As lesões ósseas são doenças raras, mas com um grande destaque, que afetam a região maxilofacial. Dentre elas podemos destacar as Lesões Centrais de Células Gigantes e as Lesões Fibro-Ósseas Benignas (Displasia Cemento-Ossificante, Fibroma Ossificante e Displasia Fibrosa). O presente estudo teve como objetivo descrever e analisar os dados encontrados nas fichas de encaminhamento clínico presentes no Serviço de Patologia Oral e Maxilofacial da Faculdade de Odontologia da Universidade de São Paulo. Foram avaliados 89.265 casos em um período que variou de 1950 até 2016, utilizando as categorias de gênero, idade, etnia, sintomatologia, hipótese diagnóstica e localização anatômica. Após as exclusões, os casos selecionados somavam 773 casos divididos em: 267 casos de Lesão Central de Células Gigantes, 231 casos de Displasia Cemento Ossificante, 142 casos de Fibroma Ossificante e 133 de Displasia Fibrosa. Os resultados do estudo estão de acordo com o que está descrito na literatura, exceto nos casos de Displasia Fibrosa que foi encontrado uma predileção maior sexo feminino do que o masculino, mesmo que a literatura expresse que não existe tal predileção. Já nos casos de Displasia Cemento-Ossificante, o presente estudo mostrou que a maior prevalência de idade é entre a 4ª e 5ª década de vida e não entre a 3ª e 4ª como encontrado na literatura. Os casos de Displasia Cemento-Ossificante, em relação à etnia dos pacientes, mostraram que a maioria dos pacientes encontrados pelos autores eram leucodermas e não melanodermas como relata a literatura. Os resultados mostraram que mesmo em um centro de referência como o Serviço de Patologia Oral da Faculdade de Odontologia da Universidade de São Paulo, as lesões ósseas são raras e alguns fatores como idade em pacientes com Displasia Fibrosa e Displasia Cemento-Ossificante e etnia em pacientes com Displasia Cemento-Ossificante não correspondem ao encontrado na literatura mundial. / Bone lesions are rare but important diseases that affect the maxillofacial region. Among them we can highlight the Central Giant Cells Lesion and the Benign Fibro-Osseous Lesions (Cemento-Osseous Dysplasia, Ossifying Fibroma and Fibrous Dysplasia). The objective of this study was to describe and analyze the data found in the clinical referral forms present at the Oral and Maxillofacial Pathology Service of the Faculty of Dentistry of the University of São Paulo. We evaluated 89.265 cases in a period ranging from 1950 to 2016, using the categories of gender, age, ethnicity, symptomatology, diagnostic hypothesis and anatomical location. After the exclusions, the selected cases totaled 773 cases divided into 267 cases of Central Giant Cell Lesion, 231 cases of Cemento-Osseous Dysplasia, 142 cases of Ossyfing Fibroma and 133 cases of Fibrous Dysplasia. The results of the study are in agreement with what is described in the literature, except in the cases of Fibrous Dysplasia that a predilection was found greater female than the male, even if the literature expresses that there is no such predilection. In the cases of Cemento-Osseous Dysplasia, the present study showed that the highest prevalence of age is between the 4th and 5th decade of life and not between the 3rd and 4th as found in the literature. The cases of Cemento-Osseous Dysplasia, in relation to the ethnicity of the patients, showed that the majority of the patients found by the authors were white and not black as reported in the literature. The results showed that even in a reference center such as the Oral Pathology Service of the Faculty of Dentistry of the University of São Paulo, bone lesions are rare and some factors such as age in patients with Fibrous Dysplasia and Cement-Ossificante Dysplasia and ethnicity in patients with Cement-Ossific Dysplasia do not correspond to that found in the world literature.

This thesis is compromised of three studies in which basic principles of operant conditioning were applied to horses. Autoshaping was examined as a method for horse training. Observational learning was investigated to confirm that naive horses can, in fact, acquire novel behavior by observing experienced horses, and the rate of acquisition with observation is more rapid than spontaneous responding without observation. A third study examined the effect of discriminative stimulus intensity on the acquisition rate of novel behavior. All subjects learned to use an operant conditioning device. Subjects in the first study autoshaped. Observational learning was also demonstrated to be a means by which horses can learn. The rate of learning was significantly improved through observation. Intensity of the discriminative stimulus affects the acquisition of novel behavior. The subject exposed to the higher intensity stimulus acquired sustained manipulandum pressing significantly faster than other subjects. It was concluded that horses acquire behavior in much the same manner as other species.

