Proefschrift Maastricht. / Met lit. opg. - Met samenvatting in het Engels.

Thesis (Ph. D.)--Göteborg University, 1983. / Added t.p. inserted. Includes bibliographical references (p. 194-203).

Motivation Soluble urokinase plasminogen activator receptor (suPAR) is a known inflammatory marker, which is found in various body fluids. SuPAR reflects the immune and pro–inflammatory status of patients caused by HIV and tuberculosis, amongst others. However, recent studies have shown that suPAR is related to cardiovascular function. The cardiovascular health of the black South African population is a major health concern as this group suffers mostly from hypertension and stroke, leading to an alarming increase in cardiovascular morbidity and mortality. SuPAR may be able to contribute to early detection and prevention of cardiovascular diseases. No studies regarding the associations of suPAR with cardiovascular function have been investigated on black South Africans. Objectives To investigate suPAR as a possible marker of cardiovascular function in African and Caucasian men and women, by determining possible gender and ethnic–specific associations of suPAR with cardiovascular function. Methodology There were 207 African and 314 Caucasian men and women (aged 20–79 yrs.) included in this study. High–sensitivity C–reactive protein, glucose, lipids and creatinine were determined in fasting serum and suPAR was analyzed in plasma samples. Blood pressure was measured using the OMRON apparatus (HEM–747), with a 5–min rest interval between measurements. The Finometer device was used to determine the Windkessel compliance and the carotid dorsalis–pedis pulse wave velocity (PWV) was measured with the Complior (SP acquisition system) on the left side of each subject in the supine position. The means, adjusted means and proportions were compared between the groups by using independent t–tests, analysis of co–variance and the chi–square test, respectively. Associations were investigated between cardiovascular variables and suPAR using single and multiple regression analyses with either pulse wave velocity, systolic blood pressure, diastolic blood pressure or Windkessel compliance as dependent variable. Covariates included were age, body mass index, smoking, alcohol use, physical activity, glucose and high–density lipoprotein cholesterol. Results and conclusion SuPAR levels were significantly higher in Africans (P<0.001) compared to Caucasians. After adjusting for body mass index, suPAR increased significantly with age in all groups, except for African women. Moreover, the suPAR levels of African men and women were significantly higher than the Caucasians within each age quartile. While adjusting for age and body mass index, the cardiovascular profiles of the African and Caucasian men were less favourable compared to women, but suPAR levels were significantly higher in Caucasian women compared to men. In single regression, various measures of cardiovascular function correlated with suPAR in African men and Caucasian men and women. After adjusting for confounders the associations disappeared in Caucasian women, and remained nonsignificant in the African women. However, the association between PWV and suPAR remained significant in African men (B=0.19; P=0.030), while the association of systolic blood pressure (B=0.20; P=0.017), diastolic blood pressure (B=0.17; P=0.020) and Windkessel compliance (B=–0.14; P=0.004) with suPAR remained significant in Caucasian men. In conclusion, Africans presented higher suPAR levels compared to Caucasians, even when stratified by age. Gender specific associations indicated that suPAR was associated with arterial stiffness in African and Caucasian men only, therefore, indicating that suPAR could be a possible biomarker for predicting cardiovascular dysfunction. / Thesis (M.Sc. (Physiology))--North-West University, Potchefstroom Campus, 2011.

