El conocimiento de la presencia del dolor en los animales por parte de los veterinarios se ha incrementado en los últimos años. Existen diversos métodos para evaluar dolor y el grado de estrés siendo uno de estos la relación Neutrófilo: Linfocitos (N:L) y Eosinófilos. El objetivo de este estudio fue determinar la variación del ratio neutrófilo: linfocito y eosinófilos con relación a la presencia de estrés en pacientes caninos sometidos a Orquiectomía; a los cuales se les evaluó mediante toma de muestra sanguínea en diferentes etapas de la cirugía (inicio y final) de acuerdo a las variables: grupo de cirujano (docentes, médico veterinario particular y alumno), y clasificación ASA (ASA I, II y III) Los resultados indicaron que de los 25 pacientes; el 56 % (14/25) presentaron estrés al término de la cirugía; siendo el grupo de Cirujano 3 (alumnos) el que presentó el mayor porcentaje de pacientes estresados 87.5% (7/8) a la finalización la cirugía. Los resultados de acuerdo al ASA quirúrgica mostraron un mayor porcentaje de estrés en el ASA 1. Es así que se comprobó la presencia de estrés postquirúrgico en la mayoría de los pacientes en estudio, recomendándose realizar un monitoreo más exhaustivo de constantes vitales en los diferentes procedimientos quirúrgicos y clasificaciones ASA, empleando las diferentes fichas de monitoreo incluyendo la medición de dolor.Knowledge of the presence of pain in animals by veterinarians has increased in recent years. There are various methods to evaluate pain and the degree of stress being one of these the ratio Neutrophil: Lymphocytes (N: L) and Eosinophils. The objective of this study was determined the variation of neutrophil:lymphocyte ratio and eosinophils in relation of stress presence in canines patients undergoing orchiectomy surgery, evaluating through a simple blood test at different stages of surgery (beginning and end) according to variables: group of surgeon: (professors, private veterinarian and students) considering the ASA clasification (ASA I,II y III). The results of the 25 patients indicated 56% (14/25) had stress at the end of surgery; being the group of Surgeon 3 (students) who had the highest percentage of 87.5% stressed patients (7/8) at the end of surgery. The surgical ASA´s showed a higher percentage of stress in the ASA 1. The presence of post-surgical stress was verified in patients under investigation, recommending a more comprehensive monitoring of vital signs in different surgical procedures and ASA classifications, using the different tabs monitoring including of the measurement of pain.

Made available in DSpace on 2014-06-11T19:23:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-08-30Bitstream added on 2014-06-13T20:10:41Z : No. of bitstreams: 1 dias_bp_me_araca.pdf: 394360 bytes, checksum: 6ce31366bd34a531d11d750f0d95e3ed (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Objetivou-se avaliar os efeitos hemogasométricos, cardiorrespiratórios, qualidade da recuperação, alterações na motilidade gastrointestinal e cortisol plasmático de equinos submetidos à orquiectomia e anestesiados com isofluorano associado à infusão continua de butorfanol. Foram utilizados doze equinos adultos, distribuídos em dois grupos dois grupos, butorfanol (GB) e controle (GC). Os animais foram pré-medicados com xilazina, induzidos com quetamina associada ao midazolam e mantidos com isofluorano. Ao GB foi administrado butorfanol (0, 025 mg/kg IV) em bolus seguido de por infusão continua do fármaco (13µg/kg/h). As observações das variáveis foram feitas no momento basal e a cada 15 minutos por 75 minutos. Foi constatada redução na FC no M45 e M75 no GC e no M45 e M60 no GB comparados ao M0. A PAS, no GC, aumentou no M30 e M45 comparado ao M0. Já a PAD e PAM aumentaram em ambos os grupos quando comparadas ao valor basal. Houve redução da motilidade gastrointestinal por 60 minutos no GB. Foi observada elevação do cortisol plasmático em M60 e T30 em relação ao M0 em ambos os grupos. Os resultados obtidos permitiram concluir que a infusão