京都大学 / 新制・課程博士 / 博士(医学) / 甲第23810号 / 医博第4856号 / 新制||医||1058(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 高橋 淳, 教授 伊佐 正, 教授 渡邉 大 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Stimulus Pairing Observational Procedure (SPOP) is an incidental teaching type procedure that has shown success in teaching typically developing children to name, independent tacting in the absence of the verbal community following a history of listener and echoic responses. The purpose of the current study was to compare SPOP and matching to sample procedures to determine the rate of acquisition for correct tact and listener responding , the rate of off task be avior, and the rate of generalization to different settings, stimuli, and instructors. Results of the study indicate that correct responding occurred at higher rates during MTS procedures than SPOP. The average rate of off task behavior was higher during SPOP sessions than during pre test, MTS sessions, or generalization probes for each participant. The results of the generalization probe may indicate that SPOP produces correct responding that increases or maintains during generalization, while MTS procedures produced more variable results.

The optically and IR-bright and starlight-scattering HR 4796A ringlike debris disk is one of the most-(and best-) studied exoplanetary debris systems. The presence of a yet-undetected planet has been inferred (or suggested) from the narrow width and inner/outer truncation radii of its r = 1.'' 05 (77 au) debris ring. We present new, highly sensitive Hubble Space Telescope (HST) visible-light images of the HR 4796A circumstellar debris system and its environment over a very wide range of stellocentric angles from 0.'' 32 (23 au) to approximate to 15 '' (1100 au). These very high-contrast images were obtained with the Space Telescope Imaging Spectrograph (STIS) using six-roll PSF template-subtracted coronagraphy suppressing the primary light of HR 4796A, with three image-plane occulters, and simultaneously subtracting the background light from its close angular proximity M2.5V companion. The resulting images unambiguously reveal the debris ring embedded within a much larger, morphologically complex, and biaxially asymmetric exo-ring scattering structure. These images at visible wavelengths are sensitive to and map the spatial distribution, brightness, and radial surface density of micron-size particles over 5 dex in surface brightness. These particles in the exo-ring environment may be unbound from the system and interacting with the local ISM. Herein, we present a new morphological and photometric view of the larger-than-prior-seen HR 4796A exoplanetary debris system with sensitivity to small particles at stellocentric distances an order of magnitude greater than has previously been observed.

Osteoporotic fractures are a major and increasing clinical and public health concern internationally. Identification of individuals at high risk for fragility fractures may enable us to target preventive interventions more effectively. In this thesis, I aimed to evaluate novel risk factors for osteoporosis and develop a fracture risk assessment model among the middle-aged and older people. I used data from the European Prospective Investigation into Cancer (EPIC)-Norfolk study, which is a large population-based prospective study started in 1993. About 25,000 men and women were assessed at baseline and about 15,000 of them returned for a second examination 4 years later. All participants are followed up to the present for clinical events including fractures. My work is in two parts. For the first part, I examined the risk of fracture associated with some novel or less well studied risk factors. These risk factors included change in height over time, respiratory function, physical activity and body fat mass. We found that men and women with annual height loss >0.5 cm are at increased risk of hip and any fracture (relative risk=1.9 (95% CI 1.3-2.7) per cm/year height loss). One litre lower forced expiratory volume in 1 second (FEV1) was associated with a 2-fold risk of hip fracture in men and women. We also observed a non-linear association, independent of body mass index, between increasing body fat mass and lower fracture risk in women but not in men. I performed a systematic review and meta-analysis of studies evaluating the association between physical activity and hip fractures. Using a new validated questionnaire in EPIC-Norfolk, we observed varying relationships between physical activity in different domains of life and fracture risk in men and women. For the second part of the thesis, I developed a biostatistical model to calculate 10-year risk of developing a fracture among EPIC-Norfolk study participants. This model incorporates clinical and radiological assessments known to be associated with fractures and can be extended to other risk factors assessed in other prospective cohorts. This helps clinicians to achieve a better estimate of the prospective risk of fracture in their patients. I applied this model to compare the predictive value of two different clinical assessment methods for osteoporosis, namely dual-energy X-ray absorptiometry (DXA) and quantitative ultrasound (QUS). We found that that the predictive power of QUS is comparable to, and independent of, predictive power of DXA. In summary, my studies have added to our knowledge about some novel and easy-to-use risk factors of osteoporosis and proposed a practical method to merge and utilise data from different risk factors for estimation of fracture risk in individuals.

This multi-method study provides detailed information about the friendships of 87 children with ADHD (77.0% boys) and 46 comparison children (73.9% boys) between the ages of 7 and 13. The methods used in the study included parent and teacher ratings, self-report measures, and direct observation of friends’ dyadic behaviours in three structured analogue tasks. Results indicated that, in contrast with comparison children, children with ADHD had friends with high levels of ADHD and oppositional symptoms; they perceived fewer positive features and more negative features, and were less satisfied in their friendships. Observational data indicated that children with ADHD performed both more legal and more illegal manoeuvres than comparison children in a fast-paced competitive game. While negotiating with their friends, children with ADHD made more insensitive and self-centred proposals than comparison children. In dyads consisting of one child with ADHD and one typically developing child, children with ADHD were often more controlling than their non-diagnosed friends. Globally, these results were robust and did not seem to be affected by age differences, ADHD subtypes, comorbidities, and medication status. Given the increased recognition of ADHD in adolescence and adulthood as well as the fact that negative peer reputation in childhood very strongly predicts mental-health status by early adulthood, this research may lead to the discovery of meaningful ways to help people with ADHD achieve improved mental health and happiness over their lifespan.