Kin recognition is the ability to identify a conspecific as a relative and can occur even when animals are complete strangers. By being able to recognise relatives, animals are able to give preferential treatment to those with which they share genes. Recognition may occur by either direct familiarisation (learning a phenotypic cue that reliably correlates to kinship), or by indirect familiarisation (learning kinship relationships through previous encounters). Rats (Rattus norvegicus) can recognise kin, however to what degree kin recognition is mediated by genetics (direct familiarisation) or social relationships (indirect familiarisation) are unknown; the influences of kinship and familiarity on the ability to learn from a conspecific is also unknown. Furthermore, the sex of an animal can also influence its ability to learn but this effect has received little attention in the literature, particularly when considering observational learning tasks. I assessed if relatedness and/or familiarity influenced a rat's ability to learn through observation, and if gender relationships influence the learning process. Eighty rats ( observers ) were given the opportunity to observe a demonstrator rat press a joystick in a given direction to obtain a food reward. Observers watched a demonstrator that had one of the following relationships with them: related and familiar, related and unfamiliar, unrelated and familiar, or unrelated and unfamiliar. When observers were given the opportunity to manipulate the joystick, the number of sniffs of the joystick, the latency to first move the joystick and the total number of presses were recorded. Rats that were both familiar and related to the demonstrator consistently performed better than any other treatment group; furthermore, rats that were familiar with the demonstrator performed the task more efficiently than rats that were not familiar with the demonstrator. When the demonstrators and observers were related, the observers produced more presses and sniffs of the joystick while having a lower latency to the first push In addition, male observers learnt better than females regardless of the demonstrator sex, with males that were familiar to their demonstrator making nearly twice as many pushes than any other treatment group. The results from this study are discussed in relation to both the mechanisms of direct and indirect recognition and the potential adaptive value on kin discrimination in the learning process. The home range hypothesis may explain why gender differences in learning were found: male rats have larger home ranges than females. Male rat will regularly encounter more rats than females and would need to ascertain if unfamiliar individuals are relatives. Females remain closer to natal sites and as such are more likely to encounter kin and therefore may not need as well as developed kin recognition ability.

To date, more than 300 planets orbiting stars other than our sun have been discovered using a range of observing techniques, with new discoveries occuring monthly. The work in this thesis focused on the detection of exoplanets using the transit method. Planets orbiting close to their host stars have a roughly 10 per cent chance of eclipsing (transiting) the star, with Jupiter?sized planets causing a one per cent dip in the flux of the star over a few hours. A wealth of orbital and physical information on the system can be extracted from these systems, including the planet density which is essential in constraining models of planetary formation. To detect these types of planets requires monitoring tens of thousands of stars over a period of months. To accomplish this, we conduct a wide-field survey using the 0.5-meter Automated Patrol Telescope (APT) at Siding Spring Observatory (SSO) in NSW, Australia. Once candidates were selected from the data?set, selection criteria were applied to separate the likely planet candidates from the false?positives. For this thesis, the methods and instrumentation used in attaining data and selecting planet candidates are discussed, as well as the results and analysis of the planet candidates selected from star fields observed from 2004?2007. Of the 65 planet candidates initially selected from the 25 target fields observed, only two were consistent with a planet transit. These candidates were later determined to be eclipsing binary stars based on follow up observations using the 40-inch telescope, 2.3-m telescope, and the 3.9-m Anglo-Australian Telescope, all located at SSO. Additionally, two planet candidates from the SuperWASP-North consortium were observed on the 40-inch telescope. Both proved to be eclipsing binary stars. While no planets were found, our search methods and results are consistent with successful transit surveys targeting similar fields with stars in a similar magnitude range and using similar methods.

<p>This thesis makes contributions to the statistical research field of causal inference in observational studies. The results obtained are directly applicable in many scientific fields where effects of treatments are investigated and yet controlled experiments are difficult or impossible to implement.</p><p>In the first paper we define a partially specified directed acyclic graph (DAG) describing the independence structure of the variables under study. Using the DAG we show that given that unconfoundedness holds we can use the observed data to select minimal sets of covariates to control for. General covariate selection algorithms are proposed to target the defined minimal subsets.</p><p>The results of the first paper are generalized in Paper II to include the presence of unobserved covariates. Morevoer, the identification assumptions from the first paper are relaxed.</p><p>To implement the covariate selection without parametric assumptions we propose in the third paper the use of a model-free variable selection method from the framework of sufficient dimension reduction. By simulation the performance of the proposed selection methods are investigated. Additionally, we study finite sample properties of treatment effect estimators based on the selected covariate sets.</p><p>In paper IV we investigate misspecifications of parametric models of a scalar summary of the covariates, the propensity score. Motivated by common model specification strategies we describe misspecifications of parametric models for which unbiased estimators of the treatment effect are available. Consequences of the misspecification for the efficiency of treatment effect estimators are also studied.</p>

