O ensino superior é considerado, atualmente, o precursor do desenvolvimento econômico e social dos países. Para desempenhar esse papel, as universidades têm buscado novas formas de gestão. Para auxiliá-las nesta missão, o planejamento estratégico tornou-se uma ferramenta importante neste sentido, utilizado tanto em instituições privadas quanto em públicas. As Instituições Federais de Ensino Superior (IFES) possuem o planejamento elaborado por meio de um modelo de Plano de Desenvolvimento Institucional (PDI) proposto pelo governo. No entanto, apesar dessa estrutura ser considerada como o planejamento estratégico, as universidades não se apropriam desse formato. Nesse cenário, as IFES carecem de um processo de planejamento que contemple as suas características. Dado isso, o objetivo desta dissertação é propor um modelo de processo de planejamento estratégico para IFES. Para atingir o objetivo, foram desenvolvidos três artigos. No primeiro artigo, foi elaborada uma revisão da literatura a fim de responder questões que embasem a proposição do modelo, enquanto no segundo artigo foi realizada uma análise documental acerca de PDIs e de Planos de Gestão (PGs) das IFES, a partir da qual foram identificados o relacionamento entre estes planos e as possíveis influências das variáveis no processo de planejamento sob as constatações detectadas na análise. Por fim, no terceiro artigo foi proposto o modelo de processo de planejamento completo, através de um estudo de caso com grupos focados aplicado em uma IFES. Como conclusão geral, identificaram-se elementos estratégicos que foram propostos com mais frequência em universidades. Confirmou-se que o modelo proposto pelo governo não atende a estas universidades, e verificou-se que os planos utilizados nas IFES não possuem elementos estratégicos. Além disso, identificaram-se as variáveis que podem influenciar o processo de planejamento estratégico e suas possíveis influências no caso em estudo. Por fim, propôs-se um modelo de processo de planejamento adaptado ao contexto das IFES, além das dinâmicas que podem ser utilizadas em cada fase desse processo. / Higher education is, nowadays, considered the precursor of economic and social development of the countries. To play this role, universities have been seeking new forms of management. To help them in this mission, the strategic planning has become a important tool in this sense, used in both private and public enterprises. The Brazilian public universities, particularly the federal ones, IFES, already have their planning drawn up by an Institutional Development Plan model (PDI) proposed by the government. However, despite this structure have been considered strategic planning, universities do not appropriated of this format. In this scenario, the IFES lack of a planning process that incorporates their characteristics. Given this, the aim of this work is to propose a strategic planning process model for IFES. To achieve this goal, we have developed three articles. In the first article, a literature review was undertaken to answer questions that could support the model proposition, while in the second article, through a documentary analysis about PDIs and Management Plans (PGs) made by IFES, by which were identified the possible relationships between these plans and the impact of variables that affect the planning process under the findings detected in the analysis. Finally in the third article, it was proposed a planning process model itself, through a case study with focus groups applied to an university. As a general conclusion, we identified strategic elements that were proposed with more often in universities. It was confirmed that the model proposed by the government does not meet the necessities of these universities, and found that the plans used in IFES have no strategic elements. In addition, we identified the variables that could affect the strategic planning and the impacts of these on the institutions under study. Finally, it was proposed a planning process model adapted to the reality of IFES in addition with the dynamics that can be used in each stage of this process.