contínua de butorfanol em equinos anestesiados pelo isofluorano promove discreta redução na motilidade gastrointestinal / The aim of this study was to evaluate the blood gases, cardiorespiratory effects, quality of recovery, changes in intestinal motility and plasma cotisol in isoflurane-anesthetized horses associated to continuous rate infusion of butorphanol and submitted to orchiectomy. Twelve adult horses distributed into two groups (BG) and control group (CG). The animals were premedicated with xylazine, induced with ketamine combined with midazolam and maintained with isoflurane. In the BG, butorphanol (0.025 mg-1 kg-1 IV) was administered followed by continuous rate infusion (13µg-1kg-1hour) of the opiod. Observations of the variables were carried out at baseline and every 15 minutes during 75 minutes. Reduction in HR was observed in M45 and M75 in the CG and M45 and M60 in BG compared to M0. The SAP increased in the CG at M30 and M45 compared to M0 whereas DAP and MAP increased in both groups compared to baseline. PaO2 and RT decreased over time in both groups. There was a reduction of gastrointestinal motility by 60 minutes in GB. And plasma cortisol was higher in M60 and T30 than M0 in both groups. The results allow conclude that the continuous rate infusion of butorphanol in horses anesthetized with isoflurane a modest intestinal motility reduction

Orientador: Paulo Sérgio Patto dos Santos / Banca: Newton Nunes / Banca: Valéria Nobre Leal de Souza Oliva / Resumo: Objetivou-se avaliar os efeitos hemogasométricos, cardiorrespiratórios, qualidade da recuperação, alterações na motilidade gastrointestinal e cortisol plasmático de equinos submetidos à orquiectomia e anestesiados com isofluorano associado à infusão continua de butorfanol. Foram utilizados doze equinos adultos, distribuídos em dois grupos dois grupos, butorfanol (GB) e controle (GC). Os animais foram pré-medicados com xilazina, induzidos com quetamina associada ao midazolam e mantidos com isofluorano. Ao GB foi administrado butorfanol (0, 025 mg/kg IV) em bolus seguido de por infusão continua do fármaco (13µg/kg/h). As observações das variáveis foram feitas no momento basal e a cada 15 minutos por 75 minutos. Foi constatada redução na FC no M45 e M75 no GC e no M45 e M60 no GB comparados ao M0. A PAS, no GC, aumentou no M30 e M45 comparado ao M0. Já a PAD e PAM aumentaram em ambos os grupos quando comparadas ao valor basal. Houve redução da motilidade gastrointestinal por 60 minutos no GB. Foi observada elevação do cortisol plasmático em M60 e T30 em relação ao M0 em ambos os grupos. Os resultados obtidos permitiram concluir que a infusão contínua de butorfanol em equinos anestesiados pelo isofluorano promove discreta redução na motilidade gastrointestinal / Abstract: The aim of this study was to evaluate the blood gases, cardiorespiratory effects, quality of recovery, changes in intestinal motility and plasma cotisol in isoflurane-anesthetized horses associated to continuous rate infusion of butorphanol and submitted to orchiectomy. Twelve adult horses distributed into two groups (BG) and control group (CG). The animals were premedicated with xylazine, induced with ketamine combined with midazolam and maintained with isoflurane. In the BG, butorphanol (0.025 mg-1 kg-1 IV) was administered followed by continuous rate infusion (13µg-1kg-1hour) of the opiod. Observations of the variables were carried out at baseline and every 15 minutes during 75 minutes. Reduction in HR was observed in M45 and M75 in the CG and M45 and M60 in BG compared to M0. The SAP increased in the CG at M30 and M45 compared to M0 whereas DAP and MAP increased in both groups compared to baseline. PaO2 and RT decreased over time in both groups. There was a reduction of gastrointestinal motility by 60 minutes in GB. And plasma cortisol was higher in M60 and T30 than M0 in both groups. The results allow conclude that the continuous rate infusion of butorphanol in horses anesthetized with isoflurane a modest intestinal motility reduction / Mestre