Made available in DSpace on 2014-06-12T18:29:42Z (GMT). No. of bitstreams: 2 arquivo8033_1.pdf: 929551 bytes, checksum: 0f1414f3589d08e56ec275e932f164dc (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2005 / Glomerulopatia associada ao HIV (GNHIV) é causa de insuficiência renal crônica (IRC) na população portadora de HIV/AIDS. Entre negros americanos de 20 a 64 anos a GNHIV é a terceira causa de IRC. No Brasil não há levantamentos recentes sobre o assunto. Proteinúria persistente (PTp), especialmente acima de 1,5g nas 24h, é o principal marcador desta doença. Objetivo: Determinar a prevalência e fatores de risco para desenvolvimento de PTp, assim como sua associação com GNHIV. Metodologia: Foram incluídos todos os pacientes que compareceram à consulta regular no ambulatório de HIV/AIDS do HC/UFPE entre Janeiro e Junho de 2004. PTp foi determinada através de fita urinária reagente em pelo menos 2 ocasiões e esta foi quantificada através da relação proteína/creatinina urinária (RP/C). Foram comparadas as variáveis raça negra, nível de CD4<200cel/mm3, nível de carga viral>100.000cópias/mL e uso de anti-retrovirais potentes (ARVp) nos grupos com e sem PTp. Em relação ao nível de proteinúria os pacientes foram agrupados de acordo com RP/C urinária em < 1,0; entre 1,0 e 3,0 e > 3,0. Os pacientes com RP/C urinária > 3,0 foram submetidos a biópsia renal. Resultados: Foram estudados 411 pacientes com idade média de 37 anos e predominância do sexo masculino (70,3%). Cerca de 44,3% eram pardos, 37,5% negros e 18,2% brancos. O tempo médio de diagnóstico do HIV foi de 4,7 anos, o nível médio de linfócitos CD4 363cel/mm3 (DP 94,7) e carga viral média 44475cópias/mL (DP 40369). Creatinina sérica acima de 1,3mg/dl foi encontrada em 4,1% dos pacientes e 92,2% desta população estava em uso de ARVp. A prevalência de PTp foi de 5,6% (IC95%; 3,6% a 8,3%). Houve associação entre nível de CD4<200cel/mm3 e a presença de PTp (p<0,048); as demais variáveis analisadas, isto é, raça negra (p=0,784), nível de carga viral >100.000cópias/mL (p=0,787) e uso de ARVp (p=1,0) não mostraram associação. Dos pacientes com PTp, um apresentava forma clássica de GNHIV, um apresentava RP/C>3,0 e alterações podocitárias à histologia e outros dois pacientes apresentavam quadro compatível com GNHIV em remissão. Conclusões: A prevalência de PTp encontrada neste estudo foi 5,6%. Houve associação estatistística com o nível de CD4<200cel/mm3 nos grupos com e sem PTp. Apenas um paciente apresentava GNHIV e dois estavam em fase de remissão da glomerulopatia associada ao uso de ARVp

ITC/USA 2015 Conference Proceedings / The Fifty-First Annual International Telemetering Conference and Technical Exhibition / October 26-29, 2015 / Bally's Hotel & Convention Center, Las Vegas, NV / The network switch is a critical element in the flight test network. All devices in the network are configured, synchronised and managed via the switch. In addition to this all acquired data is routed through the switch. For these reasons, the flight test network switch has always needed to be rugged and reliable with high throughput and simple intuitive setup. Ethernet technology and the move towards open standards within FTI systems have enabled flight test networks to become increasingly flexible and heterogeneous. Modern FTI networks may have different synchronisation and data transmission protocols running simultaneously. It is also important to quickly switch network configurations for different flight profiles and to enable new features to be easily added to existing installations. This paper examines the increasing network interoperability and flexibility challenges and discusses how the network switch is best placed to provide solutions.

The research in this dissertation documents connections between the primary amino acid sequence of proteins, the dynamics of proteins, and their catalytic function. This research project studied two proteins called protein-tyrosine phosphatases (PTPs): the human enzyme PTP1B, and the bacterial enzyme YopH. PTP1B is a human enzyme that down regulates the insulin receptor on the outer cellular membrane, and causes the insulin receptor to be less responsive to insulin. A deeper knowledge of how PTP1B is different from other human PTPs might be useful in designing drugs to increase insulin sensitivity in diabetics. Yersinia Pestis is the bacteria that caused the Black Plague, and YopH is an essential for virulence factor that helps Yersinia Pestis to escape the human immune response. Using these proteins, the primary sequence of amino acids in a small but critical loop region was altered and the effect on the catalytic efficiency was measured. This research shows how some residues are key to the catalytic efficiency of PTPs while others could be changed with little to no effect on the catalytic efficiency. A deeper understanding of the difference between key residues and structural residues may allow future scientists to create designer enzymes and perhaps design pharmaceuticals that mediate enzyme activity by affecting their protein dynamics.