O ensino superior é considerado, atualmente, o precursor do desenvolvimento econômico e social dos países. Para desempenhar esse papel, as universidades têm buscado novas formas de gestão. Para auxiliá-las nesta missão, o planejamento estratégico tornou-se uma ferramenta importante neste sentido, utilizado tanto em instituições privadas quanto em públicas. As Instituições Federais de Ensino Superior (IFES) possuem o planejamento elaborado por meio de um modelo de Plano de Desenvolvimento Institucional (PDI) proposto pelo governo. No entanto, apesar dessa estrutura ser considerada como o planejamento estratégico, as universidades não se apropriam desse formato. Nesse cenário, as IFES carecem de um processo de planejamento que contemple as suas características. Dado isso, o objetivo desta dissertação é propor um modelo de processo de planejamento estratégico para IFES. Para atingir o objetivo, foram desenvolvidos três artigos. No primeiro artigo, foi elaborada uma revisão da literatura a fim de responder questões que embasem a proposição do modelo, enquanto no segundo artigo foi realizada uma análise documental acerca de PDIs e de Planos de Gestão (PGs) das IFES, a partir da qual foram identificados o relacionamento entre estes planos e as possíveis influências das variáveis no processo de planejamento sob as constatações detectadas na análise. Por fim, no terceiro artigo foi proposto o modelo de processo de planejamento completo, através de um estudo de caso com grupos focados aplicado em uma IFES. Como conclusão geral, identificaram-se elementos estratégicos que foram propostos com mais frequência em universidades. Confirmou-se que o modelo proposto pelo governo não atende a estas universidades, e verificou-se que os planos utilizados nas IFES não possuem elementos estratégicos. Além disso, identificaram-se as variáveis que podem influenciar o processo de planejamento estratégico e suas possíveis influências no caso em estudo. Por fim, propôs-se um modelo de processo de planejamento adaptado ao contexto das IFES, além das dinâmicas que podem ser utilizadas em cada fase desse processo. / Higher education is, nowadays, considered the precursor of economic and social development of the countries. To play this role, universities have been seeking new forms of management. To help them in this mission, the strategic planning has become a important tool in this sense, used in both private and public enterprises. The Brazilian public universities, particularly the federal ones, IFES, already have their planning drawn up by an Institutional Development Plan model (PDI) proposed by the government. However, despite this structure have been considered strategic planning, universities do not appropriated of this format. In this scenario, the IFES lack of a planning process that incorporates their characteristics. Given this, the aim of this work is to propose a strategic planning process model for IFES. To achieve this goal, we have developed three articles. In the first article, a literature review was undertaken to answer questions that could support the model proposition, while in the second article, through a documentary analysis about PDIs and Management Plans (PGs) made by IFES, by which were identified the possible relationships between these plans and the impact of variables that affect the planning process under the findings detected in the analysis. Finally in the third article, it was proposed a planning process model itself, through a case study with focus groups applied to an university. As a general conclusion, we identified strategic elements that were proposed with more often in universities. It was confirmed that the model proposed by the government does not meet the necessities of these universities, and found that the plans used in IFES have no strategic elements. In addition, we identified the variables that could affect the strategic planning and the impacts of these on the institutions under study. Finally, it was proposed a planning process model adapted to the reality of IFES in addition with the dynamics that can be used in each stage of this process.

Submitted by Erika Demachki (erikademachki@gmail.com) on 2017-03-23T20:39:38Z No. of bitstreams: 2 Dissertação - Denize Silva Brazil - 2017.pdf: 5061634 bytes, checksum: 34802ff0a8ca3775ced77fb220378cf1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-03-24T11:03:03Z (GMT) No. of bitstreams: 2 Dissertação - Denize Silva Brazil - 2017.pdf: 5061634 bytes, checksum: 34802ff0a8ca3775ced77fb220378cf1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-03-24T11:03:04Z (GMT). No. of bitstreams: 2 Dissertação - Denize Silva Brazil - 2017.pdf: 5061634 bytes, checksum: 34802ff0a8ca3775ced77fb220378cf1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-02-20 / Leptospirosis is an important zoonosis and it causes economic losses due to abortion, mastitis, infertility, and drop in milk production in affected herds. The disease may be disseminated through urine, water, contaminated soils, venereal and transplacental routes, and there is a risk of transmission by in vitro embryo manipulation. Thus, with the advancement of reproductive biotechnology, the concern with the sanity of animals or herds in the face of any disease also transmitted by semen or embryos has increased. As an alternative for the inactivation of infectious agents, the technique of photodynamic inactivation (PDI) has became prominent as it does not cause natural microbial resistance. The method consists in the combination of a photosensitizer (PS), light, and molecular oxygen, resulting in the formation of reactive oxygen species (ROS) that at high levels induce cell death. In this study, in order to inactivate in vitro Leptospira interrogans, six PSs were tested at a concentration of 10 μM and at the irradiation times of 30 and or 60 min. The TMPP and ZnTMPP porphyrins were efficient, the first one in the 30 min irradiation, the second one in both irradiation times. Methylene Blue (MB) demonstrated satisfactory inactivation when irradiated for 60 min. Hematoporphyrin and phthalocyanines did not demonstrate efficiency in the inactivation of leptospires in the experimental parameters used. When evaluating the action of ZnTMPP and MB on oocyte viability, both demonstrated to be innocuous to cumulus-oocyte (CCOs) complexes matured in the 30 min, which makes them potential candidates for the disinfection of biological materials or by-products of animal origin in place of antibiotics, known to cause bacterial resistance. / A leptospirose é uma importante zoonose e traz consideráveis perdas econômicas em decorrência de abortamentos, mastites, infertilidade e queda da produção de leite em rebanhos acometidos. A doença pode ser disseminada pela urina, água, solos contaminados, via venérea, transplacentária e há risco de transmissão pela manipulação de embriões in vitro. Dessa forma, com o avanço das biotécnicas reprodutivas, a preocupação com a sanidade de animais ou rebanhos frente a qualquer enfermidade também transmitida por sêmen ou embriões tem aumentado. Como alternativa para a inativação de agentes infecciosos, a técnica de inativação fotodinâmica (PDI) vem ganhando destaque por não causar resistência microbiana natural. O método consiste na combinação de um fotossensibilizador (PS), luz e oxigênio molecular, resultando na formação de espécies reativas de oxigênio (ROS) que em altos níveis induzem a morte celular. Neste trabalho, com o objetivo de inativar a Leptospira interrogans in vitro, seis PSs foram testados na concentração de 10 μM e em tempos de irradiações de 30 e ou 60 min. As Porfirinas TMPP e ZnTMPP mostraram-se eficientes, a primeira na irradiação de 30 min, a segunda em ambos os tempos de irradiação testados. O Azul de Metileno (MB) demonstrou uma inativação satisfatória quando irradiado por 60 min. Hematoporfirina e Ftalocianinas testadas não demostraram eficiência na inativação das leptospiras nos parâmetros experimentais analisados. Ao avaliar a ação da ZnTMPP e do MB sobre a viabilidade dos oócitos, ambos demonstraram ser inócuos aos complexos cumulusovócitos (CCO’s) maturados no tempo de 30 min, o que os torna potenciais candidatos à utilização para a desinfecção de materiais biológicos ou subprodutos de origem animal em substituição aos antibióticos, conhecidamente causadores de resistência bacteriana.

