O tráfego de leucócitos é um processo complexo, dependente da ação de inúmeras substâncias químicas, além da perfeita interação celular. Desta forma, este estudo teve como objetivo avaliar a ação dos GCe e da ANXA1 sobre o eixo SDF-1α/CXCR4 e IL-17/IL-23/G-CSF e sobre a expressão de moléculas de adesão CD18, CD49d e CD62L. Foram utilizados camundongos machos Balb/C selvagens (WT) ou ANXA1-/-. As avaliações foram realizadas em condições basais, na presença de altas concentrações de GCe e na vigência de processo inflamatório, induzidos pela administração de ACTH (5 µg/animal, i.p.) ou pela injeção de LPS (100 µg/kg, i.p.), respectivamente, ou na ausência da ação dos GCe, pela ação do RU 38486 (RU, 10 mg/kg, i.p.). A participação da ANXA1 e do receptor FPR2 foi avaliada pelo pré-tratamento com Ac2-26 (1 mg/Kg, i.p.) ou com BOC2 (10 µg/animal, i.p.) durante 4 dias, 1 vez ao dia. A quantificação total e diferencial das células foi realizada em câmara de Neubauer e em esfregaços corados por May-Grunwald ou citometria de fluxo. As quantificações de CXCR2, CXCR4, FPR2, CD18, CD49d, CD62L e maturação granulocítica (CD11b/Ly6G) em células da medula e da circulação foram realizadas por citometria de fluxo. A expressão de ANXA1 nos tecidos do estomago e do baço foi realizada por western blotting e nas células da medula óssea e sangue circulante foi realizada por imunofluorescência. As quantificações de IL-17, IL-23, G-CSF, SDF-1α e corticosterona foram realizadas por ELISA. A quimiotaxia de neutrófilos da medula óssea e sangue periférico foi ensaiada na placa de quimiotaxia com filtro de poro de 8 µm. A fagocitose de neutrófilos apoptóticos por macrófagos da medula óssea foi avaliada por ensaio in vitro. Para verificar os efeitos do ACTH na migração de neutrófilos no processo inflamatório, foi empregado o modelo de bolsa de ar (100 µg/mL; LPS); e o comportamento dos leucócitos circulantes de animais tratados com ACTH foi avaliado pela técnica de microscopia intravital. Os resultados obtidos, que estão apresentados em quatro temáticas, mostraram que: 1) neutrófilos da medula óssea e sangue periférico expressam ANXA1 no citoplasma e membrana, bem como o receptor FPR2, constitutivamente, e a expressão de ambos é regulada pelos GCe. A ANXA1, via receptor FPR2 expresso em células da medula óssea, controlam a maturação neutrofílica e o tráfego destas células da medula óssea para o sangue. A ANXA1, via interação ao FPR2, controla o clearance de neutrófilos do sangue para a medula óssea, modulando o eixo SDF-1α/CXCR4; 2) A administração do ACTH causa neutrofilia e os neutrófilos circulantes são ANXA1+, CD18+, CD49d+, CD62L+, mostrando que injeção do ACTH in vivo altera o fenótipo destas células na circulação. Estas modificações alteram o comportamento dos neutrófilos na circulação, bem como a migração para a bolsa de ar na vigência de inflamação e para os tecidos de clearance. Estes efeitos podem ser dependentes, pelo menos em parte, da inibição de migração orientada, já que quimiotaxia frente ao fMLP ou ao SDF-1α estavam reduzidas. Ainda, o clearance de neutrófilos é reduzido em animais tratados com o ACTH pela menor atividade fagocítica e secretora dos macrófagos medulares; 3) Animais tratados com RU 38486 e ANXA1-/- mobilizam granulócitos da medula óssea para o sangue circulante e, deste compartimento para o foco de inflamação com maior intensidade que o observado em animais controles. O eixo IL-17/IL-23/G-CSF parece estar envolvido na granulopoiese e na mobilização de neutrófilos para o sangue durante a inflamação, mas não é alvo de ação da ANXA1 e o GCe nesta etapa do processo inflamatório. Adicionalmente, foi observado que na vigência de peritonite, as moléculas de adesão, CD49d e CD62L estão envolvidas no processo de migração de neutrófilos da medula óssea para o sangue. Os resultados aqui obtidos permitem concluir que os GCe e a ANXA1 são relevantes para granulopoiese e tráfego dos neutrófilos da medula óssea em condições fisiológicas e na vigência de processo inflamatório. Ainda, em conjunto com os dados da literatura, os nossos resultados podem sugerir a participação da ANXA1 dos GCe na plasticidade fenotípica dos neutrófilos de acordo com os estímulos a que são submetidos, e podem auxiliar na compreensão dos novos conceitos sobre a produção, tempo de