With the ever-increasing number of people accessing the Internet and the recent explosion of e-commerce world wide, there are considerable implications for the tourism industry. Tourism suppliers are investing in the Internet via web pages, advertising and e-commerce, but what role does the Internet actually play in tourism? Before more money is placed into this new 'e-economy', it is important to study the effectiveness of the Internet as a marketing tool in tourism. In order to better address the concerns described above, this research accomplishes several tasks. First, the significance of researching Internet use within the tourism context is established. Specifically, theories and concepts from postmodernism, post-industrialism and post-structuralism are drawn upon as they frame this study. Second, this research explores motivation and decision making within tourism and how the Internet is used during stages of travel preparation, planning and activities. Third, this research explores tourist preferences for novelty and familiarity in three dimensions; travel services, social contact and destination choices, and examines how these are associated with Internet use. The general structure of tourism markets in relation to Internet use as well as novelty and familiarity preferences are also discussed. Three case studies are undertaken to examine these matters: winter tourists, summer tourists and cruise tourists. Novelty-seekers were found to be the most frequent group of Internet users, and also were the most likely to consult a wider variety of information sources when making travel-related decisions. Results also indicate that Internet use for travel varies according to seasonality and destination choices rather than primary activity.

With the ever-increasing number of people accessing the Internet and the recent explosion of e-commerce world wide, there are considerable implications for the tourism industry. Tourism suppliers are investing in the Internet via web pages, advertising and e-commerce, but what role does the Internet actually play in tourism? Before more money is placed into this new 'e-economy', it is important to study the effectiveness of the Internet as a marketing tool in tourism. In order to better address the concerns described above, this research accomplishes several tasks. First, the significance of researching Internet use within the tourism context is established. Specifically, theories and concepts from postmodernism, post-industrialism and post-structuralism are drawn upon as they frame this study. Second, this research explores motivation and decision making within tourism and how the Internet is used during stages of travel preparation, planning and activities. Third, this research explores tourist preferences for novelty and familiarity in three dimensions; travel services, social contact and destination choices, and examines how these are associated with Internet use. The general structure of tourism markets in relation to Internet use as well as novelty and familiarity preferences are also discussed. Three case studies are undertaken to examine these matters: winter tourists, summer tourists and cruise tourists. Novelty-seekers were found to be the most frequent group of Internet users, and also were the most likely to consult a wider variety of information sources when making travel-related decisions. Results also indicate that Internet use for travel varies according to seasonality and destination choices rather than primary activity.

Adolescence is a time of high risk behavior and increased exploration. This developmental period is marked by a greater probability to initiate drug use and is associated with an increased risk to develop addiction and dependency in adulthood. Human adolescents are predisposed toward an increased likelihood of risk taking behaviors (Zuckerman M, 1986), including drug use or initiation. The purpose of this study was to examine differences in developmental risk taking behaviors and neurochemical responsivity to cocaine based on these behavioral characteristics. Adolescent and adult animals were exposed to a novel stimulus in a familiar environment to assess impulsivity, novelty preference and exploratory behaviors, subsequently, in vivo microdialysis was performed to assess dopaminergic responsivity to cocaine. Adolescent animals had greater novelty-induced locomotor activity, greater novelty preference, were more impulsive and showed higher exploratory behaviors compared to adult animals. Furthermore, the results demonstrate neurochemical differences between adolescent and adult animals in novel environment exploratory behavior, novel object preference, novelty-induced impulsivity and novelty-induced exploration. These data support the notion that adolescents may be predisposed toward sensation seeking and consequently are more likely to engage in risk taking behaviors, such as drug use initiation.

One unresolved issue in early word learning research is the relationship between word learning, categorization, and attention. Two distinct cognitive processes, attentional preferences related to categorical processing and inter-modal matching are involved in this relationship. Keeping the effects of these processes separate and controlled can be a difficult task. Not doing so can potentially confound the interpretation of research in this area. In a series of four preferential looking studies, the effects of referential assignment and novelty seeking in infancy were teased apart. In Study 1, 13-month olds preferred to look toward a monitor on which the stimuli changed category on every trial, and away from a monitor on which the stimuli were drawn from a single category. This preference developed in conditions in which infants listened to labels, non-language sound, or participated in silence. In Study 2, 18-month-olds developed the same preference when listening to non-language sounds or when participating in silence, but developed no preference when listening to labels. Results of studies 3 and 4 suggest that the lack of preference by 18-month-olds in the label condition result from competing behaviors of novelty seeking and referential assignment. / text

This diploma thesis examines the linkage between -141C Ins/Del polymorphism in dopamine receptor D2 gene and novelty seeking behavior (NSB). Novelty seeking is a personality trait characterized as a tendency to seek out various, complex and intense sensations and experiences at the cost of physical, social, legal, and financial risk. It also appears to be related to the onset of young drug use and aggressive behavior. It has been suggested that there is a relatively high occupancy of dopamine receptors in the brain of individuals with this characteristic feature. Generally, dopamine receptors are extensively studied in relation to many psychiatric diseases or personality disorders. Although there are studies focusing on personality traits such as novelty seeking, subjects of their research are mainly dopamine receptors D1, D3 or D4. Very little is known about dopamine receptor D2 and its relation to NSB despite the fact, that DRD2 is the key negative regulator of dopamine action. Currently, determination of occupancy of dopamine D2 receptors in the brain is possible with positron emission tomography (PET). However, using PET in neuropsychological research is not always financially viable. To date, only few studies associated with PET and NSB vs D2 receptors occupancy have appeared in published...