Currently the mammalian endoplasmic reticulum (ER) is known to contain at least 20 different protein disulphide isomerase (PDI) family members. The oxidoreductases in the PDI family are thought to catalyse the formation and rearrangement of disulphide bonds in newly synthesised proteins. The focus of this work was to characterise two of the PDI family members: PDI and ERp46. In vitro translation reactions of major histocompatibility complex (MHC), β1-integrin (β1-I), haemagglutinin (HA), procollagen α1(III) and preprolaction (pPL) were carried out in untreated or PDI-depleted cells. The depletion of PDI decreased the rate of folding of MHC and β1-I and also prevented the oligomerisation of HA, suggesting a role for PDI in folding these putative substrates. However, when PDI was depleted neither the folding of pPL or HA was affected, implying that they may not be substrates for PDI. To determine the role of ERp46 in the cell, a substrate-trapping approach was used. Here substrates interacting with ERp46 were trapped as mixed disulphides isolated by immunoprecipitation, separated by 2D SDS-PAGE and identified by mass spectrometry. It was demonstrated that ERp46 forms mixed disulphides with at least 23 proteins, including heavily secreted proteins such as laminins, integrins and collagens. In particular, interactions with Ero1, Prx IV, EDEM3 and ERAP2 were found and confirmed by immunoprecipitation of radiolabelled in vitro translated protein. Notably nine of these clients of ERp46 have previously been identified as substrates of ERp57 (Jessop, Watkins et al. 2009). This would support the hypothesis that several different oxidoreductases, working in concert, are required to fold certain substrate proteins. Also, it was confirmed that Prx IV and Ero1 each form a mixed disulphide with PDI. These results highlight the importance of PDI family members in recruiting co-factors to substrates. Additionally, the over-expression of ERp46 led to increased cell survival following DTT treatment, yet after depletion of ERp46, cells were less able to grow, perhaps suggesting a role for ERp46 in maintaining ER redox homeostasis and cell survival. This suggestion was supported by the finding that ERp46 is able to catalyse the reduction of Prx IV in the presence of glutathione. These results suggest that Prx IV provides a novel mechanism for the transfer of disulphide bonds to nascent proteins in the ER via PDI family members such as ERp46 and PDI.