vida, localização e funções de neutrófilos. / The traffic leukocytes is a complex process dependent on the action of severals chemical mediators, in addition to perfect cell interaction. Therefore, this study aimed to evaluate the effect of GCe and ANXA1 on SDF-1α/CXCR4 and IL-17/IL-23/G-CSF and on the expression of adhesion molecules CD18, CD49d and CD62L. Balb/C wild type and ANXA1-/- male mice were employed. The analysis were performed at physiological conditions, in the presence of high concentrations of GCe and during of inflammatory process induced by ACTH administration (5 µg/animal, i.p.) or LPS injection (100 µg/kg, i.p.), respectively or in the absence of GCe action, by the action of RU 38486 (RU, 10 mg/kg , i.p.). The involvement of the receptor FPR2 and ANXA1 was assessed by pre-treatment with Ac2-26 (1 mg/kg, i.p.) or BOC2 (10 µg/animal, i.p.) for 4 days, once a day. The quantification of total and differential cell was performed in a Neubauer chamber and stained smears by May-Grunwald and flow cytometry. Quantification of expression of CXCR2, CXCR4, FPR2, CD18, CD49d, CD62L and granulocytic maturation (CD11b/Ly6G) in the bone marrow and circulation were performed by flow cytometry. The expression of ANXA1 on tissues was performed by western blotting and on cells from bone marrow and blood by immunocytochemistry. Quantification of IL-17, IL-23, G-CSF, SDF-1α and corticosterone were performed by ELISA. The chemotaxis of neutrophils from the bone marrow and blood was tested in the chemotaxis chamber with filter pore of 8 microns. The phagocytosis of apoptotic neutrophils by bone marrow macrophages was assessed by in vitro assay. To investigate the effects of ACTH in the migration of neutrophils in the inflammatory process, the model employed was air pouch (100 µg/ ml, LPS), and the behavior of circulating leukocytes from animals treated with ACTH were evaluated by intravital microscopy. The results obtained, which are presented in three sections, showed that: 1) neutrophils from the bone marrow and blood expressed ANXA1 in the cytoplasm and membrane, as well as FPR2, constitutively and the expression of both is regulated by GCe. The ANXA1 via FPR2 receptor expressed in bone marrow cells, controls the neutrophilic maturation and traffic of these cells from the bone marrow into the blood. The ANXA1 via interaction to FPR2 controls the clearance of neutrophils from the blood to the bone marrow by modulating the SDF-1α/CXCR4 axis; 2) the administration of ACTH induces neutrophilia and the circulating neutrophils are ANXA1+, CD18+, CD49d+ and CD62L+, showing that the injection of ACTH in vivo alters the phenotype of these cells in the blood. These modifications alter the behavior of neutrophils in the blood, as well as the migration to the air pouch in the presence of inflammation and to the tissue clearance, and these effects may be dependent, at least in part, on inhibition of migration oriented events, as chemotaxis in response to fMLP or SDF-1α were reduced. Further, the clearance of neutrophils is reduced in animals treated with ACTH due to the lower phagocytic and secretory activity of medullary macrophages; 3) Animals treated with RU 38486 and ANXA1-/- mobilize granulocytes from bone marrow into the blood, and from this compartment to the focus of inflammation with higher intensity than that observed in the control group. The axis IL-17/IL-23/G-CSF seems to be involved in granulopoiesis and mobilization of neutrophils into the blood during inflammation, but it is not the target of action of ANXA1 and GCe at this step of inflammatory process. Additionally, it was observed that in the presence of peritonitis, the adhesion molecules, CD49d and CD62L are involved in the migration of neutrophils from the bone marrow into the blood. The results obtained allow concluding that the GCe and ANXA1 are relevant to the granulopoiesis and the traffic of neutrophils from bone marrow under physiological conditions and in the presence of inflammation. Furthermore, together with literature data, the data presented here may suggest the involvement of ANXA1 the GCe in phenotypic plasticity of neutrophils according to the stimuli that are submitted, and may support to understand the new concepts of production, half-life, location and function of neutrophils.