<p>The aim of this study is to, by individual interviews focusing on specific dimensions of supervision,</p><p>examine how integratively educated PTP-psychologists experience the interaction</p><p>in the supervision they receive as a part of their PTP-work and to describe if and how they</p><p>experience that these components of the supervision promote, does not exert a direct influence</p><p>on or restrain the preservation and development of an integrative psychotherapeutic</p><p>approach and -attitude. The eleven people who are interviewed for this study all belong to</p><p>the group of psychologists who graduated from the first group of psychologists with an integrative</p><p>psychotherapeutic approach at Örebro university in the year of 2007 and who are</p><p>now completing their PTP-work. The interviews were analysed according to a qualitative</p><p>content analysis. The results show that ten out of eleven PTP-psychologists experience that</p><p>the interaction in the supervision is either good or excellent and that this promotes or does</p><p>not exert a direct influence on the integrative approach.</p><p>Keywords: Supervision, PTP-psychologist, integrative approach.</p>

The aim of this study is to, by individual interviews focusing on specific dimensions of supervision, examine how integratively educated PTP-psychologists experience the interaction in the supervision they receive as a part of their PTP-work and to describe if and how they experience that these components of the supervision promote, does not exert a direct influence on or restrain the preservation and development of an integrative psychotherapeutic approach and -attitude. The eleven people who are interviewed for this study all belong to the group of psychologists who graduated from the first group of psychologists with an integrative psychotherapeutic approach at Örebro university in the year of 2007 and who are now completing their PTP-work. The interviews were analysed according to a qualitative content analysis. The results show that ten out of eleven PTP-psychologists experience that the interaction in the supervision is either good or excellent and that this promotes or does not exert a direct influence on the integrative approach. Keywords: Supervision, PTP-psychologist, integrative approach.

ITC/USA 2013 Conference Proceedings / The Forty-Ninth Annual International Telemetering Conference and Technical Exhibition / October 21-24, 2013 / Bally's Hotel & Convention Center, Las Vegas, NV / A Flight Test Instrumentation (FTI) system may consist of equipment that either supports PTPv1 (IEEE 1588 Std 2002) or PTPv2 (IEEE 1588 Std 2008). The challenge in such time distributed system is the poor compatibility between the two PTP protocol versions. This paper describes how to combine the PTP versions in the same network with minimum or no manual configuration.

In this thesis an investigation will be done on how time and frequency can be synchronized over Ethernet with help of Precision Time Protocol and Synchronous Ethernet. The goal is to achieve a high accuracy in the synchronization when a topology of 10 cascaded nodes is used. Different approaches may be used when implementing Precision Time Protocol for synchronization. They will be investigated and the best approach for a good accuracy will be proposed. Another question that this thesis will cover is how to recover a radio frequency, a multiple of 3.84 MHz from Ethernets 10.3125 GHz. By using hardware support for the timestamps and transparent clocks in the forwarding nodes the best accuracy is achieved for the time and phase synchronization. Combining this with Synchronous Ethernet for frequency synchronization, to get a traceable clock through the system, will lead to the best result. The total error does not need to be greater than 1.46~ns if the asymmetry in the medium is neglected and a welldesigned PCS and FIFO are used. Recovering the radio frequency from Ethernet is done by using the highest common frequency, either an integer phase locked loop or a fractional phase locked loop can be used. The fractional phase locked loop will give a better result but will contribute with spurs that the integer phase locked loop does not.

ITC/USA 2006 Conference Proceedings / The Forty-Second Annual International Telemetering Conference and Technical Exhibition / October 23-26, 2006 / Town and Country Resort & Convention Center, San Diego, California / Today’s data acquisition systems are typically comprised of data collectors connected to multiplexers via serial, point-to-point links. Data flows upstream from the sensors or avionics buses to the data acquisition units, to the multiplexer and finally to the recorder or telemetry transmitter. In a networked data acquisition system, data is transported through the network “cloud”. At the core of the network “cloud” is the network switch. The switch is responsible for distributing and directing data within the network. Network switches are commonplace in the commercial realm. Many businesses today could not function without them. A network-based data acquisition system, however, places additional burdens on the network switch. As in a commercial network, the switch in a data acquisition system must be able to distribute data packets within the network. In addition, it must be able to perform in a harsh environment, occupy a minimal amount of space, operate with limited or no external cooling, be configurable, and deal with the distribution of time information. This paper describes the required features of a ruggedized network switch and the implementation challenges facing its design. As a core component of a network-based data acquisition system, an ideal switch must be capable of operating in a large number of configurations, transporting and aggregating data between data sources and data sinks, with a mixture of devices operating at rates ranging from a few thousand bits per second to several gigabits per second, over twisted pair or fiber optic links. To ensure time coherency, the switch must also facilitate a time distribution mechanism, e.g., IEEE-1588 Precision Time Protocol (PTP). The gigabit switch described here uses the PTP to implement an end-to-end clock synchronization, for distributed acquisition nodes, to within 300 nanoseconds.

ITC/USA 2006 Conference Proceedings / The Forty-Second Annual International Telemetering Conference and Technical Exhibition / October 23-26, 2006 / Town and Country Resort & Convention Center, San Diego, California / One of the problems for manufacturers and users of flight test data acquisition equipment, is to guarantee synchronization between multiple units acquiring data on the vehicle. Past solutions have involved proprietary interconnects and multiple wire installations increasing weight and complexity and reducing inter-operation of units. This problem has become particularly important given the trend towards commercial busses, especially Ethernet, as a system interconnect. The IEEE1588 standard offers a way to transmitting time accurately over Ethernet. This paper discusses the standard, how it might be implemented, and examines the issues involved in adopting this standard for flight test data acquisition. A particular implementation that results in a synchronized four-wire Ethernet based distributed data acquisition system is discussed in section 3.

International Telemetering Conference Proceedings / October 22-25, 2001 / Riviera Hotel and Convention Center, Las Vegas, Nevada / CCSDS recommendations initially addressed the communication link between spacecraft and ground station. Space Link Extension (SLE) is a set of CCSDS recommended standards for extending the link to control centers, allowing distributed access to space link telecommand and telemetry services. The recommendations encompass the specification of both services and access methods. This paper discusses an implementation of SLE that will be used to provide Forward CLTU service to the upcoming INTEGRAL (International Gamma Ray Astrophysics Laboratory) mission.