<p>Resistenta bakterier är ett växande problem inom den svenska sjukvården. Extended spectrum ß-lactamases (ESBL) är bakterier som kan bilda enzymer som bryter ned antibiotika så att den på så sätt blir resistent. En av de stora anledningarna till spridning av resistenta bakterier är personalens brist på korrekt utförande av basala hygienrutiner. Syftet med studien var att undersöka hur sjukvårdspersonal på en infektionsavdelning tillämpar de riktlinjer för basala hygienrutiner som finns fastställda för personal inom hälso- och sjukvården. Data samlades in genom observationer på en infektionsavdelning på ett sjukhus i Mellansverige. Resultatet visade att följsamheten till basala hygienrutiner var mindre än hälften bland de två jämförda personalgrupperna. Resultatet visade hög följsamhet till handskanvändning vid vård av patienter som inte var ESBL-bärare, medan följsamheten var sämre vid vård av patienter med ESBL. Detta resultat visade på en signifikant skillnad, dvs. att personalen var bättre på att använda handskar vid vård av patienter som inte var bärare av ESBL. Resultatet visade att nära hälften av de observerade inte spritar händerna innan patientkontakt, vare sig det rör sig om en patient som är bärare av ESBL-bakterier eller inte. Det tyder på stora brister i följsamheten till hygienrutiner på den observerade infektionsavdelningen.</p> / <p>Resistant bacteria are an increasingly large problem within the Swedish health care system. Extended spectrum ß-lactamases (ESBL) are bacteria that produce enzymes capable of breaking down antibiotics, a characteristic which renders them resistant to antibiotics. One of the main causes for the spreading of resistant bacteria is low compliance to hand hygiene procedures.</p><p>The aim of this study was to examine how the health care workers of an infectious disease ward apply the hygiene guidelines that have been established for health care staff. Data was collected through observations in an infectious disease ward in Central Sweden. The results showed that compliance towards hand hygiene procedures was less than 50% within the two staff groups compared. It also showed good compliance to the guidelines for glove use when caring for patients not carrying ESBL, but less compliance when caring for patients with the infection. The difference was statistically significant, i.e. health care staff used gloves more often when caring for patients not carrying ESBL than they did with patients who were carriers. The results showed that that almost 50% of the observed health care workers did not use hand disinfection before contact with patients, whether these were ESBL carriers or not. This indicates that compliance to hand hygiene procedures is not as good as one could hope for.</p>

Resistenta bakterier är ett växande problem inom den svenska sjukvården. Extended spectrum ß-lactamases (ESBL) är bakterier som kan bilda enzymer som bryter ned antibiotika så att den på så sätt blir resistent. En av de stora anledningarna till spridning av resistenta bakterier är personalens brist på korrekt utförande av basala hygienrutiner. Syftet med studien var att undersöka hur sjukvårdspersonal på en infektionsavdelning tillämpar de riktlinjer för basala hygienrutiner som finns fastställda för personal inom hälso- och sjukvården. Data samlades in genom observationer på en infektionsavdelning på ett sjukhus i Mellansverige. Resultatet visade att följsamheten till basala hygienrutiner var mindre än hälften bland de två jämförda personalgrupperna. Resultatet visade hög följsamhet till handskanvändning vid vård av patienter som inte var ESBL-bärare, medan följsamheten var sämre vid vård av patienter med ESBL. Detta resultat visade på en signifikant skillnad, dvs. att personalen var bättre på att använda handskar vid vård av patienter som inte var bärare av ESBL. Resultatet visade att nära hälften av de observerade inte spritar händerna innan patientkontakt, vare sig det rör sig om en patient som är bärare av ESBL-bakterier eller inte. Det tyder på stora brister i följsamheten till hygienrutiner på den observerade infektionsavdelningen. / Resistant bacteria are an increasingly large problem within the Swedish health care system. Extended spectrum ß-lactamases (ESBL) are bacteria that produce enzymes capable of breaking down antibiotics, a characteristic which renders them resistant to antibiotics. One of the main causes for the spreading of resistant bacteria is low compliance to hand hygiene procedures. The aim of this study was to examine how the health care workers of an infectious disease ward apply the hygiene guidelines that have been established for health care staff. Data was collected through observations in an infectious disease ward in Central Sweden. The results showed that compliance towards hand hygiene procedures was less than 50% within the two staff groups compared. It also showed good compliance to the guidelines for glove use when caring for patients not carrying ESBL, but less compliance when caring for patients with the infection. The difference was statistically significant, i.e. health care staff used gloves more often when caring for patients not carrying ESBL than they did with patients who were carriers. The results showed that that almost 50% of the observed health care workers did not use hand disinfection before contact with patients, whether these were ESBL carriers or not. This indicates that compliance to hand hygiene procedures is not as good as one could hope for.