Motivation Soluble urokinase plasminogen activator receptor (suPAR) is a known inflammatory marker, which is found in various body fluids. SuPAR reflects the immune and pro–inflammatory status of patients caused by HIV and tuberculosis, amongst others. However, recent studies have shown that suPAR is related to cardiovascular function. The cardiovascular health of the black South African population is a major health concern as this group suffers mostly from hypertension and stroke, leading to an alarming increase in cardiovascular morbidity and mortality. SuPAR may be able to contribute to early detection and prevention of cardiovascular diseases. No studies regarding the associations of suPAR with cardiovascular function have been investigated on black South Africans. Objectives To investigate suPAR as a possible marker of cardiovascular function in African and Caucasian men and women, by determining possible gender and ethnic–specific associations of suPAR with cardiovascular function. Methodology There were 207 African and 314 Caucasian men and women (aged 20–79 yrs.) included in this study. High–sensitivity C–reactive protein, glucose, lipids and creatinine were determined in fasting serum and suPAR was analyzed in plasma samples. Blood pressure was measured using the OMRON apparatus (HEM–747), with a 5–min rest interval between measurements. The Finometer device was used to determine the Windkessel compliance and the carotid dorsalis–pedis pulse wave velocity (PWV) was measured with the Complior (SP acquisition system) on the left side of each subject in the supine position. The means, adjusted means and proportions were compared between the groups by using independent t–tests, analysis of co–variance and the chi–square test, respectively. Associations were investigated between cardiovascular variables and suPAR using single and multiple regression analyses with either pulse wave velocity, systolic blood pressure, diastolic blood pressure or Windkessel compliance as dependent variable. Covariates included were age, body mass index, smoking, alcohol use, physical activity, glucose and high–density lipoprotein cholesterol. Results and conclusion SuPAR levels were significantly higher in Africans (P<0.001) compared to Caucasians. After adjusting for body mass index, suPAR increased significantly with age in all groups, except for African women. Moreover, the suPAR levels of African men and women were significantly higher than the Caucasians within each age quartile. While adjusting for age and body mass index, the cardiovascular profiles of the African and Caucasian men were less favourable compared to women, but suPAR levels were significantly higher in Caucasian women compared to men. In single regression, various measures of cardiovascular function correlated with suPAR in African men and Caucasian men and women. After adjusting for confounders the associations disappeared in Caucasian women, and remained nonsignificant in the African women. However, the association between PWV and suPAR remained significant in African men (B=0.19; P=0.030), while the association of systolic blood pressure (B=0.20; P=0.017), diastolic blood pressure (B=0.17; P=0.020) and Windkessel compliance (B=–0.14; P=0.004) with suPAR remained significant in Caucasian men. In conclusion, Africans presented higher suPAR levels compared to Caucasians, even when stratified by age. Gender specific associations indicated that suPAR was associated with arterial stiffness in African and Caucasian men only, therefore, indicating that suPAR could be a possible biomarker for predicting cardiovascular dysfunction. / Thesis (M.Sc. (Physiology))--North-West University, Potchefstroom Campus, 2011.

Thesis (Ph. D.)--Göteborg University, 1983. / Added t.p. inserted. Includes bibliographical references (p. 194-203).

The increase in the life expectancy of natural persons has become a worldwide phenomenon. People live longer and need income for longer periods of time. Individuals need to start saving for their retirement early in life while still part of the workforce. Insufficient retirement savings lead to individuals not having sufficient income for their retirement. People become dependent on the government for assistance in paying for their day-to-day living expenses, leading to increases in social grants payable by the government. In South Africa the National Treasury needs to budget through taxation for the increase in the old age pension, which increases government expenditure. Additional income tax will therefore need to be raised to ensure that the national deficit does not increase further. Personal income taxes will directly be affected by the increase in the life expectancy. Research has been done internationally on the increase in life expectancy and the possible effect on the governments of those countries. No research has, however, been done in such detail in South Africa. This study provided information on the increase in the life expectancy of the South African population and the effect on the increase of old age pension as a social grant expense paid by the Government to qualifying beneficiaries. The aim of this study was to gain insight in the increase in the number of elderly people, those individuals aged 60 years and older, and the relation between this increase and the increase in the number of old age pension beneficiaries together with the increase in the budgeted expenses by the Government for old age pension. From a theoretical perspective, this study aimed to identify the possibility of increasing the retirement age to help people receive an income from employment for longer and to provide for themselves during the longer years in retirement. Finally the study aimed to assess this impact on taxation. A number of factors play a role in the increase of the number of old age pension beneficiaries and the resulting old age pension expense in the government budget. This study only focused on the role that the increase in life expectancy plays. AFRIKAANS : Die toename in die lewensverwagting van natuurlike persone het ’n wêreldwye verskynsel geword. Mense leef langer en moet ’n inkomste vir ’n baie langer tydperk hê. Individue moet reeds vroeg, terwyl hulle nog deel is van die werksmag, begin spaar vir hul aftrede. Onvoldoende aftreefondse lei daartoe dat pensioenarisse nie voldoende inkomste tydens hul aftrede verdien nie. Hierdie tekort lei daartoe dat individue afhanklik is van die regering om hulle by te staan vir die betaling van daaglikse uitgawes. Dit lei tot die verhoging in die maatskaplike toelaes wat deur die regering betaal word. In Suid-Afrika moet die Nasionale Tesourie in die begroting voorsiening maak vir die toename in die ouderdomspensioen wat tot ’n toename in regeringsuitgawes lei. Ekstra inkomste moet ook verkry word om te verseker dat die nasionale tekort nie verder toeneem nie. Persoonlike inkomstebelasting word regstreeks hierdeur beïnvloed. Internasionale navorsing is gedoen op die toename in lewensverwagting en die moontlike invloed op die regerings van daardie lande. Soortgelyke navorsing is egter nog nie in Suid-Afrika gedoen nie. Dié studie bied meer inligting oor die toename in lewensverwagting van die Suid-Afrikaanse bevolking en die effek daarvan op die toename in die ouderdomspensioen as ’n maatskaplike toelaag wat deur die regering betaal word aan begunstigdes wat daarvoor kwalifiseer. Die doel van hierdie studie was om insig te verkry in die toename in die aantal bejaardes, individue van 60 jaar en ouer, en die verwantskap tussen hierdie toename en die toename in die aantal ouderdomspensioen begunstigdes asook die begrote regeringsuitgawe vir ouderdomspensioene. Die studie het gepoog om vanuit ’n teoretiese oogpunt te kyk na die moontlikheid om die aftreeouderdom te verhoog sodat mense langer inkomste kan verdien en vir hulleself kan sorg in die langer aftreetydperk. Die studie het ook gekyk na die invloed hiervan op belasting. Verskeie faktore speel ’n rol in die groei van die aantal individue wat ouderdomspensioen ontvang en gepaardgaande toename in die ouderdomspensioenbegroting van die regering. Die studie het slegs gefokus op die rol wat die verhoging in lewensverwagting speel. / Dissertation (MCom)--University of Pretoria, 2012. / Taxation / unrestricted

