Orientador: Agueda Bernadete Bittencourt / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Educação / Made available in DSpace on 2018-08-03T14:59:04Z (GMT). No. of bitstreams: 1 Leonardi_Paula_M.pdf: 11157226 bytes, checksum: de41da50c9c95f3c2197ee0e0cf90291 (MD5) Previous issue date: 2002 / Resumo: Esta pesquisa tem como tema central um colégio confessional católico instalado na cidade de Rio Claro, interior do Estado de São Paulo: o Colégio Puríssimo Coração de Maria. Em 1909, no início do regime republicano, o Colégio foi instalado na cidade presenciando e participando de importantes mudanças políticas e culturais ocorridas no país, especialmente para a Igreja Católica com o fim do padroado. Durante seus noventa e três anos de história o Colégio desenvolveu, perante os habitantes da cidade, uma imagem de escola de qualidade e que oferece formação integral. O objetivo destá pesquisa é compreender como o Colégio construiu essa imagem ao longo dos anos o que interesses estavam em jogo em sua instalação e permanência em Rio Claro, a fim de olhar para seu desenvolvimento no campo material e simbólico. A hipótese norteadora desta pesquisa traz a idéia de que a formação de mulheres professoras em meados da década de 30 foi parte fundamental dessa construção. Desse modo, duas datas delimitam este estudo: a instalação da escola em 1909 e a instalação do curso normal em 1928 / Abstract: This research have, as central subject, a confessional catholic school in the city of Rio Claro, in Sao Paulo State: the ¿Colegio Purissimo Coraqao de Maria¿. In 1909, in the beggining of the Republican Era, the ¿Colegio¿ initiated its activities in Rio Claro, presenting and participating on important politics and economics changes occurred in Brazil, at that date, specially for the Catholic Church, with the end of ¿padroado¿. In its nineteeth three years of history, the ¿Colegio Purissimo¿ developed, for the city population, a image of ¿quality school that offers integral education¿. The objective of the present research is to understand how the Colegio build up this image, and what personal concerns were considered to for its installation and permanence at Rio Claro, at a glance to its development on material and simbolic fields. The hipothesis that drives this research bring us the idea that the education of women to be teachers in middle 1930 decade was fundamental part of this construction. In this way, two dates limits this research: The ¿Colegio Purissimo¿ installation in 1909 and the establistablishment of the ¿Normal¿ course in 1928 / Mestrado / Educação, Conhecimento, Linguagem e Arte / Mestre em Educação

Orientador: Liliana Rolfsen Petrilli Segnini / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Educação / Made available in DSpace on 2018-07-19T23:47:28Z (GMT). No. of bitstreams: 1 Freitas_AnamariaGoncalvesBuenode_M.pdf: 11865090 bytes, checksum: 1936fbd759da1f0d658d301924e47698 (MD5) Previous issue date: 1995 / Resumo: Esta dissertação tem como objetivo analisar as representações das ex normalistas do Instituto de Educação Rui Barbosa - Escola Normal - acerca da formação profissional e do ingresso na carreira do magistério. Para realizar este estudo foram coletadas histórias de vida resumidas das ex alunas que se formaram na instituição no período que compreende as décadas entre 20 e 50. Foram também analisados documentos oficiais. Buscou-se apreender, durante a análise, aspectos relacionados ao processo de ingresso no curso normal; à duração e estrutura do curso; à convivência no espaço escolar entre professores e alunas e ao início da carreira das ex-normalistas. o relato destas experiências acerca do cotidiano da formação da Escola Normal e do processo de ingresso na carreira permitiram conhecer não só as trajetórias individuais, como também as vivências coletivas no espaço escolar e a inserção no mercado de trabalho das professoras primárias de Aracaju, no período estudado / Mestrado / Ciencias Sociais Aplicadas à Educação / Mestre em Educação

Normal subgroups can be thought of as the primary building blocks for decomposing mathematicalgroups into quotient groups. The properties of the resulting quotient groups are oftenused to determine properties of the group itself. This thesis considers normal subgroups of threedimensionalcrystallographic space groups that are themselves three-dimensional crystallographicspace groups; for convenience, we refer to such a subgroup as a csg-normal subgroup. We identifypractical restrictions on csg-normal subgroups that facilitate their tabulation. First, the point groupof an csg-normal subgroup must be a normal subgroup of the crystallographic point group of thespace group, which we refer to for convenience as a cpg-normal subgroup. For each of the cpgnormalsubgroups, which are all well known, we identify the abstract quotient group. Secondly,we identify necessary conditions on the sublattice basis of any csg-normal subgroup, and tabulatethe “normally supportive“ sublattices that meet these conditions, where some tables are symbolicforms that represent infinite families of sublattices. For a given space group, every csg-normalsubgroup must be an extension of such a normally supportive sublattice, though some normallysupportive sublattices may not actually support such extensions.