<p>Although it has been hypothesized that chronic emotional invalidation by a parent may have lasting effects on later ability to regulate emotions, and possibly increase the chances of experiencing symptoms of psychopathology, the possible mechanisms surrounding this relationship have not been adequately explored. Further, many investigations have used retrospective reports of invalidation, which may be subject to bias. This pilot study of 19 adolescent-parent dyads explored associations between invalidation, experiential avoidance, and child symptoms of psychopathology in a cross sectional design. Retrospective reports of invalidation as well as an observationally-coded measure of invalidation during laboratory discussions of emotion were utilized, and compared for agreement. The feasibility and acceptability of a larger investigation of these questions is also discussed. It was found that adolescent-reported recalled invalidation seemed to show a stronger pattern of association with observationally coded invalidation than do parent reports. Additionally, several alternative mechanistic hypotheses showed some promise for further exploration. This pilot study was found to be acceptable to participants; however, recruitment of adolescents from a clinical population - and their parents to participate with them - was the greatest obstacle to feasibility for a larger study.</p> / Dissertation

The after–action review (AAR; also known as the after–event review or debriefing) is a training approach that is based on reviews of trainees’ performance on recently completed tasks or performance events. Used by the military for decades, the use of AAR–based training has increased dramatically in recent years. Empirical research investigating AARs, however, is almost non–existent, and theoretical work on the effectiveness AAR–based training and the underlying processes have been limited. The present study presents a theoretical framework for the AAR by integrating the AAR into the existing training literature. In addition, this study presents an empirical evaluation of the effectiveness of AAR–based training, and an investigation of whether objective AAR–based training is more effective than subjective AAR–based training. One–hundred twenty individuals were trained in 30 4–person teams on a cognitively complex performance task. Teams were trained using a non–AAR–, subjective AAR–, or objective AAR–based training approach. Declarative knowledge, team performance, and team–efficacy served as the measures of training effectiveness. It was hypothesized that AAR–based training (subjective AAR– and objective AAR– based training combined) would be more effective than non–AAR–based training. Further, it was hypothesized that objective AAR–based training would be more effective than subjective AAR–based training. The study results indicated that AAR–based training was more effective than the non–AAR–based training approach in terms of team performance and team–efficacy, but not team declarative knowledge. Objective AAR–based training was no more effective than subjective AAR–based training. Teams performed equally well on the training outcome measures regardless of whether they used an objective or subjective AAR– based training approach. It is anticipated that the theoretical framework and empirical results of this study will serve as a catalyst for the integration of AAR–based training into existing training literatures and to inform the design and practice of AAR–based training systems to take full advantage of their efficacy as training interventions.

Propensity score analysis has been used to minimize the selection bias in observational studies to identify causal relationships. A propensity score is an estimate of an individual's probability of being placed in a treatment group given a set of covariates. Propensity score analysis aims to use the estimate to create balanced groups, akin to a randomized experiment. This study used Monte Carlo methods to examine the appropriateness of using propensity score methods to achieve balance between groups on observed covariates and reproduce treatment effect estimates in multilevel studies. Specifically, this study examined the extent to which four different propensity score estimation models and three different propensity score conditioning methods produced balanced samples and reproduced the treatment effects with clustered data. One single-level logistic model and three multilevel models were investigated. Conditioning methods included: (a) covariance adjustment, (b) matching, and (c) stratification. Design factors investigated included: (a) level-1sample size, (b) level-2 sample size, (c) level-1 covariate relationship to treatment, (d) level-2 covariate relationship to treatment, (e) level-1 covariate relationship to outcome, (f) level-2 covariate relationship to outcome, and (g) population effect size. The results of this study suggest the degree to which propensity score analyses are able to create balanced groups and reproduce treatment effect estimates with clustered data is largely dependent upon the propensity score estimation model and conditioning method selected. Overall, the single-level logistic and random intercepts models fared slightly better than the more complex multilevel models while covariance adjustment and matching methods tended to be more stable in terms of balancing groups than stratification. Additionally, the results indicate propensity score analysis should not be conducted with small samples. Finally, this study did not identify an estimation model or conditioning method that was consistently able to create adequately balanced groups and reproduce treatment effect estimates.