As an employee in the South African Police Service, Family Violence, Child Protection Unit the researcher has noticed that there is an increase in the number of rape incidents in children. This became evident from the intake statistics which indicate that there is an estimate of 15 children per month from the Queenstown district who reported incidents of alleged sexual abuse and/ or rape at the offices of the Family Violence Child Protection Unit during 2009. The number of intakes at the Family Violence, Child Protection Unit increased even more after an awareness campaign on sexual abuse and rape was launched in the Queenstown area. Out of these office statistics it is clear that the phenomenon of child sexual abuse and rape is a very serious problem in Queenstown. Unfortunately no research is available regarding the unique situation of victims in the specific geographical area that contributes to the high incident levels. The aim of the research was to explore the nature of rape incidents involving children in the Queenstown area in order to assist social worker in this area to better understand possible risk factors contributing to child sexual abuse, as well as how to address the phenomenon better by means of effective prevention programmes and forensic social work services. Purposive sampling was conducted among forensic social workers and children from the caseload of the researcher who had been raped in the Queenstown area. This research reveals that children in the Queenstown area do not have adequate knowledge on child sexual abuse and rape. The children in this area are vulnerable because of many circumstances and become, therefore, victims of rape. Looking at the nature of rape incidents in the Queenstown area, there is a definite need for social workers with specialized knowledge, skills and experience regarding forensic social work who can render services to children who were raped. / MSW (Forensic Practice), North-West University, Potchefstroom Campus, 2014

As an employee in the South African Police Service, Family Violence, Child Protection Unit the researcher has noticed that there is an increase in the number of rape incidents in children. This became evident from the intake statistics which indicate that there is an estimate of 15 children per month from the Queenstown district who reported incidents of alleged sexual abuse and/ or rape at the offices of the Family Violence Child Protection Unit during 2009. The number of intakes at the Family Violence, Child Protection Unit increased even more after an awareness campaign on sexual abuse and rape was launched in the Queenstown area. Out of these office statistics it is clear that the phenomenon of child sexual abuse and rape is a very serious problem in Queenstown. Unfortunately no research is available regarding the unique situation of victims in the specific geographical area that contributes to the high incident levels. The aim of the research was to explore the nature of rape incidents involving children in the Queenstown area in order to assist social worker in this area to better understand possible risk factors contributing to child sexual abuse, as well as how to address the phenomenon better by means of effective prevention programmes and forensic social work services. Purposive sampling was conducted among forensic social workers and children from the caseload of the researcher who had been raped in the Queenstown area. This research reveals that children in the Queenstown area do not have adequate knowledge on child sexual abuse and rape. The children in this area are vulnerable because of many circumstances and become, therefore, victims of rape. Looking at the nature of rape incidents in the Queenstown area, there is a definite need for social workers with specialized knowledge, skills and experience regarding forensic social work who can render services to children who were raped. / MSW (Forensic Practice), North-West University, Potchefstroom Campus, 2014