Discrete Differential Geometry (DDG) concerns discrete counterparts of notions and methods in differential geometry. This thesis deals with a core subject in DDG, discrete curvature theories on various types of polyhedral surfaces that are practically important for free-form architecture, sunlight-redirecting shading systems, and face recognition. Modeled as polyhedral surfaces, the shapes of free-form structures may have to satisfy different geometric or physical constraints. We study a combination of geometry and physics – the discrete surfaces that can stand on their own, as well as having proper shapes for the manufacture. These proper shapes, known as circular and conical meshes, are closely related to discrete principal curvatures. We study curvature theories that make such surfaces possible. Shading systems of freeform building skins are new types of energy-saving structures that can re-direct the sunlight. From these systems, discrete line congruences across polyhedral surfaces can be abstracted. We develop a new curvature theory for polyhedral surfaces equipped with normal congruences – a particular type of congruences defined by linear interpolation of vertex normals. The main results are a discussion of various definitions of normality, a detailed study of the geometry of such congruences, and a concept of curvatures and shape operators associated with the faces of a triangle mesh. These curvatures are compatible with both normal congruences and the Steiner formula. In addition to architecture, we consider the role of discrete curvatures in face recognition. We use geometric measure theory to introduce the notion of asymptotic cones associated with a singular subspace of a Riemannian manifold, which is an extension of the classical notion of asymptotic directions. We get a simple expression of these cones for polyhedral surfaces, as well as convergence and approximation theorems. We use the asymptotic cones as facial descriptors and demonstrate the practicability and accuracy of their applications in face recognition.

No description available.

In many regions worldwide, older adults now form the fastest growing portion of the population. As such, aging research has seen tremendous growth in recent years, with a focus on identifying early biomarkers of age-related disease. However, crucial to understanding age-related disease is to identify what constitutes normal brain aging, and the life-course factors associated with positive outcomes in later life. In support of this goal, the current dissertation is comprised of three manuscripts that aim to investigate the functional and structural correlates of normal aging in a sample of community-dwelling younger and older adults, from both a multimodal and multi-analysis perspective. Study 1: The first study examined how cumulative cardiovascular risk and self-reported levels of physical, social, and cognitive activity are associated with differences in hippocampal volumes in early and later adulthood. Results indicated that greater cumulative cardiovascular risk was associated with smaller hippocampal volumes across age cohorts. Moreover, a negative association found between frequency of social activities and bilateral hippocampal volumes in older adults, suggesting that social activities with a low cognitive load may not be beneficial to structural brain outcomes in older age. Study 2: This study employed novel advances in functional magnetic resonance imaging (fMRI) to study fluctuations in the blood-oxygen-level dependent (BOLD) signal in relation to age and markers of brain health. Specifically, the study examined the relationship between resting-state BOLD variability and markers of both vascular health and lifestyle activity levels. Results indicated that resting-state BOLD variability is increased in older relative to younger adults. The findings also suggest that the association between BOLD variability and lifestyle activity levels may differ depending on age. Study 3: The final study aimed to further investigate the origins of the BOLD variability signal by examining the feasibility of combining functional near infrared spectroscopy (fNIRS) with fMRI brain signal fluctuation data. In addition to providing proof of concept of combining fNIRS hemoglobin metrics with fMRI BOLD variability maps, the results of this study also indicate that the patterns of regional association between resting hemoglobin concentrations and BOLD fluctuations may vary according to age cohort. Together, the three studies comprising this dissertation illustrate the value of adopting a multimodal, life-course perspective in the study of normal aging. These findings also support increasing evidence of a relationship between the BOLD variability signal and age. Given the limitations of cross-sectional designs for demonstrating change over time, longitudinal investigations with larger sample sizes across multiple age groups are needed to further the development of public health measures aimed at promoting successful aging from early adulthood. / Graduate / 2022-12-08

Purpose: Use of ampicillin in outpatient parenteral antimicrobial therapy (OPAT) has historically been complicated by frequent dosing and short beyond use dates. However historic stability data relied on inaccurate testing methods. The purpose of this study is to evaluate the stability of ampicillin using high-pressure liquid chromatography (HPLC), the gold standard, in a real-world OPAT dosing model using continuous infusion at room temperature over 24 hours immediately following preparation compared to batches stored under refrigeration for 24 hours, 72 hours, and 7 days. Methods: An HPLC method was developed and validated as stability – indicating according to guidance in USP general Chapter < 1225 >. Method development included linearity, precision, accuracy, repeatability and forced degradation. Four batches were prepared using 4 different lots from 2 different manufacturers for each storage condition (immediate, 24 hours, 72 hours, and 7 days). Three 2-gram vials were each reconstituted with 10 mL of sterile water for injection (SWFI) and added to 250 mL of normal saline by a licensed pharmacist and stored in a laboratory refrigerator (2 – 8oC). A pump system was used to continuously circulate the solutions through medical grade tubing at room temperature. One milliliter aliquots were removed from each batch at time 0, 4 hours, 8 hours, 12 hours and 24 hours and analyzed for ampicillin concentration using the aforementioned HPLC method. The samples were filtered prior to analysis using a 0.22-micron syringe filter and analyzed in triplicates along with freshly prepared calibration samples (24 – 12 mg/mL). Peak area was used to determine percent recovery for each sample. Results:Each batch was assayed for initial concentration (20.34 – 21.50 mg/mL) upon preparation, and percent recovery was compared to that initial concentration thereafter. Acceptable recovery was defined as 90 – 110% of initial concentration. On the day of product preparation (immediate use), the average percent recovery over 24 hours was 96.4%. The other average percent recoveries were as follows: 95.8% (24-hour storage), 94.6% (72-hour storage) and 90.3% (7-day storage). These data represent the average percent recovery for all time points during the 24 hours sampling (n = 60 for each experiment). When evaluating individual time points, the percent recovery remained above 90% for all batches and time points except for the 7-day storage experiment. Under 7-day storage conditions, the percent recovery fell below 90% after 4 hours of circulation through the medical grade tubing. Furthermore, 95% confidence interval for percent recovery for ampicillin in the samples stayed within 90 – 110% of the initial concentration for the duration of the experiment for all test groups except 7-day storage. Conclusion:Ampicillin can be prepared and stored in a refrigerator for up to 72-hours prior to continuously infusing at room temperature over 24 hours with less than a 10% loss of potency over the dosing period. This model supports twice weekly OPAT delivery of ampicillin.