La technique d'intégration des systèmes éoliens verticaux (VAWT) au service des logements individuels, collectifs et tertiaires est une approche intéressante pour les acteurs de la maitrise d'énergie pour promouvoir une utilisation rationnelle de l'énergie. Le choix de l'implantation d'une éolienne en milieu urbain est déterminé par la hauteur des bâtiments, la vitesse du vent et l'intensité de turbulence du site. Les conditions de vents sévères à faible altitude sont favorables à une implantation de VAWT. Dans certaines villes, la hauteur moyenne des bâtiments est relativement faible et ceci fait qu'en ces lieux, les VAWTs sont appréciables par rapport aux HAWTs. La mécanique des fluides numériques (CFD) est mise en œuvre pour modéliser les écoulements d'air au travers d'éoliennes et des bâtiments. Un problème CFD modélisé avec un modèle de turbulence approprié donneront des résultats de simulations qui s'approcheront des réalités physiques et des résultats de l'expérimentation. Dans cette étude, les modèles standard k-" et SST k-! ont été utilisés. Après analyse des possibilités d'intégration d'une VAWT, la toiture reste la zone d'intégration la plus intéressante. En plus de l'étude aérodynamique, nous avons entamé une modélisation électrique de la chaîne de conversion de l'éolienne en utilisant le logiciel Matlab/Simulink. Le travail a été effectué dans le but de déterminer la puissance électrique susceptible d'être produite par l'éolienne. Pour finaliser cette étude, un modèle de couplage électrique de VAWTs avec un bâtiment considéré comme un modèle de charge est présenté. / The building integration of the vertical axis wind turbine (VAWT) to supply the individual, collective and tertiary residences consumption is an interesting approach that can help architects and the actors of the energy control to promote a rational use of renewable energy in the in homes. The choice of the location of the urban wind turbine type is determined by building height, wind speed and turbulence intensity of the site. The severe conditions of wind at low altitude are favorable for a VAWT installation. In some cities, the average buildings height is low, in these places, the VAWTs must be appreciable compared to the HAWTs. The modelling of the air flow through the wind turbine and the couple building-wind turbine involves the computation fluid dynamics (CFD). A problem modeled with a suitable turbulence model will give results that approach the physical reality and the experiment results. In this study, the standard k-" and SST k-! models were used. After analyzing the possibilities of VAWT integration, the roof is the most interesting integration area. In addition to CFD method, we have started to study the electrical model of the VAWT. The work was conducted to determine the electrical power generated by the wind turbine using Matlab/Simulink software. To complete the study, a VAWT model coupled with a building where the building is considered as a consumption model is presented.

