaver, but can be read as being out of step with the ideal that emerges concerning resource distribution. / Thesis / Master of Arts (MA)

<p> The theory of canonical correlation analysis has been combined with that of trend surface analysis in order to construct a multivariate trend surface which is called a canonical trend surface. </p> <p> A canonical trend surface is a parsimonious summarization of areal variations of a set of geological variates. This trend has a property of maximum correlation between variates and geographic coordinates. It does not show the absolute value of each variate, but it shows the nature of the variation of a linear combination of the variates. The Permian system in western Kansas and eastern Colorado was studied as a numerical example to illustrate the general procedures in solving practical problems and also to demonstrate the validity of this technique. By use of this type of trend it is possible to reveal the underlying pattern of geographic variation common to a set of variates. </p> <p> Other applications of canonical correlation analysis in geology have been explained with illustrative geological examples, namely: the relationships between two sets of variates, matching two factor patterns, Q-technique canonical correlation, and discriminatory analysis. </p> <p> Comparison of canonical correlation analysis and principal factor solution in factor analysis suggests that factor analysis may be more appropriate for suggesting interrelationships among variables, while canonical correlation analysis may be a suitable tool for prediction problems. </p> <p> FORTRAN IV programs for these computations are listed in appendices with instructions for using them. </p> / Thesis / Doctor of Philosophy (PhD)

<p> This dissertation argues that the corpus of so-called Catholic Epistles in the New Testament canon, that is James, 1 and 2 Peter, 1, 2, and 3 John, and Jude, should be accurately called the Jerusalem Apostolic Epistles. These epistles were written by the alleged Jerusalem Apostles, namely James, Peter, John and Jude. Instead of looking at these writings separately, it is proposed that the mission of the Jerusalem Apostles can be discovered by an authorial, historical, and canonical reconstruction of their epistles if they are studied as a collection. These four canonical authors represented three locations of origin, James and Jude from Jerusalem to the Diaspora Jews, Peter from Rome to the Diaspora Jews of eastern Asia Minor, and John from Asia Minor to the vicinity. The seven epistles were closely knitted together like a web through various kinds of connections and similarities.</p> <p> In the process of the canonization of these epistles, we find that the Jerusalem Apostolicity representing the Jewish Christianity played a role in the church in, on the one hand, separating from first-century Judaism, and, on the other, counterbalancing the Gentile Christianity represented by Paulinism. The latter parting of the ways has been in existence from the days of the apostles to even the days of Augustine. The rise of heresies indirectly stimulated the making of creeds and regula fidei.</p> <p> Papyrological and patristic evidences show that some of these epistles existed and were in circulation as early as the second century. The Jerusalem Apostles and their writings were recognized, mentioned, quoted, and circulated. There were obstacles for some of the writings of the Jerusalem Apostles to be recognized into the canon. However, in view of the final product and the placement of the canon, all these epistles were compiled together following the Book of Acts to form a single unit of the Apostolos. I propose a canon-logical reconstruction of the Jerusalem Apostolic Theology, and a reading of the Catholic Epistles with literary rearrangement within the Apostolos as part of the discussion of the final canonical product.</p> <p> This dissertation concludes with my attempt of an authorial, historical, and canonical reconstruction of the mission of the Jerusalem Apostles.</p> / Thesis / Doctor of Philosophy (PhD)

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Bayesian Model Averaging (BMA) is a new area in modern applied statistics that provides data analysts with an efficient tool for discovering promising models and obtaining esti-mates of their posterior probabilities via Markov chain Monte Carlo (MCMC). These probabilities can be further used as weights for model averaged predictions and estimates of the parameters of interest. As a result, variance components due to model selection are estimated and accounted for, contrary to the practice of conventional data analysis (such as, for example, stepwise model selection). In addition, variable activation probabilities can be obtained for each variable of interest. This dissertation is aimed at connecting BMA and various ramifications of the multivari-ate technique called Reduced-Rank Regression (RRR). In particular, we are concerned with Canonical Correspondence Analysis (CCA) in ecological applications where the data are represented by a site by species abundance matrix with site-specific covariates. Our goal is to incorporate the multivariate techniques, such as Redundancy Analysis and Ca-nonical Correspondence Analysis into the general machinery of BMA, taking into account such complicating phenomena as outliers and clustering of observations within a single data-analysis strategy. Traditional implementations of model averaging are concerned with selection of variables. We extend the methodology of BMA to selection of subgroups of observations and im-plement several approaches to cluster and outlier analysis in the context of the multivari-ate regression model. The proposed algorithm of cluster analysis can accommodate re-strictions on the resulting partition of observations when some of them form sub-clusters that have to be preserved when larger clusters are formed. / Ph. D.

