Global ETD Search

291	Anatomical Analysis of Olfactory Sensory Neuron Regeneration Via Glomerular Synaptic Activity Markers in Adult Mice Wamack, William 01 December 2022 (has links) (PDF) The olfactory system is a great model for studying regeneration due to the olfactory epithelium’s regenerative capability which makes it a potential a source of neural stem cells. The olfactory epithelium presents three types of cells: sustentacular cells which provide support and act as glial supporting cells; olfactory sensory neurons that are in charge of detecting odorant molecules in the air; and the stem cells that generated the aforementioned cell types. Olfactory sensory neurons are constantly dying and being replaced by new neurons originating from the stem cells that lie at the base of the olfactory epithelium. We have used an injury model that allows us to remove all the olfactory sensory neurons from the olfactory epithelium, via a single injection of methimazole. Then, at different timepoints after injury we measure the functional recovery of the olfactory epithelium by analyzing the expression of specific synaptic associated markers. Specifically, we analyzed the expression of synaptophysin, tyrosine hydroxylase, vesicular glutamate transporter 1, and vesicular glutamate transporter 2. Simultaneously, we measured glomerular size in order to serve as an indicator of anatomical recovery. Finally, we correlate these findings with previously generated data in the lab associated with functional recovery through behavior. olfactory sensory neuron regeneration glomerular synaptic activity Behavioral Neurobiology Molecular and Cellular Neuroscience Systems Neuroscience
292	The olfactory anatomy and upper respiratory tracts of whales, dolphins, and their terrestrial relatives: Perspectives from morphology, histology, embryology, and evolutionary biology Farnkopf, Ian Chun 28 June 2022 (has links) No description available. Anatomy and Physiology Animals Biology Evolution and Development Morphology Paleontology Histology ontogeny ontogenetic series cetology Cetacea cetacean whale dolphin porpoise olfactory receptor gene olfactory neuroepithelium nose nasal cavity ethmoturbinal olfactory receptor neuron cetaceans olfactory marker protein nasal sense of smell land to water transition Artiodactyla artiodactyl even-toed ungulate Cetartiodactyla
293	The unfolded protein response couples neuronal identity to circuit formation in the developing mouse olfactory system Shayya, Hani January 2023 (has links) Complex genetic mechanisms both endow developing neuronal subtypes with distinct molecular identities and translate those identities into the signatures of cell surface axon guidance molecules that direct neural circuit assembly. The final steps of this process, where axon guidance molecules instruct circuit outcomes, are well-understood. However, the upstream identity molecules that define guidance molecule signatures, and the molecular mechanisms by which cell type identity is transformed into these signatures, remain enigmatic. The murine olfactory system contains nearly 1,5000 olfactory sensory neuron (OSN) subtypes which are intermixed in the olfactory epithelium (OE). Each OSN subtype expresses a unique olfactory receptor (OR) protein which both tunes its response properties to odorants in the environment and acts as an identity molecule that ensures all axons of a given OSN type converge to a single set of target glomeruli in the olfactory bulb (OB). Using a combination of bioinformatic and mouse genetic approaches, we have discovered an unanticipated role for endoplasmic reticulum stress (ER stress) and the unfolded protein response (UPR) in the translation of OR identity to OSN axon guidance molecule expression and glomerular targeting. We find that slight differences in OR amino acid sequences lead to differential activation of the ER stress sensor PERK in different OSN subtypes. Graded patterns of the UPR are then interpreted through a master regulator transcription factor, Ddit3, which controls a set of stress-responsive axon guidance molecules that orchestrate the process of glomerular segregation in the OB. Our results define a novel paradigm for axon guidance in which graded activation of a canonical stress response pathway is leveraged towards the conversion of discrete neuronal identities into discrete circuit formation outcomes. These findings may be widely relevant for the formation of neural circuits across a variety of systems. Neurosciences Developmental biology Mice--Genetics Mice--Development Olfactory receptors Axons Neural circuitry
294	Bbs7 and Bbs10 Homozygosity cause Structural and Functional Deficits in Inbred Mouse Olfactory Sensory Neuronal Cilia and Postnatal Lethality Ali, Saima 22 October 2020 (has links) No description available. Developmental Biology Bardet Biedl Syndrome Olfactory neuronal cilia Bbs7 Bbs10 Anosmia cilia
295	Novel methods to assess olfactory processing Thaploo, Divesh 13 November 2023 (has links) Research in olfaction is been quite diverse, for example with studies on semantics, brain activations, or distorted smells. Olfactory dysfunction can lead to reduced quality of life, poor dietary habits, sexual and/or mental dysfunctions. Especially in terms of the investigation of olfactory loss it is not only important to assess olfactory function with ratings subjectively assess but more objective measures should be considered. Use of EEG and fMRI has been quite well studied. I have focused my thesis on the use of newer or updated use of existing processing pipelines in order to understand olfaction in a better way. info:eu-repo/classification/ddc/610 ddc:610
296	Dr Pressler, Richard T. 24 July 2006 (has links) No description available. Biology, Neuroscience
297	INVESTIGATION OF THE ELECTROPHYSIOLOGICAL PROPERTIES OF THE MAJOR CELL TYPES IN THE RAT OLFACTORY TUBERCLE Chiang, Elizabeth C. January 2008 (has links) No description available. rat olfactory tubercle electrophysiology patch-clamp major cell types cocaine bursting regular-spiking intermittent-discharging
298	An Olfactory Enrichment Study at the Ashland Cat Shelter Myatt, Alicia Elaine 03 December 2014 (has links) No description available. Biology Behavioral Sciences olfactory enrichment, feline cats cat shelter lavender rabbit scent catnip silver vine
299	Effects of Age, Diet, and Sex on the Gustatory and Olfactory Sensing Capabilities of the Forensically Important Blow Fly, Lucilia Sericata (Diptera: Calliphoridae) Blystone, Allissa M. 27 August 2015 (has links) No description available. Entomology Biology Lucilia sericata Calliphoridae Nutrition Diet Olfactory Sensing Gustatory Sensing Electroantennogram Proboscis Extension Reflex
300	Regional Contributions to Neuronal Diversity in the Developing Mouse Telencephalon Qin, Shenyue 15 December 2017 (has links) No description available. Developmental Biology Gsx2 cis-regulation ventral telencephalon basal ganglia olfactory bulb neurogenesis

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