With increasing world tensions and improvements of satellites and their sensors, the interest and possibility of using space and satellites for defensive purposes has increased greatly. However, not much research has been conducted into the needs and possibilities of satellite constellations over Sweden, especially using SAR and optical sensors combined with AI object detection. This thesis provides insight in to the needs and requirements to achieve certain coverage and gap times and explores different constellation design methods to do so. This is done by combining large scale tests performed with genetic algorithm and a dual-axis propagator with theoretical and analytical methods. Results show that for micro-satellites under 100 kg based on current commercial technology, it is found that between 24 to 63 satellites are needed for 1 hour gap times depending on what combination of SAR and optical satellites are used. The genetic algorithm was found to not generate optimal constellations as the number of satellites increased beyond 12. It was however useful in mapping out possibilities and finding certain optimal parameters such as the inclination. The dual-axis propagator tested for its low processing load was found to be good for coverage analysis and estimating the shapes of the orbits. It was noted to have large positional errors however, limiting its use to analysis and not full constellation design. / Med ökande världsspänningar och förbättringar av satelliter och deras sensorer har intresset och möjligheterna att använda rymden och satelliter för försvarssyften ökat avsevärt. Dock har inte mycket forskning gjorts om behoven och möjligheterna med satellitkonstellationer över Sverige, särskilt när det gäller användningen av SAR och optiska sensorer i kombination med AI-objektdetektering. Denna avhandling ger insikt i behoven och kraven för att uppnå viss täckning och tidsgap samt utforskar olika metoder för konstellationsdesign för att uppnå detta. Detta görs genom att kombinera storskaliga tester med genetiska algoritmer och en dual-axis propagator med teoretiska och analytiska metoder. Resultaten visar att för mikrosatelliter under 100 kg, baserat på nuvarande kommersiell teknik, krävs mellan 24 och 63 satelliter för att uppnå gapptider på 1 timme, beroende på vilken kombination av SAR- och optiska satelliter som används. Det konstaterades att genetiska algoritmen inte tillförlitligt kunde hitta optimala konstellationer när antalet satelliter ökade bortom 12 st. Dualaxelpropagatorn, som testades för sin låga processbelastning, ansågs vara bra för täckningsanalys och uppskattning av omloppsbanornas former. Den hade dock stora positionsfel, vilket begränsade dess användning till analys och inte fullständig konstellationsdesign.

Postpartum depression is a psychiatric disorder affecting a substantial proportion of newly delivered women, and remains a significant cause of childbirth-related morbidity. The aim of the present thesis was to examine psychological, endocrine and genetic aspects of postpartum depression in a large, population-based sample of women in Uppsala, Sweden. All included studies were undertaken as parts of the BASIC-project, a longitudinal study on psychological wellbeing during pregnancy and the postpartum period. Study participants were screened for depressive symptoms in pregnancy week 17 and 32 as well as at six weeks and six months postpartum, mainly by use of the Swedish version of the Edinburgh Postnatal Depression Scale (EPDS). Furthermore, personality was assessed with the Swedish universities Scale of Personality (SSP) in pregnancy week 32. Evening cortisol levels in saliva were measured in pregnancy week 36 and at six weeks postpartum. Blood samples were obtained to measure corticotropin-releasing hormone levels (CRH) and to perform genetic analyses. The results of this thesis demonstrate that neuroticism is a strong and independent predictive factor of depressive symptoms at six weeks and six months postpartum, and has a significant mediatory role in the association between a single nucleotide polymorphism in the hydroxysteroid (11-beta) dehydrogenase 1 gene (HSD11B1) and postpartum depression. Furthermore, women with postpartum depressive symptoms present with a dysregulated hypothalamic-pituitary-adrenal axis activity in terms of elevated cortisol levels postpartum, as well as elevated CRH levels in mid-gestation. In conclusion, this thesis develops current knowledge on several attributes of postpartum depression. Further studies are required to replicate and expand on these results, which would further contribute to early identification of women at risk of postpartum depression and adoption of proper interventions that may moderate the short- and long-term consequences of the disorder.