This dissertation is concerned with the problem of the exact pole-placement by minimum control effort using state and output feedback for linear multivariable systems. The novelty of the design lies in obtaining a direct transformation of the system matrices into a modified controllable canonical form. Two realizations are identified, and the algorithms to obtain them are derived. In both cases, the transformation matrix has some degrees of freedom by tuning a scalar or a set of scalars within the matrix. These degrees of freedom are utilized in the solution to reduce further the norm of the state feedback matrix. Then the pole-placement problem is solved by minimizing a certain functional, subject to a set of specified constraints. A non-canonical form approach to the problem is also proposed, where it was only necessary to transform the input matrix to a special form. The transformation matrix, in this method, has larger degrees of freedom which can be utilized in the solution. Moreover, a new pole-placement method based on the non-canonical approach is derived. The solution, in this method, was made possible by solving the Lyapunov matrix equation. Finally, an iterative algorithm for pole-placement by output feedback is extended so as to obtain an output feedback matrix with a small norm. The extension has been accomplished by applying the successive pole shifting method. Two schemes for the pole shifting are proposed. The first is to successively shift the poles through straight paths starting from the open loop poles and ending at the desired poles, whereas the second scheme shifts the poles according to a successive change of their characteristic polynomial coefficients. / Ph. D. / incomplete_metadata

Cette thèse propose une repréesentation de la notion de type, avec un intérêt particulier pour les types d'ependants, en Ludique.La Ludique est une th'eorie introduite par Girard. Elle vient d'une fine analyse du fragment multiplicative, additive polarisé de la Logique Linéaire (MALL_p). Un des ses buts est de reconstruire la logique à partir de la notion d'intéraction. Un type est une classe d'objets qui se comportent de la m^eme fac{c}on par rapport aux autres objets. La notion de type est commune à plusieurs domaines comme la Théorie de la Calculabilité, la Sémantique des Jeux et la Théorie Intuitioniste de Types de Martin-Lof. Avec la terminologie de Martin-Lof, le termes canoniques d'un type sont les éléments primitives du type, c'est à dire les objets qui le caractérisent. Les termes non canoniques sont les termes obtenu appliquant une opération aux termes canoniques et une fois calculés donnent un terme canonique. Les termes sont vu comme des programmes et deux termes sont égaux quand leur calcul donne le même résultat, c'est à dire le même terme canonique. On introduit la notion de comportement principal, qui est bien adapté à la représentation des termes canoniques. On introduit aussi la notion de comportement séparable, qui nous donne un outil pour définir les fonctions de manière simple.On représente les nombres naturelles, les listes, les records, les fonctions dépendantes, les couples et on discutes les records dépendantes.On se focalise après sur la Théorie de Martin-Lof pour proposer une représentation de certaines types de base et constructions. / This thesis proposes a representation of the notion of type, with a particular interest on dependent types, in Ludics.Ludics is a theory introduced by Girard cite{LocSol}. It comes from a fine analysis of the multiplicative, additive fragment of polarized Linear Logic (MALL_p). One of its aim is to reconstruct logic from the notion of interaction. A type is a class of objects that behave in the same way with respect to other objects.The notion of type is common to several domains as Computation Theory, Game Semantics and Martin-Lof's Intuitionistic Type Theory.Using the terminology of Martin-Lof, the canonical terms of a type are the primitive elements of the type, that is the objects that characterize it. The non-canonical terms are the terms obtained by applying some operations on canonical terms and that once computed give a canonical term. Terms are seen as programs and two terms are equal when their computation gives the same result, that is the same canonical term.We introduce the notion of principal behaviour, that is well-suited to represent canonical terms. We introduce also the notion of separable behaviour, that gives us a tool to define functions in a simple way.We represent natural numbers, lists, records, dependent functions, pairs and discuss dependent record types. We focus then on Martin-Lof's Type Theory and propose a representation for some basic types and constructions.

<p>  </p> <p>There is a plethora of information surrounding the stages of infant vocal development, and canonical babble’s predictive power concerning future language outcomes. However, there is less information regarding how the acoustic features of early babble differ between canonical and non-canonical syllable types over the course of development. Furthermore, previous studies rely on small sample sizes which limit their findings’ generalizability. This project examined the pitch range, mean pitch, and syllabic nuclei duration of monosyllabic canonical and non-canonical infant vocalizations over the course of development. </p> <p>Audio files of monosyllabic utterances were obtained from 29 infants at low risk for developing a speech or language disorder, aged 10-26 months. The infants were divided into three age bands: 10-12 months (M=11.74, N=10, 5=F), 13-22 months (M=16.08, N=9, 6=F), and 23-26 months (M=24.67, N=9, 2=F). We listened to each utterance and marked syllable nucleus boundaries prior to running scripts to measure acoustic cues. Between 6 and 15 utterances were selected from each participant. The number of canonical utterances was matched to the number of noncanonical utterances (e.g., if 13 canonical utterances were selected for a specific participant, 13 non-canonical utterances were also selected). We then ran a Praat script which yielded the mean pitch, pitch range, and duration of the syllabic nucleus for each audio file. </p> <p>We found that there was a significant effect of syllable type on duration, as canonical syllables were shorter in duration than non-canonical syllables (F (1, 618.34) = 10.64, <em>p </em>= .001), and on mean pitch, as canonical syllables were lower in mean pitch than non-canonical syllables (F (1, 618.57) = 7.18, <em>p</em> = .008). We did not find an effect of syllable type on pitch range, age on mean pitch or duration, or any interaction effects between syllable type and age. However, we did find an effect of age on pitch range, because infants in the oldest age bracket (23-26 months) were more likely to have a wider pitch range than younger infants (F (2, 44.77) = 5.05, <em>p</em> = .011). </p> <p>This provides preliminary evidence that there are pitch and duration distinctions between canonical and non-canonical syllable types and suggests that as infants age they are more likely to use greater pitch variation within their vocalizations. However, as our study only examined monosyllabic utterances, further research is necessary in order to thoroughly investigate pitch and duration distinctions present in canonical and non-canonical syllables. </p>