Text in Afrikaans / Hierdie navorsing handel oor ouderdom en geslag as veranderlikes in die salutogenese paradigma. Die salutogenese paradigma het sy ontstaan en ontwikkeling aan verskeie navorsingsperspektiewe te danke. Daar is reeds op internasionale gebied breedvoerig navorsing oor hierdie paradigma gedoen. In die Suid-Afrika is die navorsing van Strumpfer en Wissing goed bekend. In hierdie navorsing is daar deur middel van faktorontleding gepoog om die onderliggende dimensies van die konstrukte gevoel van koherensie en geharde persoonlikheid bloot te le. Daar is onderskeidelik twee duidelike faktore vir beide konstrukte bepaal. Die faktore op die Lewensorientasievraelys (OLQ) het noue ooreenstemming getoon met die komponente betekenisvolheid en hanteerbaarheid (OLQ1 ), en verstaanbaarheid (OLQ2) soos deur Antonovsky (1987) bespreek. Die faktore op die "Personal Views Survey" (PVS) het ooreenstemming getoon met die komponente verbintenis en beheer (PVS1) en uitdaging (PVS2), soos deur Kobasa (1979) daargestel. Hierdie navorsingsresultate toon verder dat ouderdom wel die mate van gevoel van koherensie wat 'n individu mag ervaar, kan be"invloed. Alhoewel geslag in 'n mindere mate 'n invloed op die mate van gevoel van koherensie getoon het, behoort geslag (in perspektief van die totale steekproef beskou) nie 'n bepalende invloed uit te oefen nie. In terme van die mate van geharde persoonlikheid wat 'n individu mag ervaar, het ouderdom en geslag geen invloed getoon nie. Daar is ook geen interaksie-effek tussen ouderdom en geslag en die onderskeie konstrukte vasgestel nie. / This research project deals with age and gender as variables in the salutogenesis paradigm. The salutogenesis paradigm owes its origin and development to various research projects. Research in the international field has already been done on this paradigm on a wide sphere. The research of Strumpfer and Wissing is well known in South Africa. In this area of research an attempt is made through the analysis of factors to expose the underlying dimensions of the construct sense of coherence and the construct hardy personality. Two certain factors for both constructs have been indicated. The factors influencing the Orientation to Life Questionnaire indicated a close resemblance with the components of meaningfulness and manageability (OLQ1), and comprehensibility (OLQ2), discussed by Antonovsky (1987). The factors of the Personal Views Survey (PVS) demonstrated a similarity with the components commitment and control (PVS 1) and challenge (PVS2), as stated by Kobasa (1979). The results of this research demonstrates that age may well influence the measure of the sense of coherence which an individual may experience. Although gender indicated a minor measure of influence on the degree of sense of coherence, gender should not (in perspective of this research findings) have a deciding influence. Age and gender indicated no deciding influence in the measure of hardy personality experienced by an individual. Age and gender did not manifest any interaction in the various constructs. / Industrial and Organisational Psychology / M. Com. (Bedryfsielkunde)

Background: In 2007 the population density for the Gauteng Province was 614 persons per km2 and in the Northern Cape Province it was 2.9 persons per km2 . High population density leads to an increase in crime. This was evident in the percentage distribution of total crime reported from 2000 to 2003 of 27.4% in Gauteng Province, while the percentage distribution of total crime reported in the Northern Cape for the same period of time was 2,8%. Stress and insomnia can be caused by crime which is influenced by population density. Crime and high population density, may cause stress and fear, which may lead to insomnia and anxiety, which in turn may lead to an increase in benzodiazepine usage. Objective: The general objective of this study was to investigate the benzodiazepine usage in the private health care sector in South Africa based on age, sex, geographical areas, prescriber type and days between refills. Methods: The data were obtained from a medicine claims database of a pharmacy benefit management company covering the periods from 1 January 2006 to 31 December 2006 and 1 January 2008 to 31 December 2008. The statistical analysis was performed by making use of the Statistical Analysis System®. A drug utilisation review was performed. Results: Patients claiming benzodiazepines represented about 7.25% of all patients in total database in 2006 and 7.97% in 2008. Female patients claimed more benzodiazepines than male patients in both Gauteng (67.24% in 2006 & 67.36% in 2008 respectively) and Northern Cape Province (67.77% in 2006 & 67.70% in 2008 respectively). Patients aged 40 years to 65 years claimed the highest number of benzodiazepine items, while patients younger than 12 years claimed the lowest number of benzodiazepine items. The number of patients that claimed benzodiazepines in the Northern Cape was lower than those in Gauteng. The percentage of patients that claimed benzodiazepines in 2006 was 7.91% in Gauteng versus 8.96% in Northern Cape. In 2008 the percentage of patients that claimed benzodiazepines was 8.47% in Gauteng versus 9.51% in Northern Cape. The percentage of benzodiazepine prescriptions claimed in Gauteng was 4.79% in 2006 and 5.10% in 2008. In the Northern Cape the percentages of benzodiazepine prescriptions claimed in 2006 and 2008 were 4.62% and 4.30% respectively. General medical practitioners prescribed most of the benzodiazepine prescriptions in both Northern Cape and Gauteng Province. Trade name products that were mostly prescribed in the Gauteng was Adco–Alzam® 0.5 mg and in the Northern Cape it was Brazepam® 3 mg for both 2006 and 2008. Conclusion: The difference in the prescribing patterns of benzodiazepines in Gauteng and the Northern Cape was not statistically significant. Recommendations for future research were made. / Thesis (M.Pharm (Pharmacy Practice))--North-West University, Potchefstroom Campus, 2011.