Electrohydraulic drives are primarily used whenever a low power/weight ratio, a compact build and/or large forces are required for individual applications. These drives are often used together with electric drive technology in machines. However, in terms of automation, unlike electric drives, electrohydraulic drives are still largely connected via analog interfaces and centralized closed control loops today. To compensate for this competitive disadvantage of hydraulic drive technology and, at the same time, significantly enhance its performance and diagnostics capability, a consistent automation solution has been developed that can be configured for both centralized and decentralized solutions. This contribution firstly gives an overview over this complete solution already available and its classification in the automation world. In a second step, the subset of decentralized drive solutions contained therein is presented in more detail and their benefits are explained on the basis of some exemplary applications.

Thesis (MscEng)--Stellenbosch University, 2012. / ENGLISH ABSTRACT: The Cape Peninsula University of Technology, in collaboration with Stellenbosch University, is developing a 3-unit CubeSat for a low earth polar orbit. The two main payloads are a camera and a radio frequency beacon. This beacon will be used to calibrate the radar antenna patterns of an antenna of the Hermanus Magnetic Observatory at their base in Antarctica. This thesis describes the development of an aerodynamic attitude determination and control system needed to achieve three-axis stabilisation of the satellite and to perform accurate pointing of the camera. The satellite structure is designed to utilise aerodynamic means of control. It includes four feather antennae for passive pitch-yaw stabilisation and two active aerodynamic roll control paddles. The sensors used are a three-axis magnetometer, ne sun sensor and nadir sensor. Three attitude determination methods are investigated, namely the Triad, Rate Kalman Filter and Extended Kalman Filter algorithm. Apart from the aerodynamic control elements of the satellite, three magnetic torque rods and three nano-reaction wheels are also included in the design. Three control modes for the satellite are identi ed and various control methods are investigated for these control modes. The various attitude determination and control methods are evaluated through simulations and the results are compared to determine the nal methods to be used by the satellite. The magnetic Rate Kalman Filter is chosen as attitude determination method to be used when the satellite is tumbling and a combination of the sun Rate Kalman Filter and the Triad algorithm is to be used when the satellite experiences low angular rates. The B-dot and Y-spin controller is chosen for the detumbling control mode, the aerodynamic and cross-product control method for the three-axis stabilisation control mode and the quaternion feedback control method for the pointing control mode of the satellite. The combination of magnetic and aerodynamic control proved to be su cient for the initial stabilisation of the satellite, but the three nano-reaction wheels are required for the pointing control of the imaging process. / AFRIKAANSE OPSOMMING: Die Kaapse Skiereiland Universiteit van Tegnologie, in samewerking met die Universiteit van Stellenbosch, is tans besig met die ontwikkeling van 'n 3-eenheid CubeSat vir 'n pol^ere, lae aard-wentelbaan. Die twee loonvragte van die satelliet bestaan uit 'n kamera en 'n radiofrekwensie-baken. Die radiofrekwensie-baken sal gebruik word om 'n antenna van die Hermanus Magnetiese Observatorium, by hul basis in Antarktika, se radar antenna patrone te kalibreer. Hierdie tesis beskryf die ontwikkeling van 'n aerodinamiese ori entasiebepaling en -beheerstelsel wat benodig word om die satelliet in drie asse te stabiliseer en om die kamera noukeurig te rig. Die satelliet se struktuur word ontwerp vir aerodinamiese beheer. Dit sluit vier veerantennas in vir passiewe duik-gier beheer, asook twee aerodynamiese rolbeheer appies vir aktiewe beheer. Die sensors wat gebruik word sluit 'n drie-as magnetometer, fyn sonsensor en nadirsensor in. Drie ori entasiebepalingsmetodes word ondersoek, naamlik die Drietal, Tempo Kalman lter en die Uitgebreide Kalman lter algoritmes. Buiten die aerodinamiese beheerelemente van die satelliet, word daar ook drie magneetstange en drie nano-reaksiewiele ingesluit in die ontwerp. Daar word onderskeid getref tussen drie beheermodusse en verskeie beheermetodes word ondersoek vir hierdie beheermodusse. Die verskeie ori entasiebepalings- en ori entasiebeheermetodes word ge evalueer deur middel van simulasies en die resultate word vergelyk om die beste metodes vir die satelliet se gebruik te bepaal. Die magnetiese Tempo Kalman lter word gekies as ori entasiebepalingsmetode vir 'n tuimelende satelliet en die kombinasie van die son Tempo Kalman lter en Drietal algoritme word gebruik vir 'n satelliet met lae hoektempos. Die B-dot en Y-spin beheerder word gekies vir die tuimelbeheermodus, die aerodinamiese en kruisproduk beheermetode vir die drie-as-stabilisasie-beheermodus en die kwaternioon terugvoer beheermetode vir die rigbeheermodus van die satelliet. Daar word bepaal dat die samespanning van magnetiese en aerodinamiese beheer voldoende is vir die aanvanklike stabilisering van die satelliet, maar dat die drie nano-reaksiewiele benodig word om die kamera te rig tydens die beeldvormingproses.