This paper presents a general-purpose distributed lookup service, denoted Passive Distributed Indexing (PDI). PDI stores entries in form of (key, value) pairs in index caches located in each mobile device. Index caches are filled by epidemic dissemination of popular index entries. By exploiting node mobility, PDI can resolve most queries locally without sending messages outside the radio coverage of the inquiring node. Thus, PDI reduces network traffic for the resolution of keys to values. For keeping index caches coherent, configurable value timeouts implementing implicit invalidation and lazy invalidation caches implementing explicit invalidation are introduced. Inconsistency in index caches due to weak connectivity or node failure is handled by value timeouts. Lazy invalidation caches reduce the fraction of stale index entries due to modified data at the origin node. Similar to index caches, invalidation caches are filled by epidemic distributions of invalidation messages. Simulation results show that with the suitable integration of both invalidation mechanisms, more than 95% of results delivered by PDI index caches are up-to-date for the considered scenario.

This paper presents a general-purpose distributed lookup service, denoted Passive Distributed Indexing (PDI). PDI stores entries in form of (key, value) pairs in index caches located at mobile devices. Index caches are filled by epidemic dissemination of popular index entries. By exploiting node mobility, PDI can resolve most queries locally without sending messages outside the radio coverage of the inquiring node. For keeping index caches coherent, configurable value timeouts implementing implicit invalidation and lazy invalidation caches implementing explicit invalidation are introduced. Inconsistency in index caches due to weak connectivity or node failure is handled by value timeouts. Lazy invalidation caches reduce the fraction of stale index entries due to modified data at the origin node. Similar to index caches, invalidation caches are filled by epidemic distributions of invalidation messages. We evaluate the performance of PDI for a mobile P2P file sharing a mobile instant messaging application. Simulation results show that with the suitable integration of both invalidation mechanisms, up to 80% of the lookup operations return correct results and more than 90% of results delivered by PDI index caches are up-to-date.

The surface and interface of the metal nanoclusters and semiconducting nanomaterials play a key role in determining the electronic structure and overall photophysical properties. A single strand DNA stabilizes the metal nanoclusters, but it also influences the structural change, solvation free energy, and photophysical properties. On the other hand, surface and interface states in Pb and Cd chalcogenide nanomaterials affect the phonon mediated hot carrier relaxation. We applied DFT and DFT based non-adiabatic dynamics methods to study the surface and interface?s effects on the photoexcited processes. In the first part, we have studied the Ag nanoclusters' photophysical properties that are affected by the structural isomers, redox potential, nucleobase passivation, and cluster size. Ag nanoclusters are shown alternative reduction potential, which makes nanoclusters of singlet spin multiplicity thermodynamically favorable. Besides, the optically bright transition in the range of 2.5-3.5 eV is shown metal to ligand charge transfer. It is modulated by the s+p+d orbital mixing in the hole and electron states. We also simulate the charge transfer from the photoexcited PbS QD to organic dye (PDI) attached to the QD surface. Depending on the linker group and the dipole moment of neighboring passivating ligands, the PDI-QD conformations are varies. In response to structural change, the total dipole moment is modulated, changing its electronic structure and hence the photoexcited electron transfer rate from the PbS QD to PDI. We also investigate the inorganic-inorganic interactions in the PbCl2 bridged PbSe NPL and PbSe|CdSe Janus heterostructure. The energy dissipation rate of hot electrons is slower in NPL than the hot hole, while hot e-h relaxed to the band-edge by ?1.0ps in the QD. The slower relaxation rate is rationalized by a large average intraband energy difference and smaller coupling term. Besides, the hot carriers in the NPL are spatially separated by ?1.00 ps, which is a favorable condition for the carrier multiplication process. In Janus QD, (100) interfacial layer creates a structural mismatch in the CdSe part. Besides, the energy offset between the valance localized on PbSe and CdSe part is minimum in the PbSe Janus QD of an interface of (111) facet.

No description available.

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

The ability of a parent to step back from their own experiences in order to understand those of their child, reflective functioning (RF), can be impacted by myriad factors. We explored RF among refugee mothers in the context of having a child born of sexual violence (CBSV). A sample of 10 mothers now residing in the Netherlands, both with (n = 5) and without (n = 5) a CBSV, were interviewed, seeking to explore parents’ representations of their children, themselves as parents, and their relationship with their children. After deriving a score of RF, interview narratives were qualitatively analyzed using thematic analysis. An ordinary level of reflective functioning was identified in this sample overall (average score 4.5); which was reduced in the group with CBSV (average score 3.0). Trends within the qualitative analyses indicated that emotion regulation and ambivalence as well as parenting challenges are factors that affect RF capabilities for mothers with CBSV. Wider findings show that the asylum process and mental well-being also impinge on RF capabilities. Experiences of having a CBSV as well as those pertaining to being a refugee appear to interact and impact reflective functioning for some mothers. Further investigation would add weight to this pilot data.