In light of collated research linking temperament traits and executive performance, the aim of this study is to explore, in a large non-clinical sample, the differences in executive performance profiles among participants with different intensities of the trait Novelty Seeking (NS). A further aim is to establish which facets of NS contribute to these differences. The NS temperament dimension and its subscales were operationalised as scores on the Temperament and Character Inventory (TCI), which is based on the psychobiological theory of personality. The University of Pennsylvania Computerised Neuropsychological Test Battery (PennCNP) of executive functioning (EF) and abstract reasoning was used to measure participants’ neuropsychological EF. The total sample of participants (n= 461) was divided into high NS (n= 216) and low NS (n= 245) groups to investigate any significant differences between them. Further analysis was then conducted in order to analyse the relationship between the NS scale, the four subscales (Exploratory Excitability, Impulsiveness, Extravagance, and Disorderliness), and performance in executive tasks. The findings of this study indicated significant differences between groups with different intensities of NS, with the high NS group functioning notably better in performance and reaction time. Furthermore, this study showed that facets of NS, such as impulsiveness was a significant contributor to EF performance outcomes. / Dissertation (MA)--University of Pretoria, 2013. / Psychology / unrestricted

Evidence suggests that certain genotypic variants associated with novelty-seeking and aggressiveness, such as the 7-repeat dopamine D4 receptor variant (DRD4-7R), short (s) allele of the serotonin transporter (5-HTT), and the low-activity variant of the MAOa promoter (MAOa-L), are more prevalent in human groups that radiated out of Africa than human groups that remained in Africa. Rhesus macaques (Macaca mulatta), like humans, are a widespread species of primates that needed to adapt to different regional environments with one group, Indian-derived rhesus macaques, largely occupying predictable and resource-rich environments, while the other group, the Chinese-derived rhesus macaques, has come to occupy less predictable and resource-abundant environments. Rhesus macaques possess orthologues of these trait-related genes, making it possible to compare the frequency of genotypes associated with these traits between members of two strains. DNA was obtained from N=212 rhesus macaques (n=54 Chinese-derived, n=158 Indian-derived) and genotyped for DRD4 (n=98), 5-HTT (n=190), and MAOA (n=97). Analyses showed that Chinese-derived subjects exhibited higher frequencies of the DRD4-7R and 5-HTT-s-allele when compared to Indian-derived subjects. There were no strain differences in MAOA-L genotype groupings, but the Chinese-derived subjects exhibited a more frequent high-activity (MAOA-H-6R) allele when compared to the Indian-derived subjects. The results suggest that the Chinese-derived rhesus macaques possess a higher frequency of alleles associated with novelty-seeking, impulsivity, and aggressiveness compared to their Indian-derived peers and that those genotypically-mediated traits may have beneficial to both humans and rhesus macaques as they spread into novel and unfamiliar environments.

Evidence suggests that certain genotypic variants associated with novelty-seeking and aggressiveness, such as the 7-repeat dopamine D4 receptor variant (DRD4-7R), short (s) allele of the serotonin transporter (5-HTT), and the low-activity variant of the MAOa promoter (MAOa-L), are more prevalent in human groups that radiated out of Africa than human groups that remained in Africa. Rhesus macaques (Macaca mulatta), like humans, are a widespread species of primates that needed to adapt to different regional environments with one group, Indian-derived rhesus macaques, largely occupying predictable and resource-rich environments, while the other group, the Chinese-derived rhesus macaques, has come to occupy less predictable and resource-abundant environments. Rhesus macaques possess orthologues of these trait-related genes, making it possible to compare the frequency of genotypes associated with these traits between members of two strains. DNA was obtained from N=212 rhesus macaques (n=54 Chinese-derived, n=158 Indian-derived) and genotyped for DRD4 (n=98), 5-HTT (n=190), and MAOA (n=97). Analyses showed that Chinese-derived subjects exhibited higher frequencies of the DRD4-7R and 5-HTT-s-allele when compared to Indian-derived subjects. There were no strain differences in MAOA-L genotype groupings, but the Chinese-derived subjects exhibited a more frequent high-activity (MAOA-H-6R) allele when compared to the Indian-derived subjects. The results suggest that the Chinese-derived rhesus macaques possess a higher frequency of alleles associated with novelty-seeking, impulsivity, and aggressiveness compared to their Indian-derived peers and that those genotypically-mediated traits may have beneficial to both humans and rhesus macaques as they spread into novel and unfamiliar environments.