Dorsal-ventral (DV) polarity in the Drosophila embryo is defined by spatially regulated activation of the transmembrane receptor Toll, which is uniformly distributed throughout the early embryo's plasma membrane. Ventral activation of Toll is accomplished through the local production of its activating ligand, a processed C-terminal fragment of the Spätzle protein, which is generated in the last step of a proteolytic cascade involving the sequentially-acting proteases Gastrulation Defective (GD), Snake and Easter. Pipe protein, a homologue of vertebrate glycosaminoglycan modifying enzymes, which is expressed during oogenesis in ventral follicle cells adjacent to the developing oocyte, is believed to control the ventrally restricted processing of Spätzle. pipe expression and the sulfation of its enzymatic target in the ventral follicle cells leads to the formation of a stable ventral cue, embedded in the eggshell. Recently the Pipe enzymatic target has been identified as several protein components of the vitelline membrane, the inner layer of the eggshell. Prior to this work, an important piece of information missing from our understanding of Drosophila DV patterning was the identity of the initial step in the protease cascade that requires Pipe activity. Here, I show that the processing of Snake is independent of Pipe activity, while the processing of Easter requires Pipe function, indicating that Easter processing by Snake is the key proteolytic step that is controlled by Pipe activity and presumably the first cleavage event that is spatially regulated. A second key gap in our understanding of Drosophila embryonic DV patterning concerned the role of GD in the protease cascade. While GD is the protease that cleaves and activates Snake, the existence of two distinct classes of complementing gd alleles has suggested that GD provides another, distinct function. Investigations described here indicate that the second function of GD is to promote the ability of activated Snake to process Easter, independent of its Snake-processing function. Finally, I provide evidence for the formation of protein complexes containing various components of the serine protease cascade, which suggest that conformational changes in the complexes, which act to promote productive interactions between the proteins, are an important aspect of their activation. / text

Computed tomography is a very useful technic which allow non-invasive diagnosis in many applications for example is used with success in industry and medicine. However, manual analysis of the interesting structures can be tedious and extremely time consuming, or even impossible due its complexity. Therefore in this thesis we study and develop discrete geometry and topology algorithms suitable for use in many practical applications, especially, in the problem of automatic quantitative analysis of the human airway trees based on computed tomography images. In the first part, we define basic notions used in discrete topology and geometry then we showed that several class of discrete methods like skeletonisation algorithms, medial axes, tunnels closing algorithms and tangent estimators, are widely used in several different practical application. The second part consist of a proposition and theory of a new methods for solving particular problems. We introduced two new medial axis filtering method. The hierarchical scale medial axis which is based on previously proposed scale axis transform, however, is free of drawbacks introduced in the previously proposed method and the discrete adaptive medial axis where the filtering parameter is dynamically adapted to the local size of the object. In this part we also introduced an efficient and parameter less new tangent estimators along three-dimensional discrete curves, called 3D maximal segment tangent direction. Finally, we showed that discrete geometry and topology algorithms can be useful in the problem of quantitative analysis of the human airway trees based on computed tomography images. According to proposed in the literature design of such system we applied discrete topology and geometry algorithms to solve particular problems at each step of the quantitative analysis process. First, we propose a robust method for segmenting airway tree from CT datasets. The method is based on the tunnel closing algorithm and is used as a tool to repair, damaged by acquisition errors, CT images. We also proposed an algorithm for creation of an artificial model of the bronchial tree and we used such model to validate algorithms presented in this work. Then, we compare the quality of different algorithms using set of experiments conducted on computer phantoms and real CT dataset. We show that recently proposed methods which works in cubical complex framework, together with methods introduced in this work can overcome problems reported in the literature and can be a good basis for the further implementation of the system for automatic quantification of bronchial tree properties