U.S. Food and Drug Administration (FDA) recalls of medical devices are at historically high levels despite efforts by manufacturers to meet stringent agency requirements to ensure quality and patient safety. A factor in the release of potentially dangerous devices might be the interpretations of nonnormal test data by statistically unsophisticated engineers. The purpose of this study was to test the hypothesis that testing by lot provides a better indicator of true process behavior than process capability indices (PCIs) calculated from the mixed lots that often occur in a typical production situation. The foundations of this research were in the prior work of Bertalanffy, Kane, Shewhart, and Taylor. The research questions examined whether lot traceability allows the decomposition of the combination distribution to allow more accurate calculations of PCIs used to monitor medical device production. The study was semiexperimental, using simulated data. While the simulated data were random, the study was a quasiexperimental design because of the control of the simulated data through parameter selection. The results of this study indicate that decomposition does not increase the accuracy of the PCI. The conclusion is that a systems approach using the PCI, additional statistical tools, and expert knowledge could yield more accurate results than could decomposition alone. More accurate results could ensure the production of safer medical devices by correctly identifying noncapable processes (i.e., processes that may not produce required results), while also preventing needless waste of resources and delays in potentially life-savings technology, reaching patients in cases where processes evaluate as noncapable when they are actually capable.

Advances in medical technology have provided the mechanisms for sustaining life in premature and low-birthweight infants, resulting in the survival of more of these infants. Low-birthweight (LBW) and preterm infants are placed at risk by a number of medical complications, including intraventricular hemorrhage (IVH). The outcome of low-birthweight infants with intraventricular hemorrhage has been the subject of a great deal of research and continues to be a much-discussed topic in the medical and psychological communities. As more data become available, it appears that more questions arise concerning the later neuodevelopmental and neuropsychological outcome of these infants. For this reason, research concerning the later status of infants born with intraventricular hemorrhage is needed. The purpose of this study was to determine if there are differences in cognitive and motor functioning among infants with intraventricular hemorrhage (IVH), infants who were low birthweight (LBW), and normal-birthweight (NBW) infants. Forty-four subjects (10 with mild IVH, 9 with severe IVH, 12 LBW, and 13 NBW), who were born between January 1, 1984, and June 1, 1985, and were either patients in the neonatal intensive care unit at University of Utah Medical Center (the IVH and LBW infants) or were residents of the well-baby nursery (the NBW infants) at University of Utah Medical Center, served as the sample population. The subjects were tested at 3 to 4.5 years of age using the Stanford-Binet Intelligence Scales (Fourth Edition) and the motor section of the McCarthy Scales of Children's Abilities. In addition, infant medical data were obtained from medical records, and demographic data were collected including mother's age at time of birth, family income, mother's and father's education level, and birth order of the infant. The MIVH, SIVH, and LBW groups had significantly lower gestational ages and birthweights and significantly more medical complications than did the NBW group. The MIVH and SIVH groups also had significantly lower birthweight and gestational ages than did the LBW group, but approximately equivalent numbers of medical complications. Significant group differences were found only between the MIVH and NBW groups on the McCarthy motor score, with the MIVH group appearing to outperform the NBW group following statistical manipulation with analysis of covariance. No other significant group differences were found. Further research with a larger sample is recommended in order to more fully understand the later outcome following LBW and IVH.

Films of three depress ed persons, one manic, and one normal individual were analyzed frame-by-frame to determine body activity rates. Speech rates were also determined. It was found that the manic had the highest activity rate, followed by the normal comparison, and with the depressed patients having the lowest activity rates. The depressed subjects also had lower speech rates than did the normal or the manic subjects. The term 'psychomotor retardation 1 is called into question, as the frequency distributions of movement durations were similar for all subjects. Implications for treatment and for development are also discussed.