No / This paper examines the continuous intention by healthcare professionals to use the Internet of Medical Things (IoMT) in combination with responsible artificial intelligence (AI). Using the theory of Diffusion of Innovation (DOI), a model was developed to determine the continuous intention to use IoMT taking into account the risks and complexity involved in using AI. Data was gathered from 276 healthcare professionals through a survey questionnaire across hospitals in Bahrain. Empirical outcomes reveal nine significant relationships amongst the constructs. The findings show that despite contradictions associated with AI, continuous intention to use behaviour can be predicted during the diffusion of IoMT. This study advances the under- standing of the role of responsible AI in the continued use of IoMT in healthcare and extends DOI to address the diffusion of two innovations concurrently.

Befunde zu Einflüssen genetischer Variation auf Temperamentsunterschiede und die Entwicklung psychiatrischer Störungen haben in den letzten Jahren bedeutende Beiträge zum eingehenderen Verständnis neurobiologischer Grundlagen von Verhaltensunterschieden geleistet. Eine der am eingehendsten untersuchten genetischen Variationen ist ein Polymorphismus des Dopamin-D4-Rezeptor-Gens (DRD4 Exon III). Nichtsdestoweniger ist seine funktionelle und verhaltenswirksame Rolle bisher weitgehend unklar: Zwar wurden bestimmte Varianten des Polymorphismus mit einer höheren Ausprägung in der Temperamentsdimension Novelty Seeking in Verbindung gebracht, Nachfolgeuntersuchungen erbrachten jedoch inkonsistente Resultate. Angesichts der methodischen und demografischen Heterogenität der einzelnen Studien war es das Anliegen zweier erster Studien der Dissertation, die Ursprungsbefunde möglichst exakt zu replizieren. Während in einer Voruntersuchung bei 136 Studierenden signifikant höhere Werte in Novelty Seeking bei Vorliegen des DRD4 Exon III 7-Repeat-Allels bzw. des 4/7-Genotyps festgestellt wurde, ergaben sich in Studie I, in der 276 Personen der selben Population mit der selben Methodik untersucht wurden, keinerlei Effekte des Polymorphismus. Auch anhand von Meta-Analysen ist gegenwärtig davon auszugehen, dass derzeit keine ausreichende empirische Grundlage für einen Haupteffekt von DRD4 Exon III auf Novelty Seeking vorliegt. Allerdings stellt ein einzelner Polymorphismus nur einen von vielen endogenen und exogenen Einflussfaktoren auf Temperamentsunterschiede dar, und inzwischen liegen auch Befunde zu Interaktionseffekten von DRD4 Exon III mit weiteren Polymorphismen vor. Derartigen Interaktionen wurde in Studie II nachgegangen, bei der für die Stichprobe aus Studie I zusätzlich zwei weitere genetische Polymorphismen genotypisiert wurden, die direkt oder indirekt die Dopamin-Funktion beeinflussen (COMT, 5-HTTLPR). In Studie II konnten die Ergebnisse einer vorhergehenden Arbeit repliziert werden, die einen Effekt des DRD4 Exon III 7-Repeat-Allels nur für bestimmte Genotyp-Gruppierungen der anderen beiden Polymorphismen zeigte. Zudem kann anhand der Befunde eine Abhängigkeit des Effektes von DRD4 Exon III von tonischen Dopamin-Niveaus vermutet werden. Ein neuerer Ansatz für die Aufklärung der funktionellen Rolle genetischer Variation geht davon aus, dass die relativ geringen Effekte von Polymorphismen auf endophänotypischer Ebene, also der Ebene etwa psychophysiologischer Maße wie dem EEG, möglicherweise besser erfassbar sind als auf Fragebogen-Ebene. Daher wurde in Studie III der Einfluss des DRD4 Exon III Polymorphismus auf einen Endophänotyp der Responsivität gegenüber Neuheit unter Berücksichtigung tonischer Dopamin-Niveaus untersucht. Als ein plausibler solcher Endophänotyp wurde die Novelty P3 des akustisch evozierten Potenzials im EEG in einer Stichprobe von 72 Personen im Hinblick auf ihre Modulation durch DRD4 Exon III untersucht. Tonische Dopamin-Niveaus wurden über die spontane Lidschlagrate als einem indirekten Indikator der Dopamin-Aktivität erhoben. Es zeigten sich keine Haupteffekte von DRD4 Exon III oder Lidschlagrate auf die akustisch evozierte Novelty P3. Es fand sich hingegen eine signifikante Interaktion der beiden Faktoren: Unter den Personen mit niedriger Lidschlagrate (=niedrigen tonischen Dopamin-Niveaus) zeigten Personen mit dem DRD4 Exon III 4/7-Genotyp eine signifikant höhere Novelty P3 in Antwort auf abweichende Reize als Personen mit dem 4/4-Genotyp. Dieses Ergebnis legt nahe, dass der Effekt von DRD4 Exon III auf die Verarbeitung abweichender Information von tonischen Dopamin-Niveaus abhängig ist. Insgesamt eröffnen die Resultate der Dissertation auch weiter gehende Erklärungsmöglichkeiten für Befunde etwa zu einer Assoziation von DRD4 Exon III mit Aufmerksamkeitsdefizit/Hyperaktivitätsstörung sowie für Zusammenhänge zwischen kognitiven, motivationalen und temperamentsmäßigen Verhaltenstendenzen.