Psychopathy research has focused primarily on characteristics of male offenders. With little empirical knowledge on psychopathy in women, gender differences within psychopathy are not well understood. To gain a better understanding of these differences, the current study used prototypical analysis to compare ratings of 242 forensic experts when considering their most representative case of male or female psychopathy. The present study investigated gender differences for psychopathic traits and Cluster B personality disorder criteria. Most aspects of psychopathy were less prototypical of female psychopaths than males. In particular, the antisocial behavior facet does not appear to apply to males and females equally. The distinction between Cluster B disorders and psychopathy was more ambiguous in females than males; however, the affective deficits facet differentiated psychopathy from Cluster B disorders across genders. Current research also raises the question of potential diagnostic gender bias in the assessment of psychopathy.

Bakgrund: Stress samt stressrelaterad psykisk ohälsa ökar i samhället och det är viktigt att finna alternativ som bromsar utvecklingen. Stress är ett normalt fysiologiskt tillstånd men under längre tid utan återhämtning kan stress leda till psykisk ohälsa. Yogastudier har visat en stressreducerande effekt på humör och yoga har blivit ett populärt alternativ för att minska upplevda stressymptom. Det kan därför vara intressant att studera bakomliggande mekanismer till upplevd stressreducering. Hormonet kortisol ökar vid stress. Kanske har yoga stressreducerande effekt via sänkning av hormonet. Syfte: Studiens syfte är att studera om upplevd stressreducering vid yogautövande har ett samband med sänkta kortisolnivåer hos friska vuxna individer. Metod: En systematisk litteraturstudie genomfördes på artiklar publicerade 2009-2018. Artiklarna söktes upp i PubMed samt Web of Science. Resultat: Nio studier granskades (sju experimentella och två observationsstudier). Sex studier visade helt eller delvis sänkt kortisolnivå. En experimentell samt två observationsstudier visade inte signifikant lägre kortisolnivåer. Delvis förbättrat humör och kognitiv förmåga sågs i studierna. Slutsats: Sänkta kortisolnivåer vid yogautövande sågs. Dock fanns studier som inte visade minskade kortisolnivåer och studierna har brister som sänker bevisstyrkan. Bättre studier behövs för att kunna fastställa ett samband. / Background: Stress and stress-related mental illness is increasing in our society and it is important to find options to slow down the development. Stress is a normal physical condition but for a long time without recovery stress can lead to mental illness. Yoga studies have shown a stress-reducing effect on mood and yoga has become a popular option to reduce perceived stress symptoms. Therefore it can be interesting to study underlying mechanisms for perceived stress reduction. The hormone cortisol increases during stress. Perhaps yoga has a stress-reducing effect through decreasing the hormone. Aims: The aim of the study is to exam whether perceived stress reduction in yoga practice is related to lowered cortisol levels in healthy adults. Methods: A systematic literature study was carried out on articles published in 2009-2018. The articles were searched in PubMed and Web of Science. Results: Nine studies were reviewed (seven experimental and two observations studies). Six studies showed complete or partial reduction of cortisol levels. An experimental and two observation studies did not show significantly lower cortisol levels. Partially improved mood and cognitive ability were seen. Conclusions: Decreased cortisol levels in yoga practice were observed. However, there were studies that did not show decreased cortisol levels and the studies have shortcomings that lower the strength of evidence. Better studies are needed to establish a relationship.