An extensive survey of extragalactic objects with accurate distances is difficult to perform. Distance at that scale is commonly found with redshift and most easily identified with spectroscopic observations, which are time intensive. This is especially a concern when surveying for the elusive, possibly non-existent dwarf galaxies in the centers of voids, whose light would be so faint that a spectroscopic survey to find them would be unreasonably time consuming. Photometric methods to calculate redshift could provide a much quicker way to find distance, but the photometric methods used thus far are characterized by large errors that make them unusable for research on nearby voids. I have been testing two photometric redshift methods that have been recently developed: the Gaussian filter method and the ramp filters method. The Gaussian filter method isolates objects that have emission within the bandpass of the Gaussian filters. Spectroscopic follow-up observations of objects observed with the Gaussian filter method confirmed that 41.9% of the objects identified by the method actually had emission lines within the bandpass of the filters, which is more than a random sampling where only 7% of galaxies had emission within that wavelength range. Assuming that all the lines identified were Hα, the photometric redshift calculated from the Gaussian filter observations had an error of 945 km/s (or 430 km/s by excluding one outlier). Ramp filter observations of objects with SDSS redshifts provided a way to identify redshift with an error of 641.8 km/s. These errors are about an order of magnitude less than other redshift methods. These methods show promise for uses in observational cosmology, specifically extragalactic survey work and searching for void galaxies.

abstract: Effective communication plays a major role in the psychological adjustment and quality of the relationship of couples coping with cancer, yet only a few communicative behaviors have been examined in the context of a cancer diagnosis and treatment. This study sought to expand the extant literature by describing a wider range of communicative behaviors (beyond the frequently researched withdraw, disclosure/holding back, and avoidance behaviors) through an observable measure, as previous research has relied heavily on self-report. Couples (134 cancer patients and their caregiving partners) were video-taped discussing a cancer-related concern in the laboratory. Discussions were coded separately for patients and caregivers using the Asymmetrical Behavioral Coding System which captures 22 communicative behaviors. These behaviors contribute to four higher-level scales: positive approach, negative approach, positive avoidance, and negative avoidance. Area under the curve was calculated to describe each factor. The most frequently observed behavior was positive approach, followed by negative avoidance, negative approach, and positive avoidance. Paired samples t-test analyses examining the factors by moderating variables revealed that women engaged in more positive approach behaviors than did men; men engaged in more avoidant behaviors (both positive and negative) than did women; and caregivers engaged in more avoidant behaviors (both positive and negative) than did patients. Findings are consistent with prior research in the field and suggest consideration of tailoring possible future interventions. Further investigation is needed to assess possible interactional effects to ultimately help couples better communicate about the challenges associated with cancer treatment and recovery. / Dissertation/Thesis / Masters Thesis Counseling Psychology 2020

Observational drawing has many benefits, yet it can be a difficult and frustrating curriculum for students and teachers alike. As I was teaching elementary and college art classes simultaneously, I noticed a significant discrepancy between my younger and older students. Students in my elementary art classes loved to draw and often expressed how excited they were to make art. However, students in my college art classes were more hesitant and self-conscious about drawing and did not believe they could progress artistically. Many of these students had abandoned drawing in elementary or middle school. This pattern evokes the U curve of artistic development as discussed in Harvard's Project Zero (Davis, 1997). Because of this lack of skill and confidence, many of the students in my college classes could not fully apply themselves to reap the benefits of observational drawing. How can educators help college students reclaim their confidence as visual artists after years of avoidance and fear? In an attempt to help college students overcome these anxieties and improve their art skills, I created and implemented a mindfulness intervention in a traditional drawing curriculum. Using case study methodology, I conducted a qualitative study throughout the winter semester of 2019 at Brigham Young University to examine the affordances or limitations of implementing mindfulness in an undergraduate drawing curriculum.

The current study investigated the effect of observational learning during equivalence based instruction (EBI). Two boys (Tim and Nate) ages 11 and 12 with Autism Spectrum Disorder participated in the study. Participants received small-group EBI training with an embedded observational learning component twice weekly for six weeks. Both participants were given a trained and observation set containing three classes (Class A, Class B and Class C) consisting of four class members. Participants served as both learners and observers during each training session. Each participant was trained on match-to-sample tasks with relations A-B and B-C and tested for class formation across the trained and observation set. Results showed that Tim was able to derive the untrained A-C and C-A relation at 100% correct on both the trained and observation set of stimuli. After the initial training, Nate averaged at 40% and 55% on the trained and observation set of stimuli, indicating that he was unable to derive the untrained relations. Two remedial training sessions were conducted, where Nate was re-exposed to the A-B and B-C training. After the remedial training, Nate averaged at 85% and 67.5%, indicating strong class formation on the trained set of stimuli, and moderate class formation on the observation set. The current study demonstrated the utility of observational learning during EBI. Limitations and implications for clinical practices are discussed.

The purpose of this study was to observe and analyze the factors that lead to a child's increase in responding to a previously neutral stimulus after observing another child's behavior and consequences in the same setting. The effects of five video presentations on rate of button-pressing responses were observed across four students. Rates of button-pressing behavior on an FR3 schedule of reinforcement were collected for each student using a computer and a metal apparatus with two flat push buttons. Each student completed two baseline phases to establish neutrality of stimuli, and viewed a total of five video presentations. Each video segment contained a model engaging in button pressing and receiving tokens under various social and nonsocial conditions, which would potentially serve as reinforcers. Rates of responding were recorded immediately after each video presentation. Three of the four students' rates of responding increased and surpassed their levels of responding during baseline sessions. From these results, it was concluded that neutral stimuli can acquire reinforcing properties for children through an observational learning procedure. It is suggested that observational learning (the presentation of a model engaging in a specific behavior) might be considered and establishing operation to temporarily increase the value of a reinforcer.